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Volumn 5, Issue , 2014, Pages

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; TRANSFORMING GROWTH FACTOR BETA;

EID: 84896510761     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4495     Document Type: Article
Times cited : (130)

References (54)
  • 2
    • 77955898582 scopus 로고    scopus 로고
    • T cells and follicular dendritic cells in germinal center B-cell formation and selection
    • Vinuesa, C. G., Linterman, M. A., Goodnow, C. C. & Randall, K. L. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol. Rev. 237, 72-89 (2010).
    • (2010) Immunol. Rev , vol.237 , pp. 72-89
    • Vinuesa, C.G.1    Linterman, M.A.2    Goodnow, C.C.3    Randall, K.L.4
  • 3
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621-663 (2011).
    • (2011) Annu. Rev. Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 4
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu, D. & Vinuesa, C. G. The elusive identity of T follicular helper cells. Trends. Immunol. 31, 377-383 (2010).
    • (2010) Trends. Immunol , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 5
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-Center Organization and Cellular Dynamics
    • DOI 10.1016/j.immuni.2007.07.009, PII S1074761307003706
    • Allen, C. D., Okada, T. & Cyster, J. G. Germinal-center organization and cellular dynamics. Immunity 27, 190-202 (2007). (Pubitemid 47284923)
    • (2007) Immunity , vol.27 , Issue.2 , pp. 190-202
    • Allen, C.D.C.1    Okada, T.2    Cyster, J.G.3
  • 6
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston, R. J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006-1010 (2009).
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 7
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva, R. I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 8
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457-468 (2009).
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 9
    • 84861171827 scopus 로고    scopus 로고
    • Unraveling effector functions of B cells during infection: The hidden world beyond antibody production
    • Leon, B., Ballesteros-Tato, A., Misra, R. S., Wojciechowski, W. & Lund, F. E. Unraveling effector functions of B cells during infection: the hidden world beyond antibody production. Infect. Disord. Drug. Targets 12, 213-221 (2012).
    • (2012) Infect. Disord. Drug. Targets , vol.12 , pp. 213-221
    • Leon, B.1    Ballesteros-Tato, A.2    Misra, R.S.3    Wojciechowski, W.4    Lund, F.E.5
  • 10
    • 84858706847 scopus 로고    scopus 로고
    • Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile
    • Oestreich, K. J., Mohn, S. E. & Weinmann, A. S. Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat. Immunol. 13, 405-411 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 405-411
    • Oestreich, K.J.1    Mohn, S.E.2    Weinmann, A.S.3
  • 11
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato, A. et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36, 847-856 (2012).
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1
  • 12
    • 84863116170 scopus 로고    scopus 로고
    • STAT5 is a potent negative regulator of TFH cell differentiation
    • Johnston, R. J., Choi, Y. S., Diamond, J. A., Yang, J. A. & Crotty, S. STAT5 is a potent negative regulator of TFH cell differentiation. J. Exp. Med. 209, 243-250 (2012).
    • (2012) J. Exp. Med , vol.209 , pp. 243-250
    • Johnston, R.J.1    Choi, Y.S.2    Diamond, J.A.3    Yang, J.A.4    Crotty, S.5
  • 13
    • 84859487740 scopus 로고    scopus 로고
    • STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function
    • Nurieva, R. I. et al. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J. Biol. Chem. 287, 11234-11239 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 11234-11239
    • Nurieva, R.I.1
  • 14
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3+ regulatory T cells
    • Campbell, D. J. & Koch, M. A. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol. 11, 119-130 (2011).
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 15
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • Malek, T. R. & Castro, I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 33, 153-165 (2010).
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 17
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice: Implications for the nonredundant function of IL-2
    • DOI 10.1016/S1074-7613(02)00367-9
    • Malek, T. R., Yu, A., Vincek, V., Scibelli, P. & Kong, L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17, 167-178 (2002). (Pubitemid 35245959)
    • (2002) Immunity , vol.17 , Issue.2 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 18
    • 0036839102 scopus 로고    scopus 로고
    • + T cell numbers
    • Almeida, A. R., Legrand, N., Papiernik, M. & Freitas, A. A. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169, 4850-4860 (2002). (Pubitemid 35217148)
    • (2002) Journal of Immunology , vol.169 , Issue.9 , pp. 4850-4860
    • Almeida, A.R.M.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 19
    • 36248976097 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1038/ni1536, PII NI1536
    • Pandiyan, P., Zheng, L., Ishihara, S., Reed, J. & Lenardo, M. J. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivationmediated apoptosis of effector CD4+ T cells. Nat. Immunol. 8, 1353-1362 (2007). (Pubitemid 350131172)
    • (2007) Nature Immunology , vol.8 , Issue.12 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 20
    • 79952769679 scopus 로고    scopus 로고
    • CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model
    • Pandiyan, P. et al. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity 34, 422-434 (2011).
    • (2011) Immunity , vol.34 , pp. 422-434
    • Pandiyan, P.1
  • 21
    • 79952761637 scopus 로고    scopus 로고
    • Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2
    • Chen, Y. et al. Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. Immunity 34, 409-421 (2011).
    • (2011) Immunity , vol.34 , pp. 409-421
    • Chen, Y.1
  • 22
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach, E. M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30, 636-645 (2009).
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 23
    • 77649242104 scopus 로고    scopus 로고
    • Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments
    • Busse, D. et al. Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc. Natl Acad. Sci. USA 107, 3058-3063 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3058-3063
    • Busse, D.1
  • 24
    • 79961151137 scopus 로고    scopus 로고
    • Foxp3+ follicular regulatory T cells control the germinal center response
    • Linterman, M. A. et al. Foxp3+ follicular regulatory T cells control the germinal center response. Nat. Med. 17, 975-982 (2011).
    • (2011) Nat. Med , vol.17 , pp. 975-982
    • Linterman, M.A.1
  • 25
    • 79961158055 scopus 로고    scopus 로고
    • Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    • Chung, Y. et al. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat. Med. 17, 983-988 (2011).
    • (2011) Nat. Med , vol.17 , pp. 983-988
    • Chung, Y.1
  • 26
    • 25444497719 scopus 로고    scopus 로고
    • + regulatory T cells
    • Lim, H. W., Hillsamer, P., Banham, A. H. & Kim, C. H. Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J. Immunol. 175, 4180-4183 (2005). (Pubitemid 41361949)
    • (2005) Journal of Immunology , vol.175 , Issue.7 , pp. 4180-4183
    • Lim, H.W.1    Hillsamer, P.2    Banham, A.H.3    Kim, C.H.4
  • 27
    • 33646567156 scopus 로고    scopus 로고
    • + T cells selectively kill B lymphocytes
    • DOI 10.1182/blood-2005-11-4502
    • Zhao, D. M., Thornton, A. M., DiPaolo, R. J. & Shevach, E. M. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107, 3925-3932 (2006). (Pubitemid 43726798)
    • (2006) Blood , vol.107 , Issue.10 , pp. 3925-3932
    • Zhao, D.-M.1    Thornton, A.M.2    DiPaolo, R.J.3    Shevach, E.M.4
  • 28
    • 79959905757 scopus 로고    scopus 로고
    • T regulatory cells participate in the control of germinal centre reactions
    • Alexander, C. M. et al. T regulatory cells participate in the control of germinal centre reactions. Immunology 133, 452-468 (2011).
    • (2011) Immunology , vol.133 , pp. 452-468
    • Alexander, C.M.1
  • 29
    • 15244363080 scopus 로고    scopus 로고
    • Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
    • DOI 10.1172/JCI200422325
    • Lim, H. W., Hillsamer, P. & Kim, C. H. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J. Clin. Invest. 114, 1640-1649 (2004). (Pubitemid 40385555)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.11 , pp. 1640-1649
    • Lim, H.W.1    Hillsamer, P.2    Kim, C.H.3
  • 30
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji, M. et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323, 1488-1492 (2009).
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1
  • 31
    • 77957838251 scopus 로고    scopus 로고
    • Polyclonal Treg cells enhance the activity of a mucosal adjuvant
    • Vendetti, S. et al. Polyclonal Treg cells enhance the activity of a mucosal adjuvant. Immunol. Cell. Biol. 88, 698-706 (2010).
    • (2010) Immunol. Cell. Biol , vol.88 , pp. 698-706
    • Vendetti, S.1
  • 32
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • DOI 10.1038/ni1428, PII NI1428
    • Kim, J. M., Rasmussen, J. P. & Rudensky, A. Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191-197 (2007). (Pubitemid 46152650)
    • (2007) Nature Immunology , vol.8 , Issue.2 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 34
    • 80555133319 scopus 로고    scopus 로고
    • Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells
    • Wollenberg, I. et al. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J. Immunol. 187, 4553-4560 (2011).
    • (2011) J. Immunol , vol.187 , pp. 4553-4560
    • Wollenberg, I.1
  • 35
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • DOI 10.1084/jem.194.5.629
    • Nakamura, K., Kitani, A. & Strober, W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194, 629-644 (2001). (Pubitemid 32844773)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.5 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 36
    • 0034897188 scopus 로고    scopus 로고
    • The basis for IL-2-induced IL-2 receptor α chain gene regulation: Importance of two widely separated IL-2 response elements
    • DOI 10.1016/S1074-7613(01)00167-4
    • Kim, H. P., Kelly, J. & Leonard, W. J. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity 15, 159-172 (2001). (Pubitemid 32728329)
    • (2001) Immunity , vol.15 , Issue.1 , pp. 159-172
    • Kim, H.-P.1    Kelly, J.2    Leonard, W.J.3
  • 37
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • DOI 10.1146/annurev.immunol.26.021607.090357
    • Malek, T. R. The biology of interleukin-2. Annu. Rev. Immunol. 26, 453-479 (2008). (Pubitemid 351600382)
    • (2008) Annual Review of Immunology , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 38
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • DOI 10.1038/ni1178
    • Sakaguchi, S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345-352 (2005). (Pubitemid 41716771)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 43
    • 0035869333 scopus 로고    scopus 로고
    • Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus
    • Solomou, E. E., Juang, Y. T., Gourley, M. F., Kammer, G. M. & Tsokos, G. C. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J. Immunol. 166, 4216-4222 (2001). (Pubitemid 32224956)
    • (2001) Journal of Immunology , vol.166 , Issue.6 , pp. 4216-4222
    • Solomou, E.E.1    Juang, Y.-T.2    Gourley, M.F.3    Kammer, G.M.4    Tsokos, G.C.5
  • 44
    • 82555196118 scopus 로고    scopus 로고
    • Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    • Saadoun, D. et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. New Engl. J. Med. 365, 2067-2077 (2011).
    • (2011) New Engl. J. Med , vol.365 , pp. 2067-2077
    • Saadoun, D.1
  • 45
    • 84869791967 scopus 로고    scopus 로고
    • Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin- 2/STAT5 signalling pathways
    • Lee, S. Y. et al. Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin- 2/STAT5 signalling pathways. Immunology 137, 305-316 (2012).
    • (2012) Immunology , vol.137 , pp. 305-316
    • Lee, S.Y.1
  • 46
    • 76249100290 scopus 로고    scopus 로고
    • Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
    • Humrich, J. Y. et al. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc. Natl Acad. Sci. USA 107, 204-209 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 204-209
    • Humrich, J.Y.1
  • 47
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Webster, K. E. et al. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206, 751-760 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 751-760
    • Webster, K.E.1
  • 48
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • DOI 10.1126/science.1078231
    • Pasare, C. & Medzhitov, R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033-1036 (2003). (Pubitemid 36222922)
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 49
    • 84870285173 scopus 로고    scopus 로고
    • Bcl6 expression specifies the T follicular helper cell program in vivo
    • S1841-1824
    • Liu, X. et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J. Exp. Med. 209, 1841-1852 S1841-1824 (2012).
    • (2012) J. Exp. Med , vol.209 , pp. 1841-1852
    • Liu, X.1
  • 50
    • 84862976472 scopus 로고    scopus 로고
    • A decade of imaging cellular motility and interaction dynamics in the immune system
    • Germain, R. N., Robey, E. A. & Cahalan, M. D. A decade of imaging cellular motility and interaction dynamics in the immune system. Science 336, 1676-1681 (2012).
    • (2012) Science , vol.336 , pp. 1676-1681
    • Germain, R.N.1    Robey, E.A.2    Cahalan, M.D.3
  • 51
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot, S. M. et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34, 947-960 (2011).
    • (2011) Immunity , vol.34 , pp. 947-960
    • Kerfoot, S.M.1
  • 52
    • 24744448228 scopus 로고    scopus 로고
    • Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    • DOI 10.1182/blood-2004-11-4494
    • Hardtke, S., Ohl, L. & Forster, R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106, 1924-1931 (2005). (Pubitemid 41291702)
    • (2005) Blood , vol.106 , Issue.6 , pp. 1924-1931
    • Hardtke, S.1    Ohl, L.2    Forster, R.3
  • 53
    • 84870864876 scopus 로고    scopus 로고
    • CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation
    • Groom, J. R. et al. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity 37, 1091-1103 (2012).
    • (2012) Immunity , vol.37 , pp. 1091-1103
    • Groom, J.R.1
  • 54
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch, M. A. et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1


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