Quantitative image analysis of HIV-1 infection in lymphoid tissue

Science

Volumn 274, Issue 5289, 1996, Pages 985-989

  Haase, Ashley T ^a   Henry, Keith ^a   Zupancic, Mary ^a   Sedgewick, Gerald ^a   Faust, Russell A ^a   Melroe, Holly ^a   Cavert, Winston ^a   Gebhard, Kristin ^a   Staskus, Katherine ^a   Zhang, Zhi Qiang ^a   Dailey, Peter J ^a   Balfour Jr , Henry H ^a   Erice, Alejo ^a   Perelson, Alan S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; IMAGE ANALYSIS; IN SITU PROCESSING; RNA; TISSUE;

HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN SITU HYBRIDIZATION; LYMPHOCYTES; LYMPHOID TISSUE; MACROPHAGES; MONONUCLEAR CELLS; PATHOGENESIS; VIRAL REPLICATION; VIRIONS;

VIRUSES;

DELAVIRDINE; LAMIVUDINE; STAVUDINE; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

ADULT; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMAGE ANALYSIS; IN SITU HYBRIDIZATION; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MONONUCLEAR CELL; PRIORITY JOURNAL; SPLEEN; TONSIL; VIRION; VIRUS REPLICATION;

ADULT; ANTISENSE ELEMENTS (GENETICS); AUTORADIOGRAPHY; CD4 LYMPHOCYTE COUNT; DENDRITIC CELLS; HIV INFECTIONS; HIV-1; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; LYMPHOID TISSUE; RNA PROBES; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; SPLEEN; TONSIL; VIRAL LOAD;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 10544241554     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5289.985     Document Type: Article

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43. We thank S, Wietgrefe and the reviewers for helpful comments; C. O'Neill and T. Leonard for preparation of the manuscript and figures; and the Ramsey Foundation, the Santa Fe Institute, the Joseph P. and Jeanne W. Sullivan Foundation, and NIH (grants AI 28246, AI 27661 and RR 06555) for support. Portions of this work were done under the auspices of the U.S. Department of Energy.