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Volumn 193, Issue 11, 2014, Pages 5613-5625

Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR5; EPITOPE; VIRUS RNA; VIRUS ANTIGEN;

EID: 84912569301     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401161     Document Type: Article
Times cited : (120)

References (62)
  • 2
    • 20444379970 scopus 로고    scopus 로고
    • Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanisms
    • Folkvord, J. M., C. Armon, and E. Connick. 2005. Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanisms. AIDS Res. Hum. Retroviruses 21: 363-370.
    • (2005) AIDS Res. Hum. Retroviruses , vol.21 , pp. 363-370
    • Folkvord, J.M.1    Armon, C.2    Connick, E.3
  • 4
    • 0032536835 scopus 로고    scopus 로고
    • The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy
    • Tenner-Racz, K., H. J. Stellbrink, J. van Lunzen, C. Schneider, J. P. Jacobs, B. Raschdorff, G. Grosschupff, R. M. Steinman, and P. Racz. 1998. The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy. J. Exp. Med. 187: 949-959.
    • (1998) J. Exp. Med. , vol.187 , pp. 949-959
    • Tenner-Racz, K.1    Stellbrink, H.J.2    Van Lunzen, J.3    Schneider, C.4    Jacobs, J.P.5    Raschdorff, B.6    Grosschupff, G.7    Steinman, R.M.8    Racz, P.9
  • 5
    • 0022979039 scopus 로고
    • HTLV-III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy
    • Biberfeld, P., K. J. Chayt, L. M. Marselle, G. Biberfeld, R. C. Gallo, and M. E. Harper. 1986. HTLV-III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy. Am. J. Pathol. 125: 436-442.
    • (1986) Am. J. Pathol. , vol.125 , pp. 436-442
    • Biberfeld, P.1    Chayt, K.J.2    Marselle, L.M.3    Biberfeld, G.4    Gallo, R.C.5    Harper, M.E.6
  • 6
    • 84869814713 scopus 로고    scopus 로고
    • + T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    • Brenchley, J. M., C. Vinton, B. Tabb, X. P. Hao, E. Connick, M. Paiardini, J. D. Lifson, G. Silvestri, and J. D. Estes. 2012. Differential infection patterns of CD4 + T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood 120: 4172-4181.
    • (2012) Blood , vol.120 , pp. 4172-4181
    • Brenchley, J.M.1    Vinton, C.2    Tabb, B.3    Hao, X.P.4    Connick, E.5    Paiardini, M.6    Lifson, J.D.7    Silvestri, G.8    Estes, J.D.9
  • 7
    • 0027516822 scopus 로고
    • Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS
    • Embretson, J., M. Zupancic, J. L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A. T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362: 359-362.
    • (1993) Nature , vol.362 , pp. 359-362
    • Embretson, J.1    Zupancic, M.2    Ribas, J.L.3    Burke, A.4    Racz, P.5    Tenner-Racz, K.6    Haase, A.T.7
  • 9
    • 0028825476 scopus 로고
    • Follicular dendritic cells and human immunodeficiency virus infectivity
    • Heath, S. L., J. G. Tew, J. G. Tew, A. K. Szakal, and G. F. Burton. 1995. Follicular dendritic cells and human immunodeficiency virus infectivity. Nature 377: 740-744.
    • (1995) Nature , vol.377 , pp. 740-744
    • Heath, S.L.1    Tew, J.G.2    Tew, J.G.3    Szakal, A.K.4    Burton, G.F.5
  • 10
    • 0028041344 scopus 로고
    • + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • Borrow, P., H. Lewicki, B. H. Hahn, G. M. Shaw, and M. B. Oldstone. 1994. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68: 6103-6110.
    • (1994) J. Virol. , vol.68 , pp. 6103-6110
    • Borrow, P.1    Lewicki, H.2    Hahn, B.H.3    Shaw, G.M.4    Oldstone, M.B.5
  • 12
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68: 4650-4655.
    • (1994) J. Virol. , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 13
    • 0033137113 scopus 로고    scopus 로고
    • Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
    • Kuroda, M. J., J. E. Schmitz, W. A. Charini, C. E. Nickerson, M. A. Lifton, C. I. Lord, M. A. Forman, and N. L. Letvin. 1999. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. J. Immunol. 162: 5127-5133.
    • (1999) J. Immunol. , vol.162 , pp. 5127-5133
    • Kuroda, M.J.1    Schmitz, J.E.2    Charini, W.A.3    Nickerson, C.E.4    Lifton, M.A.5    Lord, C.I.6    Forman, M.A.7    Letvin, N.L.8
  • 14
    • 0027404894 scopus 로고
    • + lymphocyte response in acutely infected rhesus monkeys
    • Yasutomi, Y., K. A. Reimann, C. I. Lord, M. D. Miller, and N. L. Letvin. 1993. Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys. J. Virol. 67: 1707-1711.
    • (1993) J. Virol. , vol.67 , pp. 1707-1711
    • Yasutomi, Y.1    Reimann, K.A.2    Lord, C.I.3    Miller, M.D.4    Letvin, N.L.5
  • 17
    • 0342894784 scopus 로고    scopus 로고
    • Positive role of macaque cytotoxic T lymphocytes during SIV infection: Decrease of cellular viremia and increase of asymptomatic clinical period
    • Villada, I. B., L. Mortara, A. M. Aubertin, H. Gras-Masse, J. P. Lé vy, and J. G. Guillet. 1997. Positive role of macaque cytotoxic T lymphocytes during SIV infection: decrease of cellular viremia and increase of asymptomatic clinical period. FEMS Immunol. Med. Microbiol. 19: 81-87.
    • (1997) FEMS Immunol. Med. Microbiol. , vol.19 , pp. 81-87
    • Villada, I.B.1    Mortara, L.2    Aubertin, A.M.3    Gras-Masse, H.4    Lé Vy, J.P.5    Guillet, J.G.6
  • 23
    • 0031985775 scopus 로고    scopus 로고
    • Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
    • Matano, T., R. Shibata, C. Siemon, M. Connors, H. C. Lane, and M. A. Martin. 1998. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J. Virol. 72: 164-169.
    • (1998) J. Virol. , vol.72 , pp. 164-169
    • Matano, T.1    Shibata, R.2    Siemon, C.3    Connors, M.4    Lane, H.C.5    Martin, M.A.6
  • 25
    • 0028969816 scopus 로고
    • Transfer of HIV- 1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
    • Koenig, S., A. J. Conley, Y. A. Brewah, G. M. Jones, S. Leath, L. J. Boots, V. Davey, G. Pantaleo, J. F. Demarest, C. Carter, et al. 1995. Transfer of HIV- 1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat. Med. 1: 330-336.
    • (1995) Nat. Med. , vol.1 , pp. 330-336
    • Koenig, S.1    Conley, A.J.2    Brewah, Y.A.3    Jones, G.M.4    Leath, S.5    Boots, L.J.6    Davey, V.7    Pantaleo, G.8    Demarest, J.F.9    Carter, C.10
  • 26
    • 0030854210 scopus 로고    scopus 로고
    • Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients
    • Lieberman, J., P. R. Skolnik, G. R. Parkerson, III, J. A. Fabry, B. Landry, J. Bethel, and J. Kagan. 1997. Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood 90: 2196-2206.
    • (1997) Blood , vol.90 , pp. 2196-2206
    • Lieberman, J.1    Skolnik, P.R.2    Parkerson, G.R.3    Fabry, J.A.4    Landry, B.5    Bethel, J.6    Kagan, J.7
  • 29
    • 49849090609 scopus 로고    scopus 로고
    • Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)
    • Autran, B., R. L. Murphy, D. Costagliola, R. Tubiana, B. Clotet, J. Gatell, S. Staszewski, N. Wincker, L. Assoumou, R. El-Habib, et al. 2008. Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452). AIDS 22: 1313-1322.
    • (2008) AIDS , vol.22 , pp. 1313-1322
    • Autran, B.1    Murphy, R.L.2    Costagliola, D.3    Tubiana, R.4    Clotet, B.5    Gatell, J.6    Staszewski, S.7    Wincker, N.8    Assoumou, L.9    El-Habib, R.10
  • 30
    • 35348865750 scopus 로고    scopus 로고
    • Interruption of antiretroviral therapy initiated during primary HIV-1 infection: Impact of a therapeutic vaccination strategy combined with interleukin (IL)-2 compared with IL-2 alone in the ANRS 095 randomized study
    • Goujard, C., F. Marcellin, H. Hendel-Chavez, M. Burgard, V. Meiffrédy, A. Venet, C. Rouzioux, Y. Taoufik, R. El Habib, M. Beumont-Mauviel, et al. 2007. Interruption of antiretroviral therapy initiated during primary HIV-1 infection: impact of a therapeutic vaccination strategy combined with interleukin (IL)-2 compared with IL-2 alone in the ANRS 095 Randomized Study. AIDS Res. Hum. Retroviruses 23: 1105-1113.
    • (2007) AIDS Res. Hum. Retroviruses , vol.23 , pp. 1105-1113
    • Goujard, C.1    Marcellin, F.2    Hendel-Chavez, H.3    Burgard, M.4    Meiffrédy, V.5    Venet, A.6    Rouzioux, C.7    Taoufik, Y.8    El Habib, R.9    Beumont-Mauviel, M.10
  • 32
    • 0036720475 scopus 로고    scopus 로고
    • Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination
    • Markowitz, M., X. Jin, A. Hurley, V. Simon, B. Ramratnam, M. Louie, G. R. Deschenes, M. Ramanathan, Jr., S. Barsoum, J. Vanderhoeven, et al. 2002. Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination. J. Infect. Dis. 186: 634-643.
    • (2002) J. Infect. Dis. , vol.186 , pp. 634-643
    • Markowitz, M.1    Jin, X.2    Hurley, A.3    Simon, V.4    Ramratnam, B.5    Louie, M.6    Deschenes, G.R.7    Ramanathan, M.8    Barsoum, S.9    Vanderhoeven, J.10
  • 33
    • 77955671541 scopus 로고    scopus 로고
    • AIDS clinical trials group 5197: A placebo-controlled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein
    • Schooley, R. T., J. Spritzler, H. Wang, M. M. Lederman, D. Havlir, D. R. Kuritzkes, R. Pollard, C. Battaglia, M. Robertson, D. Mehrotra, et al. 2010. AIDS clinical trials group 5197: a placebo-controlled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein. J. Infect. Dis. 202: 705-716.
    • (2010) J. Infect. Dis. , vol.202 , pp. 705-716
    • Schooley, R.T.1    Spritzler, J.2    Wang, H.3    Lederman, M.M.4    Havlir, D.5    Kuritzkes, D.R.6    Pollard, R.7    Battaglia, C.8    Robertson, M.9    Mehrotra, D.10
  • 35
    • 0028216765 scopus 로고
    • Early stages of simian immunodeficiency virus infection in lymph nodes: Evidence for high viral load and successive populations of target cells
    • Chakrabarti, L., P. Isola, M. C. Cumont, M. A. Claessens-Maire, M. Hurtrel, L. Montagnier, and B. Hurtrel. 1994. Early stages of simian immunodeficiency virus infection in lymph nodes: evidence for high viral load and successive populations of target cells. Am. J. Pathol. 144: 1226-1237.
    • (1994) Am. J. Pathol. , vol.144 , pp. 1226-1237
    • Chakrabarti, L.1    Isola, P.2    Cumont, M.C.3    Claessens-Maire, M.A.4    Hurtrel, M.5    Montagnier, L.6    Hurtrel, B.7
  • 42
    • 0034661993 scopus 로고    scopus 로고
    • Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues
    • Skinner, P. J., M. A. Daniels, C. S. Schmidt, S. C. Jameson, and A. T. Haase. 2000. Cutting edge: in situ tetramer staining of antigen-specific T cells in tissues. J. Immunol. 165: 613-617.
    • (2000) J. Immunol. , vol.165 , pp. 613-617
    • Skinner, P.J.1    Daniels, M.A.2    Schmidt, C.S.3    Jameson, S.C.4    Haase, A.T.5
  • 43
    • 15444357765 scopus 로고    scopus 로고
    • Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A∗01) that binds an immunodominant CTL epitope from simian immunodeficiency virus
    • Allen, T. M., J. Sidney, M. F. del Guercio, R. L. Glickman, G. L. Lensmeyer, D. A. Wiebe, R. DeMars, C. D. Pauza, R. P. Johnson, A. Sette, and D. I. Watkins. 1998. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A∗01) that binds an immunodominant CTL epitope from simian immunodeficiency virus. J. Immunol. 160: 6062-6071.
    • (1998) J. Immunol. , vol.160 , pp. 6062-6071
    • Allen, T.M.1    Sidney, J.2    Del Guercio, M.F.3    Glickman, R.L.4    Lensmeyer, G.L.5    Wiebe, D.A.6    DeMars, R.7    Pauza, C.D.8    Johnson, R.P.9    Sette, A.10    Watkins, D.I.11
  • 44
    • 67649172577 scopus 로고    scopus 로고
    • Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B∗08 and HLA-B∗2705, bind peptides with sequence similarity
    • Loffredo, J. T., J. Sidney, A. T. Bean, D. R. Beal, W. Bardet, A. Wahl, O. E. Hawkins, S. Piaskowski, N. A. Wilson, W. H. Hildebrand, et al. 2009. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B∗08 and HLA-B∗2705, bind peptides with sequence similarity. J. Immunol. 182: 7763-7775.
    • (2009) J. Immunol. , vol.182 , pp. 7763-7775
    • Loffredo, J.T.1    Sidney, J.2    Bean, A.T.3    Beal, D.R.4    Bardet, W.5    Wahl, A.6    Hawkins, O.E.7    Piaskowski, S.8    Wilson, N.A.9    Hildebrand, W.H.10
  • 46
    • 24744448228 scopus 로고    scopus 로고
    • Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    • Hardtke, S., L. Ohl, and R. Förster. 2005. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106: 1924-1931.
    • (2005) Blood , vol.106 , pp. 1924-1931
    • Hardtke, S.1    Ohl, L.2    Förster, R.3
  • 47
    • 0031052276 scopus 로고    scopus 로고
    • A new approach to investigating the relationship between productive infection and cytopathicity in vivo
    • Reinhart, T. A., M. J. Rogan, G. A. Viglianti, D. M. Rausch, L. E. Eiden, and A. T. Haase. 1997. A new approach to investigating the relationship between productive infection and cytopathicity in vivo. Nat. Med. 3: 218-221.
    • (1997) Nat. Med. , vol.3 , pp. 218-221
    • Reinhart, T.A.1    Rogan, M.J.2    Viglianti, G.A.3    Rausch, D.M.4    Eiden, L.E.5    Haase, A.T.6
  • 51
    • 36148975338 scopus 로고    scopus 로고
    • Do most lymphocytes in humans really reside in the gut?
    • Ganusov, V. V., and R. J. De Boer. 2007. Do most lymphocytes in humans really reside in the gut? Trends Immunol. 28: 514-518.
    • (2007) Trends Immunol. , vol.28 , pp. 514-518
    • Ganusov, V.V.1    De Boer, R.J.2
  • 52
    • 67650901819 scopus 로고    scopus 로고
    • Is the gut the major source of virus in early simian immunodeficiency virus infection?
    • Lay, M. D., J. Petravic, S. N. Gordon, J. Engram, G. Silvestri, and M. P. Davenport. 2009. Is the gut the major source of virus in early simian immunodeficiency virus infection? J. Virol. 83: 7517-7523.
    • (2009) J. Virol. , vol.83 , pp. 7517-7523
    • Lay, M.D.1    Petravic, J.2    Gordon, S.N.3    Engram, J.4    Silvestri, G.5    Davenport, M.P.6
  • 53
    • 84885360358 scopus 로고    scopus 로고
    • Estimating the contribution of the gut to plasma viral load in early SIV infection
    • Petravic, J., T. H. Vanderford, G. Silvestri, and M. Davenport. 2013. Estimating the contribution of the gut to plasma viral load in early SIV infection. Retrovirology 10: 105.
    • (2013) Retrovirology , vol.10 , pp. 105
    • Petravic, J.1    Vanderford, T.H.2    Silvestri, G.3    Davenport, M.4
  • 54
    • 79958030663 scopus 로고    scopus 로고
    • Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques
    • Vanderford, T. H., C. Bleckwehl, J. C. Engram, R. M. Dunham, N. R. Klatt, M. B. Feinberg, D. A. Garber, M. R. Betts, and G. Silvestri. 2011. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques. PLoS Pathog. 7: e1002048.
    • (2011) Plos Pathog. , vol.7
    • Vanderford, T.H.1    Bleckwehl, C.2    Engram, J.C.3    Dunham, R.M.4    Klatt, N.R.5    Feinberg, M.B.6    Garber, D.A.7    Betts, M.R.8    Silvestri, G.9
  • 55
    • 17844374605 scopus 로고    scopus 로고
    • + T cells in multiple tissues during acute SIV infection
    • Mattapallil, J. J., D. C. Douek, B. Hill, Y. Nishimura, M. Martin, and M. Roederer. 2005. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434: 1093-1097.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 56
    • 33947369301 scopus 로고    scopus 로고
    • A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum
    • Stahl-Hennig, C., M. Eisenblatter, M. Franz, H. Stoiber, K. Tenner-Racz, Y. S. Suh, E. Jasny, B. Falkensammer, M. Ugucchioni, G. Georgsson, et al. 2007. A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum. Front. Biosci. 12: 2107-2123.
    • (2007) Front. Biosci. , vol.12 , pp. 2107-2123
    • Stahl-Hennig, C.1    Eisenblatter, M.2    Franz, M.3    Stoiber, H.4    Tenner-Racz, K.5    Suh, Y.S.6    Jasny, E.7    Falkensammer, B.8    Ugucchioni, M.9    Georgsson, G.10
  • 57
    • 67650741444 scopus 로고    scopus 로고
    • + T cells independent of IFN-g and CD107a responses
    • Minang, J. T., M. T. Trivett, L. V. Coren, E. V. Barsov, M. Piatak, Jr., D. E. Ott, and C. Ohlen. 2009. Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8+ T cells independent of IFN-g and CD107a responses. Virology 391: 130-139.
    • (2009) Virology , vol.391 , pp. 130-139
    • Minang, J.T.1    Trivett, M.T.2    Coren, L.V.3    Barsov, E.V.4    Piatak, M.5    Ott, D.E.6    Ohlen, C.7
  • 58
    • 0035575987 scopus 로고    scopus 로고
    • Cutting edge: Induction of follicular homing precedes effector Th cell development
    • Schaerli, P., P. Loetscher, and B. Moser. 2001. Cutting edge: Induction of Follicular Homing Precedes Effector Th Cell Development. J. Immunol. 167: 6082-6086.
    • (2001) J. Immunol. , vol.167 , pp. 6082-6086
    • Schaerli, P.1    Loetscher, P.2    Moser, B.3
  • 59
    • 84860773241 scopus 로고    scopus 로고
    • + T cells less susceptible to HIV-1 infection
    • Elahi, S., T. Niki, M. Hirashima, and H. Horton. 2012. Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection. Blood 119: 4192-4204.
    • (2012) Blood , vol.119 , pp. 4192-4204
    • Elahi, S.1    Niki, T.2    Hirashima, M.3    Horton, H.4
  • 61
    • 81555226044 scopus 로고    scopus 로고
    • The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion
    • Hofmeyer, K. A., H. Jeon, and X. Zang. 2011. The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J. Biomed. Biotechnol. 2011: 451694.
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 451694
    • Hofmeyer, K.A.1    Jeon, H.2    Zang, X.3


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