Protein Kinase C η is Associated with Progression of Renal Cell Carcinoma (RCC)

Anticancer Research

Volumn 23, Issue 5 A, 2003, Pages 4001-4006

  Brenner, Walburgis ^a   Färber, Gloria ^a   Herget, Thomas ^a   Wiesner, Christoph ^a   Hengstler, Jan G ^a   Thüroff, Joachim W ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Carcinoma; Isoenzymes; Protein kinase C; Renal cell; Western blot

Indexed keywords

ISOPROTEIN; PROTEIN KINASE C; PROTEIN SUBUNIT;

ARTICLE; ASSOCIATION; CANCER CELL; CANCER GRADING; CANCER GROWTH; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, RENAL CELL; DISEASE PROGRESSION; HUMANS; ISOENZYMES; KIDNEY NEOPLASMS; NEOPLASM STAGING; PROTEIN KINASE C;

EID: 0344874067     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Mellor H and Parker PJ: The extended protein kinase C superfamily. Biochem J 332: 281-292, 1998.
2. Brenner W, Gross S, Steinbach F, Horn S, Hohenfellner R and Thüroff JW: Differential inhibition of renal cancer cell invasion mediated by fibronectin, collagen IV and laminin. Cancer Letters 155: 199-205, 2000.
3. Oehrlein SA, Maelicke A and Herget T: Expression of protein kinase C gene family members is temporally and spatially regulated during neural development in vitro. Eur J Cell Biol 77: 323-337, 1998.
4. Goodnight J, Mischak H and Mushinski JF: Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation. Adv Cancer Res 64: 159-209, 1994.
5. Cacace AM, Ueffing M, Philipp A, Han EK, Kolch W and Weinstein IB: PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase. Oncogene 13: 2517-2526, 1993.
6. Lu Z, Hornia A, Jiang YW, Zang O, Ohno S and Foster DA: Tumor promotion by depleting cells of protein kinase C delta. Mol Cell Biol 17: 3418-3428, 1997.
7. Fukumoto S, Nishizawa Y, Hosoi M, Koyama H, Yamakawa K, Ohno S and Morii H: Protein kinase C delta inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J Biol Chem 272: 13816-13822, 1997.
8. Brooks G, Goss MW, East JA and Hart IR: Growth of melanocytic cells is associated with down-regulation of protein kinase C alpha, delta, and epsilon isoforms. Possible role of diacylglycerol. J Biol Chem 268: 23868-23875, 1993.
9. Manni A, Buckwalter E, Etindi R, Kunselman S, Rossini A, Mauger D, Dabbs D and Demers L: Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression. Cell Growth Differ 7: 1187-98, 1996.
10. Pongracz J, Clark P, Neoptolemos JP and Lord JM: Expression of protein kinase C isoforms in colorectal cancer tissue and their differential activation by different bile acids. Int J Cancer 61: 35-39, 1995.
11. Kuranami M, Powell CT, Hug H, Zeng Z, Cohen AM and Guillem JG: Differential expression of protein kinase C isoforms in human colorectal cancers. J Surg Res 58: 233-239, 1995.
12. Cornford P, Evans J, Dodson A, Parsons K, Woolfenden A, Neoptolemos J and Foster CS: Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. Am J Pathol 154: 137-144, 1999.
13. Reutzel D, Mende M, Naumann S, Storkel S, Brenner W, Zabel B and Decker J: Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization. Cytogenet. Cell Genet 93: 221-227, 2001.
14. Wittekind C and Wagner G: TNM Classification of Malignant Tumours. Fifth edition, J Wiley & Sons, New York. 171-173, 1997.
15. Brauch H, Weirich G, Brieger J, Glavac D, Rodl H, Eichinger M, Feurer M, Weidt E, Puranakanitstha C, Neuhaus C, Pomer S, Brenner W, Schirmacher P, Storkel S, Rotter M, Masera A, Gugeler N and Decker HJ: VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. Cancer Res 60: 1942-1948, 2000.
16. Schiffer IB, Gebhard S, Heimerdinger CK, Heling A, Hast J, Wollscheid U, Seliger B, Tanner B, Gilbert S, Beckers T, Baasner S, Brenner W, Sagemüller J, Spangenberg C, Prawitt D, Trost T, Schreiber WG, Zabel B, Thelen M, Oesch F and Hengstler JG: Switching off HER-2/neu in a tetracycline controlled mouse tumor model leads to apoptosis and tumor-size dependent remission. Cancer Res, accepted, 2003.
17. Brenner W, Färber G, Herget T, Lehr H-A, Hengstler JG and Thüroff JW: Loss of the tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer 99: 53-57, 2002.
18. von Mach M-A: Primary biliary cirrhosis in classmates: Coincidence or enigmatic environmental influence? EXCLI J 1: 1-7, 2002.
19. Hengstler JG, Tanner B, Möller L, Vydra M, Oesch F, Meinert R and Kaina B: Activity of O6-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer. Int J Cancer 84: 388-395, 1999.
20. von Mach M-A, Schlosser J, Weiland M, WEiland M, Feilen PJ, Ringel M, Hengstler JG, Weilemann SS, Beyer J, Kann P, Weber MM and Schneider S: Cryopreservation of islets of Langerhans: Optimization of protocols using rat pancreatic tissue. EXCLI J 2: 6-21, 2003.
21. Brenner W, Langer P, Oesch F, Edgell C-JS and Wieser R: Tumor cell - endothelium elium adhesion in an artificial venule. Anal Biochem 225: 213-219, 1995.
22. Fritz G, Hengstler JG and Kaina B: High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines. Cancer Res 57: 454-460, 1997.
23. Brenner W, Hempel G, Steinbach F, Hohenfellner R and Thüroff JW: Enhanced expression of ELAM-1 on endothelium of renal cell carcinoma compared to the corresponding normal renal tissue. Cancer Lett 143: 14-21, 1999.
24. Hengstler JG, Böttger T, Tanner B, Dietrich B, Henrich M, Knapstein PG, Junginger Th and Oesch F: Resistance factors in colon cancer tissue and the adjacent normal colon tissue: Glutathione S-transferase α and π, glutathione, and aldehyde dehydrogenase. Cancer Lett 128: 105-112, 1998.
25. Hengstler JG, Lange J, Kett A, Dornhöfer N, Meinert R, Arand M, Knapstein PG, Becker R, Oesch F and Tanner B: Contribution of c-erbB-2 and topoisomerase IIα to chemoresistance in ovarian cancer. Cancer Res 59: 3206-3214, 1999.
26. Fukuzaki A, Kaneto H, Ikeda S and Orikasa S: Characterization of protein kinase C expression in human kidney. Tohoku J Exp Med 178: 263-269, 1996.
27. Serlachius E, Svennilson J, Schalling M and Aperia A: Protein kinase C in the developing kidney: isoform expression and effects of ceramide and PKC inhibitors. Kidney Int 52: 901-910, 1997.
28. Suga K, Sugimoto I, Ito H and Hashimoto E: Down-regulation of protein kinase C-alpha detected in human colorectal cancer. Biochem Mol Biol Int 44: 523-528, 1998.
29. Hornia A, Lu Z, Sukezane T, Zhong M, Joseph T, Frankel P and Foster DA: Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Mol Cell Biol 19: 7672-7680, 1999.
30. Shen L and Glazer RI: Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Biochem Pharmacol 55: 1711-1719, 1998.
31. Goekjian PG and Jirousek MR: Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development. Curr Med Chem 6: 877-903, 1999.
32. Chisamore MJ, Ahmed Y, Bentrem DJ, Jordan VC and Tonetti DA: Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase C alpha. Clin Cancer Res 7: 3156-3165, 2001.
33. Schonwasser DC, Marais RM, Marshall CJ and Parker PJ: Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol 18: 790-798, 1998.
34. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9: 484-496, 1995.
35. de Thonel A, Bettaieb A, Jean C, Laurent G and Quillet-Mary A: Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells. Blood 98: 3770-3777, 2001.