-
1
-
-
33745919520
-
Epidemiology of Parkinson's disease
-
de Lau LM, Breteler MM: Epidemiology of Parkinson's disease. Lancet Neurol 2006, 5: 525-535. 10.1016/S1474-4422(06)70471-9
-
(2006)
Lancet Neurol
, vol.5
, pp. 525-535
-
-
de Lau, L.M.1
Breteler, M.M.2
-
2
-
-
66949152096
-
Parkinson's disease
-
Lees AJ, Hardy J, Revesz T: Parkinson's disease. Lancet 2009, 373: 2055-2066. 10.1016/S0140-6736(09)60492-X
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
3
-
-
84872729641
-
Parkinson's disease and parkinsonism: neuropathology
-
Dickson DW: Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med 2012, 2: a009258.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Dickson, D.W.1
-
5
-
-
84871414210
-
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
-
Lashuel HA, Overk CR, Oueslati A, Masliah E: The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 2013, 14: 38-48.
-
(2013)
Nat Rev Neurosci
, vol.14
, pp. 38-48
-
-
Lashuel, H.A.1
Overk, C.R.2
Oueslati, A.3
Masliah, E.4
-
6
-
-
79960842310
-
Neuropathology underlying clinical variability in patients with synucleinopathies
-
Halliday GM, Holton JL, Revesz T, Dickson DW: Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 2011, 122: 187-204. 10.1007/s00401-011-0852-9
-
(2011)
Acta Neuropathol
, vol.122
, pp. 187-204
-
-
Halliday, G.M.1
Holton, J.L.2
Revesz, T.3
Dickson, D.W.4
-
8
-
-
84883174947
-
Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies
-
Irwin DJ, Lee VM, Trojanowski JQ: Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies. Nat Rev Neurosci 2013, 14: 626-636. 10.1038/nrn3549
-
(2013)
Nat Rev Neurosci
, vol.14
, pp. 626-636
-
-
Irwin, D.J.1
Lee, V.M.2
Trojanowski, J.Q.3
-
9
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, et al.: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276: 2045-2047. 10.1126/science.276.5321.2045
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
10
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 1998, 18: 106-108. 10.1038/ng0298-106
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schols, L.9
Riess, O.10
-
11
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, et al.: The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 2004, 55: 164-173. 10.1002/ana.10795
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
-
12
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, et al.: alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003, 302: 841. 10.1126/science.1090278
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
13
-
-
4644236043
-
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
-
Ibanez P, Bonnet AM, Debarges B, Lohmann E, Tison F, Pollak P, Agid Y, Durr A, Brice A: Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 2004, 364: 1169-1171. 10.1016/S0140-6736(04)17104-3
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Durr, A.8
Brice, A.9
-
14
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, et al.: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004, 364: 1167-1169. 10.1016/S0140-6736(04)17103-1
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
15
-
-
79951811351
-
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
-
Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simon-Sanchez J, Schulte C, Lesage S, Sveinbjornsdottir S, et al.: Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 2011, 377: 641-649.
-
(2011)
Lancet
, vol.377
, pp. 641-649
-
-
Nalls, M.A.1
Plagnol, V.2
Hernandez, D.G.3
Sharma, M.4
Sheerin, U.M.5
Saad, M.6
Simon-Sanchez, J.7
Schulte, C.8
Lesage, S.9
Sveinbjornsdottir, S.10
-
16
-
-
84865861347
-
Molecular chaperones and co-chaperones in Parkinson disease
-
Dimant H, Ebrahimi-Fakhari D, McLean PJ: Molecular chaperones and co-chaperones in Parkinson disease. Neuroscientist 2012, 18: 589-601. 10.1177/1073858412441372
-
(2012)
Neuroscientist
, vol.18
, pp. 589-601
-
-
Dimant, H.1
Ebrahimi-Fakhari, D.2
McLean, P.J.3
-
17
-
-
84858263923
-
Molecular Chaperones in Parkinson's Disease - Present and Future
-
Ebrahimi-Fakhari D, Wahlster L, McLean PJ: Molecular Chaperones in Parkinson's Disease - Present and Future. J Parkinsons Dis 2011, 1: 299-320.
-
(2011)
J Parkinsons Dis
, vol.1
, pp. 299-320
-
-
Ebrahimi-Fakhari, D.1
Wahlster, L.2
McLean, P.J.3
-
18
-
-
84865860748
-
Protein degradation pathways in Parkinson's disease: curse or blessing
-
Ebrahimi-Fakhari D, Wahlster L, McLean PJ: Protein degradation pathways in Parkinson's disease: curse or blessing. Acta Neuropathol 2012, 124: 153-172. 10.1007/s00401-012-1004-6
-
(2012)
Acta Neuropathol
, vol.124
, pp. 153-172
-
-
Ebrahimi-Fakhari, D.1
Wahlster, L.2
McLean, P.J.3
-
19
-
-
84875415994
-
Lang AE: alpha-Synuclein oligomers and clinical implications for Parkinson disease
-
Kalia LV, Kalia SK, McLean PJ, Lozano AM: Lang AE: alpha-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol 2013, 73: 155-169. 10.1002/ana.23746
-
(2013)
Ann Neurol
, vol.73
, pp. 155-169
-
-
Kalia, L.V.1
Kalia, S.K.2
McLean, P.J.3
Lozano, A.M.4
-
20
-
-
84857254436
-
Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease
-
Ebrahimi-Fakhari D, McLean PJ, Unni VK: Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease. Autophagy 2012, 8: 281-283. 10.4161/auto.8.2.18938
-
(2012)
Autophagy
, vol.8
, pp. 281-283
-
-
Ebrahimi-Fakhari, D.1
McLean, P.J.2
Unni, V.K.3
-
22
-
-
78649239916
-
Molecular chaperones as rational drug targets for Parkinson's disease therapeutics
-
Kalia SK, Kalia LV, McLean PJ: Molecular chaperones as rational drug targets for Parkinson's disease therapeutics. CNS Neurol Disord Drug Targets 2010, 9: 741-753. 10.2174/187152710793237386
-
(2010)
CNS Neurol Disord Drug Targets
, vol.9
, pp. 741-753
-
-
Kalia, S.K.1
Kalia, L.V.2
McLean, P.J.3
-
23
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
Nixon RA: The role of autophagy in neurodegenerative disease. Nat Med 2013, 19: 983-997. 10.1038/nm.3232
-
(2013)
Nat Med
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
24
-
-
27544507306
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra S, Gallardo G, Fernandez-Chacon R, Schluter OM, Sudhof TC: Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 2005, 123: 383-396. 10.1016/j.cell.2005.09.028
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernandez-Chacon, R.3
Schluter, O.M.4
Sudhof, T.C.5
-
25
-
-
77957347060
-
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burre J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Sudhof TC: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010, 329: 1663-1667. 10.1126/science.1195227
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burre, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Sudhof, T.C.6
-
26
-
-
0032540327
-
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
-
Davidson WS, Jonas A, Clayton DF, George JM: Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem 1998, 273: 9443-9449. 10.1074/jbc.273.16.9443
-
(1998)
J Biol Chem
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
27
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT Jr: NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 1996, 35: 13709-13715. 10.1021/bi961799n
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, P.T.5
-
28
-
-
80052398365
-
alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
Bartels T, Choi JG, DJ S: alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011, 477: 107-110. 10.1038/nature10324
-
(2011)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
-
29
-
-
80055078029
-
A soluble alpha-synuclein construct forms a dynamic tetramer
-
Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, et al.: A soluble alpha-synuclein construct forms a dynamic tetramer. Proc Natl Acad Sci U S A 2011, 108: 17797-17802. 10.1073/pnas.1113260108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17797-17802
-
-
Wang, W.1
Perovic, I.2
Chittuluru, J.3
Kaganovich, A.4
Nguyen, L.T.5
Liao, J.6
Auclair, J.R.7
Johnson, D.8
Landeru, A.9
Simorellis, A.K.10
-
30
-
-
84874769548
-
In vivo cross-linking reveals principally oligomeric forms of alpha-synuclein and beta-synuclein in neurons and non-neural cells
-
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D: In vivo cross-linking reveals principally oligomeric forms of alpha-synuclein and beta-synuclein in neurons and non-neural cells. J Biol Chem 2013, 288: 6371-6385. 10.1074/jbc.M112.403311
-
(2013)
J Biol Chem
, vol.288
, pp. 6371-6385
-
-
Dettmer, U.1
Newman, A.J.2
Luth, E.S.3
Bartels, T.4
Selkoe, D.5
-
31
-
-
84878994255
-
Properties of native brain alpha-synuclein
-
Burre J, Vivona S, Diao J, Sharma M, Brunger AT, Sudhof TC: Properties of native brain alpha-synuclein. Nature 2013, 498: E4-E6. discussion E6-7 10.1038/nature12125
-
(2013)
Nature
, vol.498
, pp. E4-E6
-
-
Burre, J.1
Vivona, S.2
Diao, J.3
Sharma, M.4
Brunger, A.T.5
Sudhof, T.C.6
-
32
-
-
84859577559
-
alpha-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
-
Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, et al.: alpha-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. J Biol Chem 2012, 287: 15345-15364. 10.1074/jbc.M111.318949
-
(2012)
J Biol Chem
, vol.287
, pp. 15345-15364
-
-
Fauvet, B.1
Mbefo, M.K.2
Fares, M.B.3
Desobry, C.4
Michael, S.5
Ardah, M.T.6
Tsika, E.7
Coune, P.8
Prudent, M.9
Lion, N.10
-
33
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
-
Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr: Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc Natl Acad Sci U S A 2000, 97: 571-576. 10.1073/pnas.97.2.571
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury, P.T.6
-
34
-
-
0033577159
-
Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro
-
Hashimoto M, Hsu LJ, Xia Y, Takeda A, Sisk A, Sundsmo M, Masliah E: Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro. Neuroreport 1999, 10: 717-721. 10.1097/00001756-199903170-00011
-
(1999)
Neuroreport
, vol.10
, pp. 717-721
-
-
Hashimoto, M.1
Hsu, L.J.2
Xia, Y.3
Takeda, A.4
Sisk, A.5
Sundsmo, M.6
Masliah, E.7
-
35
-
-
0036174010
-
alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T: alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002, 4: 160-164.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
36
-
-
77749341497
-
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions
-
Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, et al.: Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci 2010, 30: 3184-3198. 10.1523/JNEUROSCI.5922-09.2010
-
(2010)
J Neurosci
, vol.30
, pp. 3184-3198
-
-
Paleologou, K.E.1
Oueslati, A.2
Shakked, G.3
Rospigliosi, C.C.4
Kim, H.Y.5
Lamberto, G.R.6
Fernandez, C.O.7
Schmid, A.8
Chegini, F.9
Gai, W.P.10
-
37
-
-
13844320376
-
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
-
Li W, West N, Colla E, Pletnikova O, Troncoso JC, Marsh L, Dawson TM, Jakala P, Hartmann T, Price DL, Lee MK: Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A 2005, 102: 2162-2167. 10.1073/pnas.0406976102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2162-2167
-
-
Li, W.1
West, N.2
Colla, E.3
Pletnikova, O.4
Troncoso, J.C.5
Marsh, L.6
Dawson, T.M.7
Jakala, P.8
Hartmann, T.9
Price, D.L.10
Lee, M.K.11
-
38
-
-
34250832784
-
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation
-
Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT: Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am J Pathol 2007, 170: 1725-1738. 10.2353/ajpath.2007.061232
-
(2007)
Am J Pathol
, vol.170
, pp. 1725-1738
-
-
Dufty, B.M.1
Warner, L.R.2
Hou, S.T.3
Jiang, S.X.4
Gomez-Isla, T.5
Leenhouts, K.M.6
Oxford, J.T.7
Feany, M.B.8
Masliah, E.9
Rohn, T.T.10
-
39
-
-
0035834655
-
Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
-
Perrin RJ, Woods WS, Clayton DF, George JM: Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem 2001, 276: 41958-41962. 10.1074/jbc.M105022200
-
(2001)
J Biol Chem
, vol.276
, pp. 41958-41962
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
40
-
-
0037456578
-
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
-
Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ: The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 2003, 37: 583-595. 10.1016/S0896-6273(03)00024-2
-
(2003)
Neuron
, vol.37
, pp. 583-595
-
-
Sharon, R.1
Bar-Joseph, I.2
Frosch, M.P.3
Walsh, D.M.4
Hamilton, J.A.5
Selkoe, D.J.6
-
41
-
-
53949108957
-
N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules
-
Karube H, Sakamoto M, Arawaka S, Hara S, Sato H, Ren CH, Goto S, Koyama S, Wada M, Kawanami T, et al.: N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules. FEBS Lett 2008, 582: 3693-3700. 10.1016/j.febslet.2008.10.001
-
(2008)
FEBS Lett
, vol.582
, pp. 3693-3700
-
-
Karube, H.1
Sakamoto, M.2
Arawaka, S.3
Hara, S.4
Sato, H.5
Ren, C.H.6
Goto, S.7
Koyama, S.8
Wada, M.9
Kawanami, T.10
-
42
-
-
65249162241
-
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
-
Paleologou KE, Kragh CL, Mann DM, Salem SA, Al-Shami R, Allsop D, Hassan AH, Jensen PH, El-Agnaf OM: Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain 2009, 132: 1093-1101.
-
(2009)
Brain
, vol.132
, pp. 1093-1101
-
-
Paleologou, K.E.1
Kragh, C.L.2
Mann, D.M.3
Salem, S.A.4
Al-Shami, R.5
Allsop, D.6
Hassan, A.H.7
Jensen, P.H.8
El-Agnaf, O.M.9
-
43
-
-
44849125207
-
Formation of toxic oligomeric alpha-synuclein species in living cells
-
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ: Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One 2008, 3: e1867. 10.1371/journal.pone.0001867
-
(2008)
PLoS One
, vol.3
-
-
Outeiro, T.F.1
Putcha, P.2
Tetzlaff, J.E.3
Spoelgen, R.4
Koker, M.5
Carvalho, F.6
Hyman, B.T.7
McLean, P.J.8
-
44
-
-
49649125680
-
CHIP targets toxic alpha-Synuclein oligomers for degradation
-
Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ: CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem 2008, 283: 17962-17968. 10.1074/jbc.M802283200
-
(2008)
J Biol Chem
, vol.283
, pp. 17962-17968
-
-
Tetzlaff, J.E.1
Putcha, P.2
Outeiro, T.F.3
Ivanov, A.4
Berezovska, O.5
Hyman, B.T.6
McLean, P.J.7
-
45
-
-
77249101456
-
Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity
-
Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ: Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. J Pharmacol Exp Ther 2010, 332: 849-857. 10.1124/jpet.109.158436
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 849-857
-
-
Putcha, P.1
Danzer, K.M.2
Kranich, L.R.3
Scott, A.4
Silinski, M.5
Mabbett, S.6
Hicks, C.D.7
Veal, J.M.8
Steed, P.M.9
Hyman, B.T.10
McLean, P.J.11
-
46
-
-
79251565507
-
Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity
-
Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ: Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity. Faseb J 2011, 25: 326-336. 10.1096/fj.10-164624
-
(2011)
Faseb J
, vol.25
, pp. 326-336
-
-
Danzer, K.M.1
Ruf, W.P.2
Putcha, P.3
Joyner, D.4
Hashimoto, T.5
Glabe, C.6
Hyman, B.T.7
McLean, P.J.8
-
47
-
-
79952742454
-
In vivo demonstration that alpha-synuclein oligomers are toxic
-
Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, et al.: In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A 2011, 108: 4194-4199. 10.1073/pnas.1100976108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4194-4199
-
-
Winner, B.1
Jappelli, R.2
Maji, S.K.3
Desplats, P.A.4
Boyer, L.5
Aigner, S.6
Hetzer, C.7
Loher, T.8
Vilar, M.9
Campioni, S.10
-
48
-
-
85005846700
-
Direct detection of alpha synuclein oligomers in vivo
-
Dimant H, Kalia S, Kalia L, Zhu L, Kibuuka L, Ebrahimi-Fakhari D, McFarland N, Fan Z, Hyman B, McLean P: Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathologica Communications 2013, 1: 6. 10.1186/2051-5960-1-6
-
(2013)
Acta Neuropathologica Communications
, vol.1
, pp. 6
-
-
Dimant, H.1
Kalia, S.2
Kalia, L.3
Zhu, L.4
Kibuuka, L.5
Ebrahimi-Fakhari, D.6
McFarland, N.7
Fan, Z.8
Hyman, B.9
McLean, P.10
-
49
-
-
77957939093
-
Are synucleinopathies prion-like disorders
-
Angot E, Steiner JA, Hansen C, Li JY, Brundin P: Are synucleinopathies prion-like disorders Lancet Neurol 2010, 9: 1128-1138. 10.1016/S1474-4422(10)70213-1
-
(2010)
Lancet Neurol
, vol.9
, pp. 1128-1138
-
-
Angot, E.1
Steiner, J.A.2
Hansen, C.3
Li, J.Y.4
Brundin, P.5
-
50
-
-
84860501370
-
Beyond alpha-synuclein transfer: pathology propagation in Parkinson's disease
-
Hansen C, Li JY: Beyond alpha-synuclein transfer: pathology propagation in Parkinson's disease. Trends Mol Med 2012, 18: 248-255. 10.1016/j.molmed.2012.03.002
-
(2012)
Trends Mol Med
, vol.18
, pp. 248-255
-
-
Hansen, C.1
Li, J.Y.2
-
51
-
-
85005896337
-
The prion hypothesis in Parkinson's disease: Braak to the future
-
Visanji N, Brooks P, Hazrati L-N, Lang A: The prion hypothesis in Parkinson's disease: Braak to the future. Acta Neuropathologica Communications 2013, 1: 2. 10.1186/2051-5960-1-2
-
(2013)
Acta Neuropathologica Communications
, vol.1
, pp. 2
-
-
Visanji, N.1
Brooks, P.2
Hazrati, L.-N.3
Lang, A.4
-
52
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl FU, Bracher A, Hayer-Hartl M: Molecular chaperones in protein folding and proteostasis. Nature 2011, 475: 324-332. 10.1038/nature10317
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
53
-
-
77958487260
-
Cellular strategies for controlling protein aggregation
-
Tyedmers J, Mogk A, Bukau B: Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol 2010, 11: 777-788. 10.1038/nrm2993
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 777-788
-
-
Tyedmers, J.1
Mogk, A.2
Bukau, B.3
-
55
-
-
84883049362
-
Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis
-
Finka A, Goloubinoff P: Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis. Cell Stress Chaperones 2013, 18: 591-605. 10.1007/s12192-013-0413-3
-
(2013)
Cell Stress Chaperones
, vol.18
, pp. 591-605
-
-
Finka, A.1
Goloubinoff, P.2
-
56
-
-
66849143696
-
Converging concepts of protein folding in vitro and in vivo
-
Hartl FU, Hayer-Hartl M: Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol 2009, 16: 574-581. 10.1038/nsmb.1591
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 574-581
-
-
Hartl, F.U.1
Hayer-Hartl, M.2
-
57
-
-
80054026084
-
Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy Lysosomal Pathway in the Degradation of (alpha}-Synuclein
-
Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, Rockenstein E, Masliah E, Hyman BT, McLean PJ, Unni VK: Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of (alpha}-Synuclein. J Neurosci 2011, 31: 14508-14520. 10.1523/JNEUROSCI.1560-11.2011
-
(2011)
J Neurosci
, vol.31
, pp. 14508-14520
-
-
Ebrahimi-Fakhari, D.1
Cantuti-Castelvetri, I.2
Fan, Z.3
Rockenstein, E.4
Masliah, E.5
Hyman, B.T.6
McLean, P.J.7
Unni, V.K.8
-
58
-
-
79951681576
-
Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells
-
Finka A, Mattoo RU, Goloubinoff P: Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells. Cell Stress Chaperones 2011, 16: 15-31. 10.1007/s12192-010-0216-8
-
(2011)
Cell Stress Chaperones
, vol.16
, pp. 15-31
-
-
Finka, A.1
Mattoo, R.U.2
Goloubinoff, P.3
-
59
-
-
78649346692
-
The heat shock response: life on the verge of death
-
Richter K, Haslbeck M, Buchner J: The heat shock response: life on the verge of death. Mol Cell 2010, 40: 253-266. 10.1016/j.molcel.2010.10.006
-
(2010)
Mol Cell
, vol.40
, pp. 253-266
-
-
Richter, K.1
Haslbeck, M.2
Buchner, J.3
-
61
-
-
0032555685
-
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1
-
Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R: Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 1998, 94: 471-480. 10.1016/S0092-8674(00)81588-3
-
(1998)
Cell
, vol.94
, pp. 471-480
-
-
Zou, J.1
Guo, Y.2
Guettouche, T.3
Smith, D.F.4
Voellmy, R.5
-
62
-
-
0023815651
-
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells
-
Mosser DD, Theodorakis NG, Morimoto RI: Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol Cell Biol 1988, 8: 4736-4744.
-
(1988)
Mol Cell Biol
, vol.8
, pp. 4736-4744
-
-
Mosser, D.D.1
Theodorakis, N.G.2
Morimoto, R.I.3
-
63
-
-
0032535245
-
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
-
Morimoto RI: Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 1998, 12: 3788-3796. 10.1101/gad.12.24.3788
-
(1998)
Genes Dev
, vol.12
, pp. 3788-3796
-
-
Morimoto, R.I.1
-
64
-
-
0032031725
-
Molecular chaperones as HSF1-specific transcriptional repressors
-
Shi Y, Mosser DD, Morimoto RI: Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev 1998, 12: 654-666. 10.1101/gad.12.5.654
-
(1998)
Genes Dev
, vol.12
, pp. 654-666
-
-
Shi, Y.1
Mosser, D.D.2
Morimoto, R.I.3
-
65
-
-
84864318195
-
Chaperone-mediated autophagy: a unique way to enter the lysosome world
-
Kaushik S, Cuervo AM: Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 2012, 22: 407-417. 10.1016/j.tcb.2012.05.006
-
(2012)
Trends Cell Biol
, vol.22
, pp. 407-417
-
-
Kaushik, S.1
Cuervo, A.M.2
-
66
-
-
0025294506
-
Peptide sequences that target cytosolic proteins for lysosomal proteolysis
-
Dice JF: Peptide sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem Sci 1990, 15: 305-309. 10.1016/0968-0004(90)90019-8
-
(1990)
Trends Biochem Sci
, vol.15
, pp. 305-309
-
-
Dice, J.F.1
-
67
-
-
0024975155
-
A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
-
Chiang HL, Terlecky SR, Plant CP, Dice JF: A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 1989, 246: 382-385. 10.1126/science.2799391
-
(1989)
Science
, vol.246
, pp. 382-385
-
-
Chiang, H.L.1
Terlecky, S.R.2
Plant, C.P.3
Dice, J.F.4
-
68
-
-
0034914206
-
A molecular chaperone complex at the lysosomal membrane is required for protein translocation
-
Agarraberes FA, Dice JF: A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci 2001, 114: 2491-2499.
-
(2001)
J Cell Sci
, vol.114
, pp. 2491-2499
-
-
Agarraberes, F.A.1
Dice, J.F.2
-
69
-
-
0029837453
-
A receptor for the selective uptake and degradation of proteins by lysosomes
-
Cuervo AM, Dice JF: A receptor for the selective uptake and degradation of proteins by lysosomes. Science 1996, 273: 501-503. 10.1126/science.273.5274.501
-
(1996)
Science
, vol.273
, pp. 501-503
-
-
Cuervo, A.M.1
Dice, J.F.2
-
70
-
-
0030923854
-
An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
-
Agarraberes FA, Terlecky SR, Dice JF: An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J Cell Biol 1997, 137: 825-834. 10.1083/jcb.137.4.825
-
(1997)
J Cell Biol
, vol.137
, pp. 825-834
-
-
Agarraberes, F.A.1
Terlecky, S.R.2
Dice, J.F.3
-
71
-
-
51349130544
-
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
-
Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo AM: The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol 2008, 28: 5747-5763. 10.1128/MCB.02070-07
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5747-5763
-
-
Bandyopadhyay, U.1
Kaushik, S.2
Varticovski, L.3
Cuervo, A.M.4
-
72
-
-
0031041902
-
A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins
-
Cuervo AM, Dice JF, Knecht E: A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J Biol Chem 1997, 272: 5606-5615. 10.1074/jbc.272.9.5606
-
(1997)
J Biol Chem
, vol.272
, pp. 5606-5615
-
-
Cuervo, A.M.1
Dice, J.F.2
Knecht, E.3
-
73
-
-
0034613294
-
Age-related decline in chaperone-mediated autophagy
-
Cuervo AM, Dice JF: Age-related decline in chaperone-mediated autophagy. J Biol Chem 2000, 275: 31505-31513.
-
(2000)
J Biol Chem
, vol.275
, pp. 31505-31513
-
-
Cuervo, A.M.1
Dice, J.F.2
-
74
-
-
33847690636
-
Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age
-
Kiffin R, Kaushik S, Zeng M, Bandyopadhyay U, Zhang C, Massey AC, Martinez-Vicente M, Cuervo AM: Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J Cell Sci 2007, 120: 782-791. 10.1242/jcs.001073
-
(2007)
J Cell Sci
, vol.120
, pp. 782-791
-
-
Kiffin, R.1
Kaushik, S.2
Zeng, M.3
Bandyopadhyay, U.4
Zhang, C.5
Massey, A.C.6
Martinez-Vicente, M.7
Cuervo, A.M.8
-
75
-
-
0031838352
-
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
-
Cummings CJ, Mancini MA, Antalffy B, DeFranco DB, Orr HT, Zoghbi HY: Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat Genet 1998, 19: 148-154. 10.1038/502
-
(1998)
Nat Genet
, vol.19
, pp. 148-154
-
-
Cummings, C.J.1
Mancini, M.A.2
Antalffy, B.3
DeFranco, D.B.4
Orr, H.T.5
Zoghbi, H.Y.6
-
76
-
-
0034629073
-
Genetic suppression of polyglutamine toxicity in Drosophila
-
Kazemi-Esfarjani P, Benzer S: Genetic suppression of polyglutamine toxicity in Drosophila. Science 2000, 287: 1837-1840. 10.1126/science.287.5459.1837
-
(2000)
Science
, vol.287
, pp. 1837-1840
-
-
Kazemi-Esfarjani, P.1
Benzer, S.2
-
77
-
-
0033499931
-
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
-
Chai Y, Koppenhafer SL, Bonini NM, Paulson HL: Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease. J Neurosci 1999, 19: 10338-10347.
-
(1999)
J Neurosci
, vol.19
, pp. 10338-10347
-
-
Chai, Y.1
Koppenhafer, S.L.2
Bonini, N.M.3
Paulson, H.L.4
-
78
-
-
0032727617
-
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
-
Warrick JM, Chan HY, Gray-Board GL, Chai Y, Paulson HL, Bonini NM: Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet 1999, 23: 425-428. 10.1038/70532
-
(1999)
Nat Genet
, vol.23
, pp. 425-428
-
-
Warrick, J.M.1
Chan, H.Y.2
Gray-Board, G.L.3
Chai, Y.4
Paulson, H.L.5
Bonini, N.M.6
-
79
-
-
0036846119
-
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation
-
McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT: TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J Neurochem 2002, 83: 846-854. 10.1046/j.1471-4159.2002.01190.x
-
(2002)
J Neurochem
, vol.83
, pp. 846-854
-
-
McLean, P.J.1
Kawamata, H.2
Shariff, S.3
Hewett, J.4
Sharma, N.5
Ueda, K.6
Breakefield, X.O.7
Hyman, B.T.8
-
80
-
-
33644640684
-
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies
-
Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, et al.: Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Am J Pathol 2006, 168: 947-961. 10.2353/ajpath.2006.050770
-
(2006)
Am J Pathol
, vol.168
, pp. 947-961
-
-
Uryu, K.1
Richter-Landsberg, C.2
Welch, W.3
Sun, E.4
Goldbaum, O.5
Norris, E.H.6
Pham, C.T.7
Yazawa, I.8
Hilburger, K.9
Micsenyi, M.10
-
81
-
-
0036468432
-
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
-
Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM: Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 2002, 295: 865-868. 10.1126/science.1067389
-
(2002)
Science
, vol.295
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.2
Trojanowski, J.Q.3
Lee, V.M.4
Bonini, N.M.5
-
82
-
-
33947537591
-
Proteomic identification of novel proteins in cortical lewy bodies
-
Leverenz JB, Umar I, Wang Q, Montine TJ, McMillan PJ, Tsuang DW, Jin J, Pan C, Shin J, Zhu D, Zhang J: Proteomic identification of novel proteins in cortical lewy bodies. Brain Pathol 2007, 17: 139-145. 10.1111/j.1750-3639.2007.00048.x
-
(2007)
Brain Pathol
, vol.17
, pp. 139-145
-
-
Leverenz, J.B.1
Umar, I.2
Wang, Q.3
Montine, T.J.4
McMillan, P.J.5
Tsuang, D.W.6
Jin, J.7
Pan, C.8
Shin, J.9
Zhu, D.10
Zhang, J.11
-
83
-
-
4644291645
-
Analysis of alpha-synuclein-associated proteins by quantitative proteomics
-
Zhou Y, Gu G, Goodlett DR, Zhang T, Pan C, Montine TJ, Montine KS, Aebersold RH, Zhang J: Analysis of alpha-synuclein-associated proteins by quantitative proteomics. J Biol Chem 2004, 279: 39155-39164. 10.1074/jbc.M405456200
-
(2004)
J Biol Chem
, vol.279
, pp. 39155-39164
-
-
Zhou, Y.1
Gu, G.2
Goodlett, D.R.3
Zhang, T.4
Pan, C.5
Montine, T.J.6
Montine, K.S.7
Aebersold, R.H.8
Zhang, J.9
-
84
-
-
0037237358
-
The mouse MPTP model: gene expression changes in dopaminergic neurons
-
Kuhn K, Wellen J, Link N, Maskri L, Lubbert H, Stichel CC: The mouse MPTP model: gene expression changes in dopaminergic neurons. Eur J Neurosci 2003, 17: 1-12. 10.1046/j.1460-9568.2003.02408.x
-
(2003)
Eur J Neurosci
, vol.17
, pp. 1-12
-
-
Kuhn, K.1
Wellen, J.2
Link, N.3
Maskri, L.4
Lubbert, H.5
Stichel, C.C.6
-
85
-
-
33847699408
-
Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra
-
St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ: Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. J Neurochem 2007, 100: 1449-1457.
-
(2007)
J Neurochem
, vol.100
, pp. 1449-1457
-
-
St Martin, J.L.1
Klucken, J.2
Outeiro, T.F.3
Nguyen, P.4
Keller-McGandy, C.5
Cantuti-Castelvetri, I.6
Grammatopoulos, T.N.7
Standaert, D.G.8
Hyman, B.T.9
McLean, P.J.10
-
86
-
-
84855929223
-
SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones
-
Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, Guarente L: SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. J Neurosci 2012, 32: 124-132. 10.1523/JNEUROSCI.3442-11.2012
-
(2012)
J Neurosci
, vol.32
, pp. 124-132
-
-
Donmez, G.1
Arun, A.2
Chung, C.Y.3
McLean, P.J.4
Lindquist, S.5
Guarente, L.6
-
87
-
-
33646555755
-
Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+in SK-N-SH cells
-
Fan GH, Zhou HY, Yang H, Chen SD: Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+in SK-N-SH cells. FEBS Lett 2006, 580: 3091-3098. 10.1016/j.febslet.2006.04.057
-
(2006)
FEBS Lett
, vol.580
, pp. 3091-3098
-
-
Fan, G.H.1
Zhou, H.Y.2
Yang, H.3
Chen, S.D.4
-
88
-
-
33751216491
-
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation
-
Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ: Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochem Biophys Res Commun 2006, 351: 631-638. 10.1016/j.bbrc.2006.10.085
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 631-638
-
-
Outeiro, T.F.1
Klucken, J.2
Strathearn, K.E.3
Liu, F.4
Nguyen, P.5
Rochet, J.C.6
Hyman, B.T.7
McLean, P.J.8
-
89
-
-
1642356755
-
Payne Smith MD, Latchman DS: HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells
-
Zourlidou A: Payne Smith MD, Latchman DS: HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells. J Neurochem 2004, 88: 1439-1448. 10.1046/j.1471-4159.2003.02273.x
-
(2004)
J Neurochem
, vol.88
, pp. 1439-1448
-
-
Zourlidou, A.1
-
90
-
-
7444256611
-
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity
-
Klucken J, Shin Y, Hyman BT, McLean PJ: A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity. Biochem Biophys Res Commun 2004, 325: 367-373. 10.1016/j.bbrc.2004.10.037
-
(2004)
Biochem Biophys Res Commun
, vol.325
, pp. 367-373
-
-
Klucken, J.1
Shin, Y.2
Hyman, B.T.3
McLean, P.J.4
-
91
-
-
2942620074
-
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity
-
Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ: Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. J Biol Chem 2004, 279: 25497-25502. 10.1074/jbc.M400255200
-
(2004)
J Biol Chem
, vol.279
, pp. 25497-25502
-
-
Klucken, J.1
Shin, Y.2
Masliah, E.3
Hyman, B.T.4
McLean, P.J.5
-
92
-
-
77956297983
-
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy
-
Shimshek DR, Mueller M, Wiessner C, Schweizer T, van der Putten PH: The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. PLoS One 2010, 5: e10014. 10.1371/journal.pone.0010014
-
(2010)
PLoS One
, vol.5
-
-
Shimshek, D.R.1
Mueller, M.2
Wiessner, C.3
Schweizer, T.4
van der Putten, P.H.5
-
93
-
-
17644392138
-
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans
-
Cao S, Gelwix CC, Caldwell KA, Caldwell GA: Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J Neurosci 2005, 25: 3801-3812. 10.1523/JNEUROSCI.5157-04.2005
-
(2005)
J Neurosci
, vol.25
, pp. 3801-3812
-
-
Cao, S.1
Gelwix, C.C.2
Caldwell, K.A.3
Caldwell, G.A.4
-
94
-
-
84869756871
-
Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models
-
Li X, Lee J, Parsons D, Janaurajs K, Standaert DG: Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models. PLoS One 2012, 7: e50063. 10.1371/journal.pone.0050063
-
(2012)
PLoS One
, vol.7
-
-
Li, X.1
Lee, J.2
Parsons, D.3
Janaurajs, K.4
Standaert, D.G.5
-
95
-
-
56749117866
-
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly
-
Luk KC, Mills IP, Trojanowski JQ, Lee VM: Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly. Biochemistry 2008, 47: 12614-12625. 10.1021/bi801475r
-
(2008)
Biochemistry
, vol.47
, pp. 12614-12625
-
-
Luk, K.C.1
Mills, I.P.2
Trojanowski, J.Q.3
Lee, V.M.4
-
96
-
-
33750873994
-
Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates
-
Huang C, Cheng H, Hao S, Zhou H, Zhang X, Gao J, Sun QH, Hu H, Wang CC: Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates. J Mol Biol 2006, 364: 323-336. 10.1016/j.jmb.2006.08.062
-
(2006)
J Mol Biol
, vol.364
, pp. 323-336
-
-
Huang, C.1
Cheng, H.2
Hao, S.3
Zhou, H.4
Zhang, X.5
Gao, J.6
Sun, Q.H.7
Hu, H.8
Wang, C.C.9
-
97
-
-
84866556269
-
Identification of Protein Interfaces between alpha-Synuclein, the Principal Component of Lewy Bodies in Parkinson Disease, and the Molecular Chaperones Human Hsc70 and the Yeast Ssa1p
-
Redeker V, Pemberton S, Bienvenut W, Bousset L, Melki R: Identification of Protein Interfaces between alpha-Synuclein, the Principal Component of Lewy Bodies in Parkinson Disease, and the Molecular Chaperones Human Hsc70 and the Yeast Ssa1p. J Biol Chem 2012, 287: 32630-32639. 10.1074/jbc.M112.387530
-
(2012)
J Biol Chem
, vol.287
, pp. 32630-32639
-
-
Redeker, V.1
Pemberton, S.2
Bienvenut, W.3
Bousset, L.4
Melki, R.5
-
98
-
-
33750117120
-
Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging
-
Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT: Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. FASEB J 2006, 20: 2050-2057. 10.1096/fj.05-5422com
-
(2006)
FASEB J
, vol.20
, pp. 2050-2057
-
-
Klucken, J.1
Outeiro, T.F.2
Nguyen, P.3
McLean, P.J.4
Hyman, B.T.5
-
99
-
-
80052569506
-
Inhibition of alpha-synuclein aggregation by small heat shock proteins
-
Bruinsma IB, Bruggink KA, Kinast K, Versleijen AA, Segers-Nolten IM, Subramaniam V, Kuiperij HB, Boelens W, de Waal RM, Verbeek MM: Inhibition of alpha-synuclein aggregation by small heat shock proteins. Proteins 2011, 79: 2956-2967. 10.1002/prot.23152
-
(2011)
Proteins
, vol.79
, pp. 2956-2967
-
-
Bruinsma, I.B.1
Bruggink, K.A.2
Kinast, K.3
Versleijen, A.A.4
Segers-Nolten, I.M.5
Subramaniam, V.6
Kuiperij, H.B.7
Boelens, W.8
de Waal, R.M.9
Verbeek, M.M.10
-
100
-
-
84863683967
-
Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans
-
Duennwald ML, Echeverria A, Shorter J: Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans. PLoS Biol 2012, 10: e1001346. 10.1371/journal.pbio.1001346
-
(2012)
PLoS Biol
, vol.10
-
-
Duennwald, M.L.1
Echeverria, A.2
Shorter, J.3
-
101
-
-
71449111785
-
The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein
-
Falsone SF, Kungl AJ, Rek A, Cappai R, Zangger K: The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein. J Biol Chem 2009, 284: 31190-31199. 10.1074/jbc.M109.057240
-
(2009)
J Biol Chem
, vol.284
, pp. 31190-31199
-
-
Falsone, S.F.1
Kungl, A.J.2
Rek, A.3
Cappai, R.4
Zangger, K.5
-
102
-
-
84886728386
-
Hsp90 Inhibits alpha-Synuclein Aggregation by Interacting with Soluble Oligomers
-
Daturpalli S, Waudby CA, Meehan S, Jackson SE: Hsp90 Inhibits alpha-Synuclein Aggregation by Interacting with Soluble Oligomers. J Mol Biol 2013, 22: 4614-4628.
-
(2013)
J Mol Biol
, vol.22
, pp. 4614-4628
-
-
Daturpalli, S.1
Waudby, C.A.2
Meehan, S.3
Jackson, S.E.4
-
103
-
-
79960046164
-
Cellular stress response pathways and ageing: intricate molecular relationships
-
Kourtis N, Tavernarakis N: Cellular stress response pathways and ageing: intricate molecular relationships. Embo J 2011, 30: 2520-2531. 10.1038/emboj.2011.162
-
(2011)
Embo J
, vol.30
, pp. 2520-2531
-
-
Kourtis, N.1
Tavernarakis, N.2
-
104
-
-
0026539546
-
Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions
-
Iwaki T, Wisniewski T, Iwaki A, Corbin E, Tomokane N, Tateishi J, Goldman JE: Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions. Am J Pathol 1992, 140: 345-356.
-
(1992)
Am J Pathol
, vol.140
, pp. 345-356
-
-
Iwaki, T.1
Wisniewski, T.2
Iwaki, A.3
Corbin, E.4
Tomokane, N.5
Tateishi, J.6
Goldman, J.E.7
-
105
-
-
0034774011
-
Nerve cells expressing heat-shock proteins in Parkinson's disease
-
Braak H, Del Tredici K, Sandmann-Kiel D, Rub U, Schultz C: Nerve cells expressing heat-shock proteins in Parkinson's disease. Acta Neuropathol 2001, 102: 449-454.
-
(2001)
Acta Neuropathol
, vol.102
, pp. 449-454
-
-
Braak, H.1
Del Tredici, K.2
Sandmann-Kiel, D.3
Rub, U.4
Schultz, C.5
-
106
-
-
77749240461
-
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation
-
Waudby CA, Knowles TP, Devlin GL, Skepper JN, Ecroyd H, Carver JA, Welland ME, Christodoulou J, Dobson CM, Meehan S: The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophys J 2010, 98: 843-851. 10.1016/j.bpj.2009.10.056
-
(2010)
Biophys J
, vol.98
, pp. 843-851
-
-
Waudby, C.A.1
Knowles, T.P.2
Devlin, G.L.3
Skepper, J.N.4
Ecroyd, H.5
Carver, J.A.6
Welland, M.E.7
Christodoulou, J.8
Dobson, C.M.9
Meehan, S.10
-
107
-
-
33644797646
-
Alpha-synuclein and chaperones in dementia with Lewy bodies
-
Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP, Hyman BT, Standaert DG: Alpha-synuclein and chaperones in dementia with Lewy bodies. J Neuropathol Exp Neurol 2005, 64: 1058-1066. 10.1097/01.jnen.0000190063.90440.69
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 1058-1066
-
-
Cantuti-Castelvetri, I.1
Klucken, J.2
Ingelsson, M.3
Ramasamy, K.4
McLean, P.J.5
Frosch, M.P.6
Hyman, B.T.7
Standaert, D.G.8
-
108
-
-
33646197357
-
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies
-
Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon J, McLean P, Hyman BT: Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. Acta Neuropathol 2006, 111: 101-108. 10.1007/s00401-005-0027-7
-
(2006)
Acta Neuropathol
, vol.111
, pp. 101-108
-
-
Klucken, J.1
Ingelsson, M.2
Shin, Y.3
Irizarry, M.C.4
Hedley-Whyte, E.T.5
Frosch, M.6
Growdon, J.7
McLean, P.8
Hyman, B.T.9
-
109
-
-
78149469728
-
Chaperone-mediated autophagy markers in Parkinson disease brains
-
Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, Caballero C, Ferrer I, Obeso JA, Schapira AH: Chaperone-mediated autophagy markers in Parkinson disease brains. Arch Neurol 2010, 67: 1464-1472.
-
(2010)
Arch Neurol
, vol.67
, pp. 1464-1472
-
-
Alvarez-Erviti, L.1
Rodriguez-Oroz, M.C.2
Cooper, J.M.3
Caballero, C.4
Ferrer, I.5
Obeso, J.A.6
Schapira, A.H.7
-
110
-
-
20844436594
-
Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism
-
Hauser MA, Li YJ, Xu H, Noureddine MA, Shao YS, Gullans SR, Scherzer CR, Jensen RV, McLaurin AC, Gibson JR, et al.: Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. Arch Neurol 2005, 62: 917-921.
-
(2005)
Arch Neurol
, vol.62
, pp. 917-921
-
-
Hauser, M.A.1
Li, Y.J.2
Xu, H.3
Noureddine, M.A.4
Shao, Y.S.5
Gullans, S.R.6
Scherzer, C.R.7
Jensen, R.V.8
McLaurin, A.C.9
Gibson, J.R.10
-
111
-
-
68149123529
-
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
-
Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH: Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 2009, 35: 385-398. 10.1016/j.nbd.2009.05.023
-
(2009)
Neurobiol Dis
, vol.35
, pp. 385-398
-
-
Chu, Y.1
Dodiya, H.2
Aebischer, P.3
Olanow, C.W.4
Kordower, J.H.5
-
112
-
-
77949504405
-
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
-
Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E: Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 2010, 5: e9313. 10.1371/journal.pone.0009313
-
(2010)
PLoS One
, vol.5
-
-
Crews, L.1
Spencer, B.2
Desplats, P.3
Patrick, C.4
Paulino, A.5
Rockenstein, E.6
Hansen, L.7
Adame, A.8
Galasko, D.9
Masliah, E.10
-
113
-
-
77956855813
-
Pathogenic lysosomal depletion in Parkinson's disease
-
Dehay B, Bove J, Rodriguez-Muela N, Perier C, Recasens A, Boya P, Vila M: Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci 2010, 30: 12535-12544. 10.1523/JNEUROSCI.1920-10.2010
-
(2010)
J Neurosci
, vol.30
, pp. 12535-12544
-
-
Dehay, B.1
Bove, J.2
Rodriguez-Muela, N.3
Perier, C.4
Recasens, A.5
Boya, P.6
Vila, M.7
-
114
-
-
84862598619
-
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway
-
Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlotzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J: Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy 2012, 8: 754-766. 10.4161/auto.19371
-
(2012)
Autophagy
, vol.8
, pp. 754-766
-
-
Klucken, J.1
Poehler, A.M.2
Ebrahimi-Fakhari, D.3
Schneider, J.4
Nuber, S.5
Rockenstein, E.6
Schlotzer-Schrehardt, U.7
Hyman, B.T.8
McLean, P.J.9
Masliah, E.10
Winkler, J.11
-
115
-
-
79953167820
-
Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies
-
Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, et al.: Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies. J Neuropathol Exp Neurol 2011, 70: 264-280. 10.1097/NEN.0b013e318211c86a
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 264-280
-
-
Higashi, S.1
Moore, D.J.2
Minegishi, M.3
Kasanuki, K.4
Fujishiro, H.5
Kabuta, T.6
Togo, T.7
Katsuse, O.8
Uchikado, H.9
Furukawa, Y.10
-
116
-
-
78649640867
-
Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones
-
Hinault MP, Cuendet AF, Mattoo RU, Mensi M, Dietler G, Lashuel HA, Goloubinoff P: Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. J Biol Chem 2010, 285: 38173-38182. 10.1074/jbc.M110.127753
-
(2010)
J Biol Chem
, vol.285
, pp. 38173-38182
-
-
Hinault, M.P.1
Cuendet, A.F.2
Mattoo, R.U.3
Mensi, M.4
Dietler, G.5
Lashuel, H.A.6
Goloubinoff, P.7
-
117
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D: Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305: 1292-1295. 10.1126/science.1101738
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
118
-
-
53049098471
-
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L: Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008, 283: 23542-23556. 10.1074/jbc.M801992200
-
(2008)
J Biol Chem
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
119
-
-
65849127844
-
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
-
Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L: Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One 2009, 4: e5515. 10.1371/journal.pone.0005515
-
(2009)
PLoS One
, vol.4
-
-
Xilouri, M.1
Vogiatzi, T.2
Vekrellis, K.3
Park, D.4
Stefanis, L.5
-
120
-
-
38849174979
-
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, et al.: Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008, 118: 777-788.
-
(2008)
J Clin Invest
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
Massey, A.C.4
Mazzulli, J.5
Mosharov, E.V.6
Hodara, R.7
Fredenburg, R.8
Wu, D.C.9
Follenzi, A.10
-
121
-
-
58149215720
-
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy
-
Yang Q, She H, Gearing M, Colla E, Lee M, Shacka JJ, Mao Z: Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 2009, 323: 124-127. 10.1126/science.1166088
-
(2009)
Science
, vol.323
, pp. 124-127
-
-
Yang, Q.1
She, H.2
Gearing, M.3
Colla, E.4
Lee, M.5
Shacka, J.J.6
Mao, Z.7
-
122
-
-
0031763264
-
The synuclein family
-
Lavedan C: The synuclein family. Genome Res 1998, 8: 871-880.
-
(1998)
Genome Res
, vol.8
, pp. 871-880
-
-
Lavedan, C.1
-
123
-
-
77951541740
-
Lysosomal degradation of alpha-synuclein in vivo
-
Mak SK, McCormack AL, Manning-Bog AB, Cuervo AM, Di Monte DA: Lysosomal degradation of alpha-synuclein in vivo. J Biol Chem 2010, 285: 13621-13629. 10.1074/jbc.M109.074617
-
(2010)
J Biol Chem
, vol.285
, pp. 13621-13629
-
-
Mak, S.K.1
McCormack, A.L.2
Manning-Bog, A.B.3
Cuervo, A.M.4
Di Monte, D.A.5
-
124
-
-
84875876495
-
Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease
-
Alvarez-Erviti L, Seow Y, Schapira AH, Rodriguez-Oroz MC, Obeso JA, Cooper JM: Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease. Cell Death Dis 2013, 4: e545. 10.1038/cddis.2013.73
-
(2013)
Cell Death Dis
, vol.4
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Schapira, A.H.3
Rodriguez-Oroz, M.C.4
Obeso, J.A.5
Cooper, J.M.6
-
125
-
-
84860833596
-
Regional deficiencies in chaperone-mediated autophagy underlie alpha-synuclein aggregation and neurodegeneration
-
Malkus KA, Ischiropoulos H: Regional deficiencies in chaperone-mediated autophagy underlie alpha-synuclein aggregation and neurodegeneration. Neurobiol Dis 2012, 46: 732-744. 10.1016/j.nbd.2012.03.017
-
(2012)
Neurobiol Dis
, vol.46
, pp. 732-744
-
-
Malkus, K.A.1
Ischiropoulos, H.2
-
126
-
-
84879962810
-
Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration
-
Xilouri M, Brekk OR, Landeck N, Pitychoutis PM, Papasilekas T, Papadopoulou-Daifoti Z, Kirik D, Stefanis L: Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration. Brain 2013, 136: 2130-2146. 10.1093/brain/awt131
-
(2013)
Brain
, vol.136
, pp. 2130-2146
-
-
Xilouri, M.1
Brekk, O.R.2
Landeck, N.3
Pitychoutis, P.M.4
Papasilekas, T.5
Papadopoulou-Daifoti, Z.6
Kirik, D.7
Stefanis, L.8
-
128
-
-
67649460932
-
Mitochondrial membrane permeabilization in neuronal injury
-
Galluzzi L, Blomgren K, Kroemer G: Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 2009, 10: 481-494. 10.1038/nrn2665
-
(2009)
Nat Rev Neurosci
, vol.10
, pp. 481-494
-
-
Galluzzi, L.1
Blomgren, K.2
Kroemer, G.3
-
129
-
-
44149104599
-
Heat shock proteins: essential proteins for apoptosis regulation
-
Lanneau D, Brunet M, Frisan E, Solary E, Fontenay M, Garrido C: Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med 2008, 12: 743-761. 10.1111/j.1582-4934.2008.00273.x
-
(2008)
J Cell Mol Med
, vol.12
, pp. 743-761
-
-
Lanneau, D.1
Brunet, M.2
Frisan, E.3
Solary, E.4
Fontenay, M.5
Garrido, C.6
-
130
-
-
77955965172
-
Cellular stress responses: cell survival and cell death
-
Fulda S, Gorman AM, Hori O, Samali A: Cellular stress responses: cell survival and cell death. Int J Cell Biol 2010, 2010: 214074.
-
(2010)
Int J Cell Biol
, vol.2010
, pp. 214074
-
-
Fulda, S.1
Gorman, A.M.2
Hori, O.3
Samali, A.4
-
131
-
-
79951587313
-
Heat shock proteins: multiple neuroprotective functions and implications for neurologic disease
-
Benarroch EE: Heat shock proteins: multiple neuroprotective functions and implications for neurologic disease. Neurology 2011, 76: 660-667. 10.1212/WNL.0b013e31820c3119
-
(2011)
Neurology
, vol.76
, pp. 660-667
-
-
Benarroch, E.E.1
-
132
-
-
33244474580
-
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation
-
Stankiewicz AR, Lachapelle G, Foo CP, Radicioni SM, Mosser DD: Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. J Biol Chem 2005, 280: 38729-38739. 10.1074/jbc.M509497200
-
(2005)
J Biol Chem
, vol.280
, pp. 38729-38739
-
-
Stankiewicz, A.R.1
Lachapelle, G.2
Foo, C.P.3
Radicioni, S.M.4
Mosser, D.D.5
-
133
-
-
1842843854
-
Mori M: hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria
-
Gotoh T, Terada K, Oyadomari S: Mori M: hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ 2004, 11: 390-402. 10.1038/sj.cdd.4401369
-
(2004)
Cell Death Differ
, vol.11
, pp. 390-402
-
-
Gotoh, T.1
Terada, K.2
Oyadomari, S.3
-
134
-
-
0034253474
-
Negative regulation of the Apaf-1 apoptosome by Hsp70
-
Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES: Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2000, 2: 476-483. 10.1038/35019510
-
(2000)
Nat Cell Biol
, vol.2
, pp. 476-483
-
-
Saleh, A.1
Srinivasula, S.M.2
Balkir, L.3
Robbins, P.D.4
Alnemri, E.S.5
-
135
-
-
17944366977
-
Heat-shock protein 70 antagonizes apoptosis-inducing factor
-
Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jaattela M, Penninger JM, Garrido C, Kroemer G: Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001, 3: 839-843. 10.1038/ncb0901-839
-
(2001)
Nat Cell Biol
, vol.3
, pp. 839-843
-
-
Ravagnan, L.1
Gurbuxani, S.2
Susin, S.A.3
Maisse, C.4
Daugas, E.5
Zamzami, N.6
Mak, T.7
Jaattela, M.8
Penninger, J.M.9
Garrido, C.10
Kroemer, G.11
-
136
-
-
84867581392
-
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis
-
Sabirzhanov B, Stoica BA, Hanscom M, Piao CS, Faden AI: Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. J Neurochem 2012, 123: 542-554. 10.1111/j.1471-4159.2012.07927.x
-
(2012)
J Neurochem
, vol.123
, pp. 542-554
-
-
Sabirzhanov, B.1
Stoica, B.A.2
Hanscom, M.3
Piao, C.S.4
Faden, A.I.5
-
137
-
-
0034253533
-
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
-
Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR: Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000, 2: 469-475. 10.1038/35019501
-
(2000)
Nat Cell Biol
, vol.2
, pp. 469-475
-
-
Beere, H.M.1
Wolf, B.B.2
Cain, K.3
Mosser, D.D.4
Mahboubi, A.5
Kuwana, T.6
Tailor, P.7
Morimoto, R.I.8
Cohen, G.M.9
Green, D.R.10
-
138
-
-
33646384157
-
Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation
-
Ruchalski K, Mao H, Li Z, Wang Z, Gillers S, Wang Y, Mosser DD, Gabai V, Schwartz JH, Borkan SC: Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation. J Biol Chem 2006, 281: 7873-7880. 10.1074/jbc.M513728200
-
(2006)
J Biol Chem
, vol.281
, pp. 7873-7880
-
-
Ruchalski, K.1
Mao, H.2
Li, Z.3
Wang, Z.4
Gillers, S.5
Wang, Y.6
Mosser, D.D.7
Gabai, V.8
Schwartz, J.H.9
Borkan, S.C.10
-
139
-
-
0242606282
-
Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor
-
Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C: Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 2003, 22: 6669-6678. 10.1038/sj.onc.1206794
-
(2003)
Oncogene
, vol.22
, pp. 6669-6678
-
-
Gurbuxani, S.1
Schmitt, E.2
Cande, C.3
Parcellier, A.4
Hammann, A.5
Daugas, E.6
Kouranti, I.7
Spahr, C.8
Pance, A.9
Kroemer, G.10
Garrido, C.11
-
140
-
-
21344458358
-
Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury
-
Matsumori Y, Hong SM, Aoyama K, Fan Y, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J: Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab 2005, 25: 899-910. 10.1038/sj.jcbfm.9600080
-
(2005)
J Cereb Blood Flow Metab
, vol.25
, pp. 899-910
-
-
Matsumori, Y.1
Hong, S.M.2
Aoyama, K.3
Fan, Y.4
Kayama, T.5
Sheldon, R.A.6
Vexler, Z.S.7
Ferriero, D.M.8
Weinstein, P.R.9
Liu, J.10
-
141
-
-
0034282104
-
Hsp27 negatively regulates cell death by interacting with cytochrome c
-
Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C, Gurbuxani S, Arrigo AP, Kroemer G, Solary E, Garrido C: Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2000, 2: 645-652. 10.1038/35023595
-
(2000)
Nat Cell Biol
, vol.2
, pp. 645-652
-
-
Bruey, J.M.1
Ducasse, C.2
Bonniaud, P.3
Ravagnan, L.4
Susin, S.A.5
Diaz-Latoud, C.6
Gurbuxani, S.7
Arrigo, A.P.8
Kroemer, G.9
Solary, E.10
Garrido, C.11
-
142
-
-
4344651318
-
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
-
Nylandsted J, Gyrd-Hansen M, Danielewicz A, Fehrenbacher N, Lademann U, Hoyer-Hansen M, Weber E, Multhoff G, Rohde M, Jaattela M: Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 2004, 200: 425-435. 10.1084/jem.20040531
-
(2004)
J Exp Med
, vol.200
, pp. 425-435
-
-
Nylandsted, J.1
Gyrd-Hansen, M.2
Danielewicz, A.3
Fehrenbacher, N.4
Lademann, U.5
Hoyer-Hansen, M.6
Weber, E.7
Multhoff, G.8
Rohde, M.9
Jaattela, M.10
-
143
-
-
70149124059
-
Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment
-
Tantucci M, Mariucci G, Taha E, Spaccatini C, Tozzi A, Luchetti E, Calabresi P, Ambrosini MV: Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. Neuroscience 2009, 163: 735-740. 10.1016/j.neuroscience.2009.06.070
-
(2009)
Neuroscience
, vol.163
, pp. 735-740
-
-
Tantucci, M.1
Mariucci, G.2
Taha, E.3
Spaccatini, C.4
Tozzi, A.5
Luchetti, E.6
Calabresi, P.7
Ambrosini, M.V.8
-
144
-
-
0345283071
-
Heat shock protects PC12 cells against MPP+toxicity
-
Quigney DJ, Gorman AM, Samali A: Heat shock protects PC12 cells against MPP+toxicity. Brain Res 2003, 993: 133-139. 10.1016/j.brainres.2003.09.004
-
(2003)
Brain Res
, vol.993
, pp. 133-139
-
-
Quigney, D.J.1
Gorman, A.M.2
Samali, A.3
-
145
-
-
0030898710
-
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance
-
Bush KT, Goldberg AL, Nigam SK: Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem 1997, 272: 9086-9092. 10.1074/jbc.272.14.9086
-
(1997)
J Biol Chem
, vol.272
, pp. 9086-9092
-
-
Bush, K.T.1
Goldberg, A.L.2
Nigam, S.K.3
-
146
-
-
10944241135
-
Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease
-
Dong Z, Wolfer DP, Lipp HP, Bueler H: Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease. Mol Ther 2005, 11: 80-88.
-
(2005)
Mol Ther
, vol.11
, pp. 80-88
-
-
Dong, Z.1
Wolfer, D.P.2
Lipp, H.P.3
Bueler, H.4
-
147
-
-
42249103388
-
Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease
-
Nagel F, Falkenburger BH, Tonges L, Kowsky S, Poppelmeyer C, Schulz JB, Bahr M, Dietz GP: Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease. J Neurochem 2008, 105: 853-864. 10.1111/j.1471-4159.2007.05204.x
-
(2008)
J Neurochem
, vol.105
, pp. 853-864
-
-
Nagel, F.1
Falkenburger, B.H.2
Tonges, L.3
Kowsky, S.4
Poppelmeyer, C.5
Schulz, J.B.6
Bahr, M.7
Dietz, G.P.8
-
148
-
-
11844274735
-
Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells
-
Gorman AM, Szegezdi E, Quigney DJ, Samali A: Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells. Biochem Biophys Res Commun 2005, 327: 801-810. 10.1016/j.bbrc.2004.12.066
-
(2005)
Biochem Biophys Res Commun
, vol.327
, pp. 801-810
-
-
Gorman, A.M.1
Szegezdi, E.2
Quigney, D.J.3
Samali, A.4
-
149
-
-
82255173966
-
The unfolded protein response: from stress pathway to homeostatic regulation
-
Walter P, Ron D: The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011, 334: 1081-1086. 10.1126/science.1209038
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
150
-
-
84863740827
-
The impact of the unfolded protein response on human disease
-
Wang S, Kaufman RJ: The impact of the unfolded protein response on human disease. J Cell Biol 2012, 197: 857-867. 10.1083/jcb.201110131
-
(2012)
J Cell Biol
, vol.197
, pp. 857-867
-
-
Wang, S.1
Kaufman, R.J.2
-
151
-
-
84870159094
-
Structural basis of the unfolded protein response
-
Korennykh A, Walter P: Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol 2012, 28: 251-277. 10.1146/annurev-cellbio-101011-155826
-
(2012)
Annu Rev Cell Dev Biol
, vol.28
, pp. 251-277
-
-
Korennykh, A.1
Walter, P.2
-
152
-
-
84859799949
-
Stress management at the ER: regulators of ER stress-induced apoptosis
-
Gorman AM, Healy SJ, Jager R, Samali A: Stress management at the ER: regulators of ER stress-induced apoptosis. Pharmacol Ther 2012, 134: 306-316. 10.1016/j.pharmthera.2012.02.003
-
(2012)
Pharmacol Ther
, vol.134
, pp. 306-316
-
-
Gorman, A.M.1
Healy, S.J.2
Jager, R.3
Samali, A.4
-
153
-
-
33846605587
-
Activation of the unfolded protein response in Parkinson's disease
-
Hoozemans JJ, van Haastert ES, Eikelenboom P, de Vos RA, Rozemuller JM, Scheper W: Activation of the unfolded protein response in Parkinson's disease. Biochem Biophys Res Commun 2007, 354: 707-711. 10.1016/j.bbrc.2007.01.043
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 707-711
-
-
Hoozemans, J.J.1
van Haastert, E.S.2
Eikelenboom, P.3
de Vos, R.A.4
Rozemuller, J.M.5
Scheper, W.6
-
154
-
-
84860219621
-
Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease
-
Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Scheper W: Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease. Neurodegener Dis 2012, 10: 212-215. 10.1159/000334536
-
(2012)
Neurodegener Dis
, vol.10
, pp. 212-215
-
-
Hoozemans, J.J.1
van Haastert, E.S.2
Nijholt, D.A.3
Rozemuller, A.J.4
Scheper, W.5
-
155
-
-
77956700757
-
Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy
-
Makioka K, Yamazaki T, Fujita Y, Takatama M, Nakazato Y, Okamoto K: Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy. J Neurol Sci 2010, 297: 60-65. 10.1016/j.jns.2010.06.019
-
(2010)
J Neurol Sci
, vol.297
, pp. 60-65
-
-
Makioka, K.1
Yamazaki, T.2
Fujita, Y.3
Takatama, M.4
Nakazato, Y.5
Okamoto, K.6
-
156
-
-
29644434199
-
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
-
Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA: Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 2005, 14: 3801-3811. 10.1093/hmg/ddi396
-
(2005)
Hum Mol Genet
, vol.14
, pp. 3801-3811
-
-
Smith, W.W.1
Jiang, H.2
Pei, Z.3
Tanaka, Y.4
Morita, H.5
Sawa, A.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
157
-
-
33746533924
-
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, et al.: Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006, 313: 324-328. 10.1126/science.1129462
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
-
158
-
-
53149133169
-
Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death
-
Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, Wakabayashi K, Itoyama Y: Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J Biol Chem 2008, 283: 23179-23188. 10.1074/jbc.M802223200
-
(2008)
J Biol Chem
, vol.283
, pp. 23179-23188
-
-
Sugeno, N.1
Takeda, A.2
Hasegawa, T.3
Kobayashi, M.4
Kikuchi, A.5
Mori, F.6
Wakabayashi, K.7
Itoyama, Y.8
-
159
-
-
79551647443
-
Induction of the unfolded protein response by alpha-synuclein in experimental models of Parkinson's disease
-
Bellucci A, Navarria L, Zaltieri M, Falarti E, Bodei S, Sigala S, Battistin L, Spillantini M, Missale C, Spano P: Induction of the unfolded protein response by alpha-synuclein in experimental models of Parkinson's disease. J Neurochem 2011, 116: 588-605. 10.1111/j.1471-4159.2010.07143.x
-
(2011)
J Neurochem
, vol.116
, pp. 588-605
-
-
Bellucci, A.1
Navarria, L.2
Zaltieri, M.3
Falarti, E.4
Bodei, S.5
Sigala, S.6
Battistin, L.7
Spillantini, M.8
Missale, C.9
Spano, P.10
-
160
-
-
84863230467
-
Endoplasmic reticulum stress is important for the manifestations of alpha-synucleinopathy in vivo
-
Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK: Endoplasmic reticulum stress is important for the manifestations of alpha-synucleinopathy in vivo. J Neurosci 2012, 32: 3306-3320. 10.1523/JNEUROSCI.5367-11.2012
-
(2012)
J Neurosci
, vol.32
, pp. 3306-3320
-
-
Colla, E.1
Coune, P.2
Liu, Y.3
Pletnikova, O.4
Troncoso, J.C.5
Iwatsubo, T.6
Schneider, B.L.7
Lee, M.K.8
-
161
-
-
84863498486
-
Glucose regulated protein 78 diminishes alpha-synuclein neurotoxicity in a rat model of Parkinson disease
-
Gorbatyuk MS, Shabashvili A, Chen W, Meyers C, Sullivan LF, Salganik M, Lin JH, Lewin AS, Muzyczka N, Gorbatyuk OS: Glucose regulated protein 78 diminishes alpha-synuclein neurotoxicity in a rat model of Parkinson disease. Mol Ther 2012, 20: 1327-1337. 10.1038/mt.2012.28
-
(2012)
Mol Ther
, vol.20
, pp. 1327-1337
-
-
Gorbatyuk, M.S.1
Shabashvili, A.2
Chen, W.3
Meyers, C.4
Sullivan, L.F.5
Salganik, M.6
Lin, J.H.7
Lewin, A.S.8
Muzyczka, N.9
Gorbatyuk, O.S.10
-
162
-
-
84863229691
-
Accumulation of toxic alpha-synuclein oligomer within endoplasmic reticulum occurs in alpha-synucleinopathy in vivo
-
Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK: Accumulation of toxic alpha-synuclein oligomer within endoplasmic reticulum occurs in alpha-synucleinopathy in vivo. J Neurosci 2012, 32: 3301-3305. 10.1523/JNEUROSCI.5368-11.2012
-
(2012)
J Neurosci
, vol.32
, pp. 3301-3305
-
-
Colla, E.1
Jensen, P.H.2
Pletnikova, O.3
Troncoso, J.C.4
Glabe, C.5
Lee, M.K.6
-
164
-
-
84880673845
-
Pharmacological approaches to restore mitochondrial function
-
Andreux PA, Houtkooper RH, Auwerx J: Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov 2013, 12: 465-483. 10.1038/nrd4023
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 465-483
-
-
Andreux, P.A.1
Houtkooper, R.H.2
Auwerx, J.3
-
165
-
-
79955622718
-
Priorities in Parkinson's disease research
-
Meissner WG, Frasier M, Gasser T, Goetz CG, Lozano A, Piccini P, Obeso JA, Rascol O, Schapira A, Voon V, et al.: Priorities in Parkinson's disease research. Nat Rev Drug Discov 2011, 10: 377-393. 10.1038/nrd3430
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 377-393
-
-
Meissner, W.G.1
Frasier, M.2
Gasser, T.3
Goetz, C.G.4
Lozano, A.5
Piccini, P.6
Obeso, J.A.7
Rascol, O.8
Schapira, A.9
Voon, V.10
-
166
-
-
77955844171
-
Chaperone networks: tipping the balance in protein folding diseases
-
Voisine C, Pedersen JS, Morimoto RI: Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis 2010, 40: 12-20. 10.1016/j.nbd.2010.05.007
-
(2010)
Neurobiol Dis
, vol.40
, pp. 12-20
-
-
Voisine, C.1
Pedersen, J.S.2
Morimoto, R.I.3
-
167
-
-
0036852712
-
Pharmacological prevention of Parkinson disease in Drosophila
-
Auluck PK, Bonini NM: Pharmacological prevention of Parkinson disease in Drosophila. Nat Med 2002, 8: 1185-1186. 10.1038/nm1102-1185
-
(2002)
Nat Med
, vol.8
, pp. 1185-1186
-
-
Auluck, P.K.1
Bonini, N.M.2
-
168
-
-
4344569643
-
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro
-
McLean PJ, Klucken J, Shin Y, Hyman BT: Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro. Biochem Biophys Res Commun 2004, 321: 665-669. 10.1016/j.bbrc.2004.07.021
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 665-669
-
-
McLean, P.J.1
Klucken, J.2
Shin, Y.3
Hyman, B.T.4
-
169
-
-
13244267202
-
Mechanisms of Suppression of (alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila
-
Auluck PK, Meulener MC, Bonini NM: Mechanisms of Suppression of (alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. J Biol Chem 2005, 280: 2873-2878.
-
(2005)
J Biol Chem
, vol.280
, pp. 2873-2878
-
-
Auluck, P.K.1
Meulener, M.C.2
Bonini, N.M.3
-
170
-
-
23644442282
-
Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease
-
Flower TR, Chesnokova LS, Froelich CA, Dixon C, Witt SN: Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J Mol Biol 2005, 351: 1081-1100. 10.1016/j.jmb.2005.06.060
-
(2005)
J Mol Biol
, vol.351
, pp. 1081-1100
-
-
Flower, T.R.1
Chesnokova, L.S.2
Froelich, C.A.3
Dixon, C.4
Witt, S.N.5
-
171
-
-
59649097036
-
Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein
-
Liu J, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J: Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. J Neurosci 2009, 29: 1480-1485. 10.1523/JNEUROSCI.6202-08.2009
-
(2009)
J Neurosci
, vol.29
, pp. 1480-1485
-
-
Liu, J.1
Zhang, J.P.2
Shi, M.3
Quinn, T.4
Bradner, J.5
Beyer, R.6
Chen, S.7
Zhang, J.8
-
172
-
-
77951976610
-
Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
-
Emmanouilidou E, Stefanis L, Vekrellis K: Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol Aging 2010, 31: 953-968. 10.1016/j.neurobiolaging.2008.07.008
-
(2010)
Neurobiol Aging
, vol.31
, pp. 953-968
-
-
Emmanouilidou, E.1
Stefanis, L.2
Vekrellis, K.3
-
173
-
-
77649305375
-
17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy
-
Riedel M, Goldbaum O, Schwarz L, Schmitt S, Richter-Landsberg C: 17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy. PLoS One 2010, 5: e8753. 10.1371/journal.pone.0008753
-
(2010)
PLoS One
, vol.5
-
-
Riedel, M.1
Goldbaum, O.2
Schwarz, L.3
Schmitt, S.4
Richter-Landsberg, C.5
-
174
-
-
84880516534
-
Chemical Induction of Hsp70 Reduces alpha-Synuclein Aggregation in Neuroglioma Cells
-
Kilpatrick K, Novoa JA, Hancock T, Guerriero CJ, Wipf P, Brodsky JL, Segatori L: Chemical Induction of Hsp70 Reduces alpha-Synuclein Aggregation in Neuroglioma Cells. ACS Chem Biol 2013, 7: 1460-1468.
-
(2013)
ACS Chem Biol
, vol.7
, pp. 1460-1468
-
-
Kilpatrick, K.1
Novoa, J.A.2
Hancock, T.3
Guerriero, C.J.4
Wipf, P.5
Brodsky, J.L.6
Segatori, L.7
-
175
-
-
34247161367
-
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
-
Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC: Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007, 282: 5641-5652.
-
(2007)
J Biol Chem
, vol.282
, pp. 5641-5652
-
-
Sarkar, S.1
Davies, J.E.2
Huang, Z.3
Tunnacliffe, A.4
Rubinsztein, D.C.5
-
176
-
-
84861899099
-
Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils
-
Yu WB, Jiang T, Lan DM, Lu JH, Yue ZY, Wang J, Zhou P: Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils. Arch Biochem Biophys 2012, 523: 144-150. 10.1016/j.abb.2012.04.021
-
(2012)
Arch Biochem Biophys
, vol.523
, pp. 144-150
-
-
Yu, W.B.1
Jiang, T.2
Lan, D.M.3
Lu, J.H.4
Yue, Z.Y.5
Wang, J.6
Zhou, P.7
-
177
-
-
84879052027
-
A blood-brain barrier (BBB) disrupter is also a potent alpha-synuclein (alpha-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD)
-
Shaltiel-Karyo R, Frenkel-Pinter M, Rockenstein E, Patrick C, Levy-Sakin M, Schiller A, Egoz-Matia N, Masliah E, Segal D, Gazit E: A blood-brain barrier (BBB) disrupter is also a potent alpha-synuclein (alpha-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD). J Biol Chem 2013, 288: 17579-17588. 10.1074/jbc.M112.434787
-
(2013)
J Biol Chem
, vol.288
, pp. 17579-17588
-
-
Shaltiel-Karyo, R.1
Frenkel-Pinter, M.2
Rockenstein, E.3
Patrick, C.4
Levy-Sakin, M.5
Schiller, A.6
Egoz-Matia, N.7
Masliah, E.8
Segal, D.9
Gazit, E.10
-
178
-
-
84877839143
-
Inhibition of formation of alpha-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease
-
Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H: Inhibition of formation of alpha-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease. Biochim Biophys Acta 1830, 2013: 4065-4072.
-
(1830)
Biochim Biophys Acta
, vol.2013
, pp. 4065-4072
-
-
Faria, C.1
Jorge, C.D.2
Borges, N.3
Tenreiro, S.4
Outeiro, T.F.5
Santos, H.6
-
179
-
-
70350150325
-
A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P+A53T transgenic mice
-
Ono K, Ikemoto M, Kawarabayashi T, Ikeda M, Nishinakagawa T, Hosokawa M, Shoji M, Takahashi M, Nakashima M: A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P+A53T transgenic mice. Parkinsonism Relat Disord 2009, 15: 649-654. 10.1016/j.parkreldis.2009.03.002
-
(2009)
Parkinsonism Relat Disord
, vol.15
, pp. 649-654
-
-
Ono, K.1
Ikemoto, M.2
Kawarabayashi, T.3
Ikeda, M.4
Nishinakagawa, T.5
Hosokawa, M.6
Shoji, M.7
Takahashi, M.8
Nakashima, M.9
-
180
-
-
77952551024
-
Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy
-
Porter JR, Fritz CC, Depew KM: Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy. Curr Opin Chem Biol 2010, 14: 412-420. 10.1016/j.cbpa.2010.03.019
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 412-420
-
-
Porter, J.R.1
Fritz, C.C.2
Depew, K.M.3
-
181
-
-
28844451001
-
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice
-
Shen HY, He JC, Wang Y, Huang QY, Chen JF: Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. J Biol Chem 2005, 280: 39962-39969. 10.1074/jbc.M505524200
-
(2005)
J Biol Chem
, vol.280
, pp. 39962-39969
-
-
Shen, H.Y.1
He, J.C.2
Wang, Y.3
Huang, Q.Y.4
Chen, J.F.5
-
182
-
-
0031875042
-
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
-
Schulte TW, Neckers LM: The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 1998, 42: 273-279. 10.1007/s002800050817
-
(1998)
Cancer Chemother Pharmacol
, vol.42
, pp. 273-279
-
-
Schulte, T.W.1
Neckers, L.M.2
-
183
-
-
74249085361
-
Update on Hsp90 inhibitors in clinical trial
-
Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, Trepel JB: Update on Hsp90 inhibitors in clinical trial. Curr Top Med Chem 2009, 9: 1479-1492. 10.2174/156802609789895728
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 1479-1492
-
-
Kim, Y.S.1
Alarcon, S.V.2
Lee, S.3
Lee, M.J.4
Giaccone, G.5
Neckers, L.6
Trepel, J.B.7
-
184
-
-
23844529468
-
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity
-
Cleren C, Calingasan NY, Chen J, Beal MF: Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. J Neurochem 2005, 94: 995-1004. 10.1111/j.1471-4159.2005.03253.x
-
(2005)
J Neurochem
, vol.94
, pp. 995-1004
-
-
Cleren, C.1
Calingasan, N.Y.2
Chen, J.3
Beal, M.F.4
-
185
-
-
79952104480
-
The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells
-
Casarejos MJ, Solano RM, Gomez A, Perucho J, de Yebenes JG, Mena MA: The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells. Neurochem Int 2011, 58: 512-520. 10.1016/j.neuint.2011.01.008
-
(2011)
Neurochem Int
, vol.58
, pp. 512-520
-
-
Casarejos, M.J.1
Solano, R.M.2
Gomez, A.3
Perucho, J.4
de Yebenes, J.G.5
Mena, M.A.6
-
186
-
-
34249814605
-
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone
-
Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, et al.: Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem 2007, 101: 1491-1504. 10.1111/j.1471-4159.2006.04440.x
-
(2007)
J Neurochem
, vol.101
, pp. 1491-1504
-
-
Inden, M.1
Kitamura, Y.2
Takeuchi, H.3
Yanagida, T.4
Takata, K.5
Kobayashi, Y.6
Taniguchi, T.7
Yoshimoto, K.8
Kaneko, M.9
Okuma, Y.10
-
187
-
-
84874901074
-
Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy
-
Malik B, Nirmalananthan N, Gray AL, La Spada AR, Hanna MG, Greensmith L: Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy. Brain 2013, 136: 926-943. 10.1093/brain/aws343
-
(2013)
Brain
, vol.136
, pp. 926-943
-
-
Malik, B.1
Nirmalananthan, N.2
Gray, A.L.3
La Spada, A.R.4
Hanna, M.G.5
Greensmith, L.6
-
188
-
-
46249117510
-
Arimoclomol at dosages up to 300mg/day is well tolerated and safe in amyotrophic lateral sclerosis
-
Cudkowicz ME, Shefner JM, Simpson E, Grasso D, Yu H, Zhang H, Shui A, Schoenfeld D, Brown RH, Wieland S, Barber JR: Arimoclomol at dosages up to 300mg/day is well tolerated and safe in amyotrophic lateral sclerosis. Muscle Nerve 2008, 38: 837-844. 10.1002/mus.21059
-
(2008)
Muscle Nerve
, vol.38
, pp. 837-844
-
-
Cudkowicz, M.E.1
Shefner, J.M.2
Simpson, E.3
Grasso, D.4
Yu, H.5
Zhang, H.6
Shui, A.7
Schoenfeld, D.8
Brown, R.H.9
Wieland, S.10
Barber, J.R.11
-
189
-
-
72249101104
-
Arimoclomol: a potential therapy under development for ALS
-
Lanka V, Wieland S, Barber J, Cudkowicz M: Arimoclomol: a potential therapy under development for ALS. Expert Opin Investig Drugs 2009, 18: 1907-1918. 10.1517/13543780903357486
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 1907-1918
-
-
Lanka, V.1
Wieland, S.2
Barber, J.3
Cudkowicz, M.4
-
190
-
-
70349574602
-
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease
-
Faust K, Gehrke S, Yang Y, Yang L, Beal MF, Lu B: Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC Neurosci 2009, 10: 109. 10.1186/1471-2202-10-109
-
(2009)
BMC Neurosci
, vol.10
, pp. 109
-
-
Faust, K.1
Gehrke, S.2
Yang, Y.3
Yang, L.4
Beal, M.F.5
Lu, B.6
-
191
-
-
75749136948
-
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease
-
Neef DW, Turski ML, Thiele DJ: Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol 2010, 8: e1000291. 10.1371/journal.pbio.1000291
-
(2010)
PLoS Biol
, vol.8
-
-
Neef, D.W.1
Turski, M.L.2
Thiele, D.J.3
-
192
-
-
84874832163
-
Protein homeostasis as a therapeutic target for diseases of protein conformation
-
Calamini B, Morimoto RI: Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem 2012, 12: 2623-2640.
-
(2012)
Curr Top Med Chem
, vol.12
, pp. 2623-2640
-
-
Calamini, B.1
Morimoto, R.I.2
-
193
-
-
1642633757
-
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
-
Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, Kurosawa M, Nekooki M, Nukina N: Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med 2004, 10: 148-154. 10.1038/nm985
-
(2004)
Nat Med
, vol.10
, pp. 148-154
-
-
Tanaka, M.1
Machida, Y.2
Niu, S.3
Ikeda, T.4
Jana, N.R.5
Doi, H.6
Kurosawa, M.7
Nekooki, M.8
Nukina, N.9
-
194
-
-
84884294596
-
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
-
Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C: Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 2013, 9: 1308-1320. 10.4161/auto.25188
-
(2013)
Autophagy
, vol.9
, pp. 1308-1320
-
-
Castillo, K.1
Nassif, M.2
Valenzuela, V.3
Rojas, F.4
Matus, S.5
Mercado, G.6
Court, F.A.7
van Zundert, B.8
Hetz, C.9
-
195
-
-
84866737855
-
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant alpha-synuclein
-
Lan DM, Liu FT, Zhao J, Chen Y, Wu JJ, Ding ZT, Yue ZY, Ren HM, Jiang YP, Wang J: Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant alpha-synuclein. Neurochem Res 2012, 37: 2025-2032. 10.1007/s11064-012-0823-0
-
(2012)
Neurochem Res
, vol.37
, pp. 2025-2032
-
-
Lan, D.M.1
Liu, F.T.2
Zhao, J.3
Chen, Y.4
Wu, J.J.5
Ding, Z.T.6
Yue, Z.Y.7
Ren, H.M.8
Jiang, Y.P.9
Wang, J.10
-
196
-
-
84863210676
-
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
-
Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, Goedert M: Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. Brain 2012, 135: 2169-2177. 10.1093/brain/aws143
-
(2012)
Brain
, vol.135
, pp. 2169-2177
-
-
Schaeffer, V.1
Lavenir, I.2
Ozcelik, S.3
Tolnay, M.4
Winkler, D.T.5
Goedert, M.6
-
197
-
-
84862285881
-
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
-
Kruger U, Wang Y, Kumar S, Mandelkow EM: Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging 2012, 33: 2291-2305. 10.1016/j.neurobiolaging.2011.11.009
-
(2012)
Neurobiol Aging
, vol.33
, pp. 2291-2305
-
-
Kruger, U.1
Wang, Y.2
Kumar, S.3
Mandelkow, E.M.4
|