The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles

Biomaterials

Volumn 32, Issue 20, 2011, Pages 4609-4620

  Mo, Ran ^a   Jin, Xiang ^a   Li, Nan ^a   Ju, Caoyun ^a   Sun, Minjie ^a   Zhang, Can ^a   Ping, Qineng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Micelle; N octyl O sulfate chitosan; Oral drug delivery; P glycoprotein; Paclitaxel

Indexed keywords

CACO-2 CELLS; CAVEOLAE; CLATHRINS; CRITICAL MICELLAR CONCENTRATIONS; IN-VITRO; IN-VIVO; INTERCELLULAR TIGHT JUNCTIONS; N-OCTYL-O-SULFATE CHITOSAN; ORAL ABSORPTION; ORAL DRUG DELIVERY; P-GLYCOPROTEIN; PACLITAXEL; PERMEABILITY COEFFICIENTS; RHODAMINE 123; TRANSCYTOSIS; TRANSEPITHELIAL ELECTRICAL RESISTANCES; VERAPAMIL;

ABSORPTION; BIOCHEMISTRY; CHITIN; CHITOSAN; DRUG DELIVERY; DRUG PRODUCTS; GLYCOPROTEINS; HYDROGELS; MOLECULAR BIOLOGY; MONOLAYERS; MULTILAYERS;

MICELLES;

CHITOSAN DERIVATIVE; CHITOSAN N OCTYL O SULFATE; CLATHRIN; GLYCOPROTEIN P; PACLITAXEL; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; CAVEOLA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG UPTAKE; ENDOCYTOSIS; MICELLE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCYTOSIS;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOCOMPATIBLE MATERIALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; CHITOSAN; ENDOCYTOSIS; HUMANS; MATERIALS TESTING; MICELLES; P-GLYCOPROTEIN; PACLITAXEL; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

EID: 79955522520     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.005     Document Type: Article

References (44)

1. Rowinsky E.K., Onetto N., Canetta R.M., Arbuck S.G. Taxol: the first of the taxanes, an important new class of antitumor agents. Semin Oncol 1992, 19:646-662.
2. Singla A.K., Garg A., Aggarwal D. Paclitaxel and its formulations. Int J Pharm 2002, 235:179-192.
3. Kasim N.A., Whitehouse M., Ramachandran C., Barnejo M., Lennernas H., Hussain A.S., et al. Molecular properties of WHO essential drugs and provisional biopharmaceutic classification. Mol Pharmacol 2003, 1:85-96.
4. Szebeni J., Muggia F.M., Alving C.R. Complement activation by Cremophor EL as a possible contributor to hypersensitivity to PTX: an in vitro study. J Natl Cancer Inst 1998, 90:300-306.
5. Malingré M.M., Beijnen J.H., Schellens J.H. Oral delivery of taxanes. Invest New Drugs 2001, 19:155-162.
6. van Asperen J., van Tellingen O., van der Valk M.A., Rozenhart M., Beijnen J.H. Enhanced oral absorption and decreased elimination of paclitaxel in mice cotreated with cyclosporin A. Clin Cancer Res 1998, 4:2293-2297.
7. Nornoo A.O., Zheng H., Lopes L.B., Johnson-Restrepo B., Kannan K., Reed R. Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies. Eur J Pharm Biopharm 2009, 71:310-317.
8. Agüeros M., Zabaleta V., Espuelas S., Campanero M.A., Irache J.M. Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly(anhydride) nanoparticles. J Control Release 2010, 145:2-8.
9. Bhardwaj V., Ankola D.D., Gupta S.C., Schneider M., Lehr C.M., Kumar M.N. PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat. Pharm Res 2009, 26:2495-2503.
10. Dabholkar R.D., Sawant R.M., Mongayt D.A., Devarajan P.V., Torchilin V.P. Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int J Pharm 2006, 315:148-157.
11. Iqbal J., Sarti F., Perera G., Bernkop-Schnürch A. Development and in vivo evaluation of an oral drug delivery system for paclitaxel. Biomaterials 2010, 32:170-175.
12. Bromberg L. Polymeric micelles in oral chemotherapy. J Control Release 2008, 128:99-112.
13. Chiappetta D.A., Hocht C., Taira C., Sosnik A. Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailability. Nanomedicine 2010, 5:11-23.
14. Francis M.F., Cristea M., Winnik F.M. Exploiting the vitamin B12 p.thway to enhance oral drug delivery via polymeric micelles. Biomacromolecules 2005, 6:2462-2467.
15. Zhang Y., Li X., Zhou Y., Fan Y., Wang X., Huang Y., et al. Cyclosporin A-loaded poly(ethylene glycol)-b-poly(d, l-lactic acid) micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Mol Pharm 2010, 7:1169-1182.
16. Zastre J., Jackson J.K., Wong W., Burt H.M. Methoxypolyethylene glycol-block-polycaprolactone diblock copolymers reduce P-glycoprotein efflux in the absence of a membrane fluidization effect while stimulating P-glycoprotein ATPase activity. J Pharm Sci 2007, 96:864-875.
17. Collnot E.M., Baldes C., Wempe M.F., Kappl R., Hüttermann J., Hyatt J.A., et al. Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol Pharm 2007, 4:465-474.
18. Zhang C., Qu G., Sun Y., Wu X., Yao Z., Guo Q., et al. Pharmacokinetics, biodistribution, efficacy and safety of N-octyl-O-sulfate chitosan micelles loaded with paclitaxel. Biomaterials 2008, 29:1233-1241.
19. Kitchens K.M., Kolhatkar R.B., Swaan P.W., Ghandehari H. Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells. Mol Pharm 2008, 5:364-369.
20. Perry J.W., Wobus C.E. Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol. J Virol 2010, 84:6163-6176.
21. Koivusalo M., Welch C., Hayashi H., Scott C.C., Kim M., Alexander T., et al. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol 2010, 188:547-563.
22. Chaudhary P.M., Mechetner E.B., Roninson I.B. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 1992, 80:2735-2739.
23. Mechetner E.B., Roninson I.B. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A 1992, 89:5824-5828.
24. Mathot F., des Rieux A., Ariën A., Schneider Y.J., Brewster M., Préat V. Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier. J Control Release 2007, 124:34-43.
25. Xu Y., Jin X., Ping Q., Cheng J., Sun M., Cao F., et al. A novel lipoprotein-mimic nanocarrier composed of the modified protein and lipid for tumor cell targeting delivery. J Control Release 2010, 146:299-308.
26. Sparreboom A., van Asperen J., Mayer U., Schinkel A.H., Smit J.W., Meijer D.K., et al. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci U S A 1997, 94:2031-2035.
27. Li H., Huo M., Zhou J., Dai Y., Deng Y., Shi X., et al. Enhanced oral absorption of paclitaxel in N-deoxycholic acid-N, O-hydroxyethyl chitosan micellar system. J Pharm Sci 2010, 99:4543-4553.
28. Bardelmeijer H.A., Ouwehand M., Beijnen J.H., Schellens J.H., van Tellingen O. Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice. Invest New Drugs 2004, 22:219-229.
29. Woo J.S., Lee C.H., Shim C.K., Hwang S.J. Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031. Pharm Res 2003, 20:24-30.
30. Zhang Y., Li H., Wang H., Su F., Qu R., Yin D., et al. Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action. Cancer Chemother Pharmacol 2010, 66:851-859.
31. Constantinides P.P., Wasan K.M. Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies. J Pharm Sci 2007, 96:235-248.
32. Zhang C., Qu G., Sun Y., Yang T., Yao Z., Shen W., et al. Biological evaluation of N-octyl-O-sulfate chitosan as a new nano-carrier of intravenous drugs. Eur J Pharm Sci 2008, 33:415-423.
33. Zhang C., Ping Q., Zhang H. Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system. Colloids Surf B Biointerfaces 2004, 39:69-75.
34. Roger E., Lagarce F., Garcion E., Benoit J.P. Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. J Control Release 2009, 140:174-181.
35. Conner S.D., Schmid S.L. Regulated portals of entry into the cell. Nature 2003, 422:37-44.
36. Gao X., Wang T., Wu B., Chen J., Chen J., Yue Y., et al. Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles. Biochem Biophys Res Commun 2008, 377:35-40.
37. Sahay G., Batrakova E.V., Kabanov A.V. Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport. Bioconjug Chem 2008, 19:2023-2029.
38. Kotzé A.F., Luessen H.L., de Leeuw B.J., de Boer A.G., Verhoef J.C., Junginger H.E. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release 1998, 51:35-46.
39. Lin Y.H., Mi F.L., Chen C.T., Chang W.C., Peng S.F., Liang H.F., et al. Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 2007, 8:146-152.
40. Kapitza S.B., Michel B.R., van Hoogevest P., Leigh M.L., Imanidis G. Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model. Eur J Pharm Biopharm 2007, 66:146-158.
41. Prego C., García M., Torres D., Alonso M.J. Transmucosal macromolecular drug delivery. J Control Release 2005, 101:151-162.
42. Mi F.L., Wu Y.Y., Lin Y.H., Sonaje K., Ho Y.C., Chen C.T., et al. Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gammaglutamic acid) and a chitosan derivative functionalized by trimethylation. Bioconjug Chem 2008, 19:1248-1255.
43. Hu Y., Litwin T., Nagaraja A.R., Kwong B., Katz J., Watson N., et al. Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles. Nano Lett 2007, 7:3056-3064.
44. Win K.Y., Feng S.S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 2005, 26:2713-2722.