PKCα tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1

Experimental Cell Research

Volumn 315, Issue 8, 2009, Pages 1415-1428

  Pysz, Marybeth A ^a   Leontieva, Olga V ^a   Bateman, Nicholas W ^a   Uronis, Joshua M ^b   Curry, Kathryn J ^a   Threadgill, David W ^b   Janssen, Klaus Peter ^c   Robine, Sylvie ^d   Velcich, Anna ^e   Augenlicht, Leonard H ^e   Black, Adrian R ^a   Black, Jennifer D ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d INSTITUT CURIE   (France)

^e MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

4E BP1; Colon cancer; Cyclin D1; Mouse models; Protein kinase C; Transcriptional control; catenin

Indexed keywords

APC PROTEIN; BETA CATENIN; CYCLIN D1; INITIATION FACTOR 4E BINDING PROTEIN 1; ISOENZYME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN SERINE THREONINE KINASE INHIBITOR; PROTEIN KINASE C;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL LINE; COLON CARCINOMA; COLON TUMOR; CONTROLLED STUDY; DOWN REGULATION; FETUS; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; STEADY STATE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOBLOTTING; INTESTINE TUMOR; METABOLISM; PATHOPHYSIOLOGY; PROMOTER REGION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CYCLIN D1; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOBLOTTING; INTESTINAL NEOPLASMS; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 64049104386     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.02.002     Document Type: Article

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