HLA-E-restricted regulatory CD8+ T cells are involved in development and control of human autoimmune type 1 diabetes

Journal of Clinical Investigation

Volumn 120, Issue 10, 2010, Pages 3641-3650

  Jiang, Hong ^a   Canfield, Steve M ^a   Gallagher, Mary P ^b   Jiang, Hong H ^a   Jiang, Yihua ^a   Zheng, Zongyu ^a   Chess, Leonard ^a  

^a Department of Medicine ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 60; HLA E ANTIGEN; CHAPERONIN 60; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA-E ANTIGEN;

ARTICLE; AUTOIMMUNE DISEASE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE FUNCTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; AMINO ACID SEQUENCE; CELL LINE; DIABETES MELLITUS, TYPE 1; IMMUNOLOGY; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CHAPERONIN 60; DIABETES MELLITUS, TYPE 1; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES, REGULATORY;

EID: 77957855176     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI43522     Document Type: Article

References (33)

1. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature. 1953;172(4379):603-606.
2. Zinkernagel RM. Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control. Immunol Rev. 1978;42:224-270.
3. Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell. 1987;49(2):273-280.
4. Hengartner H, et al. Deletion of self-reactive T cells before entry into the thymus medulla. Nature. 1988;336(6197):388-390.
5. Pircher H, Rohrer UH, Moskophidis D, Zinkernagel RM, Hengartner H. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature. 1991;351(6326):482-485. (Pubitemid 21896624)
6. Jiang H, et al. An affinity/avidity model of peripheral T cell regulation. J Clin Invest. 2005;115(2):302-312.
7. Chen W, et al. Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation. Proc Natl Acad Sci U S A. 2007;104(51):20472-20477.
8. Wu Y, Zheng Z, Jiang Y, Chess L, Jiang H. The specificity of T cell regulation that enables self non-self discrimination in the periphery. Proc Natl Acad Sci U S A. 2009;106(2):534-539.
9. Jiang H, Chess L. How the immune system achieves self non-self discrimination during adaptive immunity. Adv Immunol. 2009;102:95-133.
10. Bouneaud C, Kourilsky P, Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity. 2000;13(6):829-840.
11. Sandberg JK, et al. T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity. J Immunol. 2000;165(1):25-33.
12. Jiang H, Curran S, Ruiz-Vazquez E, Liang B, Winchester R, Chess L. Regulatory CD8+ T cells finetune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2003;100(14):8378-8383. (Pubitemid 36842553)
13. Anderton SM, Radu CG, Lowrey PA, Ward ES, Wraith DC. Negative selection during the peripheral immune response to antigen. J Exp Med. 2001;193(1):1-11.
14. Han B, et al. Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes. J Clin Invest. 2005;115(7):1879-1887.
15. Zehn D, Bevan MJ. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity. 2006;25(2):261-270. (Pubitemid 44224142)
16. Jiang H, Chess L. The specific regulation of immune responses by CD8+ T cells restricted by the MHC class IB molecule, QA-1. Annu Rev Immunol. 2000;18:185-216.
17. Cohen IR. The cognitive paradigm and the immunological homunculus. Immunol Today. 1992;13(12):490-494.
18. Homann D, Eisenbarth GS. An immunologic homunculus for type 1 diabetes. J Clin Invest. 2006;116(5):1212-1215.
19. Aldrich CJ, DeClousc A, Woods AS, Cotter RJ, Soloski MJ, Forman J. Identification of a TAP-dependent header peptide recognized by alloreactive T cells specific for a Class I-b antigen. Cell. 1994;79(4):649-659.
20. Cotterill LA, et al. Qa-1 interaction and T cell recognition of the Qa-1 determinant modifier peptide. Eur J Immunol. 1997;27(9):2123-2132.
21. Kurepa Z, Hasemann CA, Forman J. Qa-1b binds conserved class I leader peptides derived from several mammalian species. J Exp Med. 1998;188(5):973-978. (Pubitemid 28433423)
22. Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H. Regulation of Activated CD4(+) T Cells by NK Cells via the Qa-1-NKG2A Inhibitory Pathway. Immunity. 2007;26(5):593-604.
23. Michaelsson J, Teixeira de Matos C, Achour A, Lanier LL, Karre K, Soderstrom K. A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med. 2002;196(11):1403-1414.
24. Lee N, Goodlett DR, Ishitani A, Marquardt H, Geraghty DE. HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J Immunol. 1998;160(10):4951-4960.
25. Ishitani A, et al. Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition. J Immunol. 2003;171(3):1376-1384. (Pubitemid 36900070)
26. Koshland DE Jr. Recognizing self from nonself. Science. 1990;248(4961):1273.
27. Cohn M. Whither T-suppressors: if they didn't exist would we have to invent them? Cell Immunol. 2004;227(2):81-92.
28. Jiang H, Chess L. Regulation of immune responses by T cells. N Engl J Med. 2006;354(11):1166-1176.
29. Jiang H, Chess L. Qa-1/HLA-E-restricted regulatory CD8+ T cells and self-nonself discrimination: an essay on peripheral T-cell regulation. Hum Immunol. 2008;69(11):721-727.
30. Hu D, Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 T cells in mice deficient in the Qa-1 class Ib molecule, H2-T23. Nat Immunol. 2004;5(5):516-523.
31. Lu L, Kim HJ, Werneck MB, Cantor H. Regulation of CD8+ regulatory T cells: interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008;105(49):19420-19425.
32. Bingley PJ, et al. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes. 1994;43(11):1304-1310.
33. Verge CF, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes. 1996;45(7):926-933.