Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo, in vitro and ex vivo studies

International Journal of Pharmaceutics

Volumn 502, Issue 1-2, 2016, Pages 161-169

  Fangueiro, Joana F ^a,b,c   Calpena, Ana C ^d   Clares, Beatriz ^e   Andreani, Tatiana ^b,f   Egea, Maria A ^d   Veiga, Francisco J ^a,c   Garcia, Maria L ^d   Silva, Amélia M ^b,g   Souto, Eliana B ^a,c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF BARCELONA   (Spain)

^e UNIVERSITY OF GRANADA   (Spain)

^f UNIVERSITY OF PORTO   (Portugal)

^g UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

Author keywords

Draize test; Epigallocatechin gallate; HET CAM test; Lipid nanoparticles; Ocular delivery

Indexed keywords

CATIONIC LIPID NANOPARTICLE; CETRIMIDE; EPIGALLOCATECHIN GALLATE; NANOPARTICLE; UNCLASSIFIED DRUG; CATECHIN; DELAYED RELEASE FORMULATION; DIMETHYLDIOCTADECYLAMMONIUM; EMULSION; LIPID; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR EYE SEGMENT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHORIOALLANTOIC MEMBRANE ASSAY; CORNEA EDEMA; CORNEA PERMEABILITY; DRUG PENETRATION; DRUG SAFETY; EYE DISEASE; EYE EDEMA; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN RESIDENCE TIME; NONHUMAN; OCULAR TISSUE; POSTERIOR EYE SEGMENT; PRIORITY JOURNAL; ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CHICKEN; CHORIOALLANTOIS; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG RELEASE; EMULSION; EYE; METABOLISM; PERMEABILITY; PHARMACOKINETICS; RABBITS AND HARES; TOXICITY;

ANIMALS; CATECHIN; CETRIMONIUM COMPOUNDS; CHICKENS; CHORIOALLANTOIC MEMBRANE; DELAYED-ACTION PREPARATIONS; DRUG LIBERATION; EMULSIONS; EYE; LIPIDS; MALE; NANOPARTICLES; PERMEABILITY; QUATERNARY AMMONIUM COMPOUNDS; RABBITS;

EID: 84959473069     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.02.039     Document Type: Article

References (48)

1. H. Abdelkader, S. Ismail, A. Hussein, Z. Wu, R. Al-Kassas, and R.G. Alany Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models Int. J. Pharm. 432 2012 1 10
2. G. Abrego, H. Alvarado, E.B. Souto, B. Guevara, L.H. Bellowa, A. Parra, A. Calpena, and M.L. Garcia Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration Eur. J. Pharm. Biopharm. 95 2015 261 270
3. A. Albanese, P.S. Tang, and W.C.W. Chan The effect of nanoparticle size, shape, and surface chemistry on biological systems Annu. Rev. Biomed. Eng. 14 2012 1 16
4. J. Ambati, C.S. Canakis, J.W. Miller, E.S. Gragoudas, A. Edwards, D.J. Weissgold, I. Kim, F.C. Delori, and A.P. Adamis Diffusion of high molecular weight compounds through sclera Invest. Ophthalmol. Vis. Sci. 41 2000 1181 1185
5. T. Andreani, C.P. Souza A.L.R. d. Kiill, E.N. Lorenzón, J.F. Fangueiro, A.C. Calpena, M.V. Chaud, M.L. Garcia, M.P.D. Gremiaõ, A.M. Silva, and E.B. Souto Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery Int. J. Pharm. 473 2014 627 635
6. J. Araujo, E. Gonzalez, M.A. Egea, M.L. Garcia, and E.B. Souto Nanomedicines for ocular NSAIDs: Safety on drug delivery Nanomedicine 5 2009 394 401
7. J. Araujo, S. Nikolic, M.A. Egea, E.B. Souto, and M.L. Garcia Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye Colloids Surf. B Biointerfaces 88 2011 150 157
8. J. Araujo, M.L. Garcia, M. Mallandrich, E.B. Souto, and A.C. Calpena Release profile and transscleral permeation of triamcinolone acetonide loaded nanostructured lipid carriers (TA-NLC): In vitro and ex vivo studies Nanomedicine 8 2012 1034 1041
9. H.Z. Bu, H.J. Gukasyan, L. Goulet, X.J. Lou, C. Xiang, and T. Koudriakova Ocular disposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs Curr. Drug Metab. 8 2007 91 107
10. N. Chidambaram, and D.J. Burgess A novel in vitro release method for submicron sized dispersed systems AAPS PharmSci. 1 1999 E11
11. J. Doménech, J. Martínez, and J. Plá Biofarmacia y Farmacocinética II 1998 Síntesis Madrid, Spain
12. G.J. Du, Z. Zhang, X.D. Wen, C. Yu, T. Calway, C.S. Yuan, and C.Z. Wang Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea Nutrients 4 2012 1679 1691
13. H.F. Edelhauser, C.L. Rowe-Rendleman, M.R. Robinson, D.G. Dawson, G.J. Chader, H.E. Grossniklaus, K.D. Rittenhouse, C.G. Wilson, D.A. Weber, B.D. Kuppermann, K.G. Csaky, T.W. Olsen, U.B. Kompella, V.M. Holers, G.S. Hageman, B.C. Gilger, P.A. Campochiaro, S.M. Whitcup, and W.T. Wong Ophthalmic drug delivery systems for the treatment of retinal diseases: Basic research to clinical applications Invest. Ophthalmol. Visual Sci. 51 2010 5403 5420
14. N. Elsaid, S. Somavarapu, and T.L. Jackson Cholesterol-poly(ethylene) glycol nanocarriers for the transscleral delivery of sirolimus Exp. Eye Res. 121 2014 121 129
15. J.F. Fangueiro, T. Andreani, M.A. Egea, M.L. Garcia, S.B. Souto, A.M. Silva, and E.B. Souto Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity Int. J. Pharm. 461 2014 64 73
16. J.F. Fangueiro, T. Andreani, L. Fernandes, M.L. Garcia, M.A. Egea, A.M. Silva, and E.B. Souto Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation Colloids Surf. B: Biointerfaces 123 2014 452 460
17. J.F. Fangueiro, A. Parra, A.M. Silva, M.A. Egea, E.B. Souto, M.L. Garcia, and A.C. Calpena Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate Int. J. Pharm. 475 2014 181 190
18. J.F. Fangueiro, A.M. Silva, M.L. Garcia, and E.B. Souto Current nanotechnology approaches for the treatment and management of diabetic retinopathy Eur. J. Pharm. Biopharm. 95 2015 307 322
19. J.F. Fangueiro, F. Veiga, A.M. Silva, and E.B. Souto Ocular Drug Delivery-New Strategies for targeting anterior and posterior segments of the eye Curr. Pharm. Des. 22 2016 1 12
20. R. Gaudana, H.K. Ananthula, A. Parenky, and A.K. Mitra Ocular drug delivery AAPS J. 12 2010 348 360
21. L. Gilleron, S. Coecke, M. Sysmans, E. Hansen, S. Van Oproy, D. Marzin, H. Van Cauteren, and P. Vanparys Evaluation of a modified HET-CAM assay as a screening test for eye irritancy Toxicol. In Vitro 10 1996 431 446
22. K.E. Heim, A.R. Tagliaferro, and D.J. Bobilya Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships J. Nutr. Biochem. 13 2002 572 584
23. B. Howard, H. van Herck, J. Guillen, B. Bacon, R. Joffe, and M. Ritskes-Hoitinga Report of the FELASA Working Group on evaluation of quality systems for animal units Lab. Anim. 38 2004 103 118
24. J.H. Kay, and J.K. Calandra Interpretation of eye irritation test J. Soc. Cosmet. Chem. 13 1962 281 289
25. Y.C. Kim, B. Chiang, X. Wu, and M.R. Prausnitz Ocular delivery of macromolecules J. Control. Release 190 2014 172 181
26. K. Kobayashi, J. Wei, R. Iida, K. Ijiro, and K. Niikura Surface engineering of nanoparticles for therapeutic applications Polym. J. 46 2014 460 468
27. R.A. Kowluru, and P.S. Chan Oxidative stress and diabetic retinopathy Exp. Diabetes Res. 2007 2007 43603
28. J. Li, L. Wu, W. Wu, B. Wang, Z. Wang, H. Xin, and Q. Xu A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate Int. J. Pharm. 455 2013 75 84
29. R.H. Müller, K. Mäder, and S. Gohla Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art Eur. J. Pharm. Biopharm. 50 2000 161 177
30. S.A. Madsen-Bouterse, and R.A. Kowluru Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives Rev. Endocr. Metab. Disord. 9 2008 315 327
31. M. Malhotra, and D.K. Majumdar Permeation through cornea Indian J. Exp. Biol. 39 2001 11 24
32. B. Mishra, B.B. Patel, and S. Tiwari Colloidal nanocarriers: A review on formulation technology, types and applications toward targeted drug delivery Nanomedicine 6 2010 9 24
33. S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi Porcine sclera as a model of human sclera for in vitro transport experiments: Histology, SEM, and comparative permeability Mol. Vis. 15 2009 259 266
34. V. Pade, and S. Stavchansky Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model Pharm. Res. 14 1997 1210 1215
35. M.R. Prausnitz, and J.S. Noonan Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye J. Pharm. Sci. 87 1998 1479 1488
36. V.R. Sinha, S. Srivastava, H. Goel, and V. Jindal Solid lipid nanoparticles (SLNs)-Trends and implications in drug targeting Int. J. Adv. Pharm. Sci. 1 2011 212 238
37. E.B. Souto, and S. Doktorovova Chapter 6-Solid lipid nanoparticle formulations pharmacokinetic and biopharmaceutical aspects in drug delivery Methods Enzymol. 464 2009 105 129
38. E.B. Souto, and R.H. Müller Lipid nanoparticles (SLN and NLC) for drug delivery J. Domb, Y. Tabata, M.N.V.R. Kumar, S. Farber, Nanoparticles for Pharmaceutical Applications. American Scientific Publishers 2007 103 122
39. E.B. Souto, and R.H. Muller Solid lipid nanoparticles and nanostructures lipid carriers ? lipid nanoparticles for medicals and pharmaceuticals (Chapter 64) H.S. Nalwa, Encyclopedia of Nanoscience and Nanotechnology 2010 American Scientific Publishers 313-328
40. E.B. Souto, V. Teeranachaideekul, P. Boonme, R.H. Muller, and V.B. Junyapraset Lipid-Based nanocarriers for cutaneous administration of pharmaceutics (Chapter 217) H.S. Nalwa, Encyclopedia of Nanoscience and Nanotechnology 2010 American Scientific Publishers 479 491
41. E.B. Souto, J.F. Fangueiro, and R.H. Müller Solid lipid nanoparticles (SLN™) I.F. Uchegbu, A.G. Schätzlein, W.P. Cheng, A. Lalatsa, Fundamentals of Pharmaceutical Nanoscience 2013 Springer New York New York 91 116
42. N. Srikantha, F. Mourad, K. Suhling, N. Elsaid, J. Levitt, P.H. Chung, S. Somavarapu, and T.L. Jackson Influence of molecular shape, conformability, net surface charge, and tissue interaction on transscleral macromolecular diffusion Exp. Eye Res. 102 2012 85 92
43. T.R. Thrimawithana, S. Young, C.R. Bunt, C. Green, and R.G. Alany Drug delivery to the posterior segment of the eye Drug Discov. Today 16 2011 270 277
44. A. Urtti Challenges and obstacles of ocular pharmacokinetics and drug delivery Adv. Drug Deliv. Rev. 58 2006 1131 1135
45. A. Vargas, M. Zeisser-Labouèbe, N. Lange, R. Gurny, and F. Delie The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems Adv. Drug Deliv. Rev. 59 2007 1162 1176
46. M. Vazzana, T. Andreani, J. Fangueiro, C. Faggio, C. Silva, A. Santini, M.L. Garcia, A.M. Silva, and E.B. Souto Tramadol hydrochloride: Pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems Biomed. Pharm. 70 2015 234 238
47. T.H. Wakamatsu, M. Dogru, and K. Tsubota Tearful relations: Oxidative stress, inflammation and eye diseases Arq. Bras. Oftalmol. 71 2008 72 79
48. R. Yamauchi, K. Sasaki, and K. Yoshida Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549 Toxicol. In Vitro 23 2009 834 839