Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand T fh cells and promote germinal center induction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages 1080-1085

  Moon, James J ^a   Suh, Heikyung ^a,e   Li, Adrienne V ^a   Ockenhouse, Christian F ^b   Yadava, Anjali ^b   Irvine, Darrell J ^a,c,d,e  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HARVARD UNIVERSITY   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; IMMUNOGLOBULIN G; MALARIA VACCINE; NANOPARTICLE; PHOSPHORYL LIPID A; RECOMBINANT PLASMODIUM VIVAX CIRCUMSPOROZOITE ANTIGEN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG SAFETY; FEMALE; FOOD AND DRUG ADMINISTRATION; GERMINAL CENTER; HELPER CELL; HUMORAL IMMUNITY; HYDRODYNAMICS; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; LIPID VESICLE; LOW DRUG DOSE; LYMPH NODE; MALARIA; MOUSE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; VACCINATION;

ANALYSIS OF VARIANCE; ANTIGENS, PROTOZOAN; B-LYMPHOCYTES; CROSS REACTIONS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GERMINAL CENTER; IMMUNOHISTOCHEMISTRY; LIPID A; LIPID BILAYERS; MALARIA VACCINES; MICROSCOPY, CONFOCAL; NANOPARTICLES; PARTICLE SIZE; PLASMODIUM VIVAX; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; T-LYMPHOCYTES, HELPER-INDUCER; TRANSPORT VESICLES;

MUS; PLASMODIUM VIVAX;

EID: 84856387516     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112648109     Document Type: Article

References (30)

1. Price RN, et al. (2007) Vivax malaria: Neglected and not benign. Am J Trop Med Hyg 77:79-87.
2. Mueller I, et al. (2009) Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite. Lancet Infect Dis 9:555-566.
3. Nussenzweig V, Nussenzweig RS (1985) Circumsporozoite proteins of malaria parasites. Cell 42:401-403.
4. Ballou WR (2009) The development of the RTS,S malaria vaccine candidate: Challenges and lessons. Parasite Immunol 31:492-500.
5. Yadava A, et al. (2007) A novel chimeric Plasmodium vivax circumsporozoite protein induces biologically functional antibodies that recognize both VK210 and VK247 sporozoites. Infect Immun 75:1177-1185. (Pubitemid 46385808)
6. Bell BA, et al. (2009) Process development for the production of an E.coli produced clinical grade recombinant malaria vaccine for Plasmodium vivax. Vaccine 27:1448-1453.
7. Schwenk R, et al. (2003) Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine. Parasite Immunol 25:17-25. (Pubitemid 38019095)
8. Ancsin JB, Kisilevsky R (2004) A binding site for highly sulfated heparan sulfate is identified in the N terminus of the circumsporozoite protein: Significance for malarial sporozoite attachment to hepatocytes. J Biol Chem 279:21824-21832. (Pubitemid 38679371)
9. Blander JM, Medzhitov R (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440:808-812.
10. Moon JJ, et al. (2011) Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater 10:243-251.
11. Reddy ST, et al. (2007) Exploiting lymphatic transport and complement activation in nanoparticle vaccines. Nat Biotechnol 25:1159-1164. (Pubitemid 47538111)
12. Heit A, Schmitz F, Haas T, Busch DH, Wagner H (2007) Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity. Eur J Immunol 37:2063-2074. (Pubitemid 47250198)
13. Kasturi SP, et al. (2011) Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470:543-547.
14. Demento SL, et al. (2010) TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol 185:2989-2997.
15. Jegerlehner A, et al. (2002) Regulation of IgG antibody responses by epitope density and CD21-mediated costimulation. Eur J Immunol 32:3305-3314. (Pubitemid 35414888)
16. Liu W, Chen YH (2005) High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: A novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins. Eur J Immunol 35:505-514. (Pubitemid 40331328)
17. Jones TR, et al. (1992) Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody. Am J Trop Med Hyg 47:837-843. (Pubitemid 23019156)
18. Wirtz RA, et al. (1991) Evaluation of monoclonal antibodies against Plasmodium vivax sporozoites for ELISA development. Med Vet Entomol 5:17-22.
19. Udhayakumar V, et al. (1998) Immunogenicity of Plasmodium falciparum and Plasmodium vivax circumsporozoite protein repeat multiple antigen constructs (MAC). Vaccine 16:982-988. (Pubitemid 28276012)
20. Bilsborough J, Baumgart K, Bathurst I, Barr P, Good MF (1997) Fine epitope specificity of antibodies to region II of the Plasmodium vivax circumsporozoite protein correlates with ability to bind recombinant protein and sporozoites. Acta Trop 65:59-80. (Pubitemid 27219777)
21. McHeyzer-Williams LJ, McHeyzer-Williams MG (2005) Antigen-specific memory B cell development. Annu Rev Immunol 23:487-513. (Pubitemid 40563178)
22. Nutt SL, Tarlinton DM (2011) Germinal center B and follicular helper T cells: Siblings, cousins or just good friends? Nat Immunol 131:472-477.
23. Breitfeld D, et al. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192:1545-1552.
24. Deenick EK, et al. (2010) Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33:241-253.
25. Bojang KA, et al. (2001) Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: A randomised trial. Lancet 358:1927-1934. (Pubitemid 34072872)
26. Charoenvit Y, et al. (1991) Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence. Science 251:668-671. (Pubitemid 21916891)
27. Carrasco YR, Batista FD (2007) B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 27:160-171. (Pubitemid 47089026)
28. Junt T, et al. (2007) Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450:110-114. (Pubitemid 350070574)
29. Manolova V, et al. (2008) Nanoparticles target distinct dendritic cell populations according to their size. Eur J Immunol 38:1404-1413.
30. Yue Y, Xu W, Hu L, Jiang Z, Xiong S (2009) Enhanced resistance to coxsackievirus B3-induced myocarditis by intranasal co-immunization of lymphotactin gene encapsulated in chitosan particle. Virology 386:438-447.