CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

Journal of Experimental Medicine

Volumn 192, Issue 11, 2000, Pages 1553-1562

  Schaerli, Patrick ^a   Willimann, Katharina ^a   Lang, Alois B ^b   Lipp, Martin ^c   Loetscher, Pius ^a   Moser, Bernhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Berna Biotech AG   (Switzerland)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Antibodies; B cell follicle; Chemokines; CXC chemokine receptor 5; Lymphocytes

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD69 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CYTOKINE; HLA DR ANTIGEN;

ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD45; B-LYMPHOCYTES; CHEMOKINES, CC; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN ISOTYPES; LEUKOCYTES, MONONUCLEAR; LYMPHOID TISSUE; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; RECEPTORS, LYMPHOCYTE HOMING; T-LYMPHOCYTES, HELPER-INDUCER; TONSIL;

EID: 0034606348     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.11.1553     Document Type: Article

References (47)

1. Chemokines and leukocyte traffic
2. Chemokines and their receptors in lymphocyte traffic and HIV infection
3. International union of pharmacology. XXII. Nomenclature for chemokine receptors
4. The role of chemokine receptors in primary, effector, and memory immune responses
5. Chemokines: A new classification system and their role in immunity
6. Chemokines and cell migration in secondary lymphoid organs
7. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
8. The role of chemokines in regulating cell migration during humoral immune responses
9. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4
10. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
11. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
12. The reduced expression of 6Ckine in the pit mouse results from the deletion of one of two 6Ckine genes
13. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
14. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
15. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
16. Developmental switches in chemokine response profiles during B cell differentiation and maturation
17. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
18. A chemokine-driven positive feedback loop organizes lymphoid follicles
19. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
20. CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone
21. Chemokines and B-cell homing to follicles
22. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
23. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma
24. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
25. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes
26. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7
27. Cloning of a human seventransmembrane domain receptor, LESTR, that is highly expressed in leukocytes
28. Activation-dependent modulation of B lymphocyte migration to chemokines
29. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
30. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
31. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules
32. Activation of blood T lymphocytes down-regulates CXCR4 expression and interferes with propagation of X4 HIV strains
33. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: Rapid internalization and recycling upon activation
34. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation
35. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
36. Lymphocyte homing and homeostasis
37. Chemokines and the arrest of lymphocytes rolling under flow conditions
38. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
39. 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow
40. CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
41. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
42. Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the Skin to regional lymph nodes
43. Lymphocyte homing: The scent of a follicle
44. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
45. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha
46. T-cell co-stimulation through B7RP-1 and ICOS
47. Cutting edge: Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor