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Volumn 275, Issue 1, 2017, Pages 62-78

Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies

Author keywords

autoantibody; broadly neutralizing antibody; CD4+ T follicular helper cell; CD4+ T follicular regulatory cell; human immunodeficiency virus; regulatory T cell

Indexed keywords

ADENOVIRUS VECTOR; AUTOANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 85010901238     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12504     Document Type: Review
Times cited : (45)

References (294)
  • 1
    • 84991389476 scopus 로고    scopus 로고
    • Geneva, World Health Organisation
    • UNAIDS. Prevention Gap Report. Geneva: World Health Organisation, 2016.
    • (2016) Prevention Gap Report
  • 2
    • 84893570591 scopus 로고    scopus 로고
    • Ending AIDS—Is an HIV vaccine necessary?
    • Fauci AS, Marston HD. Ending AIDS—Is an HIV vaccine necessary? N Engl J Med. 2014;370:495–498.
    • (2014) N Engl J Med , vol.370 , pp. 495-498
    • Fauci, A.S.1    Marston, H.D.2
  • 3
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder SP, Mehrotra DV, Duerr A, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372:1881–1893.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3
  • 4
    • 13944250922 scopus 로고    scopus 로고
    • Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
    • Gilbert PB, Peterson ML, Follmann D, et al. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J Infect Dis. 2005;191:666–677.
    • (2005) J Infect Dis , vol.191 , pp. 666-677
    • Gilbert, P.B.1    Peterson, M.L.2    Follmann, D.3
  • 5
    • 79959301474 scopus 로고    scopus 로고
    • Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study
    • Gray GE, Allen M, Moodie Z, et al. Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis. 2011;11:507–515.
    • (2011) Lancet Infect Dis , vol.11 , pp. 507-515
    • Gray, G.E.1    Allen, M.2    Moodie, Z.3
  • 6
    • 84887865083 scopus 로고    scopus 로고
    • Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine
    • Hammer SM, Sobieszczyk ME, Janes H, et al. Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med. 2013;369:2083–2092.
    • (2013) N Engl J Med , vol.369 , pp. 2083-2092
    • Hammer, S.M.1    Sobieszczyk, M.E.2    Janes, H.3
  • 7
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum P, Gilbert P, Gurwith M, et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis. 2006;194:1661–1671.
    • (2006) J Infect Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3
  • 8
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009;361:2209–2220.
    • (2009) N Engl J Med , vol.361 , pp. 2209-2220
    • Rerks-Ngarm, S.1    Pitisuttithum, P.2    Nitayaphan, S.3
  • 9
    • 84897521911 scopus 로고    scopus 로고
    • Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity
    • Liu P, Williams LD, Shen X, et al. Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. J Virol. 2014;88:5165–5170.
    • (2014) J Virol , vol.88 , pp. 5165-5170
    • Liu, P.1    Williams, L.D.2    Shen, X.3
  • 10
    • 84880310997 scopus 로고    scopus 로고
    • Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees
    • Liu P, Yates NL, Shen X, et al. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. J Virol. 2013;87:7828–7836.
    • (2013) J Virol , vol.87 , pp. 7828-7836
    • Liu, P.1    Yates, N.L.2    Shen, X.3
  • 11
    • 0034958413 scopus 로고    scopus 로고
    • Antibody from patients with acute human immunodeficiency virus (HIV) infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cells
    • Forthal DN, Landucci G, Daar ES. Antibody from patients with acute human immunodeficiency virus (HIV) infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cells. J Virol. 2001;75:6953–6961.
    • (2001) J Virol , vol.75 , pp. 6953-6961
    • Forthal, D.N.1    Landucci, G.2    Daar, E.S.3
  • 12
    • 34548496893 scopus 로고    scopus 로고
    • Fc receptor but not complement binding is important in antibody protection against HIV
    • Hessell AJ, Hangartner L, Hunter M, et al. Fc receptor but not complement binding is important in antibody protection against HIV. Nature. 2007;449:101–104.
    • (2007) Nature , vol.449 , pp. 101-104
    • Hessell, A.J.1    Hangartner, L.2    Hunter, M.3
  • 13
    • 0023608640 scopus 로고
    • Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC
    • Lyerly HK, Reed DL, Matthews TJ, et al. Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC. AIDS Res Hum Retroviruses. 1987;3:409–422.
    • (1987) AIDS Res Hum Retroviruses , vol.3 , pp. 409-422
    • Lyerly, H.K.1    Reed, D.L.2    Matthews, T.J.3
  • 15
    • 77951080820 scopus 로고    scopus 로고
    • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines
    • Moody MA, Liao HX, Alam SM, et al. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. J Exp Med. 2010;207:763–776.
    • (2010) J Exp Med , vol.207 , pp. 763-776
    • Moody, M.A.1    Liao, H.X.2    Alam, S.M.3
  • 16
    • 45849125030 scopus 로고    scopus 로고
    • Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays
    • Montefiori DC. Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays. Curr Protoc Immunol. 2005;12:12.11.
    • (2005) Curr Protoc Immunol , vol.12 , pp. 12.11
    • Montefiori, D.C.1
  • 17
    • 60349089294 scopus 로고    scopus 로고
    • Measuring HIV neutralization in a luciferase reporter gene assay
    • Montefiori DC. Measuring HIV neutralization in a luciferase reporter gene assay. Methods Mol Biol. 2009;485:395–405.
    • (2009) Methods Mol Biol , vol.485 , pp. 395-405
    • Montefiori, D.C.1
  • 18
    • 0031058045 scopus 로고    scopus 로고
    • Antibody-mediated neutralization of primary isolates of human immunodeficiency virus type 1 in peripheral blood mononuclear cells is not affected by the initial activation state of the cells
    • Zhou JY, Montefiori DC. Antibody-mediated neutralization of primary isolates of human immunodeficiency virus type 1 in peripheral blood mononuclear cells is not affected by the initial activation state of the cells. J Virol. 1997;71:2512–2517.
    • (1997) J Virol , vol.71 , pp. 2512-2517
    • Zhou, J.Y.1    Montefiori, D.C.2
  • 19
    • 0037389643 scopus 로고    scopus 로고
    • Rapid evolution of the neutralizing antibody response to HIV type 1 infection
    • Richman DD, Wrin T, Little SJ, Petropoulos CJ. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc Natl Acad Sci USA. 2003;100:4144–4149.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4144-4149
    • Richman, D.D.1    Wrin, T.2    Little, S.J.3    Petropoulos, C.J.4
  • 20
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei X, Decker JM, Wang S, et al. Antibody neutralization and escape by HIV-1. Nature. 2003;422:307–312.
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1    Decker, J.M.2    Wang, S.3
  • 21
    • 84888991613 scopus 로고    scopus 로고
    • Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses
    • Pollara J, Bonsignori M, Moody MA, Pazgier M, Haynes BF, Ferrari G. Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Curr HIV Res. 2013;11:378–387.
    • (2013) Curr HIV Res , vol.11 , pp. 378-387
    • Pollara, J.1    Bonsignori, M.2    Moody, M.A.3    Pazgier, M.4    Haynes, B.F.5    Ferrari, G.6
  • 22
    • 84959296091 scopus 로고    scopus 로고
    • Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody
    • Bonsignori M, Zhou T, Sheng Z, et al. Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody. Cell. 2016;165:449–463.
    • (2016) Cell , vol.165 , pp. 449-463
    • Bonsignori, M.1    Zhou, T.2    Sheng, Z.3
  • 23
    • 84905369598 scopus 로고    scopus 로고
    • Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
    • Gao F, Bonsignori M, Liao HX, et al. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. 2014;158:481–491.
    • (2014) Cell , vol.158 , pp. 481-491
    • Gao, F.1    Bonsignori, M.2    Liao, H.X.3
  • 24
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao HX, Lynch R, Zhou T, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496:469–476.
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.X.1    Lynch, R.2    Zhou, T.3
  • 25
    • 84941285955 scopus 로고    scopus 로고
    • Strain-specific V3 and CD4 binding site autologous HIV-1 neutralizing antibodies select neutralization-resistant viruses
    • Moody MA, Gao F, Gurley TC, et al. Strain-specific V3 and CD4 binding site autologous HIV-1 neutralizing antibodies select neutralization-resistant viruses. Cell Host Microbe. 2015;18:354–362.
    • (2015) Cell Host Microbe , vol.18 , pp. 354-362
    • Moody, M.A.1    Gao, F.2    Gurley, T.C.3
  • 26
    • 84908391100 scopus 로고    scopus 로고
    • Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1
    • Sather DN, Carbonetti S, Malherbe DC, et al. Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1. J Virol. 2014;88:12968–12981.
    • (2014) J Virol , vol.88 , pp. 12968-12981
    • Sather, D.N.1    Carbonetti, S.2    Malherbe, D.C.3
  • 27
    • 84929896699 scopus 로고    scopus 로고
    • Antibody responses to envelope glycoproteins in HIV-1 infection
    • Burton DR, Mascola JR. Antibody responses to envelope glycoproteins in HIV-1 infection. Nat Immunol. 2015;16:571–576.
    • (2015) Nat Immunol , vol.16 , pp. 571-576
    • Burton, D.R.1    Mascola, J.R.2
  • 28
    • 0033952103 scopus 로고    scopus 로고
    • Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
    • Baba TW, Liska V, Hofmann-Lehmann R, et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med. 2000;6:200–206.
    • (2000) Nat Med , vol.6 , pp. 200-206
    • Baba, T.W.1    Liska, V.2    Hofmann-Lehmann, R.3
  • 29
    • 67249131966 scopus 로고    scopus 로고
    • Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    • Hessell AJ, Rakasz EG, Poignard P, et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. 2009;5:e1000433.
    • (2009) PLoS Pathog , vol.5
    • Hessell, A.J.1    Rakasz, E.G.2    Poignard, P.3
  • 30
    • 0033951746 scopus 로고    scopus 로고
    • Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
    • Mascola JR, Stiegler G, VanCott TC, et al. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat Med. 2000;6:207–210.
    • (2000) Nat Med , vol.6 , pp. 207-210
    • Mascola, J.R.1    Stiegler, G.2    VanCott, T.C.3
  • 31
    • 84869232528 scopus 로고    scopus 로고
    • Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
    • Moldt B, Rakasz EG, Schultz N, et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci USA. 2012;109:18921–18925.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 18921-18925
    • Moldt, B.1    Rakasz, E.G.2    Schultz, N.3
  • 32
    • 0034864776 scopus 로고    scopus 로고
    • Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    • Parren PW, Marx PA, Hessell AJ, et al. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J Virol. 2001;75:8340–8347.
    • (2001) J Virol , vol.75 , pp. 8340-8347
    • Parren, P.W.1    Marx, P.A.2    Hessell, A.J.3
  • 33
    • 84904497424 scopus 로고    scopus 로고
    • Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
    • Pegu A, Yang ZY, Boyington JC, et al. Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med. 2014;6:243ra288.
    • (2014) Sci Transl Med , vol.6 , pp. 243ra288
    • Pegu, A.1    Yang, Z.Y.2    Boyington, J.C.3
  • 34
    • 84860759632 scopus 로고    scopus 로고
    • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
    • Haynes BF, Kelsoe G, Harrison SC, Kepler TB. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol. 2012;30:423–433.
    • (2012) Nat Biotechnol , vol.30 , pp. 423-433
    • Haynes, B.F.1    Kelsoe, G.2    Harrison, S.C.3    Kepler, T.B.4
  • 35
    • 84952980275 scopus 로고    scopus 로고
    • Structural constraints of vaccine-induced tier-2 autologous HIV neutralizing antibodies targeting the receptor-binding site
    • Bradley T, Fera D, Bhiman J, et al. Structural constraints of vaccine-induced tier-2 autologous HIV neutralizing antibodies targeting the receptor-binding site. Cell Rep. 2016;14:43–54.
    • (2016) Cell Rep , vol.14 , pp. 43-54
    • Bradley, T.1    Fera, D.2    Bhiman, J.3
  • 36
    • 84937469192 scopus 로고    scopus 로고
    • HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers
    • Sanders RW, van Gils MJ, Derking R, et al. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science. 2015;349:aac4223.
    • (2015) Science , vol.349 , pp. aac4223
    • Sanders, R.W.1    van Gils, M.J.2    Derking, R.3
  • 38
    • 44649102135 scopus 로고    scopus 로고
    • Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
    • Keele BF, Giorgi EE, Salazar-Gonzalez JF, et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci USA. 2008;105:7552–7557.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7552-7557
    • Keele, B.F.1    Giorgi, E.E.2    Salazar-Gonzalez, J.F.3
  • 39
    • 84941745031 scopus 로고    scopus 로고
    • + T cell activation during hyperacute HIV infection impact viral set point
    • + T cell activation during hyperacute HIV infection impact viral set point. Immunity. 2015;43:591–604.
    • (2015) Immunity , vol.43 , pp. 591-604
    • Ndhlovu, Z.M.1    Kamya, P.2    Mewalal, N.3
  • 40
    • 67449147145 scopus 로고    scopus 로고
    • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    • Goonetilleke N, Liu MK, Salazar-Gonzalez JF, et al. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J Exp Med. 2009;206:1253–1272.
    • (2009) J Exp Med , vol.206 , pp. 1253-1272
    • Goonetilleke, N.1    Liu, M.K.2    Salazar-Gonzalez, J.F.3
  • 41
    • 57349127300 scopus 로고    scopus 로고
    • Initial B-cell responses to transmitted human immunodeficiency virus type 1: Virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia
    • Tomaras GD, Yates NL, Liu P, et al. Initial B-cell responses to transmitted human immunodeficiency virus type 1: Virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. J Virol. 2008;82:12449–12463.
    • (2008) J Virol , vol.82 , pp. 12449-12463
    • Tomaras, G.D.1    Yates, N.L.2    Liu, P.3
  • 42
    • 80055118908 scopus 로고    scopus 로고
    • Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated
    • Liao HX, Chen X, Munshaw S, et al. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med. 2011;208:2237–2249.
    • (2011) J Exp Med , vol.208 , pp. 2237-2249
    • Liao, H.X.1    Chen, X.2    Munshaw, S.3
  • 43
    • 84898538468 scopus 로고    scopus 로고
    • Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection
    • Derdeyn CA, Moore PL, Morris L. Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection. Curr Opin HIV AIDS. 2014;9:210–216.
    • (2014) Curr Opin HIV AIDS , vol.9 , pp. 210-216
    • Derdeyn, C.A.1    Moore, P.L.2    Morris, L.3
  • 44
    • 84919949772 scopus 로고    scopus 로고
    • HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria
    • Trama AM, Moody MA, Alam SM, et al. HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria. Cell Host Microbe. 2014;16:215–226.
    • (2014) Cell Host Microbe , vol.16 , pp. 215-226
    • Trama, A.M.1    Moody, M.A.2    Alam, S.M.3
  • 45
  • 47
    • 85010862425 scopus 로고    scopus 로고
    • Immune perturbations in HIV-1—infected individuals who make broadly neutralizing antibodies
    • Moody MA, Pedroza-Pacheco I, Vandergrift NA, et al. Immune perturbations in HIV-1—infected individuals who make broadly neutralizing antibodies. Sci Immunol. 2016;1:aag0851.
    • (2016) Sci Immunol , vol.1 , pp. aag0851
    • Moody, M.A.1    Pedroza-Pacheco, I.2    Vandergrift, N.A.3
  • 48
    • 79955389756 scopus 로고    scopus 로고
    • + T cell decline and high viral load during acute infection
    • + T cell decline and high viral load during acute infection. J Virol. 2011;85:4828–4840.
    • (2011) J Virol , vol.85 , pp. 4828-4840
    • Gray, E.S.1    Madiga, M.C.2    Hermanus, T.3
  • 49
    • 73949084963 scopus 로고    scopus 로고
    • Breadth of human immunodeficiency virus-specific neutralizing activity in sera: Clustering analysis and association with clinical variables
    • Doria-Rose NA, Klein RM, Daniels MG, et al. Breadth of human immunodeficiency virus-specific neutralizing activity in sera: Clustering analysis and association with clinical variables. J Virol. 2010;84:1631–1636.
    • (2010) J Virol , vol.84 , pp. 1631-1636
    • Doria-Rose, N.A.1    Klein, R.M.2    Daniels, M.G.3
  • 50
    • 84956714697 scopus 로고    scopus 로고
    • Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort
    • Landais E, Huang X, Havenar-Daughton C, et al. Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. PLoS Pathog. 2016;12:e1005369.
    • (2016) PLoS Pathog , vol.12
    • Landais, E.1    Huang, X.2    Havenar-Daughton, C.3
  • 51
    • 84860723906 scopus 로고    scopus 로고
    • Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: Implications for vaccine design
    • Bonsignori M, Montefiori DC, Wu X, et al. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: Implications for vaccine design. J Virol. 2012;86:4688–4692.
    • (2012) J Virol , vol.86 , pp. 4688-4692
    • Bonsignori, M.1    Montefiori, D.C.2    Wu, X.3
  • 52
    • 77958115264 scopus 로고    scopus 로고
    • A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals
    • Walker LM, Simek MD, Priddy F, et al. A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Pathog. 2010;6:e1001028.
    • (2010) PLoS Pathog , vol.6
    • Walker, L.M.1    Simek, M.D.2    Priddy, F.3
  • 53
    • 34249950588 scopus 로고    scopus 로고
    • Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors
    • Dhillon AK, Donners H, Pantophlet R, et al. Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors. J Virol. 2007;81:6548–6562.
    • (2007) J Virol , vol.81 , pp. 6548-6562
    • Dhillon, A.K.1    Donners, H.2    Pantophlet, R.3
  • 54
    • 69249208675 scopus 로고    scopus 로고
    • Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors
    • Gray ES, Taylor N, Wycuff D, et al. Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors. J Virol. 2009;83:8925–8937.
    • (2009) J Virol , vol.83 , pp. 8925-8937
    • Gray, E.S.1    Taylor, N.2    Wycuff, D.3
  • 55
    • 58149517700 scopus 로고    scopus 로고
    • Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals
    • Li Y, Svehla K, Louder MK, et al. Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals. J Virol. 2009;83:1045–1059.
    • (2009) J Virol , vol.83 , pp. 1045-1059
    • Li, Y.1    Svehla, K.2    Louder, M.K.3
  • 56
    • 58149487645 scopus 로고    scopus 로고
    • Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
    • Sather DN, Armann J, Ching LK, et al. Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J Virol. 2009;83:757–769.
    • (2009) J Virol , vol.83 , pp. 757-769
    • Sather, D.N.1    Armann, J.2    Ching, L.K.3
  • 57
    • 84877618448 scopus 로고    scopus 로고
    • Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization
    • Georgiev IS, Doria-Rose NA, Zhou T, et al. Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science. 2013;340:751–756.
    • (2013) Science , vol.340 , pp. 751-756
    • Georgiev, I.S.1    Doria-Rose, N.A.2    Zhou, T.3
  • 58
    • 69049119032 scopus 로고    scopus 로고
    • HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits
    • Xu W, Santini PA, Sullivan JS, et al. HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat Immunol. 2009;10:1008–1017.
    • (2009) Nat Immunol , vol.10 , pp. 1008-1017
    • Xu, W.1    Santini, P.A.2    Sullivan, J.S.3
  • 59
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey AR, Norris PJ, Qin L, et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol. 2009;83:3719–3733.
    • (2009) J Virol , vol.83 , pp. 3719-3733
    • Stacey, A.R.1    Norris, P.J.2    Qin, L.3
  • 60
    • 84877329810 scopus 로고    scopus 로고
    • Characterization of plasmablasts in the blood of HIV-infected viremic individuals: Evidence for nonspecific immune activation
    • Buckner CM, Moir S, Ho J, et al. Characterization of plasmablasts in the blood of HIV-infected viremic individuals: Evidence for nonspecific immune activation. J Virol. 2013;87:5800–5811.
    • (2013) J Virol , vol.87 , pp. 5800-5811
    • Buckner, C.M.1    Moir, S.2    Ho, J.3
  • 61
    • 46049112339 scopus 로고    scopus 로고
    • Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    • Moir S, Ho J, Malaspina A, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med. 2008;205:1797–1805.
    • (2008) J Exp Med , vol.205 , pp. 1797-1805
    • Moir, S.1    Ho, J.2    Malaspina, A.3
  • 62
    • 17944373021 scopus 로고    scopus 로고
    • HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
    • Moir S, Malaspina A, Ogwaro KM, et al. HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals. Proc Natl Acad Sci USA. 2001;98:10362–10367.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10362-10367
    • Moir, S.1    Malaspina, A.2    Ogwaro, K.M.3
  • 63
    • 68049135892 scopus 로고    scopus 로고
    • Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection
    • Levesque MC, Moody MA, Hwang KK, et al. Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS Med. 2009;6:e1000107.
    • (2009) PLoS Med , vol.6
    • Levesque, M.C.1    Moody, M.A.2    Hwang, K.K.3
  • 64
    • 84903765782 scopus 로고    scopus 로고
    • Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals
    • Kardava L, Moir S, Shah N, et al. Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. J Clin Invest. 2014;124:3252–3262.
    • (2014) J Clin Invest , vol.124 , pp. 3252-3262
    • Kardava, L.1    Moir, S.2    Shah, N.3
  • 65
    • 84864387150 scopus 로고    scopus 로고
    • B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth
    • Boliar S, Murphy MK, Tran TC, et al. B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth. J Virol. 2012;86:8031–8040.
    • (2012) J Virol , vol.86 , pp. 8031-8040
    • Boliar, S.1    Murphy, M.K.2    Tran, T.C.3
  • 66
    • 58149399396 scopus 로고    scopus 로고
    • Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies
    • Doria-Rose NA, Klein RM, Manion MM, et al. Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J Virol. 2009;83:188–199.
    • (2009) J Virol , vol.83 , pp. 188-199
    • Doria-Rose, N.A.1    Klein, R.M.2    Manion, M.M.3
  • 67
    • 77749306129 scopus 로고    scopus 로고
    • Cross-reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression
    • Euler Z, van Gils MJ, Bunnik EM, et al. Cross-reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression. J Infect Dis. 2010;201:1045–1053.
    • (2010) J Infect Dis , vol.201 , pp. 1045-1053
    • Euler, Z.1    van Gils, M.J.2    Bunnik, E.M.3
  • 68
    • 0033119374 scopus 로고    scopus 로고
    • Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo
    • Poignard P, Sabbe R, Picchio GR, et al. Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo. Immunity. 1999;10:431–438.
    • (1999) Immunity , vol.10 , pp. 431-438
    • Poignard, P.1    Sabbe, R.2    Picchio, G.R.3
  • 69
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • Trkola A, Kuster H, Rusert P, et al. Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat Med. 2005;11:615–622.
    • (2005) Nat Med , vol.11 , pp. 615-622
    • Trkola, A.1    Kuster, H.2    Rusert, P.3
  • 70
    • 84954445565 scopus 로고    scopus 로고
    • Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
    • Lynch RM, Boritz E, Coates EE, et al. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med. 2015;7:319ra206.
    • (2015) Sci Transl Med , vol.7 , pp. 319ra206
    • Lynch, R.M.1    Boritz, E.2    Coates, E.E.3
  • 71
    • 84976406858 scopus 로고    scopus 로고
    • HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption
    • Scheid JF, Horwitz JA, Bar-On Y, et al. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature. 2016;535:556–560.
    • (2016) Nature , vol.535 , pp. 556-560
    • Scheid, J.F.1    Horwitz, J.A.2    Bar-On, Y.3
  • 72
    • 84887627657 scopus 로고    scopus 로고
    • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
    • Shingai M, Nishimura Y, Klein F, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature. 2013;503:277–280.
    • (2013) Nature , vol.503 , pp. 277-280
    • Shingai, M.1    Nishimura, Y.2    Klein, F.3
  • 73
    • 84966341056 scopus 로고    scopus 로고
    • HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1
    • Schoofs T, Klein F, Braunschweig M, et al. HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science. 2016;352:997–1001.
    • (2016) Science , vol.352 , pp. 997-1001
    • Schoofs, T.1    Klein, F.2    Braunschweig, M.3
  • 74
    • 79958131570 scopus 로고    scopus 로고
    • Broadly cross-neutralizing antibodies in HIV-1 patients with undetectable viremia
    • Medina-Ramirez M, Sanchez-Merino V, Sanchez-Palomino S, et al. Broadly cross-neutralizing antibodies in HIV-1 patients with undetectable viremia. J Virol. 2011;85:5804–5813.
    • (2011) J Virol , vol.85 , pp. 5804-5813
    • Medina-Ramirez, M.1    Sanchez-Merino, V.2    Sanchez-Palomino, S.3
  • 75
    • 0024410488 scopus 로고
    • Rheumatologic manifestations of infection with human immunodeficiency virus (HIV)
    • Kaye BR. Rheumatologic manifestations of infection with human immunodeficiency virus (HIV). Ann Intern Med. 1989;111:158–167.
    • (1989) Ann Intern Med , vol.111 , pp. 158-167
    • Kaye, B.R.1
  • 76
    • 0023912169 scopus 로고
    • Association of human immunodeficiency virus infection and autoimmune phenomena
    • Kopelman RG, Zolla-Pazner S. Association of human immunodeficiency virus infection and autoimmune phenomena. Am J Med. 1988;84:82–88.
    • (1988) Am J Med , vol.84 , pp. 82-88
    • Kopelman, R.G.1    Zolla-Pazner, S.2
  • 77
    • 0027166292 scopus 로고
    • False-positive human immunodeficiency virus testing in patients with lupus erythematosus
    • Barthel HR, Wallace DJ. False-positive human immunodeficiency virus testing in patients with lupus erythematosus. Semin Arthritis Rheum. 1993;23:1–7.
    • (1993) Semin Arthritis Rheum , vol.23 , pp. 1-7
    • Barthel, H.R.1    Wallace, D.J.2
  • 78
    • 0038813708 scopus 로고    scopus 로고
    • Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy
    • Calza L, Manfredi R, Colangeli V, D'Antuono A, Passarini B, Chiodo F. Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy. Int J STD AIDS. 2003;14:356–359.
    • (2003) Int J STD AIDS , vol.14 , pp. 356-359
    • Calza, L.1    Manfredi, R.2    Colangeli, V.3    D'Antuono, A.4    Passarini, B.5    Chiodo, F.6
  • 79
    • 2342532359 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection and systemic lupus erythematosus
    • Palacios R, Santos J. Human immunodeficiency virus infection and systemic lupus erythematosus. Int J STD AIDS. 2004;15:277–278.
    • (2004) Int J STD AIDS , vol.15 , pp. 277-278
    • Palacios, R.1    Santos, J.2
  • 80
    • 0036179274 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection and systemic lupus erythematosus. An unusual case and a review of the literature
    • Palacios R, Santos J, Valdivielso P, Marquez M. Human immunodeficiency virus infection and systemic lupus erythematosus. An unusual case and a review of the literature. Lupus. 2002;11:60–63.
    • (2002) Lupus , vol.11 , pp. 60-63
    • Palacios, R.1    Santos, J.2    Valdivielso, P.3    Marquez, M.4
  • 81
    • 84897492743 scopus 로고    scopus 로고
    • An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
    • Bonsignori M, Wiehe K, Grimm SK, et al. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. J Clin Invest. 2014;124:1835–1843.
    • (2014) J Clin Invest , vol.124 , pp. 1835-1843
    • Bonsignori, M.1    Wiehe, K.2    Grimm, S.K.3
  • 82
    • 21344434534 scopus 로고    scopus 로고
    • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    • Haynes BF, Fleming J, St Clair EW, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science. 2005;308:1906–1908.
    • (2005) Science , vol.308 , pp. 1906-1908
    • Haynes, B.F.1    Fleming, J.2    St Clair, E.W.3
  • 83
    • 84919430580 scopus 로고    scopus 로고
    • Polyreactivity and autoreactivity among HIV-1 antibodies
    • Liu M, Yang G, Wiehe K, et al. Polyreactivity and autoreactivity among HIV-1 antibodies. J Virol. 2015;89:784–798.
    • (2015) J Virol , vol.89 , pp. 784-798
    • Liu, M.1    Yang, G.2    Wiehe, K.3
  • 84
    • 84874562109 scopus 로고    scopus 로고
    • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
    • Yang G, Holl TM, Liu Y, et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med. 2013;210:241–256.
    • (2013) J Exp Med , vol.210 , pp. 241-256
    • Yang, G.1    Holl, T.M.2    Liu, Y.3
  • 85
  • 86
    • 0034823216 scopus 로고    scopus 로고
    • Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
    • Meffre E, Milili M, Blanco-Betancourt C, Antunes H, Nussenzweig MC, Schiff C. Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development. J Clin Invest. 2001;108:879–886.
    • (2001) J Clin Invest , vol.108 , pp. 879-886
    • Meffre, E.1    Milili, M.2    Blanco-Betancourt, C.3    Antunes, H.4    Nussenzweig, M.C.5    Schiff, C.6
  • 87
    • 56349161598 scopus 로고    scopus 로고
    • B-cell tolerance checkpoints in health and autoimmunity
    • Meffre E, Wardemann H. B-cell tolerance checkpoints in health and autoimmunity. Curr Opin Immunol. 2008;20:632–638.
    • (2008) Curr Opin Immunol , vol.20 , pp. 632-638
    • Meffre, E.1    Wardemann, H.2
  • 88
    • 84884215837 scopus 로고    scopus 로고
    • Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10
    • Doyle-Cooper C, Hudson KE, Cooper AB, et al. Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10. J Immunol. 2013;191:3186–3191.
    • (2013) J Immunol , vol.191 , pp. 3186-3191
    • Doyle-Cooper, C.1    Hudson, K.E.2    Cooper, A.B.3
  • 89
    • 84884262472 scopus 로고    scopus 로고
    • B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates
    • Ota T, Doyle-Cooper C, Cooper AB, et al. B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates. J Immunol. 2013;191:3179–3185.
    • (2013) J Immunol , vol.191 , pp. 3179-3185
    • Ota, T.1    Doyle-Cooper, C.2    Cooper, A.B.3
  • 90
    • 80053529030 scopus 로고    scopus 로고
    • Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls
    • Verkoczy L, Chen Y, Bouton-Verville H, et al. Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. J Immunol. 2011;187:3785–3797.
    • (2011) J Immunol , vol.187 , pp. 3785-3797
    • Verkoczy, L.1    Chen, Y.2    Bouton-Verville, H.3
  • 91
    • 84883348588 scopus 로고    scopus 로고
    • Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: Selection against membrane proximal external region-associated autoreactivity limits T-dependent responses
    • Verkoczy L, Chen Y, Zhang J, et al. Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: Selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. J Immunol. 2013;191:2538–2550.
    • (2013) J Immunol , vol.191 , pp. 2538-2550
    • Verkoczy, L.1    Chen, Y.2    Zhang, J.3
  • 92
    • 76249083814 scopus 로고    scopus 로고
    • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
    • Verkoczy L, Diaz M, Holl TM, et al. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc Natl Acad Sci USA. 2010;107:181–186.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 181-186
    • Verkoczy, L.1    Diaz, M.2    Holl, T.M.3
  • 93
    • 70350221801 scopus 로고    scopus 로고
    • Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region
    • Verkoczy L, Moody MA, Holl TM, et al. Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region. PLoS ONE. 2009;4:e7215.
    • (2009) PLoS ONE , vol.4
    • Verkoczy, L.1    Moody, M.A.2    Holl, T.M.3
  • 94
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia A. Antigen-specific interaction between T and B cells. Nature. 1985;314:537–539.
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 96
    • 0026772133 scopus 로고
    • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
    • Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA. 1992;89:6550–6554.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6550-6554
    • Noelle, R.J.1    Roy, M.2    Shepherd, D.M.3    Stamenkovic, I.4    Ledbetter, J.A.5    Aruffo, A.6
  • 98
    • 49649120932 scopus 로고    scopus 로고
    • IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4
    • Avery DT, Bryant VL, Ma CS, de Waal Malefyt R, Tangye SG. IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4. J Immunol. 2008;181:1767–1779.
    • (2008) J Immunol , vol.181 , pp. 1767-1779
    • Avery, D.T.1    Bryant, V.L.2    Ma, C.S.3    de Waal Malefyt, R.4    Tangye, S.G.5
  • 99
    • 78751690647 scopus 로고    scopus 로고
    • Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • Morita R, Schmitt N, Bentebibel SE, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011;34:108–121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.E.3
  • 100
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    • Yusuf I, Kageyama R, Monticelli L, et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol. 2010;185:190–202.
    • (2010) J Immunol , vol.185 , pp. 190-202
    • Yusuf, I.1    Kageyama, R.2    Monticelli, L.3
  • 101
    • 79956079578 scopus 로고    scopus 로고
    • Germinal center B and follicular helper T cells: Siblings, cousins or just good friends?
    • Nutt SL, Tarlinton DM. Germinal center B and follicular helper T cells: Siblings, cousins or just good friends? Nat Immunol. 2011;12:472–477.
    • (2011) Nat Immunol , vol.12 , pp. 472-477
    • Nutt, S.L.1    Tarlinton, D.M.2
  • 102
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman MA, Beaton L, Yu D, et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med. 2010;207:353–363.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3
  • 103
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D, Coquet JM, Zhang Y, et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 2010;207:365–378.
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3
  • 104
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol. 2009;10:385–393.
    • (2009) Nat Immunol , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 105
    • 79958255209 scopus 로고    scopus 로고
    • A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center
    • Schwickert TA, Victora GD, Fooksman DR, et al. A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med. 2011;208:1243–1252.
    • (2011) J Exp Med , vol.208 , pp. 1243-1252
    • Schwickert, T.A.1    Victora, G.D.2    Fooksman, D.R.3
  • 106
    • 84859717525 scopus 로고    scopus 로고
    • Germinal center selection and the development of memory B and plasma cells
    • Shlomchik MJ, Weisel F. Germinal center selection and the development of memory B and plasma cells. Immunol Rev. 2012;247:52–63.
    • (2012) Immunol Rev , vol.247 , pp. 52-63
    • Shlomchik, M.J.1    Weisel, F.2
  • 107
    • 84939635025 scopus 로고    scopus 로고
    • T cell help controls the speed of the cell cycle in germinal center B cells
    • Gitlin AD, Mayer CT, Oliveira TY, et al. T cell help controls the speed of the cell cycle in germinal center B cells. Science. 2015;349:643–646.
    • (2015) Science , vol.349 , pp. 643-646
    • Gitlin, A.D.1    Mayer, C.T.2    Oliveira, T.Y.3
  • 108
    • 84901644301 scopus 로고    scopus 로고
    • Clonal selection in the germinal centre by regulated proliferation and hypermutation
    • Gitlin AD, Shulman Z, Nussenzweig MC. Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature. 2014;509:637–640.
    • (2014) Nature , vol.509 , pp. 637-640
    • Gitlin, A.D.1    Shulman, Z.2    Nussenzweig, M.C.3
  • 109
  • 110
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora GD, Schwickert TA, Fooksman DR, et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 2010;143:592–605.
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1    Schwickert, T.A.2    Fooksman, D.R.3
  • 111
    • 84984623206 scopus 로고    scopus 로고
    • TFH cells progressively differentiate to regulate the germinal center response
    • Weinstein JS, Herman EI, Lainez B, et al. TFH cells progressively differentiate to regulate the germinal center response. Nat Immunol. 2016;17:1197–1205.
    • (2016) Nat Immunol , vol.17 , pp. 1197-1205
    • Weinstein, J.S.1    Herman, E.I.2    Lainez, B.3
  • 112
    • 84908148200 scopus 로고    scopus 로고
    • T follicular helper cell differentiation, function, and roles in disease
    • Crotty S. T follicular helper cell differentiation, function, and roles in disease. Immunity. 2014;41:529–542.
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.1
  • 113
    • 84875444198 scopus 로고    scopus 로고
    • Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
    • Choi YS, Yang JA, Yusuf I, et al. Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol. 2013;190:4014–4026.
    • (2013) J Immunol , vol.190 , pp. 4014-4026
    • Choi, Y.S.1    Yang, J.A.2    Yusuf, I.3
  • 114
    • 84879221506 scopus 로고    scopus 로고
    • Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells
    • Choi YS, Yang JA, Crotty S. Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells. Curr Opin Immunol. 2013;25:366–372.
    • (2013) Curr Opin Immunol , vol.25 , pp. 366-372
    • Choi, Y.S.1    Yang, J.A.2    Crotty, S.3
  • 115
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva RI, Chung Y, Martinez GJ, et al. Bcl6 mediates the development of T follicular helper cells. Science. 2009;325:1001–1005.
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1    Chung, Y.2    Martinez, G.J.3
  • 116
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • Pepper M, Pagan AJ, Igyarto BZ, Taylor JJ, Jenkins MK. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity. 2011;35:583–595.
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1    Pagan, A.J.2    Igyarto, B.Z.3    Taylor, J.J.4    Jenkins, M.K.5
  • 117
    • 84924588068 scopus 로고    scopus 로고
    • Cutting edge: Circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production
    • Chavele KM, Merry E, Ehrenstein MR. Cutting edge: Circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production. J Immunol. 2015;194:2482–2485.
    • (2015) J Immunol , vol.194 , pp. 2482-2485
    • Chavele, K.M.1    Merry, E.2    Ehrenstein, M.R.3
  • 118
    • 70450265288 scopus 로고    scopus 로고
    • Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12
    • Ma CS, Suryani S, Avery DT, et al. Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol. 2009;87:590–600.
    • (2009) Immunol Cell Biol , vol.87 , pp. 590-600
    • Ma, C.S.1    Suryani, S.2    Avery, D.T.3
  • 119
    • 68249158536 scopus 로고    scopus 로고
    • Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12
    • Schmitt N, Morita R, Bourdery L, et al. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity. 2009;31:158–169.
    • (2009) Immunity , vol.31 , pp. 158-169
    • Schmitt, N.1    Morita, R.2    Bourdery, L.3
  • 120
    • 84976869213 scopus 로고    scopus 로고
    • Activin A programs the differentiation of human TFH cells
    • Locci M, Wu JE, Arumemi F, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976–984.
    • (2016) Nat Immunol , vol.17 , pp. 976-984
    • Locci, M.1    Wu, J.E.2    Arumemi, F.3
  • 121
    • 84906306956 scopus 로고    scopus 로고
    • The cytokine TGF-beta co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
    • Schmitt N, Liu Y, Bentebibel SE, et al. The cytokine TGF-beta co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells. Nat Immunol. 2014;15:856–865.
    • (2014) Nat Immunol , vol.15 , pp. 856-865
    • Schmitt, N.1    Liu, Y.2    Bentebibel, S.E.3
  • 122
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato A, Leon B, Graf BA, et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity. 2012;36:847–856.
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1    Leon, B.2    Graf, B.A.3
  • 123
  • 124
    • 84959088532 scopus 로고    scopus 로고
    • Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation
    • Liu X, Lu H, Chen T, et al. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation. Cell Rep. 2016;14:1735–1747.
    • (2016) Cell Rep , vol.14 , pp. 1735-1747
    • Liu, X.1    Lu, H.2    Chen, T.3
  • 125
    • 84953924620 scopus 로고    scopus 로고
    • IL-7 signalling represses Bcl-6 and the TFH gene program
    • McDonald PW, Read KA, Baker CE, et al. IL-7 signalling represses Bcl-6 and the TFH gene program. Nat Commun. 2016;7:10285.
    • (2016) Nat Commun , vol.7 , pp. 10285
    • McDonald, P.W.1    Read, K.A.2    Baker, C.E.3
  • 126
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity. 2011;34:932–946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3
  • 127
    • 84933678575 scopus 로고    scopus 로고
    • CD8alpha(-) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses
    • Shin C, Han JA, Koh H, et al. CD8alpha(-) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses. Cell Rep. 2015;11:1929–1940.
    • (2015) Cell Rep , vol.11 , pp. 1929-1940
    • Shin, C.1    Han, J.A.2    Koh, H.3
  • 128
    • 84971254846 scopus 로고    scopus 로고
    • EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
    • Li J, Lu E, Yi T, Cyster JG. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533:110–114.
    • (2016) Nature , vol.533 , pp. 110-114
    • Li, J.1    Lu, E.2    Yi, T.3    Cyster, J.G.4
  • 129
    • 84877710866 scopus 로고    scopus 로고
    • + T cells from a diverse repertoire produce different effector cell types during infection
    • + T cells from a diverse repertoire produce different effector cell types during infection. Cell. 2013;153:785–796.
    • (2013) Cell , vol.153 , pp. 785-796
    • Tubo, N.J.1    Pagan, A.J.2    Taylor, J.J.3
  • 130
    • 84940995726 scopus 로고    scopus 로고
    • Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo
    • Benson RA, MacLeod MK, Hale BG, Patakas A, Garside P, Brewer JM. Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. Elife. 2015;4:000.
    • (2015) Elife , vol.4 , pp. 000
    • Benson, R.A.1    MacLeod, M.K.2    Hale, B.G.3    Patakas, A.4    Garside, P.5    Brewer, J.M.6
  • 132
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med. 2000;192:1553–1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 133
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007;179:5099–5108.
    • (2007) J Immunol , vol.179 , pp. 5099-5108
    • Haynes, N.M.1    Allen, C.D.2    Lesley, R.3    Ansel, K.M.4    Killeen, N.5    Cyster, J.G.6
  • 134
    • 84876793426 scopus 로고    scopus 로고
    • Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility
    • Xu H, Li X, Liu D, et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature. 2013;496:523–527.
    • (2013) Nature , vol.496 , pp. 523-527
    • Xu, H.1    Li, X.2    Liu, D.3
  • 135
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal centre formation
    • Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature. 2008;455:764–769.
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 136
    • 84862988085 scopus 로고    scopus 로고
    • The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development
    • Kageyama R, Cannons JL, Zhao F, et al. The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity. 2012;36:986–1002.
    • (2012) Immunity , vol.36 , pp. 986-1002
    • Kageyama, R.1    Cannons, J.L.2    Zhao, F.3
  • 137
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, Poholek AC, DiToro D, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 2009;325:1006–1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    DiToro, D.3
  • 138
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, Rao S, Tsai LM, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity. 2009;31:457–468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3
  • 140
    • 84939617686 scopus 로고    scopus 로고
    • LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
    • Choi YS, Gullicksrud JA, Xing S, et al. LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol. 2015;16:980–990.
    • (2015) Nat Immunol , vol.16 , pp. 980-990
    • Choi, Y.S.1    Gullicksrud, J.A.2    Xing, S.3
  • 141
    • 84942825205 scopus 로고    scopus 로고
    • TCF1 is required for the T follicular helper cell response to viral infection
    • Wu T, Shin HM, Moseman EA, et al. TCF1 is required for the T follicular helper cell response to viral infection. Cell Rep. 2015;12:2099–2110.
    • (2015) Cell Rep , vol.12 , pp. 2099-2110
    • Wu, T.1    Shin, H.M.2    Moseman, E.A.3
  • 142
    • 84939603374 scopus 로고    scopus 로고
    • The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection
    • Xu L, Cao Y, Xie Z, et al. The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection. Nat Immunol. 2015;16:991–999.
    • (2015) Nat Immunol , vol.16 , pp. 991-999
    • Xu, L.1    Cao, Y.2    Xie, Z.3
  • 143
    • 77952304784 scopus 로고    scopus 로고
    • Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
    • Betz BC, Jordan-Williams KL, Wang C, et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010;207:933–942.
    • (2010) J Exp Med , vol.207 , pp. 933-942
    • Betz, B.C.1    Jordan-Williams, K.L.2    Wang, C.3
  • 144
    • 84861872906 scopus 로고    scopus 로고
    • Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
    • Bollig N, Brustle A, Kellner K, et al. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci USA. 2012;109:8664–8669.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8664-8669
    • Bollig, N.1    Brustle, A.2    Kellner, K.3
  • 145
    • 84897954312 scopus 로고    scopus 로고
    • Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development
    • Liu X, Chen X, Zhong B, et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014;507:513–518.
    • (2014) Nature , vol.507 , pp. 513-518
    • Liu, X.1    Chen, X.2    Zhong, B.3
  • 146
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009;10:167–175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3
  • 147
    • 84859711557 scopus 로고    scopus 로고
    • Functional STAT3 deficiency compromises the generation of human T follicular helper cells
    • Ma CS, Avery DT, Chan A, et al. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood. 2012;119:3997–4008.
    • (2012) Blood , vol.119 , pp. 3997-4008
    • Ma, C.S.1    Avery, D.T.2    Chan, A.3
  • 148
    • 84923044855 scopus 로고    scopus 로고
    • ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation
    • Stone EL, Pepper M, Katayama CD, et al. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015;42:239–251.
    • (2015) Immunity , vol.42 , pp. 239-251
    • Stone, E.L.1    Pepper, M.2    Katayama, C.D.3
  • 149
    • 84880778954 scopus 로고    scopus 로고
    • The microRNA cluster miR-17 approximately 92 promotes TFH cell differentiation and represses subset-inappropriate gene expression
    • Baumjohann D, Kageyama R, Clingan JM, et al. The microRNA cluster miR-17 approximately 92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013;14:840–848.
    • (2013) Nat Immunol , vol.14 , pp. 840-848
    • Baumjohann, D.1    Kageyama, R.2    Clingan, J.M.3
  • 150
    • 84880767787 scopus 로고    scopus 로고
    • MicroRNAs of the miR-17 approximately 92 family are critical regulators of T(FH) differentiation
    • Kang SG, Liu WH, Lu P, et al. MicroRNAs of the miR-17 approximately 92 family are critical regulators of T(FH) differentiation. Nat Immunol. 2013;14:849–857.
    • (2013) Nat Immunol , vol.14 , pp. 849-857
    • Kang, S.G.1    Liu, W.H.2    Lu, P.3
  • 151
    • 84928253323 scopus 로고    scopus 로고
    • BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms
    • Hatzi K, Nance JP, Kroenke MA, et al. BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms. J Exp Med. 2015;212:539–553.
    • (2015) J Exp Med , vol.212 , pp. 539-553
    • Hatzi, K.1    Nance, J.P.2    Kroenke, M.A.3
  • 152
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano M, Moriyama S, Ando Y, et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity. 2011;34:961–972.
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1    Moriyama, S.2    Ando, Y.3
  • 153
    • 84881252552 scopus 로고    scopus 로고
    • T follicular helper cell dynamics in germinal centers
    • Shulman Z, Moriyama S, Ando Y, et al. T follicular helper cell dynamics in germinal centers. Science. 2013;341:673–677.
    • (2013) Science , vol.341 , pp. 673-677
    • Shulman, Z.1    Moriyama, S.2    Ando, Y.3
  • 154
    • 84876780521 scopus 로고    scopus 로고
    • + T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection
    • + T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity. 2013;38:805–817.
    • (2013) Immunity , vol.38 , pp. 805-817
    • Hale, J.S.1    Youngblood, B.2    Latner, D.R.3
  • 155
    • 84870285173 scopus 로고    scopus 로고
    • Bcl6 expression specifies the T follicular helper cell program in vivo
    • Liu X, Yan X, Zhong B, et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med. 2012;209:1841–1852, S1841-1824.
    • (2012) J Exp Med , vol.209 , pp. 1841-1852
    • Liu, X.1    Yan, X.2    Zhong, B.3
  • 156
    • 84859897308 scopus 로고    scopus 로고
    • The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    • Luthje K, Kallies A, Shimohakamada Y, et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol. 2012;13:491–498.
    • (2012) Nat Immunol , vol.13 , pp. 491-498
    • Luthje, K.1    Kallies, A.2    Shimohakamada, Y.3
  • 157
    • 84864742274 scopus 로고    scopus 로고
    • T-follicular helper cells survive as long-term memory cells
    • Weber JP, Fuhrmann F, Hutloff A. T-follicular helper cells survive as long-term memory cells. Eur J Immunol. 2012;42:1981–1988.
    • (2012) Eur J Immunol , vol.42 , pp. 1981-1988
    • Weber, J.P.1    Fuhrmann, F.2    Hutloff, A.3
  • 158
    • 84875129611 scopus 로고    scopus 로고
    • + TH cells correlates with antibody responses to influenza vaccination
    • + TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med. 2013;5:176ra132.
    • (2013) Sci Transl Med , vol.5 , pp. 176ra132
    • Bentebibel, S.E.1    Lopez, S.2    Obermoser, G.3
  • 159
    • 79956196930 scopus 로고    scopus 로고
    • CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
    • Chevalier N, Jarrossay D, Ho E, et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol. 2011;186:5556–5568.
    • (2011) J Immunol , vol.186 , pp. 5556-5568
    • Chevalier, N.1    Jarrossay, D.2    Ho, E.3
  • 160
    • 84885743368 scopus 로고    scopus 로고
    • + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    • + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity. 2013;39:758–769.
    • (2013) Immunity , vol.39 , pp. 758-769
    • Locci, M.1    Havenar-Daughton, C.2    Landais, E.3
  • 161
    • 84922551023 scopus 로고    scopus 로고
    • Phenotype and functions of memory Tfh cells in human blood
    • Schmitt N, Bentebibel SE, Ueno H. Phenotype and functions of memory Tfh cells in human blood. Trends Immunol. 2014;35:436–442.
    • (2014) Trends Immunol , vol.35 , pp. 436-442
    • Schmitt, N.1    Bentebibel, S.E.2    Ueno, H.3
  • 162
    • 84885741984 scopus 로고    scopus 로고
    • Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
    • He J, Tsai LM, Leong YA, et al. Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity. 2013;39:770–781.
    • (2013) Immunity , vol.39 , pp. 770-781
    • He, J.1    Tsai, L.M.2    Leong, Y.A.3
  • 163
    • 84893746319 scopus 로고    scopus 로고
    • Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection
    • Boswell KL, Paris R, Boritz E, et al. Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog. 2014;10:e1003853.
    • (2014) PLoS Pathog , vol.10
    • Boswell, K.L.1    Paris, R.2    Boritz, E.3
  • 164
    • 84971254534 scopus 로고    scopus 로고
    • ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination
    • Bentebibel SE, Khurana S, Schmitt N, et al. ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination. Sci Rep. 2016;6:26494.
    • (2016) Sci Rep , vol.6 , pp. 26494
    • Bentebibel, S.E.1    Khurana, S.2    Schmitt, N.3
  • 165
    • 0035660401 scopus 로고    scopus 로고
    • Variable fate of virus-specific CD4(+) T cells during primary HIV-1 infection
    • Oxenius A, Fidler S, Brady M, et al. Variable fate of virus-specific CD4(+) T cells during primary HIV-1 infection. Eur J Immunol. 2001;31:3782–3788.
    • (2001) Eur J Immunol , vol.31 , pp. 3782-3788
    • Oxenius, A.1    Fidler, S.2    Brady, M.3
  • 168
    • 84859415408 scopus 로고    scopus 로고
    • Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape
    • Hong JJ, Amancha PK, Rogers K, Ansari AA, Villinger F. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol. 2012;188:3247–3256.
    • (2012) J Immunol , vol.188 , pp. 3247-3256
    • Hong, J.J.1    Amancha, P.K.2    Rogers, K.3    Ansari, A.A.4    Villinger, F.5
  • 169
    • 84904254930 scopus 로고    scopus 로고
    • Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection
    • Hong JJ, Amancha PK, Rogers KA, et al. Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection. J Immunol. 2014;193:797–806.
    • (2014) J Immunol , vol.193 , pp. 797-806
    • Hong, J.J.1    Amancha, P.K.2    Rogers, K.A.3
  • 170
    • 84962527945 scopus 로고    scopus 로고
    • Germinal center T follicular helper cells are highly permissive to HIV-1 and alter their phenotype during virus replication
    • Kohler SL, Pham MN, Folkvord JM, et al. Germinal center T follicular helper cells are highly permissive to HIV-1 and alter their phenotype during virus replication. J Immunol. 2016;196:2711–2722.
    • (2016) J Immunol , vol.196 , pp. 2711-2722
    • Kohler, S.L.1    Pham, M.N.2    Folkvord, J.M.3
  • 171
    • 84961161685 scopus 로고    scopus 로고
    • Peripheral T follicular helper cells are the major HIV reservoir within central memory CD4 T cells in peripheral blood from chronically HIV-infected individuals on combination antiretroviral therapy
    • Pallikkuth S, Sharkey M, Babic DZ, et al. Peripheral T follicular helper cells are the major HIV reservoir within central memory CD4 T cells in peripheral blood from chronically HIV-infected individuals on combination antiretroviral therapy. J Virol. 2016;90:2718–2728.
    • (2016) J Virol , vol.90 , pp. 2718-2728
    • Pallikkuth, S.1    Sharkey, M.2    Babic, D.Z.3
  • 172
    • 0031011147 scopus 로고    scopus 로고
    • + T cells are an important site of HIV replication in vivo
    • + T cells are an important site of HIV replication in vivo. AIDS. 1997;11:849–857.
    • (1997) AIDS , vol.11 , pp. 849-857
    • Hufert, F.T.1    van Lunzen, J.2    Janossy, G.3
  • 173
    • 84874519282 scopus 로고    scopus 로고
    • Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
    • Perreau M, Savoye AL, De Crignis E, et al. Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J Exp Med. 2013;210:143–156.
    • (2013) J Exp Med , vol.210 , pp. 143-156
    • Perreau, M.1    Savoye, A.L.2    De Crignis, E.3
  • 174
    • 84869814713 scopus 로고    scopus 로고
    • + T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    • + T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood. 2012;120:4172–4181.
    • (2012) Blood , vol.120 , pp. 4172-4181
    • Brenchley, J.M.1    Vinton, C.2    Tabb, B.3
  • 175
    • 84912569301 scopus 로고    scopus 로고
    • Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL
    • Connick E, Folkvord JM, Lind KT, et al. Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL. J Immunol. 2014;193:5613–5625.
    • (2014) J Immunol , vol.193 , pp. 5613-5625
    • Connick, E.1    Folkvord, J.M.2    Lind, K.T.3
  • 176
    • 84973131619 scopus 로고    scopus 로고
    • PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals
    • Banga R, Procopio FA, Noto A, et al. PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Nat Med. 2016;22:754–761.
    • (2016) Nat Med , vol.22 , pp. 754-761
    • Banga, R.1    Procopio, F.A.2    Noto, A.3
  • 177
    • 84995654922 scopus 로고    scopus 로고
    • Single-cell characterization of viral translation-competent reservoirs in HIV-infected individuals
    • Baxter AE, Niessl J, Fromentin R, et al. Single-cell characterization of viral translation-competent reservoirs in HIV-infected individuals. Cell Host Microbe. 2016;20:368–380.
    • (2016) Cell Host Microbe , vol.20 , pp. 368-380
    • Baxter, A.E.1    Niessl, J.2    Fromentin, R.3
  • 178
    • 84981318384 scopus 로고    scopus 로고
    • Multiple origins of virus persistence during natural control of HIV infection
    • Boritz EA, Darko S, Swaszek L, et al. Multiple origins of virus persistence during natural control of HIV infection. Cell. 2016;166:1004–1015.
    • (2016) Cell , vol.166 , pp. 1004-1015
    • Boritz, E.A.1    Darko, S.2    Swaszek, L.3
  • 179
    • 84922611542 scopus 로고    scopus 로고
    • B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
    • Fukazawa Y, Lum R, Okoye AA, et al. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat Med. 2015;21:132–139.
    • (2015) Nat Med , vol.21 , pp. 132-139
    • Fukazawa, Y.1    Lum, R.2    Okoye, A.A.3
  • 180
    • 10544241554 scopus 로고    scopus 로고
    • Quantitative image analysis of HIV-1 infection in lymphoid tissue
    • Haase AT, Henry K, Zupancic M, et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science. 1996;274:985–989.
    • (1996) Science , vol.274 , pp. 985-989
    • Haase, A.T.1    Henry, K.2    Zupancic, M.3
  • 181
    • 0028825476 scopus 로고
    • Follicular dendritic cells and human immunodeficiency virus infectivity
    • Heath SL, Tew JG, Tew JG, Szakal AK, Burton GF. Follicular dendritic cells and human immunodeficiency virus infectivity. Nature. 1995;377:740–744.
    • (1995) Nature , vol.377 , pp. 740-744
    • Heath, S.L.1    Tew, J.G.2    Tew, J.G.3    Szakal, A.K.4    Burton, G.F.5
  • 184
    • 34249800097 scopus 로고    scopus 로고
    • CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue
    • Connick E, Mattila T, Folkvord JM, et al. CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue. J Immunol. 2007;178:6975–6983.
    • (2007) J Immunol , vol.178 , pp. 6975-6983
    • Connick, E.1    Mattila, T.2    Folkvord, J.M.3
  • 185
    • 84988410229 scopus 로고    scopus 로고
    • + T cells curtail chronic viral infection
    • + T cells curtail chronic viral infection. Nature. 2016;537:412–428.
    • (2016) Nature , vol.537 , pp. 412-428
    • He, R.1    Hou, S.2    Liu, C.3
  • 186
    • 84988266244 scopus 로고    scopus 로고
    • + T cells that provide the proliferative burst after PD-1 therapy
    • + T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016;537:417–421.
    • (2016) Nature , vol.537 , pp. 417-421
    • Im, S.J.1    Hashimoto, M.2    Gerner, M.Y.3
  • 187
    • 84981285538 scopus 로고    scopus 로고
    • + follicular cytotoxic T cells control viral infection in B cell follicles
    • + follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187–1196.
    • (2016) Nat Immunol , vol.17 , pp. 1187-1196
    • Leong, Y.A.1    Chen, Y.2    Ong, H.S.3
  • 188
    • 84938340710 scopus 로고    scopus 로고
    • Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection
    • Yamamoto T, Lynch RM, Gautam R, et al. Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection. Sci Transl Med. 2015;7:298ra120.
    • (2015) Sci Transl Med , vol.7 , pp. 298ra120
    • Yamamoto, T.1    Lynch, R.M.2    Gautam, R.3
  • 189
    • 84865395104 scopus 로고    scopus 로고
    • CD4 T follicular helper cell dynamics during SIV infection
    • Petrovas C, Yamamoto T, Gerner MY, et al. CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest. 2012;122:3281–3294.
    • (2012) J Clin Invest , vol.122 , pp. 3281-3294
    • Petrovas, C.1    Yamamoto, T.2    Gerner, M.Y.3
  • 190
    • 84878454838 scopus 로고    scopus 로고
    • Inadequate T follicular cell help impairs B cell immunity during HIV infection
    • Cubas RA, Mudd JC, Savoye AL, et al. Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat Med. 2013;19:494–499.
    • (2013) Nat Med , vol.19 , pp. 494-499
    • Cubas, R.A.1    Mudd, J.C.2    Savoye, A.L.3
  • 191
    • 84865997747 scopus 로고    scopus 로고
    • Expansion of HIV-specific T follicular helper cells in chronic HIV infection
    • Lindqvist M, van Lunzen J, Soghoian DZ, et al. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest. 2012;122:3271–3280.
    • (2012) J Clin Invest , vol.122 , pp. 3271-3280
    • Lindqvist, M.1    van Lunzen, J.2    Soghoian, D.Z.3
  • 192
    • 84945152066 scopus 로고    scopus 로고
    • Persistent simian immunodeficiency virus infection causes ultimate depletion of follicular Th cells in AIDS
    • Xu H, Wang X, Malam N, Lackner AA, Veazey RS. Persistent simian immunodeficiency virus infection causes ultimate depletion of follicular Th cells in AIDS. J Immunol. 2015;195:4351–4357.
    • (2015) J Immunol , vol.195 , pp. 4351-4357
    • Xu, H.1    Wang, X.2    Malam, N.3    Lackner, A.A.4    Veazey, R.S.5
  • 193
    • 84875549975 scopus 로고    scopus 로고
    • Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
    • Baumjohann D, Preite S, Reboldi A, et al. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013;38:596–605.
    • (2013) Immunity , vol.38 , pp. 596-605
    • Baumjohann, D.1    Preite, S.2    Reboldi, A.3
  • 195
    • 81055157812 scopus 로고    scopus 로고
    • Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    • Harker JA, Lewis GM, Mack L, Zuniga EI. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science. 2011;334:825–829.
    • (2011) Science , vol.334 , pp. 825-829
    • Harker, J.A.1    Lewis, G.M.2    Mack, L.3    Zuniga, E.I.4
  • 196
    • 0027332299 scopus 로고
    • Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection
    • Fan J, Bass HZ, Fahey JL. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection. J Immunol. 1993;151:5031–5040.
    • (1993) J Immunol , vol.151 , pp. 5031-5040
    • Fan, J.1    Bass, H.Z.2    Fahey, J.L.3
  • 197
    • 84982994525 scopus 로고    scopus 로고
    • Altered memory circulating T follicular helper-B cell interaction in early acute HIV infection
    • Muir R, Metcalf T, Tardif V, et al. Altered memory circulating T follicular helper-B cell interaction in early acute HIV infection. PLoS Pathog. 2016;12:e1005777.
    • (2016) PLoS Pathog , vol.12
    • Muir, R.1    Metcalf, T.2    Tardif, V.3
  • 198
    • 84983776546 scopus 로고    scopus 로고
    • Induction of Th1-biased T follicular helper (Tfh) cells in lymphoid tissues during chronic simian immunodeficiency virus infection defines functionally distinct germinal center Tfh cells
    • Velu V, Mylvaganam GH, Gangadhara S, et al. Induction of Th1-biased T follicular helper (Tfh) cells in lymphoid tissues during chronic simian immunodeficiency virus infection defines functionally distinct germinal center Tfh cells. J Immunol. 2016;197:1832–1842.
    • (2016) J Immunol , vol.197 , pp. 1832-1842
    • Velu, V.1    Mylvaganam, G.H.2    Gangadhara, S.3
  • 199
    • 84958259928 scopus 로고    scopus 로고
    • Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection
    • Cubas R, van Grevenynghe J, Wills S, et al. Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection. J Immunol. 2015;195:5625–5636.
    • (2015) J Immunol , vol.195 , pp. 5625-5636
    • Cubas, R.1    van Grevenynghe, J.2    Wills, S.3
  • 200
    • 84908377312 scopus 로고    scopus 로고
    • + helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection
    • + helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection. J Virol. 2014;88:13310–13321.
    • (2014) J Virol , vol.88 , pp. 13310-13321
    • Cohen, K.1    Altfeld, M.2    Alter, G.3    Stamatatos, L.4
  • 201
    • 84960933943 scopus 로고    scopus 로고
    • CXCL13 is a plasma biomarker of germinal center activity
    • Havenar-Daughton C, Lindqvist M, Heit A, et al. CXCL13 is a plasma biomarker of germinal center activity. Proc Natl Acad Sci USA. 2016;113:2702–2707.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 2702-2707
    • Havenar-Daughton, C.1    Lindqvist, M.2    Heit, A.3
  • 202
    • 84885962913 scopus 로고    scopus 로고
    • GagPol-specific CD4(+) T-cells increase the antibody response to Env by intrastructural help
    • Nabi G, Genannt Bonsmann MS, Tenbusch M, et al. GagPol-specific CD4(+) T-cells increase the antibody response to Env by intrastructural help. Retrovirology. 2013;10:117.
    • (2013) Retrovirology , vol.10 , pp. 117
    • Nabi, G.1    Genannt Bonsmann, M.S.2    Tenbusch, M.3
  • 203
    • 84975774996 scopus 로고    scopus 로고
    • CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination
    • Knowlden ZA, Sant AJ. CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination. Sci Rep. 2016;6:28287.
    • (2016) Sci Rep , vol.6 , pp. 28287
    • Knowlden, Z.A.1    Sant, A.J.2
  • 204
    • 84880286540 scopus 로고    scopus 로고
    • Association of HLA-DRB1-restricted CD4(+) T cell responses with HIV immune control
    • Ranasinghe S, Cutler S, Davis I, et al. Association of HLA-DRB1-restricted CD4(+) T cell responses with HIV immune control. Nat Med. 2013;19:930–933.
    • (2013) Nat Med , vol.19 , pp. 930-933
    • Ranasinghe, S.1    Cutler, S.2    Davis, I.3
  • 205
    • 84862764447 scopus 로고    scopus 로고
    • Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: A post-hoc analysis of the Thai phase 3 efficacy trial RV 144
    • Robb ML, Rerks-Ngarm S, Nitayaphan S, et al. Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: A post-hoc analysis of the Thai phase 3 efficacy trial RV 144. Lancet Infect Dis. 2012;12:531–537.
    • (2012) Lancet Infect Dis , vol.12 , pp. 531-537
    • Robb, M.L.1    Rerks-Ngarm, S.2    Nitayaphan, S.3
  • 206
    • 84859393693 scopus 로고    scopus 로고
    • Immune-correlates analysis of an HIV-1 vaccine efficacy trial
    • Haynes BF, Gilbert PB, McElrath MJ, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med. 2012;366:1275–1286.
    • (2012) N Engl J Med , vol.366 , pp. 1275-1286
    • Haynes, B.F.1    Gilbert, P.B.2    McElrath, M.J.3
  • 207
    • 84899087118 scopus 로고    scopus 로고
    • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination
    • Yates NL, Liao HX, Fong Y, et al. Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Sci Transl Med. 2014;6:228ra239.
    • (2014) Sci Transl Med , vol.6 , pp. 228ra239
    • Yates, N.L.1    Liao, H.X.2    Fong, Y.3
  • 208
    • 84937131006 scopus 로고    scopus 로고
    • HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition
    • Prentice HA, Tomaras GD, Geraghty DE, et al. HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. Sci Transl Med. 2015;7:296ra112.
    • (2015) Sci Transl Med , vol.7 , pp. 296ra112
    • Prentice, H.A.1    Tomaras, G.D.2    Geraghty, D.E.3
  • 209
    • 84861173075 scopus 로고    scopus 로고
    • The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope
    • de Souza MS, Ratto-Kim S, Chuenarom W, et al. The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope. J Immunol. 2012;188:5166–5176.
    • (2012) J Immunol , vol.188 , pp. 5166-5176
    • de Souza, M.S.1    Ratto-Kim, S.2    Chuenarom, W.3
  • 210
    • 84958897465 scopus 로고    scopus 로고
    • Circulating HIV-specific interleukin-21(+)CD4(+) T cells represent peripheral Tfh cells with antigen-dependent helper functions
    • Schultz BT, Teigler JE, Pissani F, et al. Circulating HIV-specific interleukin-21(+)CD4(+) T cells represent peripheral Tfh cells with antigen-dependent helper functions. Immunity. 2016;44:167–178.
    • (2016) Immunity , vol.44 , pp. 167-178
    • Schultz, B.T.1    Teigler, J.E.2    Pissani, F.3
  • 211
    • 84891751264 scopus 로고    scopus 로고
    • Control of TFH cell numbers: Why and how?
    • Pratama A, Vinuesa CG. Control of TFH cell numbers: Why and how? Immunol Cell Biol. 2014;92:40–48.
    • (2014) Immunol Cell Biol , vol.92 , pp. 40-48
    • Pratama, A.1    Vinuesa, C.G.2
  • 212
    • 63449096041 scopus 로고    scopus 로고
    • Follicular helper T cells are required for systemic autoimmunity
    • Linterman MA, Rigby RJ, Wong RK, et al. Follicular helper T cells are required for systemic autoimmunity. J Exp Med. 2009;206:561–576.
    • (2009) J Exp Med , vol.206 , pp. 561-576
    • Linterman, M.A.1    Rigby, R.J.2    Wong, R.K.3
  • 213
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa CG, Cook MC, Angelucci C, et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature. 2005;435:452–458.
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3
  • 214
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N, Gatenby PA, Wilson A, et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 2010;62:234–244.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3
  • 215
    • 84894038785 scopus 로고    scopus 로고
    • Foxp3(+) T(reg) cells in humoral immunity
    • Wing JB, Sakaguchi S. Foxp3(+) T(reg) cells in humoral immunity. Int Immunol. 2014;26:61–69.
    • (2014) Int Immunol , vol.26 , pp. 61-69
    • Wing, J.B.1    Sakaguchi, S.2
  • 216
    • 79952814810 scopus 로고    scopus 로고
    • Human FoxP3(+)CD4(+) regulatory T cells: Their knowns and unknowns
    • Miyara M, Sakaguchi S. Human FoxP3(+)CD4(+) regulatory T cells: Their knowns and unknowns. Immunol Cell Biol. 2011;89:346–351.
    • (2011) Immunol Cell Biol , vol.89 , pp. 346-351
    • Miyara, M.1    Sakaguchi, S.2
  • 217
    • 84859385739 scopus 로고    scopus 로고
    • Immune regulatory function of B cells
    • Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol. 2012;30:221–241.
    • (2012) Annu Rev Immunol , vol.30 , pp. 221-241
    • Mauri, C.1    Bosma, A.2
  • 218
    • 84928177138 scopus 로고    scopus 로고
    • Regulatory B cells: Origin, phenotype, and function
    • Rosser EC, Mauri C. Regulatory B cells: Origin, phenotype, and function. Immunity. 2015;42:607–612.
    • (2015) Immunity , vol.42 , pp. 607-612
    • Rosser, E.C.1    Mauri, C.2
  • 219
    • 84940611449 scopus 로고    scopus 로고
    • Boosting vaccine efficacy the natural (killer) way
    • Rydyznski CE, Waggoner SN. Boosting vaccine efficacy the natural (killer) way. Trends Immunol. 2015;36:536–546.
    • (2015) Trends Immunol , vol.36 , pp. 536-546
    • Rydyznski, C.E.1    Waggoner, S.N.2
  • 220
    • 79956198905 scopus 로고    scopus 로고
    • Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells
    • Hams E, McCarron MJ, Amu S, et al. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol. 2011;186:5648–5655.
    • (2011) J Immunol , vol.186 , pp. 5648-5655
    • Hams, E.1    McCarron, M.J.2    Amu, S.3
  • 221
    • 84860123211 scopus 로고    scopus 로고
    • The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut
    • Kawamoto S, Tran TH, Maruya M, et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science. 2012;336:485–489.
    • (2012) Science , vol.336 , pp. 485-489
    • Kawamoto, S.1    Tran, T.H.2    Maruya, M.3
  • 223
    • 84963593799 scopus 로고    scopus 로고
    • T follicular regulatory cells
    • Sage PT, Sharpe AH. T follicular regulatory cells. Immunol Rev. 2016;271:246–259.
    • (2016) Immunol Rev , vol.271 , pp. 246-259
    • Sage, P.T.1    Sharpe, A.H.2
  • 224
    • 82755189880 scopus 로고    scopus 로고
    • Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells
    • Kim HJ, Cantor H. Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin Immunol. 2011;23:446–452.
    • (2011) Semin Immunol , vol.23 , pp. 446-452
    • Kim, H.J.1    Cantor, H.2
  • 225
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133:775–787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 226
    • 66949171924 scopus 로고    scopus 로고
    • + T cells expressing the FoxP3 transcription factor
    • + T cells expressing the FoxP3 transcription factor. Immunity. 2009;30:899–911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 228
    • 35448930435 scopus 로고    scopus 로고
    • +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
    • +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood. 2007;110:2983–2990.
    • (2007) Blood , vol.110 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 231
    • 82755184094 scopus 로고    scopus 로고
    • Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions
    • Yamaguchi T, Wing JB, Sakaguchi S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol. 2011;23:424–430.
    • (2011) Semin Immunol , vol.23 , pp. 424-430
    • Yamaguchi, T.1    Wing, J.B.2    Sakaguchi, S.3
  • 232
    • 0026178213 scopus 로고
    • X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
    • Godfrey VL, Wilkinson JE, Russell LB. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol. 1991;138:1379–1387.
    • (1991) Am J Pathol , vol.138 , pp. 1379-1387
    • Godfrey, V.L.1    Wilkinson, J.E.2    Russell, L.B.3
  • 233
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001;27:18–20.
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3
  • 235
    • 15244363080 scopus 로고    scopus 로고
    • Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
    • Lim HW, Hillsamer P, Kim CH. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest. 2004;114:1640–1649.
    • (2004) J Clin Invest , vol.114 , pp. 1640-1649
    • Lim, H.W.1    Hillsamer, P.2    Kim, C.H.3
  • 236
    • 79961158055 scopus 로고    scopus 로고
    • Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    • Chung Y, Tanaka S, Chu F, et al. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med. 2011;17:983–988.
    • (2011) Nat Med , vol.17 , pp. 983-988
    • Chung, Y.1    Tanaka, S.2    Chu, F.3
  • 237
    • 79961151137 scopus 로고    scopus 로고
    • + follicular regulatory T cells control the germinal center response
    • + follicular regulatory T cells control the germinal center response. Nat Med. 2011;17:975–982.
    • (2011) Nat Med , vol.17 , pp. 975-982
    • Linterman, M.A.1    Pierson, W.2    Lee, S.K.3
  • 239
    • 84872685720 scopus 로고    scopus 로고
    • The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
    • Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol. 2013;14:152–161.
    • (2013) Nat Immunol , vol.14 , pp. 152-161
    • Sage, P.T.1    Francisco, L.M.2    Carman, C.V.3    Sharpe, A.H.4
  • 240
    • 84918507355 scopus 로고    scopus 로고
    • The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells
    • Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 2014;41:1026–1039.
    • (2014) Immunity , vol.41 , pp. 1026-1039
    • Sage, P.T.1    Paterson, A.M.2    Lovitch, S.B.3    Sharpe, A.H.4
  • 241
    • 84937516776 scopus 로고    scopus 로고
    • Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging
    • Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging. Cell Rep. 2015;12:163–171.
    • (2015) Cell Rep , vol.12 , pp. 163-171
    • Sage, P.T.1    Tan, C.L.2    Freeman, G.J.3    Haigis, M.4    Sharpe, A.H.5
  • 242
    • 84915755943 scopus 로고    scopus 로고
    • Circulating T follicular regulatory and helper cells have memory-like properties
    • Sage PT, Alvarez D, Godec J, von Andrian UH, Sharpe AH. Circulating T follicular regulatory and helper cells have memory-like properties. J Clin Invest. 2014;124:5191–5204.
    • (2014) J Clin Invest , vol.124 , pp. 5191-5204
    • Sage, P.T.1    Alvarez, D.2    Godec, J.3    von Andrian, U.H.4    Sharpe, A.H.5
  • 243
    • 84908259834 scopus 로고    scopus 로고
    • Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers
    • Wallin EF, Jolly EC, Suchanek O, et al. Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers. Blood. 2014;124:2666–2674.
    • (2014) Blood , vol.124 , pp. 2666-2674
    • Wallin, E.F.1    Jolly, E.C.2    Suchanek, O.3
  • 244
    • 84960391287 scopus 로고    scopus 로고
    • Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice
    • Wu H, Chen Y, Liu H, et al. Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice. Eur J Immunol. 2016;46:1152–1161.
    • (2016) Eur J Immunol , vol.46 , pp. 1152-1161
    • Wu, H.1    Chen, Y.2    Liu, H.3
  • 245
    • 84961373922 scopus 로고    scopus 로고
    • Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
    • Aloulou M, Carr EJ, Gador M, et al. Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells. Nat Commun. 2016;7:10579.
    • (2016) Nat Commun , vol.7 , pp. 10579
    • Aloulou, M.1    Carr, E.J.2    Gador, M.3
  • 246
    • 84896885445 scopus 로고    scopus 로고
    • Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression
    • Vaeth M, Muller G, Stauss D, et al. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med. 2014;211:545–561.
    • (2014) J Exp Med , vol.211 , pp. 545-561
    • Vaeth, M.1    Muller, G.2    Stauss, D.3
  • 247
    • 84860336456 scopus 로고    scopus 로고
    • CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation
    • Good-Jacobson KL, Song E, Anderson S, Sharpe AH, Shlomchik MJ. CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol. 2012;188:4217–4225.
    • (2012) J Immunol , vol.188 , pp. 4217-4225
    • Good-Jacobson, K.L.1    Song, E.2    Anderson, S.3    Sharpe, A.H.4    Shlomchik, M.J.5
  • 248
    • 84928203976 scopus 로고    scopus 로고
    • CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection
    • Linterman MA, Denton AE, Divekar DP, et al. CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. Elife. 2014;3:e03180.
    • (2014) Elife , vol.3
    • Linterman, M.A.1    Denton, A.E.2    Divekar, D.P.3
  • 249
    • 84918576077 scopus 로고    scopus 로고
    • Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4
    • Wing JB, Ise W, Kurosaki T, Sakaguchi S. Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4. Immunity. 2014;41:1013–1025.
    • (2014) Immunity , vol.41 , pp. 1013-1025
    • Wing, J.B.1    Ise, W.2    Kurosaki, T.3    Sakaguchi, S.4
  • 250
    • 84926652101 scopus 로고    scopus 로고
    • In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses
    • Sage PT, Sharpe AH. In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods Mol Biol. 2015;1291:151–160.
    • (2015) Methods Mol Biol , vol.1291 , pp. 151-160
    • Sage, P.T.1    Sharpe, A.H.2
  • 251
    • 84907382881 scopus 로고    scopus 로고
    • Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice
    • Ding Y, Li J, Yang P, et al. Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice. Arthritis Rheumatol. 2014;66:2601–2612.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2601-2612
    • Ding, Y.1    Li, J.2    Yang, P.3
  • 252
    • 77956895738 scopus 로고    scopus 로고
    • Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance
    • Kim HJ, Verbinnen B, Tang X, Lu L, Cantor H. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature. 2010;467:328–332.
    • (2010) Nature , vol.467 , pp. 328-332
    • Kim, H.J.1    Verbinnen, B.2    Tang, X.3    Lu, L.4    Cantor, H.5
  • 253
    • 0032546001 scopus 로고    scopus 로고
    • HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    • Braud VM, Allan DS, O'Callaghan CA, et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature. 1998;391:795–799.
    • (1998) Nature , vol.391 , pp. 795-799
    • Braud, V.M.1    Allan, D.S.2    O'Callaghan, C.A.3
  • 256
    • 84945237294 scopus 로고    scopus 로고
    • Stable inhibitory activity of regulatory T cells requires the transcription factor Helios
    • Kim HJ, Barnitz RA, Kreslavsky T, et al. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015;350:334–339.
    • (2015) Science , vol.350 , pp. 334-339
    • Kim, H.J.1    Barnitz, R.A.2    Kreslavsky, T.3
  • 257
    • 77957855176 scopus 로고    scopus 로고
    • HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes
    • Jiang H, Canfield SM, Gallagher MP, et al. HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes. J Clin Invest. 2010;120:3641–3650.
    • (2010) J Clin Invest , vol.120 , pp. 3641-3650
    • Jiang, H.1    Canfield, S.M.2    Gallagher, M.P.3
  • 258
    • 84872093577 scopus 로고    scopus 로고
    • The split personality of regulatory T cells in HIV infection
    • Chevalier MF, Weiss L. The split personality of regulatory T cells in HIV infection. Blood. 2013;121:29–37.
    • (2013) Blood , vol.121 , pp. 29-37
    • Chevalier, M.F.1    Weiss, L.2
  • 260
    • 84860359331 scopus 로고    scopus 로고
    • Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue
    • Angin M, Kwon DS, Streeck H, et al. Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. J Infect Dis. 2012;205:1495–1500.
    • (2012) J Infect Dis , vol.205 , pp. 1495-1500
    • Angin, M.1    Kwon, D.S.2    Streeck, H.3
  • 262
    • 33750320502 scopus 로고    scopus 로고
    • + regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART
    • + regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood. 2006;108:3072–3078.
    • (2006) Blood , vol.108 , pp. 3072-3078
    • Epple, H.J.1    Loddenkemper, C.2    Kunkel, D.3
  • 263
    • 68249136806 scopus 로고    scopus 로고
    • + T cells in HIV-1-infected typical progressors, but not in long-term non-progressors
    • + T cells in HIV-1-infected typical progressors, but not in long-term non-progressors. Immunology. 2009;128:e366–e375.
    • (2009) Immunology , vol.128 , pp. e366-e375
    • Jiao, Y.1    Fu, J.2    Xing, S.3
  • 264
    • 34447578626 scopus 로고    scopus 로고
    • Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy
    • Lim A, Tan D, Price P, et al. Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy. AIDS. 2007;21:1525–1534.
    • (2007) AIDS , vol.21 , pp. 1525-1534
    • Lim, A.1    Tan, D.2    Price, P.3
  • 265
    • 79751470192 scopus 로고    scopus 로고
    • Normalization of FoxP3(+) regulatory T cells in response to effective antiretroviral therapy
    • Montes M, Sanchez C, Lewis DE, et al. Normalization of FoxP3(+) regulatory T cells in response to effective antiretroviral therapy. J Infect Dis. 2011;203:496–499.
    • (2011) J Infect Dis , vol.203 , pp. 496-499
    • Montes, M.1    Sanchez, C.2    Lewis, D.E.3
  • 266
    • 79960931448 scopus 로고    scopus 로고
    • CD39/adenosine pathway is involved in AIDS progression
    • Nikolova M, Carriere M, Jenabian MA, et al. CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog. 2011;7:e1002110.
    • (2011) PLoS Pathog , vol.7
    • Nikolova, M.1    Carriere, M.2    Jenabian, M.A.3
  • 267
    • 20644434609 scopus 로고    scopus 로고
    • + regulatory T cells to immune status in HIV-infected patients
    • + regulatory T cells to immune status in HIV-infected patients. AIDS. 2005;19:879–886.
    • (2005) AIDS , vol.19 , pp. 879-886
    • Tsunemi, S.1    Iwasaki, T.2    Imado, T.3
  • 269
    • 77956296064 scopus 로고    scopus 로고
    • + T cell depletion, immune activation and increased production of regulatory T cells in the thymus of HIV-infected individuals
    • + T cell depletion, immune activation and increased production of regulatory T cells in the thymus of HIV-infected individuals. PLoS ONE. 2010;5:e10788.
    • (2010) PLoS ONE , vol.5
    • Bandera, A.1    Ferrario, G.2    Saresella, M.3
  • 270
    • 55849140547 scopus 로고    scopus 로고
    • HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism
    • Manches O, Munn D, Fallahi A, et al. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism. J Clin Invest. 2008;118:3431–3439.
    • (2008) J Clin Invest , vol.118 , pp. 3431-3439
    • Manches, O.1    Munn, D.2    Fallahi, A.3
  • 271
    • 33750310898 scopus 로고    scopus 로고
    • HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
    • Nilsson J, Boasso A, Velilla PA, et al. HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood. 2006;108:3808–3817.
    • (2006) Blood , vol.108 , pp. 3808-3817
    • Nilsson, J.1    Boasso, A.2    Velilla, P.A.3
  • 272
    • 21244465055 scopus 로고    scopus 로고
    • + regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death
    • + regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death. J Immunol. 2005;175:32–36.
    • (2005) J Immunol , vol.175 , pp. 32-36
    • Fritzsching, B.1    Oberle, N.2    Eberhardt, N.3
  • 273
    • 84867741486 scopus 로고    scopus 로고
    • Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers
    • Angin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM. Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. AIDS. 2012;26:2112–2115.
    • (2012) AIDS , vol.26 , pp. 2112-2115
    • Angin, M.1    King, M.2    Altfeld, M.3    Walker, B.D.4    Wucherpfennig, K.W.5    Addo, M.M.6
  • 274
    • 57349175888 scopus 로고    scopus 로고
    • HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection
    • Kared H, Lelievre JD, Donkova-Petrini V, et al. HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection. AIDS. 2008;22:2451–2460.
    • (2008) AIDS , vol.22 , pp. 2451-2460
    • Kared, H.1    Lelievre, J.D.2    Donkova-Petrini, V.3
  • 276
    • 84864222398 scopus 로고    scopus 로고
    • Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses
    • Angin M, Streeck H, Wen F, et al. Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses. AIDS Res Hum Retroviruses. 2012;28:749–751.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , pp. 749-751
    • Angin, M.1    Streeck, H.2    Wen, F.3
  • 277
    • 15444363618 scopus 로고    scopus 로고
    • Depletion of regulatory T cells in HIV infection is associated with immune activation
    • Eggena MP, Barugahare B, Jones N, et al. Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol. 2005;174:4407–4414.
    • (2005) J Immunol , vol.174 , pp. 4407-4414
    • Eggena, M.P.1    Barugahare, B.2    Jones, N.3
  • 278
    • 77951877224 scopus 로고    scopus 로고
    • + elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses
    • + elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses. AIDS. 2010;24:1095–1105.
    • (2010) AIDS , vol.24 , pp. 1095-1105
    • Owen, R.E.1    Heitman, J.W.2    Hirschkorn, D.F.3
  • 279
    • 60849121977 scopus 로고    scopus 로고
    • Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression
    • Cao W, Jamieson BD, Hultin LE, Hultin PM, Detels R. Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression. AIDS Res Hum Retroviruses. 2009;25:183–191.
    • (2009) AIDS Res Hum Retroviruses , vol.25 , pp. 183-191
    • Cao, W.1    Jamieson, B.D.2    Hultin, L.E.3    Hultin, P.M.4    Detels, R.5
  • 280
    • 75649117427 scopus 로고    scopus 로고
    • CD4(+)CD25(+/hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons
    • Del Pozo-Balado Mdel M, Leal M, Mendez-Lagares G, Pacheco YM. CD4(+)CD25(+/hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons. J Infect Dis. 2010;201:331–335.
    • (2010) J Infect Dis , vol.201 , pp. 331-335
    • Del Pozo-Balado Mdel, M.1    Leal, M.2    Mendez-Lagares, G.3    Pacheco, Y.M.4
  • 282
    • 84942475241 scopus 로고    scopus 로고
    • Regulatory and helper follicular T cells and antibody avidity to simian immunodeficiency virus glycoprotein 120
    • Blackburn MJ, Zhong-Min M, Caccuri F, et al. Regulatory and helper follicular T cells and antibody avidity to simian immunodeficiency virus glycoprotein 120. J Immunol. 2015;195:3227–3236.
    • (2015) J Immunol , vol.195 , pp. 3227-3236
    • Blackburn, M.J.1    Zhong-Min, M.2    Caccuri, F.3
  • 283
    • 84942456010 scopus 로고    scopus 로고
    • Decreased T follicular regulatory cell/T follicular helper cell (TFH) in simian immunodeficiency virus-infected rhesus macaques may contribute to accumulation of TFH in chronic infection
    • Chowdhury A, Del Rio Estrada PM, Tharp GK, et al. Decreased T follicular regulatory cell/T follicular helper cell (TFH) in simian immunodeficiency virus-infected rhesus macaques may contribute to accumulation of TFH in chronic infection. J Immunol. 2015;195:3237–3247.
    • (2015) J Immunol , vol.195 , pp. 3237-3247
    • Chowdhury, A.1    Del Rio Estrada, P.M.2    Tharp, G.K.3
  • 284
    • 84944906896 scopus 로고    scopus 로고
    • Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection
    • Miles B, Miller SM, Folkvord JM, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608.
    • (2015) Nat Commun , vol.6 , pp. 8608
    • Miles, B.1    Miller, S.M.2    Folkvord, J.M.3
  • 285
    • 84949977270 scopus 로고    scopus 로고
    • HIV-infected spleens present altered follicular helper T Cell (Tfh) subsets and skewed B cell maturation
    • Colineau L, Rouers A, Yamamoto T, et al. HIV-infected spleens present altered follicular helper T Cell (Tfh) subsets and skewed B cell maturation. PLoS ONE. 2015;10:e0140978.
    • (2015) PLoS ONE , vol.10
    • Colineau, L.1    Rouers, A.2    Yamamoto, T.3
  • 286
    • 34247629362 scopus 로고    scopus 로고
    • The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates
    • Ansari AA, Pereira LE, Mayne AE, et al. The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. J Autoimmun. 2007;28:152–159.
    • (2007) J Autoimmun , vol.28 , pp. 152-159
    • Ansari, A.A.1    Pereira, L.E.2    Mayne, A.E.3
  • 288
    • 84930948323 scopus 로고    scopus 로고
    • New approaches to HIV vaccine development
    • Haynes BF. New approaches to HIV vaccine development. Curr Opin Immunol. 2015;35:39–47.
    • (2015) Curr Opin Immunol , vol.35 , pp. 39-47
    • Haynes, B.F.1
  • 289
    • 82955241840 scopus 로고    scopus 로고
    • Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1
    • Kwong PD, Mascola JR, Nabel GJ. Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1. Cold Spring Harb Perspect Med. 2011;1:a007278.
    • (2011) Cold Spring Harb Perspect Med , vol.1 , pp. a007278
    • Kwong, P.D.1    Mascola, J.R.2    Nabel, G.J.3
  • 290
    • 84983784130 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell responses to viral vector and protein-in-adjuvant vaccines
    • Wang C, Hart M, Chui C, et al. Germinal center B cell and T follicular helper cell responses to viral vector and protein-in-adjuvant vaccines. J Immunol. 2016;197:1242–1251.
    • (2016) J Immunol , vol.197 , pp. 1242-1251
    • Wang, C.1    Hart, M.2    Chui, C.3
  • 291
    • 80052680892 scopus 로고    scopus 로고
    • The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    • de Cassan SC, Forbes EK, Douglas A, et al. The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus. J Immunol. 2011;187:2602–2616.
    • (2011) J Immunol , vol.187 , pp. 2602-2616
    • de Cassan, S.C.1    Forbes, E.K.2    Douglas, A.3
  • 292
    • 84958555153 scopus 로고    scopus 로고
    • Vaccine induction of lymph node-resident simian immunodeficiency virus Env-specific T follicular helper cells in rhesus macaques
    • Vargas-Inchaustegui DA, Demers A, Shaw JM, et al. Vaccine induction of lymph node-resident simian immunodeficiency virus Env-specific T follicular helper cells in rhesus macaques. J Immunol. 2016;196:1700–1710.
    • (2016) J Immunol , vol.196 , pp. 1700-1710
    • Vargas-Inchaustegui, D.A.1    Demers, A.2    Shaw, J.M.3
  • 293
    • 84856387516 scopus 로고    scopus 로고
    • Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction
    • Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, Irvine DJ. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction. Proc Natl Acad Sci USA. 2012;109:1080–1085.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1080-1085
    • Moon, J.J.1    Suh, H.2    Li, A.V.3    Ockenhouse, C.F.4    Yadava, A.5    Irvine, D.J.6
  • 294
    • 10744234019 scopus 로고    scopus 로고
    • Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques
    • Keler T, Halk E, Vitale L, et al. Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques. J Immunol. 2003;171:6251–6259.
    • (2003) J Immunol , vol.171 , pp. 6251-6259
    • Keler, T.1    Halk, E.2    Vitale, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.