Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols

Journal of Functional Foods

Volumn 34, Issue , 2017, Pages 139-151

  Puligundla, Pradeep ^a   Mok, Chulkyoon ^a   Ko, Sanghoon ^b   Liang, Jin ^c   Recharla, Neeraja ^b  

^a Gachon University   (South Korea)

^b Sejong University   (South Korea)

^c ANHUI AGRICULTURAL UNIVERSITY   (China)

Author keywords

Bioavailability; Green tea; Nanoencapsulation; Polyphenols; Solid lipid nanoparticle; Therapeutic efficacy

Indexed keywords

EID: 85018783443     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2017.04.023     Document Type: Review

References (135)

1. Aditya, N.P., Aditya, S., Yang, H., Kim, H.W., Park, S.O., Ko, S., Co-delivery of hydrophobic curcumin and hydrophilic catechin by a water-in-oil-in-water double emulsion. Food Chemistry 173 (2015), 7–13.
2. Aditya, N.P., Aditya, S., Yang, H.-J., Kim, H.W., Park, S.O., Lee, J., Ko, S., Curcumin and catechin co-loaded water-in-oil-in-water emulsion and its beverage application. Journal of Functional Foods 15 (2015), 35–43.
3. Ahmad, M., Baba, W.N., Shah, U., Gani, A., Gani, A., Masoodi, F.A., Nutraceutical properties of the green tea polyphenols. Journal of Food Processing & Technology, 5, 2014, 390.
4. Ahmad, N., Mukhtar, H., Green tea polyphenols and cancer: Biologic mechanisms and practical implications. Nutrition Reviews 57 (1999), 78–83.
5. Alotaibi, A., Bhatnagar, P., Najafzadeh, M., Gupta, K.C., Anderson, D., Tea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum based-chemotherapeutic drugs. Nanomedicine (London) 8 (2013), 389–401.
6. Anu-Bhushani, J., Karthik, P., Anandharamakrishnan, C., Nanoemulsion based delivery system for improved bioaccessibility and Caco-2 cell monolayer permeability of green tea catechins. Food Hydrocolloids 56 (2016), 372–382.
7. Balentine, D.A., Wiseman, S.A., Bouwens, L.C., The chemistry of tea flavonoids. Critical Reviews in Food Science and Nutrition 37 (1997), 693–704.
8. Basu, A., Betts, N.M., Mulugeta, A., Tong, C., Newman, E., Lyons, T.J., Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome. Nutrition Research 33 (2013), 180–187.
9. Benzie, I.F., Szeto, Y.T., Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay. Journal of Agricultural and Food Chemistry 47 (1999), 633–636.
10. Bharali, D.J., Siddiqui, I., Adhami, V.M., Chamcheu, J.C., Aldahmash, A.M., Mukhtar, H., Mousa, S., Nanoparticle delivery of natural products in the prevention and treatment of cancers: Current status and future prospects. Cancers 3 (2011), 4024–4045.
11. Chen, Z.Y., Zhu, Q.Y., Wong, Y.F., Zhang, Z., Chung, H.Y., Stabilizing effect of ascorbic acid on green tea catechins. Journal of Agriculture and Food Chemistry 46 (1998), 2512–2516.
12. Chime, S.A., Kenechukwu, F.C., Attama, A.A., Nanoemulsions – Advances in formulation, characterization and applications in drug delivery. Ali, D.S., (eds.) Application of nanotechnology in drug delivery, 2014, In Tech, Croatia, 77–111.
13. Chow, H.H., Hakim, I.A., Vining, D.R., Crowell, J.A., Ranger-Moore, J., Chew, W.M.,.. Alberts, D.S., Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Clinical Cancer Research 11 (2005), 4627–4633.
14. Chung, J.H., Kim, S., Lee, S.J., Chung, J.O., Oh, Y.J., Shim, S.M., Green tea formulations with vitamin C and xylitol on enhanced intestinal transport of green tea catechins. Journal of Food Science 78 (2013), C685–690.
15. Crespy, V., Williamson, G., A review of the health effects of green tea catechins in in vivo animal models. Journal of Nutrition 134 (2004), 3431S–3440S.
16. de Pace, R.C., Liu, X., Sun, M., Nie, S., Zhang, J., Cai, Q.,.. Wang, S., Anticancer activities of (−)-epigallocatechin-3-gallate encapsulated nanoliposomes in MCF7 breast cancer cells. Journal of Liposome Research 23 (2013), 187–196.
17. Demeule, M., Michaud-Levesque, J., Annabi, B., Gingras, D., Boivin, D., Lamy, S.,.. Beliveau, R., Green tea catechins as novel antitumor and antiangiogenic compounds. Current Medicinal Chemistry-Anti-Cancer Agents 2 (2002), 441–463.
18. Desai, M.P., Labhasetwar, V., Amidon, G.L., Levy, R.J., Gastrointestinal uptake of biodegradable microparticles: Effect of particle size. Pharmaceutical Research 13 (1996), 1838–1845.
19. Dube, A., Ng, K., Nicolazzo, J.A., Larson, I., Effective use of reducing agents and nanoparticle encapsulation in stabilizing catechins in alkaline solution. Food Chemistry 122 (2010), 662–667.
20. Dube, A., Nicolazzo, J.A., Larson, I., Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (−)-epigallocatechin gallate. European Journal of Pharmaceutical Sciences 41 (2010), 219–225.
21. Dube, A., Nicolazzo, J.A., Larson, I., Chitosan nanoparticles enhance the plasma exposure of (−)-epigallocatechin gallate in mice through an enhancement in intestinal stability. European Journal of Pharmaceutical Sciences 44 (2011), 422–426.
22. Ensign, L.M., Cone, R., Hanes, J., Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers. Advanced Drug Delivery Reviews 64 (2012), 557–570.
23. Ezhilarasi, P.N., Karthik, P., Chhanwal, N., Anandharamakrishnan, C., Nanoencapsulation techniques for food bioactive components: A review. Food and Bioprocess Technology 6 (2013), 628–647.
24. Fangueiro, J.F., Andreani, T., Fernandes, L., Garcia, M.L., Egea, M.A., Silva, A.M., Souto, E.B., Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation. Colloids and Surfaces B: Biointerfaces 123 (2014), 452–460.
25. Fangueiro, J.F., Calpena, A.C., Clares, B., Andreani, T., Egea, M.A., Veiga, F.J.,.. Souto, E.B., Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo, in vitro and ex vivo studies. International Journal of Pharmaceutics 502 (2016), 161–169.
26. Ferruzzi, M.G., Green, R.J., Analysis of catechins from milk–tea beverages by enzyme assisted extraction followed by high performance liquid chromatography. Food Chemistry 99 (2006), 484–491.
27. Flanagan, J., Singh, H., Microemulsions: A potential delivery system for bioactives in food. Critical Reviews in Food Science and Nutrition 46 (2006), 221–237.
28. Florence, A.T., Nanoparticle uptake by the oral route: Fulfilling its potential?. Drug Discovery Today 2 (2005), 75–81.
29. Gadkari, P.V., Balaraman, M., Extraction of catechins from decaffeinated green tea for development of nanoemulsion using palm oil and sunflower oil based lipid carrier systems. Journal of Food Engineering 147 (2015), 14–23.
30. Granja, A., Pinheiro, M., Reis, S., Epigallocatechin gallate nanodelivery systems for cancer therapy. Nutrients, 8, 2016, 307.
31. Green, R.J., Murphy, A.S., Schulz, B., Watkins, B.A., Ferruzzi, M.G., Common tea formulations modulate in vitro digestive recovery of green tea catechins. Molecular Nutrition & Food Research 51 (2007), 1152–1162.
32. Gupta, S., Bansal, R., Maheshwari, D., Ali, J., Gabrani, R., Dang, S., Development of a nanoemulsion system for polyphenon 60 and cranberry. Advanced Science Letters 20 (2014), 1683–1686.
33. Hamman, J.H., Stander, M., Junginger, H.E., Kotze, A.F., Enhancement of paracellular drug transport across mucosal epithelia by N-trimethyl chitosan chloride. STP Pharma Sciences 10 (2000), 35–38.
34. He, X., Hwang, H.M., Nanotechnology in food science: Functionality, applicability, and safety assessment. Journal of Food and Drug Analysis 24 (2016), 671–681.
35. He, Q., Lv, Y., Yao, K., Effects of tea polyphenols on the activities of α-amylase, pepsin, trypsin and lipase. Food Chemistry 101 (2007), 1178–1182.
36. Hong, Z., Xu, Y., Yin, J.F., Jin, J., Jiang, Y., Du, Q., Improving the effectiveness of (−)-epigallocatechin gallate (EGCG) against rabbit atherosclerosis by EGCG-loaded nanoparticles prepared from chitosan and polyaspartic acid. Journal of Agricultural and Food Chemistry 62 (2014), 12603–12609.
37. Hsieh, D.S., Wang, H., Tan, S.W., Huang, Y.H., Tsai, C.Y., Yeh, M.K., Wu, C.J., The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles. Biomaterials 32 (2011), 7633–7640.
38. Hu, B., Ma, F., Yang, Y., Xie, M., Zhang, C., Xu, Y., Zeng, X., Antioxidant nanocomplexes for delivery of epigallocatechin-3-gallate. Journal of Agricultural and Food Chemistry 64 (2016), 3422–3429.
39. Hu, B., Pan, C., Sun, Y., Hou, Z., Ye, H., Hu, B., Zeng, X., Optimization of fabrication parameters to produce chitosan−tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agricultural and Food Chemistry 56 (2008), 7451–7458.
40. Hu, B., Ting, Y., Yang, X., Tang, W., Zeng, X., Huang, Q., Nanochemoprevention by encapsulation of (−)-epigallocatechin-3-gallate with bioactive peptides/chitosan nanoparticles for enhancement of its bioavailability. Chemical Communications 48 (2012), 2421–2423.
41. Hu, B., Ting, Y., Zeng, X., Huang, Q., Cellular uptake and cytotoxicity of chitosan-caseinophosphopeptides nanocomplexes loaded with epigallocatechin gallate. Carbohydrate Polymers 89 (2012), 362–370.
42. Hu, B., Ting, Y., Zeng, X., Huang, Q., Bioactive peptides/chitosan nanoparticles enhance cellular antioxidant activity of (−)-epigallocatechin-3-gallate. Journal of Agricultural and Food Chemistry 61 (2013), 875–881.
43. Huang, Q., Yu, H., Ru, Q., Bioavailability and delivery of nutraceuticals using nanotechnology. Journal of Food Science 75 (2010), R50–R57.
44. Jaiswal, M., Dudhe, R., Sharma, P.K., Nanoemulsion: An advanced mode of drug delivery system. 3 Biotech 5 (2015), 123–127.
45. Jia, X.Y., Chen, X., Xu, Y.L., Han, X.Y., Xu, Z.R., Tracing transport of chitosan nanoparticles and molecules in Caco-2 cells by fluorescent labeling. Carbohydrate Polymers 78 (2009), 323–329.
46. Johnson, R., Bryant, S., Huntley, A.L., Green tea and green tea catechin extracts: An overview of the clinical evidence. Maturitas 73 (2012), 280–287.
47. Joye, I.J., Davidov-Pardo, G., McClements, D.J., Nanotechnology for increased micronutrient bioavailability. Trends in Food Science & Technology 40 (2014), 168–182.
48. Kadam, R.S., Bourne, D.W.A., Kompella, U.B., Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: Contribution of reduced clearance. Drug Metabolism and Disposition 47 (2012), 1380–1388.
49. Kailasapathy, K., Bioencapsulation technologies for incorporating bioactive components into functional foods. Ravishankar Rai, V., (eds.) Advances in food biotechnology, 2016, John Wiley & Sons, Ltd., 313–333.
50. Karn, P.R., Vanić, Z., Pepić, I., Skalko-Basnet, N., Mucoadhesive liposomal delivery systems: The choice of coating material. Drug Development and Industrial Pharmacy 37 (2011), 482–488.
51. Katiyar, S.K., Mukhtar, H., Tea in chemoprevention of cancer: Epidemiologic and experimental studies (review). International Journal of Oncology 8 (1996), 221–238.
52. Khan, N., Bharali, D.J., Adhami, V.M., Siddiqui, I.A., Cui, H., Shabana, S.M.,.. Mukhtar, H., Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis 35 (2014), 415–423.
53. Khan, A.Y., Talegaonkar, S., Iqbal, Z., Ahmed, F.J., Khar, R.K., Multiple emulsions: An overview. Current Drug Delivery 3:4 (2006), 429–443.
54. Kim, H., Hiraishi, A., Tsuchiya, K., Sakamoto, K., (−) Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c. Cytotechnology 62 (2010), 245–255.
55. Kim, Y.J., Houng, S.J., Kim, J.H., Kim, Y.R., Ji, H.G., Lee, S.J., Nanoemulsified green tea extract shows improved hypocholesterolemic effects in C57BL/6 mice. Journal of Nutritional Biochemistry 23 (2012), 186–191.
56. Komaiko, J., McClements, D.J., Low-energy formation of edible nanoemulsions by spontaneous emulsification: Factors influencing particle size. Journal of Food Engineering 146 (2015), 122–128.
57. Kumar, A., Thakur, B.K., De, S., Selective extraction of (−) epigallocatechin gallate from green tea leaves using two-stage infusion coupled with membrane separation. Food and Bioprocess Technology 5 (2012), 2568–2577.
58. Kuriyama, S., Shimazu, T., Ohmori, K., Kikuchi, N., Nakaya, N., Nishino, Y.,.. Tsuji, I., Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: The Ohsaki study. JAMA 296 (2006), 1255–1265.
59. Lakenbrink, C., Lapczynski, S., Maiwald, B., Engelhardt, U.H., Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages. Journal of Agricultural and Food Chemistry 48 (2000), 2848–2852.
60. Langley-Evans, S.C., Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay. International Journal of Food Sciences and Nutrition 51 (2000), 181–188.
61. Lante, A., Friso, D., Oxidative stability and rheological properties of nanoemulsions with ultrasonic extracted green tea infusion. Food Research International 54 (2013), 269–276.
62. Li, Z., Jiang, H., Xu, C., Gu, L., A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals. Food Hydrocolloids 43 (2015), 153–164.
63. Liang, J., Li, F., Fang, Y., Yang, W., An, X., Zhao, L.,.. Hu, Q., Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles. Colloids and Surfaces B: Biointerfaces 82 (2011), 297–301.
64. Liang, J., Puligundla, P., Ko, S., Wan, X.C., A review on selenium-enriched green tea: Fortification methods, biological activities and application prospect. Sains Malaysiana 43 (2014), 1685–1692.
65. Liang, J., Yan, H., Puligundla, P., Gao, X., Zhou, Y., Wan, X., Applications of chitosan nanoparticles to enhance absorption and bioavailability of tea polyphenols: A review. Food Hydrocolloids 69 (2017), 286–292.
66. Lin, Y.H., Feng, C.L., Lai, C.H., Lin, J.H., Chen, H.Y., Preparation of epigallocatechin gallate-loaded nanoparticles and characterization of their inhibitory effects on Helicobacter pylori growth in vitro and in vivo. Science and Technology of Advanced Materials, 15, 2014, 045006.
67. Liu, F., Antoniou, J., Li, Y., Majeed, H., Liang, R., Ma, Y.,.. Zhong, F., Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for tea polyphenol encapsulation. Food Hydrocolloids 57 (2016), 291–300.
68. Livney, Y.D., Nanostructured delivery systems in food: Latest developments and potential future directions. Current Opinion in Food Science 3 (2015), 125–135.
69. López de Lacey, A.M., Pérez-Santín, E., López-Caballero, M.E., Montero, P., Survival and metabolic activity of probiotic bacteria in green tea. LWT-Food Science & Technology 55 (2014), 314–322.
70. Mahmood, T., Akhtar, N., Manickam, S., Interfacial film stabilized W/O/W nano multiple emulsions loaded with green tea and lotus extracts: Systematic characterization of physicochemical properties and shelf-storage stability. Journal of Nanobiotechnology, 12, 2014, 20.
71. Mandel, S., Weinreb, Amit, T., Youdim, M.B.H., Cell signaling pathways in the neuroprotective actions of green tea polyphenol (−) -epigallocatechin-3-gallate: Implications for neurodegenerative diseases. Journal of Neurochemistry 88 (2004), 1555–1569.
72. Manea, A.M., Andronescu, C., Meghea, A., Green tea extract loaded into solid lipid nanoparticles. UPB Scientific Bulletin, Series B: Chemistry and Materials Science 76 (2014), 125–136.
73. Manivasagan, P., Senthilkumar, K., Venkatesan, J., Biological applications of chitin, chitosan, oligosaccharides and their derivatives. Kim, S.K., (eds.) Chitin and chitosan derivatives: Advances in drug discovery and developments, 2013, CRC Press, 223–242.
74. Matalanis, A., Jones, O.G., McClements, D.J., Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds. Food Hydrocolloids 25 (2011), 1865–1880.
75. Mo, R., Jin, X., Li, N., Ju, C., Sun, M., Zhang, C., Ping, Q., The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles. Biomaterials 32 (2011), 4609–4620.
76. Mohanraj, V.J., Chen, Y., Nanoparticles – A review. Tropical Journal of Pharmaceutical Research 5 (2006), 561–573.
77. Muller, R.H., Radtke, M., Wissing, S.A., Nanostructured lipid matrices for improved microencapsulation of drugs. International Journal of Pharmaceutics 242 (2002), 121–128.
78. Nagavarma, B.V.N., Hemant, K.S.Y., Ayaz, A., Vasudha, L.S., Shivakumar, H.G., Different techniques for preparation of polymeric nanoparticles – A review. Asian Journal of Pharmaceutical and Clinical Research 5 (2012), 16–23.
79. Narayanan, S., Mony, U., Vijaykumar, D.K., Koyakutty, M., Paul-Prasanth, B., Menon, D., Sequential release of Epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells. Nanomedicine 11 (2015), 1399–1406.
80. Narayanan, S., Pavithran, M., Viswanath, A., Narayanan, D., Mohan, C.C., Manzoor, K., Menon, D., Sequentially releasing dual-drug-loaded PLGA–casein core/shell nanomedicine: Design, synthesis, biocompatibility and pharmacokinetics. Acta Biomaterialia 10 (2014), 2112–2124.
81. Narotzki, B., Reznick, A.Z., Aizenbud, D., Levy, Y., Green tea: A promising natural product in oral health. Archives of Oral Biology 57 (2012), 429–435.
82. Neilson, A.P., Hopf, A.S., Cooper, B.R., Pereira, M.A., Bomser, J.A., Ferruzzi, M.G., Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion. Journal of Agricultural and Food Chemistry 55 (2007), 8941–8949.
83. Okabe, S., Suganuma, M., Hayashi, M., Sueoka, E., Komori, A., Fujiki, H., Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols. Japanese Journal of Cancer Research 88 (1997), 639–643.
84. Okonogi, S., Saengsitthisak, B., Duangrat, C., Nano-size encapsulation of bioactive compound of green tea. XVth International workshop on bioencapsulation, Vienna, Au. Sept 6–8, 2007, 2007 (P1–18, 1–4).
85. Peng, G., Wargovich, M.J., Dixon, D.A., Anti-proliferative effects of green tea polyphenol EGCG on Ha-Ras-induced transformation of intestinal epithelial cells. Cancer Letters 238 (2006), 260–270.
86. Perumalla, A.V.S., Hettiarachchy, N.S., Green tea and grape seed extracts – Potential applications in food safety and quality. Food Research International 44 (2011), 827–839.
87. Peters, C.M., Green, R.J., Janle, E.M., Ferruzzi, M.G., Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea. Food Research International 43 (2010), 95–102.
88. Proniuk, S., Liederer, B.M., Blanchard, J., Preformulation study of epigallocatechin gallate, a promising antioxidant for topical skin cancer prevention. Journal of Pharmaceutical Sciences 91 (2002), 111–116.
89. Rains, T.M., Agarwal, S., Maki, K.C., Antiobesity effects of green tea catechins: A mechanistic review. Journal of Nutritional Biochemistry 22 (2011), 1–7.
90. Rashidinejad, A., Birch, E.J., Sun-Waterhouse, D., Everett, D.W., Delivery of green tea catechin and epigallocatechin gallate in liposomes incorporated into low-fat hard cheese. Food Chemistry 156 (2014), 176–183.
91. Record, I.R., Lane, J.M., Simulated intestinal digestion of green and black teas. Food Chemistry 73 (2001), 481–486.
92. Rein, M.J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S.K., da Silva Pinto, M., Bioavailability of bioactive food compounds: A challenging journey to bioefficacy. British Journal of Clinical Pharmacology 75 (2013), 588–602.
93. Ru, Q., Yu, H., Huang, Q., Encapsulation of epigallocatechin-3-gallate (EGCG) using oil-in-water (O/W) submicrometer emulsions stabilized by ι-carrageenan and β-lactoglobulin. Journal of Agricultural and Food Chemistry 58 (2010), 10373–10381.
94. Rusak, G., Komes, D., Likić, S., Horžić, D., Kovač, M., Phenolic content and antioxidative capacity of green and white tea extracts depending on extraction conditions and the solvent used. Food Chemistry 110 (2008), 852–858.
95. Safer, A.M., Hanafy, N.A., Bharali, D.J., Cui, H., Mousa, S.A., Effect of green tea extract encapsulated into chitosan nanoparticles on hepatic fibrosis collagen fibers assessed by atomic force microscopy in rat hepatic fibrosis model. Journal of Nanoscience and Nanotechnology 15 (2015), 6452–6459.
96. Sajilata, M.G., Bajaj, P.R., Singhal, R.S., Tea polyphenols as nutraceuticals. Comprehensive Reviews in Food Science and Food Safety 7 (2008), 229–254.
97. Salatin, S., Barar, J., Barzegar-Jalali, M., Adibkia, K., Milani, M.A., Jelvehgari, M., Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery. Archives of Pharmacal Research 39 (2016), 1181–1192.
98. Sanna, V., Pintus, G., Roggio, A.M., Punzoni, S., Posadino, A.M., Arca, A.,.. Sechi, M., Targeted biocompatible nanoparticles for the delivery of (−)-Epigallocatechin 3-gallate to prostate cancer cells. Journal of Medicinal Chemistry 54 (2011), 1321–1332.
99. Schmidt, M., Schmitz, H.-J., Baumgart, A., Guedon, D., Netsch, M.I., Kreuter, M.-H.,.. Schrenk, D., Toxicity of green tea extracts and their constituents in rat hepatocytes in primary culture. Food and Chemical Toxicology 43 (2005), 307–314.
100. Selvamuthukumar, S., Velmurugan, R., Nanostructured lipid carriers: A potential drug carrier for cancer chemotherapy. Lipids in Health and Disease, 11, 2012, 159.
101. Shim, S.M., Yoo, S.H., Ra, C.S., Kim, Y.K., Chung, J.O., Lee, S.J., Digestive stability and absorption of green tea polyphenols: Influence of acid and xylitol addition. Food Research International 45 (2012), 204–210.
102. Shoichet, M.S., Polymer scaffolds for biomaterials applications. Macromolecules 43 (2010), 581–591.
103. Shpigelman, A., Cohen, Y., Livney, Y.D., Thermally-induced β-lactoglobulin–EGCG nanovehicles: Loading, stability, sensory and digestive-release study. Food Hydrocolloids 29 (2012), 57–67.
104. Shpigelman, A., Israeli, G., Livney, Y.D., Thermally-induced protein–polyphenol co-assemblies: Beta lactoglobulin-based nanocomplexes as protective nanovehicles for EGCG. Food Hydrocolloids 24 (2010), 735–743.
105. Shutava, T.G., Balkundi, S.S., Vangala, P., Steffan, J.J., Bigelow, R.L., Cardelli, J.A.,.. Lvov, Y.M., Layer-by-layer-coated gelatin nanoparticles as a vehicle for delivery of natural polyphenols. ACS Nano 3 (2009), 1877–1885.
106. Siddiqui, I.A., Adhami, V.M., Ahmad, N., Mukhtar, H., Nanochemoprevention: Sustained release of bioactive food components for cancer prevention. Nutrition and Cancer 62 (2010), 883–890.
107. Siddiqui, I.A., Adhami, V.M., Bharali, D.J., Hafeez, B.B., Asim, M., Khwaja, S.I.,.. Mukhtar, H., Introducing nanochemoprevention as a novel approach for cancer control: Proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Research 69 (2009), 1712–1716.
108. Siddiqui, I.A., Bharali, D.J., Nihal, M., Adhami, V.M., Khan, N., Chamcheu, J.C.,.. Mukhtar, H., Excellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomedicine: Nanotechnology, Biology, and Medicine 10 (2014), 1619–1626.
109. Siddiqui, I.A., Shukla, Y., Mukhtar, H., Nanoencapsulation of natural products for chemoprevention. Journal of Nanomedicine & Nanotechnology, 2, 2011, 104e.
110. Suffredini, G., Levy, L., Nanopolymers and nanoconjugates for central nervous system diagnostics and therapies. Kateb, B., Heiss, J.D., (eds.) The textbook of nanoneuroscience and nanoneurosurgery, 2013, 39–50.
111. Sun, M., Su, X., Ding, B., He, X., Liu, X., Yu, A.,.. Zhai, G., Advances in nanotechnology-based delivery systems for curcumin. Nanomedicine (London) 7 (2012), 1085–1100.
112. Takeuchi, H., Yamamoto, H., Niwa, T., Hino, T., Kawashima, Y., Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharmaceutical Research 13 (1996), 896–901.
113. Tanaka, T., Kouno, I., Oxidation of tea catechins: Chemical structures and reaction mechanism. Food Science and Technology Research 9 (2003), 128–133.
114. Tang, D.W., Yu, S.H., Ho, Y.C., Huang, B.Q., Tsai, G.J., Hsieh, H.Y.,.. Mi, F.L., Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide. Food Hydrocolloids 30 (2013), 33–41.
115. Torché, A.M., Jouan, H., Le Corre, P., Albina, E., Primault, R., Jestin, A., Le Verge, R., Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment. International Journal of Pharmaceutics 201 (2000), 15–27.
116. Vaidyanathan, J.B., Walle, T., Transport and metabolism of the tea flavonoid (−)-epicatechin by the human intestinal cell line Caco-2. Pharmaceutical Research 18 (2001), 1420–1425.
117. Vaidyanathan, J.B., Walle, T., Cellular uptake and efflux of the tea flavonoid (−) epicatechin-3-gallate in the human intestinal cell line Caco-2. Journal of Pharmacology and Experimental Therapeutics 307 (2003), 745–752.
118. Vuong, Q.V., Stathopoulos, C.E., Golding, J.B., Nguyen, M.H., Roach, P.D., Isolation of green tea catechins and their utilisation in the food industry. Food Reviews International 27 (2011), 227–247.
119. Wang, S., Su, R., Nie, S., Sun, M., Zhang, J., Wu, D., Moustaid-Moussa, N., Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. Journal of Nutritional Biochemistry 25 (2014), 363–376.
120. Wang, D., Taylor, E.W., Wang, Y., Wan, X., Zhang, J., Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. International Journal of Nanomedicine 7 (2012), 1711–1721.
121. Werle, M., Natural and synthetic polymers as inhibitors of drug efflux pumps. Pharmaceutical Research 25 (2008), 500–511.
122. Xu, J., Sandstro, C., Janson, J.C., Tan, T., Chromatographic retention of epigallocatechin gallate on oligo-β-cyclodextrin-coupled sepharose media investigated using NMR. Chromatographia 64 (2006), 7–11.
123. Zaveri, N.T., Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications. Life Science 78 (2006), 2073–2080.
124. Zhang, L., Chow, M.S., Zuo, Z., Effect of the co-occurring components from green tea on the intestinal absorption and disposition of green tea polyphenols in Caco-2 monolayer model. Journal of Pharmacy and Pharmacology 58 (2006), 37–44.
125. Zhang, H., Jung, J., Zhao, Y., Preparation, characterization and evaluation of antibacterial activity of catechins and catechins-Zn complex loaded β-chitosan nanoparticles of different particle sizes. Carbohydrate Polymers 137 (2016), 82–91.
126. Zhang, J., Nie, S., Martinez-Zaguilan, R., Sennoune, S.R., Wang, S., Formulation, characteristics and antiatherogenic bioactivities of CD36-targeted epigallocatechin gallate (EGCG)-loaded nanoparticles. Journal of Nutritional Biochemistry 30 (2016), 14–23.
127. Zhang, J., Nie, S., Wang, S., Nanoencapsulation enhances epigallocatechin-3-gallate stability and its antiatherogenic bioactivities in macrophages. Journal of Agricultural and Food Chemistry 61 (2013), 9200–9209.
128. Zhang, L., Wu, S., Wang, D., Wan, X., Zhang, J., Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. Sahu, S.C., Casciano, D.A., (eds.) Handbook of nanotoxicology, nanomedicine and stem cell use in toxicology, 2014, John Wiley & Sons Ltd., Chichester, UK.
129. Zhang, H., Zhao, Y., Preparation, characterization and evaluation of tea polyphenol-Zn complex loaded β-chitosan nanoparticles. Food Hydrocolloids 48 (2015), 260–273.
130. Zhang, L., Zheng, Y., Chow, M.S., Zuo, Z., Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. International Journal of Pharmaceutics 287 (2004), 1–12.
131. Zhou, H., Sun, X., Zhang, L., Zhang, P., Li, J., Liu, Y.N., Fabrication of biopolymeric complex coacervation core micelles for efficient tea polyphenol delivery via a green process. Langmuir 28 (2012), 14553–14561.
132. Zimeri, J., Tong, C.H., Degradation kinetics of (−)-epigallocatechin gallate as a function of pH and dissolved oxygen in a liquid model system. Journal of Food Science 64 (1999), 753–758.
133. Zou, L., Liu, W., Liu, W., Liang, R., Li, T., Liu, C.,.. Liu, Z., Characterization and bioavailability of tea polyphenol nanoliposome prepared by combining an ethanol injection method with dynamic high-pressure microfluidization. Journal of Agricultural and Food Chemistry 62 (2014), 934–941.
134. Zou, L., Peng, S., Liu, W., Chen, X., Liu, C., A novel delivery system dextran sulfate coated amphiphilic chitosan derivatives-based nanoliposome: Capacity to improve in vitro digestion stability of (−)-epigallocatechin gallate. Food Research International 69 (2015), 114–120.
135. Zou, L., Peng, S., Liu, W., Gan, L., Liu, W., Liang, R.,.. Chen, X., Improved in vitro digestion stability of (−)-epigallocatechin gallate through nanoliposome encapsulation. Food Research International 64 (2014), 492–499.