Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

Journal of Neurochemistry

Volumn 100, Issue 6, 2007, Pages 1449-1457

  St Martin, Jessie L ^a   Klucken, Jochen ^a,b   Outeiro, Tiago F ^a   Nguyen, Paul ^a   Keller McGandy, Christine ^a   Cantuti Castelvetri, Ippolita ^a   Grammatopoulos, Tom N ^a   Standaert, David G ^a   Hyman, Bradley T ^a   McLean, Pamela J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

synuclein; Adeno associated virus; Heat shock proteins; Laser capture microdissection; Parkinson's disease; Substantia nigra

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SYNUCLEIN; CASPASE 9; CHAPERONE; DOPAMINE; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 40; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; LASER CAPTURE MICRODISSECTION; LEWY BODY; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; STEREOTAXIC SURGERY; SUBSTANTIA NIGRA; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; WILD TYPE;

ALPHA-SYNUCLEIN; ANIMALS; CELL DEATH; DEPENDOVIRUS; DOPAMINE; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR CHAPERONES; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBSTANTIA NIGRA; TIME FACTORS; TYROSINE 3-MONOOXYGENASE; UP-REGULATION;

ADENO-ASSOCIATED VIRUS; MUS; MUS MUSCULUS; PRIMATES; RATTUS;

EID: 33847699408     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04310.x     Document Type: Article

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