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Volumn 109, Issue 22, 2012, Pages 8664-8669

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

Author keywords

Apoptosis; CXC chemokine receptor 5; Inducible costimulator; Interleukin 21

Indexed keywords

CELL MARKER; CHEMOKINE RECEPTOR CXCR5; INTERFERON REGULATORY FACTOR 4; T LYMPHOCYTE ANTIGEN;

EID: 84861872906     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205834109     Document Type: Article
Times cited : (157)

References (39)
  • 1
    • 77956328616 scopus 로고    scopus 로고
    • Interleukin-9 as a T helper type 17 cytokine
    • Nowak EC, Noelle RJ (2010) Interleukin-9 as a T helper type 17 cytokine. Immunology 131:169-173.
    • (2010) Immunology , vol.131 , pp. 169-173
    • Nowak, E.C.1    Noelle, R.J.2
  • 2
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, et al. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545-1552.
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1
  • 3
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, et al. (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192:1553-1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1
  • 4
    • 65549114338 scopus 로고    scopus 로고
    • IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • King IL, Mohrs M (2009) IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 206:1001-1007.
    • (2009) J Exp Med , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 5
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang HE, Locksley RM (2009) Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol 10:385-393.
    • (2009) Nat Immunol , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 6
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, et al. (2004) T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 173:68-78. (Pubitemid 38797327)
    • (2004) Journal of Immunology , vol.173 , Issue.1 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 7
    • 38049101408 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    • Bryant VL, et al. (2007) Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 179:8180-8190.
    • (2007) J Immunol , vol.179 , pp. 8180-8190
    • Bryant, V.L.1
  • 8
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman MA, et al. (2010) IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 207:353-363.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1
  • 9
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, et al. (2008) A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29:127-137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1
  • 10
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D, et al. (2010) IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 207:365-378.
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1
  • 11
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, et al. (2009) Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325:1006-1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 12
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva RI, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science 325:1001-1005.
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 13
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, et al. (2009) The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31:457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 15
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • DOI 10.1016/S0092-8674(00)81798-5
    • Förster R, et al. (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037-1047. (Pubitemid 26427987)
    • (1996) Cell , vol.87 , Issue.6 , pp. 1037-1047
    • Forster, R.1    Mattis, A.E.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 16
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes NM, et al. (2007) Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 179:5099-5108.
    • (2007) J Immunol , vol.179 , pp. 5099-5108
    • Haynes, N.M.1
  • 17
    • 13444283466 scopus 로고    scopus 로고
    • Roles of interferon-regulatory factors in T-helper-cell differentiation
    • DOI 10.1038/nri1552
    • Lohoff M, Mak TW (2005) Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat Rev Immunol 5:125-135. (Pubitemid 40208902)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.2 , pp. 125-135
    • Lohoff, M.1    Mak, T.W.2
  • 21
    • 58549094107 scopus 로고    scopus 로고
    • IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    • Huber M, et al. (2008) IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci USA 105:20846-20851.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20846-20851
    • Huber, M.1
  • 25
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y, et al. (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458:351-356.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1
  • 26
    • 57449105853 scopus 로고    scopus 로고
    • IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
    • Chen Q, et al. (2008) IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 29: 899-911.
    • (2008) Immunity , vol.29 , pp. 899-911
    • Chen, Q.1
  • 27
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt V, et al. (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33:192-202.
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1
  • 29
    • 33747133955 scopus 로고    scopus 로고
    • Graded Expression of Interferon Regulatory Factor-4 Coordinates Isotype Switching with Plasma Cell Differentiation
    • DOI 10.1016/j.immuni.2006.07.009, PII S1074761306003517
    • Sciammas R, et al. (2006) Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25:225-236. (Pubitemid 44224149)
    • (2006) Immunity , vol.25 , Issue.2 , pp. 225-236
    • Sciammas, R.1    Shaffer, A.L.2    Schatz, J.H.3    Zhao, H.4    Staudt, L.M.5    Singh, H.6
  • 30
    • 0023679729 scopus 로고
    • Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis
    • Lohoff M, Matzner C, Röllinghoff M (1988) Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis. Infect Immun 56:2120-2124.
    • (1988) Infect Immun , vol.56 , pp. 2120-2124
    • Lohoff, M.1    Matzner, C.2    Röllinghoff, M.3
  • 31
    • 0029062080 scopus 로고
    • Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule
    • Lagresle C, Bella C, Daniel PT, Krammer PH, Defrance T (1995) Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule. J Immunol 154:5746-5756.
    • (1995) J Immunol , vol.154 , pp. 5746-5756
    • Lagresle, C.1    Bella, C.2    Daniel, P.T.3    Krammer, P.H.4    Defrance, T.5
  • 32
    • 0027324869 scopus 로고
    • Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells
    • Laszlo G, Hathcock KS, Dickler HB, Hodes RJ (1993) Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells. J Immunol 150:5252-5262. (Pubitemid 23180638)
    • (1993) Journal of Immunology , vol.150 , Issue.12 , pp. 5252-5262
    • Laszlo, G.1    Hathcock, K.S.2    Dickler, H.B.3    Hodes, R.J.4
  • 33
    • 45949106108 scopus 로고    scopus 로고
    • Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses
    • Watanabe M, et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J Immunol 180: 5222-5234.
    • (2008) J Immunol , vol.180 , pp. 5222-5234
    • Watanabe, M.1
  • 35
    • 15444346834 scopus 로고    scopus 로고
    • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
    • Mittrücker HW, et al. (1997) Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 275:540-543.
    • (1997) Science , vol.275 , pp. 540-543
    • Mittrücker, H.W.1
  • 36
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, et al. (2009) The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 10:167-175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1
  • 37
    • 71749089605 scopus 로고    scopus 로고
    • Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
    • Kwon H, et al. (2009) Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 31: 941-952.
    • (2009) Immunity , vol.31 , pp. 941-952
    • Kwon, H.1
  • 38
    • 34548237299 scopus 로고    scopus 로고
    • A Signaling Pathway Mediating Downregulation of BCL6 in Germinal Center B Cells Is Blocked by BCL6 Gene Alterations in B Cell Lymphoma
    • DOI 10.1016/j.ccr.2007.08.011, PII S153561080700236X
    • Saito M, et al. (2007) A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 12:280-292. (Pubitemid 47333420)
    • (2007) Cancer Cell , vol.12 , Issue.3 , pp. 280-292
    • Saito, M.1    Gao, J.2    Basso, K.3    Kitagawa, Y.4    Smith, P.M.5    Bhagat, G.6    Pernis, A.7    Pasqualucci, L.8    Dalla-Favera, R.9
  • 39
    • 0033400453 scopus 로고    scopus 로고
    • Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4
    • DOI 10.1084/jem.190.12.1837
    • Gupta S, Jiang M, Anthony A, Pernis AB (1999) Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J Exp Med 190:1837-1848. (Pubitemid 30013849)
    • (1999) Journal of Experimental Medicine , vol.190 , Issue.12 , pp. 1837-1848
    • Gupta, S.1    Jiang, M.2    Anthony, A.3    Pernis, A.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.