Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age

Journal of Cell Science

Volumn 120, Issue 5, 2007, Pages 782-791

  Kiffin, Roberta ^a   Kaushik, Susmita ^a   Zeng, Mei ^a   Bandyopadhyay, Urmi ^a   Zhang, Cong ^a   Massey, Ashish C ^a   Martinez Vicente, Marta ^a   Cuervo, Ana Maria ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Autophagy; Lipid microdomains; Lysosomal membrane proteins; Lysosomes; Proteases

Indexed keywords

CARBOXYPEPTIDASE C; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2A; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2B; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2C; MESSENGER RNA; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; ENZYME ACTIVITY; ENZYME REGULATION; LYSOSOME; LYSOSOME MEMBRANE; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; RAT; TRANSCRIPTION REGULATION;

AGING; ANIMALS; AUTOPHAGY; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION; IMMUNOBLOTTING; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MALE; MEMBRANE MICRODOMAINS; MOLECULAR CHAPERONES; PEPTIDE HYDROLASES; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA;

EID: 33847690636     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.001073     Document Type: Article

References (36)

1. Agarraberes, F. and Dice, J. F. (2001). A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J. Cell Sci. 114, 2491-2499.
2. Agarraberes, F., Terlecky, S. and Dice, J. (1997). An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J. Cell Biol. 137, 825-834.
3. Chiang, H. and Dice, J. (1988). Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J. Biol. Chem. 263, 6797-6803.
4. Cuervo, A. (2004). Autophagy: in sickness and in health. Trends Cell Biol. 14, 70-77.
5. Cuervo, A. and Dice, J. (1996). A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273, 501-503.
6. Cuervo, A. and Dice, J. (2000a). Regulation of lamp2a levels in the lysosomal membrane. Traffic 1, 570-583.
7. Cuervo, A. and Dice, J. (2000b). Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell Sci. 113, 4441-4450.
8. Cuervo, A. M. and Dice, J. F. (2000c). Age-related decline in chaperone-mediated autophagy. J. Biol. Chem. 275, 31505-31513.
9. Cuervo, A. M. and Dice, J. F. (2000d). Regulation of lamp2a levels in the lysosomal membrane. Traffic 1, 570-583.
10. Cuervo, A., Dice, J. and Knecht, E. (1997). A lysosomal population responsible for the hsc73-mediated degradation of cytosolic proteins in lysosomes. J. Biol. Chem. 272, 5606-5615.
11. Cuervo, A. M., Mann, L., Bonten, E., d'Azzo, A. and Dice, J. (2003). Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J. 22, 12-19.
12. Dice, J. (1982). Altered degradation of proteins microinjected into senescent human fibroblasts. J. Biol. Chem. 257, 14624-14627.
13. Donati, A., Cavallini, G., Paradiso, C., Vittorini S., Pollera, M., Gori, Z. and Bergamini, E. (2001). Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes. J. Gerontol. A Biol. Sci. Med. Sci. 56, B288-B293.
14. Eskelinen, E. L., Tanaka, Y. and Saftig, F. (2003). At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol. 13, 137-145.
15. Eskelinen, E., Schmidt, C., Neu, S., Willenborg, M., Fuertes, G., Salvador, N., Tanaka, Y., Lullmann-Rauch, R., Hartmann, D., Heeren, J. et al. (2004). Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAW-2 double-deficient fibroblasts. Mol. Biol. Cell 15, 3132-3145.
16. Gough, N. R., Hatem C. L. and Fambrough, D. M. (1995). The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c. DNA Cell Biol. 14, 863-867.
17. Jadot, M., Wattiaux, R., Mainferme, F., Dubois, F., Claessens, A. and Wattiaux-De Coninck, S. (1996). Soluble form of Lamp II in purified rat liver lysosomes. Biochem. Biophys. Res. Commun. 223, 353-359.
18. Kaushik, S., Massey, A. C. and Cuervo, A. M. (2006). Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J. 25, 3921-3933.
19. Kiffin, R., Christian, C., Knecht, E. and Cuervo, A. (2004). Activation of chaperone-mediated autophagy during oxidative stress. Mol. Biol. Cell 15, 4829-4840.
20. Laemmli, U. (1970). Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227, 680-685.
21. Leber, T. and Balkwill, F. (1997). Zymography: a single-step staining method for quantitation of proteolytic activity on substrate gels. Anal. Biochem. 249, 24-28.
22. Levine, B. and Klionsky, D. (2004). Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477.
23. Licheter-Konecki, U., Moter, S. E., Krawisz, B. R., Schlotter, M., Hipke, C. and Konecki, D. S. (1999). Expression patterns of murine lysosome-associated membrane protein 2 (Lamp-2) transcripts during morphogenesis. Differentiation 65, 43-58.
24. Lowry, O., Rosebrough, N., Farr, A. and Randall, R. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
25. Massey, A., Zhang, C. and Cuervo, A. (2006a). Chaperone-mediated autophagy in aging and disease. Curr. Top. Dev. Biol. 73, 205-235.
26. Massey, A. C., Kaushik, S., Sovak, G., Kiffin, R. and Cuervo, A. M. (2006b). Consequences of the selective blockage of chaperone-mediated autophagy. Proc. Natl. Acad. Sci. USA 103, 5905-5910.
27. Mizushima, N. (2005). The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ. 12, 1535-1541.
28. Nishino, I,, Fu, J., Tanji, K., Yamada, T., Shimojo, S., Koori, T., Mora, M., Riggs, J., Oh, S., Koga, Y. et al. (2000). Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature 406, 906-910.
29. Ohsumi, Y., Ishikawa, T. and Kato, K. (1983). A rapid and simplified method for the preparation of lysosomal membranes from rat liver. J. Biochem. 93, 547-556.
30. Salvador, N., Aguado, C., Horst, M. and Knecht, E. (2000). Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state. J. Biol. Chem. 275, 27447-27456.
31. Storrie, B. and Madden, E. A. (1990). Isolation of subcellular organelles. Meth. Enzymol. 182, 203-225.
32. Terman, A. (1995). The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41, 319-325.
33. Towbin, H., Staehelin, T. and Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
34. Wattiaux, R., Wattimix-De Coninek, S., Ronveaux-Dupal, M. and Dubois, F. (1978). Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient. J. Cell Biol. 78, 349-368.
35. Yorimitsu, T. and Klionsky, D. (2005). Autophagy: molecular machinery for self-eating. Cell Death Differ. 12 Suppl. 2, 1542-1552.
36. Yuspa, S., Morgan, D., Walker, R. and Bates, R. (1970). The growth of fetal mouse skin in cell culture and transplantation to F1 mice. J. Invest. Dermatol. 55, 379-389.