Sequentially releasing dual-drug-loaded PLGA-casein core/shell nanomedicine: Design, synthesis, biocompatibility and pharmacokinetics

Acta Biomaterialia

Volumn 10, Issue 5, 2014, Pages 2112-2124

  Narayanan, Sreeja ^a   Pavithran, Maya ^a   Viswanath, Aiswarya ^a   Narayanan, Dhanya ^a   Mohan, Chandini C ^a   Manzoor, K ^a   Menon, Deepthy ^a  

^a AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Casein; Core shell nanoparticles; Hemocompatibility; PLGA; Sequential release

Indexed keywords

BIOCOMPATIBILITY; BIOSYNTHESIS; CASEIN; CONTROLLED DRUG DELIVERY; EMULSIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICAL NANOTECHNOLOGY; PHARMACOKINETICS; PRECIPITATION (CHEMICAL); RATS; TARGETED DRUG DELIVERY; TOXICITY;

ACID CASEIN; CORE SHELL; CORE-SHELL NANOPARTICLES; EPIGALLOCATECHIN GALLATE; GLYCOLIC ACIDS; HAEMOCOMPATIBILITY; PACLITAXEL; POLY (L-LACTIDE); POLY-L-LACTIDE-CO-GLYCOLIC ACID; SEQUENTIAL RELEASE;

NANOPARTICLES;

CASEIN; EPIGALLOCATECHIN GALLATE; GLYCOPROTEIN IB ALPHA; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; NANOCARRIER; NANOSHELL; PACLITAXEL; PADGEM PROTEIN; POLYGLACTIN; TUMOR NECROSIS FACTOR ALPHA; BIOMATERIAL; CATECHIN; CYTOKINE; INDOCYANINE GREEN; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD COMPATIBILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG HALF LIFE; DRUG SYNTHESIS; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYDRODYNAMICS; HYDROPHILICITY; HYDROPHOBICITY; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; IONIC STRENGTH; ISOELECTRIC POINT; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NANOEMULSION; NANOMEDICINE; NANOTOXICOLOGY; NONHUMAN; NORMAL HUMAN; PARTICLE SIZE; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; CELL DEATH; CELL LINE; CHEMISTRY; DRUG EFFECTS; INFLAMMATION; MATERIALS TESTING; METABOLISM; MOUSE; PATHOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; SYNTHESIS; TISSUE DISTRIBUTION; TOXICITY; ULTRASTRUCTURE;

RATTUS;

ANIMALS; BIOCOMPATIBLE MATERIALS; CASEINS; CATECHIN; CELL DEATH; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; HUMANS; INDOCYANINE GREEN; INFLAMMATION; LACTIC ACID; MATERIALS TESTING; MICE; NANOMEDICINE; NANOPARTICLES; ORGAN SPECIFICITY; PACLITAXEL; PARTICLE SIZE; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84898057567     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.12.041     Document Type: Article

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