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Volumn 88, Issue 22, 2014, Pages 13310-13321

Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CHEMOKINE RECEPTOR CXCR5; NEUTRALIZING ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR; CXCR5 PROTEIN, HUMAN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; PDCD1 PROTEIN, HUMAN;

EID: 84908377312     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02186-14     Document Type: Article
Times cited : (66)

References (68)
  • 4
    • 58149487645 scopus 로고    scopus 로고
    • Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
    • Sather D, Armann J, Ching L, Mavrantoni A, Sellhorn G, Caldwell Z, Yu X, Wood B, Self S, Kalams S, Stamatatos L. 2009. Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J. Virol. 83:757-769. http://dx.doi.org/10.1128/JVI.02036-08.
    • (2009) J. Virol. , vol.83 , pp. 757-769
    • Sather, D.1    Armann, J.2    Ching, L.3    Mavrantoni, A.4    Sellhorn, G.5    Caldwell, Z.6    Yu, X.7    Wood, B.8    Self, S.9    Kalams, S.10    Stamatatos, L.11
  • 6
    • 72949118295 scopus 로고    scopus 로고
    • Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression
    • van Gils M, Euler Z, Schweighardt B, Wrin T, Schuitemaker H. 2009. Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression. AIDS 23:2405-2414. http://dx.doi.org/10.1097/QAD.0b013e32833243e7.
    • (2009) AIDS , vol.23 , pp. 2405-2414
    • van Gils, M.1    Euler, Z.2    Schweighardt, B.3    Wrin, T.4    Schuitemaker, H.5
  • 7
    • 79551518897 scopus 로고    scopus 로고
    • Characteristics of the earliest cross-neutralizing antibody response to HIV-1
    • e1001251
    • Mikell I, Sather DN, Kalams SA, Altfeld M, Alter G, Stamatatos L. 2011. Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog. 7:e1001251. http://dx.doi.org/10.1371/journal.ppat.1001251.
    • (2011) PLoS Pathog. , vol.7
    • Mikell, I.1    Sather, D.N.2    Kalams, S.A.3    Altfeld, M.4    Alter, G.5    Stamatatos, L.6
  • 10
    • 67249131966 scopus 로고    scopus 로고
    • Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    • e1000433
    • Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN, Koff WC, Watkins DI, Burton DR. 2009. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. 5:e1000433. http://dx.doi.org/10.1371/journal.ppat.1000433.
    • (2009) PLoS Pathog. , vol.5
    • Hessell, A.J.1    Rakasz, E.G.2    Poignard, P.3    Hangartner, L.4    Landucci, G.5    Forthal, D.N.6    Koff, W.C.7    Watkins, D.I.8    Burton, D.R.9
  • 11
    • 73949154006 scopus 로고    scopus 로고
    • Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membraneproximal external region protect against mucosal challenge by simianhuman immunodeficiency virus SHIVBa-L
    • Hessell AJ, Rakasz EG, Tehrani DM, Huber M, Weisgrau KL, Landucci G, Forthal DN, Koff WC, Poignard P, Watkins DI, Burton DR. 2010. Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membraneproximal external region protect against mucosal challenge by simianhuman immunodeficiency virus SHIVBa-L. J. Virol. 84:1302-1313. http://dx.doi.org/10.1128/JVI.01272-09.
    • (2010) J. Virol. , vol.84 , pp. 1302-1313
    • Hessell, A.J.1    Rakasz, E.G.2    Tehrani, D.M.3    Huber, M.4    Weisgrau, K.L.5    Landucci, G.6    Forthal, D.N.7    Koff, W.C.8    Poignard, P.9    Watkins, D.I.10    Burton, D.R.11
  • 15
    • 0034864776 scopus 로고    scopus 로고
    • Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    • Parren PW, Marx PA, Hessell AJ, Luckay A, Harouse J, Cheng-Mayer C, Moore JP, Burton DR. 2001. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J. Virol. 75: 8340-8347. http://dx.doi.org/10.1128/JVI.75.17.8340-8347.2001.
    • (2001) J. Virol. , vol.75 , pp. 8340-8347
    • Parren, P.W.1    Marx, P.A.2    Hessell, A.J.3    Luckay, A.4    Harouse, J.5    Cheng-Mayer, C.6    Moore, J.P.7    Burton, D.R.8
  • 17
    • 84880627533 scopus 로고    scopus 로고
    • Emergence of gp120 V3 variants confers neutralization resistance in an R5 simian-human immunodeficiency virus-infected macaque elite neutralizer that targets the N332 glycan of the human immunodeficiency virus type 1 envelope glycoprotein
    • Sadjadpour R, Donau OK, Shingai M, Buckler-White A, Kao S, Strebel K, Nishimura Y, Martin MA. 2013. Emergence of gp120 V3 variants confers neutralization resistance in an R5 simian-human immunodeficiency virus-infected macaque elite neutralizer that targets the N332 glycan of the human immunodeficiency virus type 1 envelope glycoprotein. J. Virol. 87:8798-8804. http://dx.doi.org/10.1128/JVI.00878-13.
    • (2013) J. Virol. , vol.87 , pp. 8798-8804
    • Sadjadpour, R.1    Donau, O.K.2    Shingai, M.3    Buckler-White, A.4    Kao, S.5    Strebel, K.6    Nishimura, Y.7    Martin, M.A.8
  • 23
    • 77952311370 scopus 로고    scopus 로고
    • The role of antibodies in HIV vaccines
    • Mascola JR, Montefiori DC. 2010. The role of antibodies in HIV vaccines. Annu. Rev. Immunol. 28:413-444. http://dx.doi.org/10.1146/annurev-immunol-030409-101256.
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 413-444
    • Mascola, J.R.1    Montefiori, D.C.2
  • 25
    • 84862641275 scopus 로고    scopus 로고
    • HIV vaccine design: the neutralizing antibody conundrum
    • Stamatatos L. 2012. HIV vaccine design: the neutralizing antibody conundrum. Curr. Opin. Immunol. 24:316-323. http://dx.doi.org/10.1016/j.coi.2012.04.006.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 316-323
    • Stamatatos, L.1
  • 26
    • 33746763724 scopus 로고    scopus 로고
    • Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
    • Haynes BF, Montefiori DC. 2006. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev. Vaccines 5:579-595. http://dx.doi.org/10.1586/14760584.5.4.579.
    • (2006) Expert Rev. Vaccines , vol.5 , pp. 579-595
    • Haynes, B.F.1    Montefiori, D.C.2
  • 27
    • 0011084483 scopus 로고
    • Variations in affinities of antibodies during the immune response
    • Eisen HN, Siskind GW. 1964. Variations in affinities of antibodies during the immune response. Biochemistry 3:996-1008. http://dx.doi.org/10.1021/bi00895a027.
    • (1964) Biochemistry , vol.3 , pp. 996-1008
    • Eisen, H.N.1    Siskind, G.W.2
  • 28
    • 0024362047 scopus 로고
    • The role of somatic hypermutation in the generation of antibody diversity
    • French DL, Laskov R, Scharff MD. 1989. The role of somatic hypermutation in the generation of antibody diversity. Science 244:1152-1157. http://dx.doi.org/10.1126/science.2658060.
    • (1989) Science , vol.244 , pp. 1152-1157
    • French, D.L.1    Laskov, R.2    Scharff, M.D.3
  • 29
    • 0014642258 scopus 로고
    • Cell selection by antigen in the immune response
    • Siskind GW, Benacerraf B. 1969. Cell selection by antigen in the immune response. Adv. Immunol. 10:1-50. http://dx.doi.org/10.1016/S0065-2776(08)60414-9.
    • (1969) Adv. Immunol. , vol.10 , pp. 1-50
    • Siskind, G.W.1    Benacerraf, B.2
  • 30
    • 0026515436 scopus 로고
    • Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen
    • Weiss U, Zoebelein R, Rajewsky K. 1992. Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur. J. Immunol. 22:511-517. http://dx.doi.org/10.1002/eji.1830220233.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 511-517
    • Weiss, U.1    Zoebelein, R.2    Rajewsky, K.3
  • 32
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. 2011. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29:621-663. http://dx.doi.org/10.1146/annurev-immunol-031210-101400.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 34
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Forster R. 2000. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192:1545-1552. http://dx.doi.org/10.1084/jem.192.11.1545.
    • (2000) J. Exp. Med. , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6    Forster, R.7
  • 35
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. 2000. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192:1553-1562. http://dx.doi.org/10.1084/jem.192.11.1553.
    • (2000) J. Exp. Med. , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 39
    • 79956196930 scopus 로고    scopus 로고
    • CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
    • Chevalier N, Jarrossay D, Ho E, Avery DT, Ma CS, Yu D, Sallusto F, Tangye SG, Mackay CR. 2011. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J. Immunol. 186:5556-5568. http://dx.doi.org/10.4049/jimmunol.1002828.
    • (2011) J. Immunol. , vol.186 , pp. 5556-5568
    • Chevalier, N.1    Jarrossay, D.2    Ho, E.3    Avery, D.T.4    Ma, C.S.5    Yu, D.6    Sallusto, F.7    Tangye, S.G.8    Mackay, C.R.9
  • 40
    • 79952742670 scopus 로고    scopus 로고
    • Memory CD4 T cells that express CXCR5 provide accelerated help to B cells
    • MacLeod MK, David A, McKee AS, Crawford F, Kappler JW, Marrack P. 2011. Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J. Immunol. 186:2889-2896. http://dx.doi.org/10.4049/jimmunol.1002955.
    • (2011) J. Immunol. , vol.186 , pp. 2889-2896
    • MacLeod, M.K.1    David, A.2    McKee, A.S.3    Crawford, F.4    Kappler, J.W.5    Marrack, P.6
  • 41
    • 84876780521 scopus 로고    scopus 로고
    • Distinct memory CD4 T cells with commitment to T follicular helper-and T helper 1-cell lineages are generated after acute viral infection
    • Hale JS, Youngblood B, Latner DR, Mohammed AU, Ye L, Akondy RS, Wu T, Iyer SS, Ahmed R. 2013. Distinct memory CD4 T cells with commitment to T follicular helper-and T helper 1-cell lineages are generated after acute viral infection. Immunity 38:805-817. http://dx.doi.org/10.1016/j.immuni.2013.02.020.
    • (2013) Immunity , vol.38 , pp. 805-817
    • Hale, J.S.1    Youngblood, B.2    Latner, D.R.3    Mohammed, A.U.4    Ye, L.5    Akondy, R.S.6    Wu, T.7    Iyer, S.S.8    Ahmed, R.9
  • 49
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R. 2003. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. U. S. A. 100:9440-9445. http://dx.doi.org/10.1073/pnas.1530509100.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 53
    • 58149398757 scopus 로고    scopus 로고
    • Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection
    • Cagigi A, Mowafi F, Phuong Dang LV, Tenner-Racz K, Atlas A, Grutzmeier S, Racz P, Chiodi F, Nilsson A. 2008. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood 112:4401-4410. http://dx.doi.org/10.1182/blood-2008-02-140426.
    • (2008) Blood , vol.112 , pp. 4401-4410
    • Cagigi, A.1    Mowafi, F.2    Phuong Dang, L.V.3    Tenner-Racz, K.4    Atlas, A.5    Grutzmeier, S.6    Racz, P.7    Chiodi, F.8    Nilsson, A.9
  • 58
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
    • (1994) J. Virol. , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 60
    • 80053644417 scopus 로고    scopus 로고
    • Complexes between nuclear factorkappaB p65 and signal transducer and activator of transcription 3 are key actors in inducing activation-induced cytidine deaminase expression and immunoglobulin A production in CD40L plus interleukin-10-treated human blood B cells
    • Lafarge S, Hamzeh-Cognasse H, Richard Y, Pozzetto B, Cogne M, Cognasse F, Garraud O. 2011. Complexes between nuclear factorkappaB p65 and signal transducer and activator of transcription 3 are key actors in inducing activation-induced cytidine deaminase expression and immunoglobulin A production in CD40L plus interleukin-10-treated human blood B cells. Clin. Exp. Immunol. 166:171-183. http://dx.doi.org/10.1111/j.1365-2249.2011.04465.x.
    • (2011) Clin. Exp. Immunol. , vol.166 , pp. 171-183
    • Lafarge, S.1    Hamzeh-Cognasse, H.2    Richard, Y.3    Pozzetto, B.4    Cogne, M.5    Cognasse, F.6    Garraud, O.7
  • 61
    • 0035808786 scopus 로고    scopus 로고
    • +) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants
    • +) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants. J. Exp. Med. 193:297-305. http://dx.doi.org/10.1084/jem.193.3.297.
    • (2001) J. Exp. Med. , vol.193 , pp. 297-305
    • Ciurea, A.1    Hunziker, L.2    Klenerman, P.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 63
  • 67
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies
    • Kwong PD, Mascola JR. 2012. Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity 37:412-425. http://dx.doi.org/10.1016/j.immuni.2012.08.012.
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.