-
1
-
-
0025935407
-
Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures
-
Abravaya K, Phillips B, Morimoto RI. 1991. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes Dev 5: 2117-2127.
-
(1991)
Genes Dev
, vol.5
, pp. 2117-2127
-
-
Abravaya, K.1
Phillips, B.2
Morimoto, R.I.3
-
2
-
-
0026665975
-
The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression
-
Abravaya K, Myers MP, Murphy SP, Morimoto RI. 1992. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev 6: 1153-1164.
-
(1992)
Genes Dev
, vol.6
, pp. 1153-1164
-
-
Abravaya, K.1
Myers, M.P.2
Murphy, S.P.3
Morimoto, R.I.4
-
3
-
-
77954955686
-
Heat shock factors: Integrators of cell stress, development and lifespan
-
Akerfelt M, Morimoto RI, Sistonen L. 2010. Heat shock factors: Integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol 11: 545-555.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 545-555
-
-
Akerfelt, M.1
Morimoto, R.I.2
Sistonen, L.3
-
4
-
-
0347854376
-
Regulation of C. elegans longevity by specific gustatory and olfactory neurons
-
Alcedo J, Kenyon C. 2004. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41: 45-55.
-
(2004)
Neuron
, vol.41
, pp. 45-55
-
-
Alcedo, J.1
Kenyon, C.2
-
5
-
-
70350668615
-
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity
-
Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, et al. 2009. A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. Biochem J 424: 15-26.
-
(2009)
Biochem J
, vol.424
, pp. 15-26
-
-
Allali-Hassani, A.1
Wasney, G.A.2
Chau, I.3
Hong, B.S.4
Senisterra, G.5
Loppnau, P.6
Shi, Z.7
Moult, J.8
Edwards, A.M.9
Arrowsmith, C.H.10
-
6
-
-
0022455603
-
Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes
-
Ananthan J, Goldberg AL, Voellmy R. 1986. Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. Science 232: 522-524.
-
(1986)
Science
, vol.232
, pp. 522-524
-
-
Ananthan, J.1
Goldberg, A.L.2
Voellmy, R.3
-
7
-
-
84934443868
-
Heat shock factor 1 as a coordinator of stress and developmental pathways
-
Anckar J, Sistonen L. 2007. Heat shock factor 1 as a coordinator of stress and developmental pathways. Adv Exp Med Biol 594: 78-88.
-
(2007)
Adv Exp Med Biol
, vol.594
, pp. 78-88
-
-
Anckar, J.1
Sistonen, L.2
-
8
-
-
0015859467
-
Principles that govern the folding of protein chains
-
Anfinsen CB. 1973. Principles that govern the folding of protein chains. Science 181: 223-230.
-
(1973)
Science
, vol.181
, pp. 223-230
-
-
Anfinsen, C.B.1
-
10
-
-
0021685483
-
Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes
-
Banerji SS, Theodorakis NG, Morimoto RI. 1984. Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Mol Cell Biol 4: 2437-2448.
-
(1984)
Mol Cell Biol
, vol.4
, pp. 2437-2448
-
-
Banerji, S.S.1
Theodorakis, N.G.2
Morimoto, R.I.3
-
11
-
-
66849106554
-
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms
-
Bartlett AI, Radford SE. 2009. An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Nat Struct Mol Biol 16: 582-588.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 582-588
-
-
Bartlett, A.I.1
Radford, S.E.2
-
12
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A, Miller EA, Morimoto RI. 2009. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci 106: 14914-14919.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
13
-
-
35949001344
-
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
-
Bilen J, Bonini NM. 2007. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet 3: 1950-1964.
-
(2007)
PLoS Genet
, vol.3
, pp. 1950-1964
-
-
Bilen, J.1
Bonini, N.M.2
-
14
-
-
0025998329
-
Stress-induced heat shock protein 70 expression in adrenal cortex: An adrenocorticotropic hormonesensitive, age-dependent response
-
Blake MJ, Udelsman R, Feulner GJ, Norton DD, Holbrook NJ. 1991. Stress-induced heat shock protein 70 expression in adrenal cortex: An adrenocorticotropic hormonesensitive, age-dependent response. Proc Natl Acad Sci 88: 9873-9877.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 9873-9877
-
-
Blake, M.J.1
Udelsman, R.2
Feulner, G.J.3
Norton, D.D.4
Holbrook, N.J.5
-
15
-
-
33846901901
-
Intermediates: Ubiquitous species on folding energy landscapes?
-
Brockwell DJ, Radford SE. 2007. Intermediates: Ubiquitous species on folding energy landscapes? Curr Opin Struct Biol 17: 30-37.
-
(2007)
Curr Opin Struct Biol
, vol.17
, pp. 30-37
-
-
Brockwell, D.J.1
Radford, S.E.2
-
16
-
-
0030896451
-
Correcting temperature-sensitive protein folding defects
-
Brown CR, Hong-Brown LQ, Welch WJ. 1997. Correcting temperature-sensitive protein folding defects. J Clin Invest 99: 1432-1444.
-
(1997)
J Clin Invest
, vol.99
, pp. 1432-1444
-
-
Brown, C.R.1
Hong-Brown, L.Q.2
Welch, W.J.3
-
17
-
-
77957960061
-
Temperature as a universal resetting cue for mammalian circadian oscillators
-
Buhr ED, Yoo SH, Takahashi JS. 2010. Temperature as a universal resetting cue for mammalian circadian oscillators. Science 330: 379-385.
-
(2010)
Science
, vol.330
, pp. 379-385
-
-
Buhr, E.D.1
Yoo, S.H.2
Takahashi, J.S.3
-
18
-
-
33646127577
-
Molecular chaperones and protein quality control
-
Bukau B, Weissman J, Horwich A. 2006. Molecular chaperones and protein quality control. Cell 125: 443-451.
-
(2006)
Cell
, vol.125
, pp. 443-451
-
-
Bukau, B.1
Weissman, J.2
Horwich, A.3
-
19
-
-
0034703863
-
Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila
-
Chan HY, Warrick JM, Gray-Board GL, Paulson HL, Bonini NM. 2000. Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila. Hum Mol Genet 9: 2811-2820.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2811-2820
-
-
Chan, H.Y.1
Warrick, J.M.2
Gray-Board, G.L.3
Paulson, H.L.4
Bonini, N.M.5
-
20
-
-
0032567434
-
Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery
-
Chen S, Smith DF. 1998. Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery. J Biol Chem 273: 35194-35200.
-
(1998)
J Biol Chem
, vol.273
, pp. 35194-35200
-
-
Chen, S.1
Smith, D.F.2
-
21
-
-
4644285228
-
Protein folding in the cell: Reshaping the folding funnel
-
Clark PL. 2004. Protein folding in the cell: Reshaping the folding funnel. Trends Biochem Sci 29: 527-534.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 527-534
-
-
Clark, P.L.1
-
22
-
-
0035146685
-
The co-chaperone CHip regulates protein triage decisions mediated by heat-shock proteins
-
Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Hohfeld J, Patterson C. 2001. The co-chaperone CHip regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 3: 93-96.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 93-96
-
-
Connell, P.1
Ballinger, C.A.2
Jiang, J.3
Wu, Y.4
Thompson, L.J.5
Hohfeld, J.6
Patterson, C.7
-
23
-
-
0037085381
-
A new first step in activation of steroid receptors: Hormone-induced switching of FKBP51 and FKBP52 immunophilins
-
Davies TH, Ning YM, Sanchez ER. 2002. A new first step in activation of steroid receptors: Hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem 277: 4597-4600.
-
(2002)
J Biol Chem
, vol.277
, pp. 4597-4600
-
-
Davies, T.H.1
Ning, Y.M.2
Sanchez, E.R.3
-
24
-
-
0034425698
-
EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
-
Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C. 2000. EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet 25: 406-409.
-
(2000)
Nat Genet
, vol.25
, pp. 406-409
-
-
Delepine, M.1
Nicolino, M.2
Barrett, T.3
Golamaully, M.4
Lathrop, G.M.5
Julier, C.6
-
25
-
-
0035096292
-
Recognition between flexible protein molecules: Induced and assisted folding
-
Demchenko AP. 2001. Recognition between flexible protein molecules: Induced and assisted folding. J Mol Recognit 14: 42-61.
-
(2001)
J Mol Recognit
, vol.14
, pp. 42-61
-
-
Demchenko, A.P.1
-
26
-
-
23944490117
-
Missense meanderings in sequence space: A biophysical view of protein evolution
-
DePristo MA, Weinreich DM, Hartl DL. 2005. Missense meanderings in sequence space: A biophysical view of protein evolution. Nat Rev Genet 6: 678-687.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 678-687
-
-
DePristo, M.A.1
Weinreich, D.M.2
Hartl, D.L.3
-
27
-
-
0024298711
-
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
-
Deshaies RJ, Koch BD, Werner-Washburne M, Craig EA, Schekman R. 1988. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature 332: 800-805.
-
(1988)
Nature
, vol.332
, pp. 800-805
-
-
Deshaies, R.J.1
Koch, B.D.2
Werner-Washburne, M.3
Craig, E.A.4
Schekman, R.5
-
28
-
-
11444271010
-
Chaperone-assisted folding of newly synthesized proteins in the cytosol
-
Deuerling E, Bukau B. 2004. Chaperone-assisted folding of newly synthesized proteins in the cytosol. Crit Rev Biochem Mol Biol 39: 261-277.
-
(2004)
Crit Rev Biochem Mol Biol
, vol.39
, pp. 261-277
-
-
Deuerling, E.1
Bukau, B.2
-
29
-
-
33646779541
-
Thermoregulation in the life cycle of nematodes
-
Devaney E. 2006. Thermoregulation in the life cycle of nematodes. Int J Parasitol 36: 641-649.
-
(2006)
Int J Parasitol
, vol.36
, pp. 641-649
-
-
Devaney, E.1
-
30
-
-
1842298212
-
From Levinthal to pathways to funnels
-
Dill KA, Chan HS. 1997. From Levinthal to pathways to funnels. Nat Struct Biol 4: 10-19.
-
(1997)
Nat Struct Biol
, vol.4
, pp. 10-19
-
-
Dill, K.A.1
Chan, H.S.2
-
31
-
-
0032571320
-
The role of DnaJ-like proteins in glucocorticoid receptor. hsp90 heterocomplex assembly by the reconstituted hsp90. p60. hsp70 foldosome complex
-
Dittmar KD, Banach M, Galigniana MD, Pratt WB. 1998. The role of DnaJ-like proteins in glucocorticoid receptor. hsp90 heterocomplex assembly by the reconstituted hsp90. p60. hsp70 foldosome complex. J Biol Chem 273: 7358-7366.
-
(1998)
J Biol Chem
, vol.273
, pp. 7358-7366
-
-
Dittmar, K.D.1
Banach, M.2
Galigniana, M.D.3
Pratt, W.B.4
-
32
-
-
0030869037
-
Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor. hsp90 heterocomplexes formed by hsp90. p60. hsp70
-
Dittmar KD, Demady DR, Stancato LF, Krishna P, PrattWB. 1997. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor. hsp90 heterocomplexes formed by hsp90. p60. hsp70. J Biol Chem 272: 21213-21220.
-
(1997)
J Biol Chem
, vol.272
, pp. 21213-21220
-
-
Dittmar, K.D.1
Demady, D.R.2
Stancato, L.F.3
Krishna, P.4
Pratt, W.B.5
-
33
-
-
47549097539
-
Mistranslation-induced protein misfolding as a dominant constraint on codingsequence evolution
-
Drummond DA, Wilke CO. 2008. Mistranslation-induced protein misfolding as a dominant constraint on codingsequence evolution. Cell 134: 341-352.
-
(2008)
Cell
, vol.134
, pp. 341-352
-
-
Drummond, D.A.1
Wilke, C.O.2
-
34
-
-
38649104452
-
Heat-shock protein 90α1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos
-
Du SJ, Li H, Bian Y, Zhong Y. 2008. Heat-shock protein 90α1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos. Proc Natl Acad Sci 105: 554-559.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 554-559
-
-
Du, S.J.1
Li, H.2
Bian, Y.3
Zhong, Y.4
-
35
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
Durieux J, Wolff S, Dillin A. 2011. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144: 79-91.
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
36
-
-
1542267822
-
Molecular chaperones function as steroid receptor nuclear mobility factors
-
Elbi C, Walker DA, Romero G, Sullivan WP, Toft DO, Hager GL, DeFranco DB. 2004. Molecular chaperones function as steroid receptor nuclear mobility factors. Proc Natl Acad Sci 101: 2876-2881.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 2876-2881
-
-
Elbi, C.1
Walker, D.A.2
Romero, G.3
Sullivan, W.P.4
Toft, D.O.5
Hager, G.L.6
DeFranco, D.B.7
-
37
-
-
0025382818
-
The molecular chaperone concept
-
Ellis RJ. 1990. The molecular chaperone concept. Semin Cell Biol 1: 1-9.
-
(1990)
Semin Cell Biol
, vol.1
, pp. 1-9
-
-
Ellis, R.J.1
-
38
-
-
0032822103
-
Principles of protein folding in the cellular environment
-
Ellis RJ, Hartl FU. 1999. Principles of protein folding in the cellular environment. Curr Opin Struct Biol 9: 102-110.
-
(1999)
Curr Opin Struct Biol
, vol.9
, pp. 102-110
-
-
Ellis, R.J.1
Hartl, F.U.2
-
39
-
-
0028586833
-
Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1
-
Fawcett TW, Sylvester SL, Sarge KD, Morimoto RI, Holbrook NJ. 1994. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J Biol Chem 269: 32272-32278.
-
(1994)
J Biol Chem
, vol.269
, pp. 32272-32278
-
-
Fawcett, T.W.1
Sylvester, S.L.2
Sarge, K.D.3
Morimoto, R.I.4
Holbrook, N.J.5
-
40
-
-
0033057848
-
Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
-
Feder ME, Hofmann GE. 1999. Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology. Annu Rev Physiol 61: 243-282.
-
(1999)
Annu Rev Physiol
, vol.61
, pp. 243-282
-
-
Feder, M.E.1
Hofmann, G.E.2
-
41
-
-
0026645957
-
The consequences of expressing hsp70 in Drosophila cells at normal temperatures
-
Feder JH, Rossi JM, Solomon J, Solomon N, Lindquist S. 1992. The consequences of expressing hsp70 in Drosophila cells at normal temperatures. Genes Dev 6: 1402-1413.
-
(1992)
Genes Dev
, vol.6
, pp. 1402-1413
-
-
Feder, J.H.1
Rossi, J.M.2
Solomon, J.3
Solomon, N.4
Lindquist, S.5
-
43
-
-
0028958601
-
Characterizing transition states in protein folding: An essential step in the puzzle
-
Fersht AR. 1995. Characterizing transition states in protein folding: An essential step in the puzzle. Curr Opin Struct Biol 5: 79-84.
-
(1995)
Curr Opin Struct Biol
, vol.5
, pp. 79-84
-
-
Fersht, A.R.1
-
44
-
-
0032924105
-
Chaperone-mediated protein folding
-
Fink AL. 1999. Chaperone-mediated protein folding. Physiol Rev 79: 425-449.
-
(1999)
Physiol Rev
, vol.79
, pp. 425-449
-
-
Fink, A.L.1
-
45
-
-
35648969195
-
Genetic basis of proteome variation in yeast
-
Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. 2007. Genetic basis of proteome variation in yeast. Nat Genet 39: 1369-1375.
-
(2007)
Nat Genet
, vol.39
, pp. 1369-1375
-
-
Foss, E.J.1
Radulovic, D.2
Shaffer, S.A.3
Ruderfer, D.M.4
Bedalov, A.5
Goodlett, D.R.6
Kruglyak, L.7
-
46
-
-
0026320866
-
The energy landscapes and motions of proteins
-
Frauenfelder H, Sligar SG, Wolynes PG. 1991. The energy landscapes and motions of proteins. Science 254: 1598-1603.
-
(1991)
Science
, vol.254
, pp. 1598-1603
-
-
Frauenfelder, H.1
Sligar, S.G.2
Wolynes, P.G.3
-
47
-
-
0037150683
-
Disassembly of transcriptional regulatory complexes by molecular chaperones
-
Freeman BC, Yamamoto KR. 2002. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 296: 2232-2235.
-
(2002)
Science
, vol.296
, pp. 2232-2235
-
-
Freeman, B.C.1
Yamamoto, K.R.2
-
48
-
-
0031106603
-
Chaperones get in touch: The Hip-Hop connection
-
Frydman J, Hohfeld J. 1997. Chaperones get in touch: The Hip-Hop connection. Trends Biochem Sci 22: 87-92.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 87-92
-
-
Frydman, J.1
Hohfeld, J.2
-
49
-
-
36248980418
-
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells
-
Garcia SM, Casanueva MO, Silva MC, Amaral MD, Morimoto RI. 2007. Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes Dev 21: 3006-3016.
-
(2007)
Genes Dev
, vol.21
, pp. 3006-3016
-
-
Garcia, S.M.1
Casanueva, M.O.2
Silva, M.C.3
Amaral, M.D.4
Morimoto, R.I.5
-
50
-
-
71149087504
-
Transient non-native hydrogen bonds promote activation of a signaling protein
-
Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, LabeikovskyW, Wolf-Watz M, Clarkson MW, et al. 2009. Transient non-native hydrogen bonds promote activation of a signaling protein. Cell 139: 1109-1118.
-
(2009)
Cell
, vol.139
, pp. 1109-1118
-
-
Gardino, A.K.1
Villali, J.2
Kivenson, A.3
Lei, M.4
Liu, C.F.5
Steindel, P.6
Eisenmesser, E.Z.7
Labeikovsky, W.8
Wolf-Watz, M.9
Clarkson, M.W.10
-
51
-
-
0033637153
-
Genomic expression programs in the response of yeast cells to environmental changes
-
Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO. 2000. Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11: 4241-4257.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 4241-4257
-
-
Gasch, A.P.1
Spellman, P.T.2
Kao, C.M.3
Carmel-Harel, O.4
Eisen, M.B.5
Storz, G.6
Botstein, D.7
Brown, P.O.8
-
52
-
-
0026584271
-
Protein folding in the cell
-
Gething MJ, Sambrook J. 1992. Protein folding in the cell. Nature 355: 33-45.
-
(1992)
Nature
, vol.355
, pp. 33-45
-
-
Gething, M.J.1
Sambrook, J.2
-
53
-
-
0142215475
-
Global analysis of protein expression in yeast
-
Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS. 2003. Global analysis of protein expression in yeast. Nature 425: 737-741.
-
(2003)
Nature
, vol.425
, pp. 737-741
-
-
Ghaemmaghami, S.1
Huh, W.K.2
Bower, K.3
Howson, R.W.4
Belle, A.5
Dephoure, N.6
O'Shea, E.K.7
Weissman, J.S.8
-
54
-
-
0033579556
-
The seven amino acids (547-553) of rat glucocorticoid receptor required for steroid and hsp90 binding contain a functionally independent LXXLL motif that is critical for steroid binding
-
Giannoukos G, Silverstein AM, Pratt WB, Simons SS Jr. 1999. The seven amino acids (547-553) of rat glucocorticoid receptor required for steroid and hsp90 binding contain a functionally independent LXXLL motif that is critical for steroid binding. J Biol Chem 274: 36527-36536.
-
(1999)
J Biol Chem
, vol.274
, pp. 36527-36536
-
-
Giannoukos, G.1
Silverstein, A.M.2
Pratt, W.B.3
Simons Jr., S.S.4
-
55
-
-
77749319656
-
A cellular perspective on conformational disease: The role of genetic background and proteostasis networks
-
Gidalevitz T, Kikis EA, Morimoto RI. 2010. A cellular perspective on conformational disease: The role of genetic background and proteostasis networks. Curr Opin Struct Biol 20: 23-32.
-
(2010)
Curr Opin Struct Biol
, vol.20
, pp. 23-32
-
-
Gidalevitz, T.1
Kikis, E.A.2
Morimoto, R.I.3
-
56
-
-
33644850056
-
Progressive disruption of cellular protein folding in models of polyglutamine diseases
-
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI. 2006. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311: 1471-1474.
-
(2006)
Science
, vol.311
, pp. 1471-1474
-
-
Gidalevitz, T.1
Ben-Zvi, A.2
Ho, K.H.3
Brignull, H.R.4
Morimoto, R.I.5
-
57
-
-
62149129690
-
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
-
Gidalevitz T, Krupinski T, Garcia S, Morimoto RI. 2009. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet 5: e1000399.
-
(2009)
PLoS Genet
, vol.5
-
-
Gidalevitz, T.1
Krupinski, T.2
Garcia, S.3
Morimoto, R.I.4
-
58
-
-
18244384703
-
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress
-
Guettouche T, Boellmann F, Lane WS, Voellmy R. 2005. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem 6: 4.
-
(2005)
BMC Biochem
, vol.6
, pp. 4
-
-
Guettouche, T.1
Boellmann, F.2
Lane, W.S.3
Voellmy, R.4
-
59
-
-
33947623164
-
Environmental influence on the genetic correlations between life-history traits in Caenorhabditis elegans
-
Gutteling EW, Doroszuk A, Riksen JA, Prokop Z, Reszka J, Kammenga JE. 2007. Environmental influence on the genetic correlations between life-history traits in Caenorhabditis elegans. Heredity 98: 206-213.
-
(2007)
Heredity
, vol.98
, pp. 206-213
-
-
Gutteling, E.W.1
Doroszuk, A.2
Riksen, J.A.3
Prokop, Z.4
Reszka, J.5
Kammenga, J.E.6
-
60
-
-
2942598422
-
Genome-wide analysis of the biology of stress responses through heat shock transcription factor
-
Hahn JS, Hu Z, Thiele DJ, Iyer VR. 2004. Genome-wide analysis of the biology of stress responses through heat shock transcription factor. Mol Cell Biol 24: 5249-5256.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5249-5256
-
-
Hahn, J.S.1
Hu, Z.2
Thiele, D.J.3
Iyer, V.R.4
-
61
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in Perk2/2 mice reveals a role for translational control in secretory cell survival
-
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D. 2001. Diabetes mellitus and exocrine pancreatic dysfunction in Perk2/2 mice reveals a role for translational control in secretory cell survival. Mol Cell 7: 1153-1163.
-
(2001)
Mol Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
Zeng, H.2
Zhang, Y.3
Jungries, R.4
Chung, P.5
Plesken, H.6
Sabatini, D.D.7
Ron, D.8
-
62
-
-
18844406200
-
Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation
-
Harst A, Lin H, Obermann WM. 2005. Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation. Biochem J 387: 789-796.
-
(2005)
Biochem J
, vol.387
, pp. 789-796
-
-
Harst, A.1
Lin, H.2
Obermann, W.M.3
-
63
-
-
0028117314
-
Molecular chaperones in protein folding: The art of avoiding sticky situations
-
Hartl FU, Hlodan R, Langer T. 1994. Molecular chaperones in protein folding: The art of avoiding sticky situations. Trends Biochem Sci 19: 20-25.
-
(1994)
Trends Biochem Sci
, vol.19
, pp. 20-25
-
-
Hartl, F.U.1
Hlodan, R.2
Langer, T.3
-
64
-
-
0037385213
-
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1
-
Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L. 2003. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol 23: 2953-2968.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2953-2968
-
-
Hietakangas, V.1
Ahlskog, J.K.2
Jakobsson, A.M.3
Hellesuo, M.4
Sahlberg, N.M.5
Holmberg, C.I.6
Mikhailov, A.7
Palvimo, J.J.8
Pirkkala, L.9
Sistonen, L.10
-
65
-
-
78649640867
-
Stable α-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones
-
Hinault MP, Cuendet AF, Mattoo RU, Mensi M, Dietler G, Lashuel HA, Goloubinoff P. 2010. Stable α-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. J Biol Chem 285: 38173-38182.
-
(2010)
J Biol Chem
, vol.285
, pp. 38173-38182
-
-
Hinault, M.P.1
Cuendet, A.F.2
Mattoo, R.U.3
Mensi, M.4
Dietler, G.5
Lashuel, H.A.6
Goloubinoff, P.7
-
66
-
-
17844386323
-
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
-
Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, et al. 2001. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20: 3800-3810.
-
(2001)
EMBO J
, vol.20
, pp. 3800-3810
-
-
Holmberg, C.I.1
Hietakangas, V.2
Mikhailov, A.3
Rantanen, J.O.4
Kallio, M.5
Meinander, A.6
Hellman, J.7
Morrice, N.8
McKintosh, C.9
Morimoto, R.I.10
-
67
-
-
67349176043
-
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
-
Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. 2009. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J 28: 1624-1636.
-
(2009)
EMBO J
, vol.28
, pp. 1624-1636
-
-
Hu, C.C.1
Dougan, S.K.2
McGehee, A.M.3
Love, J.C.4
Ploegh, H.L.5
-
68
-
-
0025876740
-
Protein folding: Local structures, domains, subunits, and assemblies
-
Jaenicke R. 1991. Protein folding: Local structures, domains, subunits, and assemblies. Biochemistry 30: 3147-3161.
-
(1991)
Biochemistry
, vol.30
, pp. 3147-3161
-
-
Jaenicke, R.1
-
69
-
-
31744448271
-
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
-
Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, et al. 2006. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38: 197-202.
-
(2006)
Nat Genet
, vol.38
, pp. 197-202
-
-
Jordanova, A.1
Irobi, J.2
Thomas, F.P.3
van Dijck, P.4
Meerschaert, K.5
Dewil, M.6
Dierick, I.7
Jacobs, A.8
de Vriendt, E.9
Guergueltcheva, V.10
-
70
-
-
53549116738
-
The complex interrelationships between protein flexibility and stability
-
Kamerzell TJ, Middaugh CR. 2008. The complex interrelationships between protein flexibility and stability. J Pharm Sci 97: 3494-3517.
-
(2008)
J Pharm Sci
, vol.97
, pp. 3494-3517
-
-
Kamerzell, T.J.1
Middaugh, C.R.2
-
71
-
-
77954947810
-
The HSP70 chaperone machinery: J proteins as drivers of functional specificity
-
Kampinga HH, Craig EA. 2010. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol 11: 579-592.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 579-592
-
-
Kampinga, H.H.1
Craig, E.A.2
-
72
-
-
0037184112
-
Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain
-
Kaul S, Murphy PJ, Chen J, Brown L, PrattWB, Simons SS Jr. 2002. Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain. J Biol Chem 277: 36223-36232.
-
(2002)
J Biol Chem
, vol.277
, pp. 36223-36232
-
-
Kaul, S.1
Murphy, P.J.2
Chen, J.3
Brown, L.4
Pratt, W.B.5
Simons Jr., S.S.6
-
73
-
-
0032103439
-
The J-domain family and the recruitment of chaperone power
-
Kelley WL. 1998. The J-domain family and the recruitment of chaperone power. Trends Biochem Sci 23: 222-227.
-
(1998)
Trends Biochem Sci
, vol.23
, pp. 222-227
-
-
Kelley, W.L.1
-
74
-
-
0029026540
-
Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways
-
Kimura Y, Yahara I, Lindquist S. 1995. Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways. Science 268: 1362-1365.
-
(1995)
Science
, vol.268
, pp. 1362-1365
-
-
Kimura, Y.1
Yahara, I.2
Lindquist, S.3
-
75
-
-
0030988941
-
Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation
-
Kline MP, Morimoto RI. 1997. Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17: 2107-2115.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2107-2115
-
-
Kline, M.P.1
Morimoto, R.I.2
-
76
-
-
18544382234
-
Genetic analysis of the mouse brain proteome
-
Klose J, Nock C, Herrmann M, Stuhler K, Marcus K, Bluggel M, Krause E, Schalkwyk LC, Rastan S, Brown SD, et al. 2002. Genetic analysis of the mouse brain proteome. Nat Genet 30: 385-393.
-
(2002)
Nat Genet
, vol.30
, pp. 385-393
-
-
Klose, J.1
Nock, C.2
Herrmann, M.3
Stuhler, K.4
Marcus, K.5
Bluggel, M.6
Krause, E.7
Schalkwyk, L.C.8
Rastan, S.9
Brown, S.D.10
-
77
-
-
0029804194
-
Repression of human heat shock factor 1 activity at control temperature by phosphorylation
-
Knauf U, Newton EM, Kyriakis J, Kingston RE. 1996. Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev 10: 2782-2793.
-
(1996)
Genes Dev
, vol.10
, pp. 2782-2793
-
-
Knauf, U.1
Newton, E.M.2
Kyriakis, J.3
Kingston, R.E.4
-
78
-
-
0030942057
-
Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae
-
Krebs RA, Feder ME. 1997. Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae. Cell Stress Chaperones 2: 60-71.
-
(1997)
Cell Stress Chaperones
, vol.2
, pp. 60-71
-
-
Krebs, R.A.1
Feder, M.E.2
-
79
-
-
34147116715
-
Most rare missense alleles are deleterious in humans: Implications for complex disease and association studies
-
Kryukov GV, Pennacchio LA, Sunyaev SR. 2007. Most rare missense alleles are deleterious in humans: Implications for complex disease and association studies. Am J Hum Genet 80: 727-739.
-
(2007)
Am J Hum Genet
, vol.80
, pp. 727-739
-
-
Kryukov, G.V.1
Pennacchio, L.A.2
Sunyaev, S.R.3
-
80
-
-
33748432548
-
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
-
Lee JW, Beebe K, Nangle LA, Jang J, Longo-Guess CM, Cook SA, Davisson MT, Sundberg JP, Schimmel P, Ackerman SL. 2006. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature 443: 50-55.
-
(2006)
Nature
, vol.443
, pp. 50-55
-
-
Lee, J.W.1
Beebe, K.2
Nangle, L.A.3
Jang, J.4
Longo-Guess, C.M.5
Cook, S.A.6
Davisson, M.T.7
Sundberg, J.P.8
Schimmel, P.9
Ackerman, S.L.10
-
81
-
-
0022555843
-
The heat-shock response
-
Lindquist S. 1986. The heat-shock response. Annu Rev Biochem 55: 1151-1191.
-
(1986)
Annu Rev Biochem
, vol.55
, pp. 1151-1191
-
-
Lindquist, S.1
-
83
-
-
0027255479
-
Structural and genetic analysis of protein stability
-
Matthews BW. 1993. Structural and genetic analysis of protein stability. Annu Rev Biochem 62: 139-160.
-
(1993)
Annu Rev Biochem
, vol.62
, pp. 139-160
-
-
Matthews, B.W.1
-
84
-
-
20444413061
-
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways
-
McClellan AJ, Scott MD, Frydman J. 2005. Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways. Cell 121: 739-748.
-
(2005)
Cell
, vol.121
, pp. 739-748
-
-
McClellan, A.J.1
Scott, M.D.2
Frydman, J.3
-
85
-
-
0035142877
-
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
-
Meacham GC, Patterson C, ZhangW, Younger JM, Cyr DM. 2001. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol 3: 100-105.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 100-105
-
-
Meacham, G.C.1
Patterson, C.2
Zhang, W.3
Younger, J.M.4
Cyr, D.M.5
-
86
-
-
0006849332
-
Expression of human HSP70 during the synthetic phase of the cell cycle
-
Milarski KL, Morimoto RI. 1986. Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci 83: 9517-9521.
-
(1986)
Proc Natl Acad Sci
, vol.83
, pp. 9517-9521
-
-
Milarski, K.L.1
Morimoto, R.I.2
-
87
-
-
0032931842
-
A transactivation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress
-
Morano KA, Santoro N, Koch KA, Thiele DJ. 1999. A transactivation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress. Mol Cell Biol 19: 402-411.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 402-411
-
-
Morano, K.A.1
Santoro, N.2
Koch, K.A.3
Thiele, D.J.4
-
88
-
-
0032535245
-
Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
-
Morimoto RI. 1998. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12: 3788-3796.
-
(1998)
Genes Dev
, vol.12
, pp. 3788-3796
-
-
Morimoto, R.I.1
-
89
-
-
0031297298
-
The heat-shock response: Regulation and function of heatshock proteins and molecular chaperones
-
Morimoto RI, Kline MP, Bimston DN, Cotto JJ. 1997. The heat-shock response: Regulation and function of heatshock proteins and molecular chaperones. Essays Biochem 32: 17-29.
-
(1997)
Essays Biochem
, vol.32
, pp. 17-29
-
-
Morimoto, R.I.1
Kline, M.P.2
Bimston, D.N.3
Cotto, J.J.4
-
90
-
-
1342294313
-
The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: Hsp90 complex
-
Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. 2003. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem 278: 48754-48763.
-
(2003)
J Biol Chem
, vol.278
, pp. 48754-48763
-
-
Morishima, Y.1
Kanelakis, K.C.2
Murphy, P.J.3
Lowe, E.R.4
Jenkins, G.J.5
Osawa, Y.6
Sunahara, R.K.7
Pratt, W.B.8
-
91
-
-
0025300038
-
In vitro activation of heat shock transcription factor DNAbinding by calcium and biochemical conditions that affect protein conformation
-
MosserDD, Kotzbauer PT, SargeKD, Morimoto RI. 1990. In vitro activation of heat shock transcription factor DNAbinding by calcium and biochemical conditions that affect protein conformation. Proc Natl Acad Sci 87: 3748-3752.
-
(1990)
Proc Natl Acad Sci
, vol.87
, pp. 3748-3752
-
-
Mosser, D.D.1
Kotzbauer, P.T.2
Sarge, K.D.3
Morimoto, R.I.4
-
92
-
-
0035839576
-
Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate
-
Murphy PJ, Kanelakis KC, Galigniana MD, Morishima Y, Pratt WB. 2001. Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate. J Biol Chem 276: 30092-30098.
-
(2001)
J Biol Chem
, vol.276
, pp. 30092-30098
-
-
Murphy, P.J.1
Kanelakis, K.C.2
Galigniana, M.D.3
Morishima, Y.4
Pratt, W.B.5
-
93
-
-
33750353461
-
Predicting the effects of amino acid substitutions on protein function
-
Ng PC, Henikoff S. 2006. Predicting the effects of amino acid substitutions on protein function. Annu Rev Genomics Hum Genet 7: 61-80.
-
(2006)
Annu Rev Genomics Hum Genet
, vol.7
, pp. 61-80
-
-
Ng, P.C.1
Henikoff, S.2
-
94
-
-
0037099046
-
Chaperoning signaling pathways: Molecular chaperones as stress-sensing 'heat shock' proteins
-
Nollen EA, Morimoto RI. 2002. Chaperoning signaling pathways: Molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci 115: 2809-2816.
-
(2002)
J Cell Sci
, vol.115
, pp. 2809-2816
-
-
Nollen, E.A.1
Morimoto, R.I.2
-
95
-
-
7044240678
-
Hop: More than an Hsp70/Hsp90 adaptor protein
-
Odunuga OO, Longshaw VM, Blatch GL. 2004. Hop: More than an Hsp70/Hsp90 adaptor protein. Bioessays 26: 1058-1068.
-
(2004)
Bioessays
, vol.26
, pp. 1058-1068
-
-
Odunuga, O.O.1
Longshaw, V.M.2
Blatch, G.L.3
-
96
-
-
0019720278
-
Globular protein stability: Aspects of interest in protein turnover
-
Pace CN, Fisher LM, Cupo JF. 1981. Globular protein stability: Aspects of interest in protein turnover. Acta BiolMed Ger 40: 1385-1392.
-
(1981)
Acta BiolMed Ger
, vol.40
, pp. 1385-1392
-
-
Pace, C.N.1
Fisher, L.M.2
Cupo, J.F.3
-
97
-
-
0024792699
-
Genetic analysis of protein stability and function
-
Pakula AA, Sauer RT. 1989. Genetic analysis of protein stability and function. Annu Rev Genet 23: 289-310.
-
(1989)
Annu Rev Genet
, vol.23
, pp. 289-310
-
-
Pakula, A.A.1
Sauer, R.T.2
-
98
-
-
18744391410
-
Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding
-
Park C, Marqusee S. 2005. Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding. Nat Methods 2: 207-212.
-
(2005)
Nat Methods
, vol.2
, pp. 207-212
-
-
Park, C.1
Marqusee, S.2
-
99
-
-
0025175208
-
Reduced levels of hsp90 compromise steroid receptor action in vivo
-
Picard D, Khursheed B, Garabedian MJ, Fortin MG, Lindquist S, Yamamoto KR. 1990. Reduced levels of hsp90 compromise steroid receptor action in vivo. Nature 348: 166-168.
-
(1990)
Nature
, vol.348
, pp. 166-168
-
-
Picard, D.1
Khursheed, B.2
Garabedian, M.J.3
Fortin, M.G.4
Lindquist, S.5
Yamamoto, K.R.6
-
100
-
-
0032502839
-
Contact order, transition state placement and the refolding rates of single domain proteins
-
Plaxco KW, Simons KT, Baker D. 1998. Contact order, transition state placement and the refolding rates of single domain proteins. J Mol Biol 277: 985-994.
-
(1998)
J Mol Biol
, vol.277
, pp. 985-994
-
-
Plaxco, K.W.1
Simons, K.T.2
Baker, D.3
-
101
-
-
33746871457
-
Components of the protein quality control system are expressed in a strain-dependent manner in the mouse hippocampus
-
Pollak DD, John J, Bubna-Littitz H, Schneider A, Hoeger H, Lubec G. 2006. Components of the protein quality control system are expressed in a strain-dependent manner in the mouse hippocampus. Neurochem Int 49: 500-507.
-
(2006)
Neurochem Int
, vol.49
, pp. 500-507
-
-
Pollak, D.D.1
John, J.2
Bubna-Littitz, H.3
Schneider, A.4
Hoeger, H.5
Lubec, G.6
-
102
-
-
78651100368
-
Disruption of the Chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival
-
M110 000570
-
Posokhova E, Song H, Belcastro M, Higgins L, Bigley LR, Michaud NA, Martemyanov KA, Sokolov M. 2010. Disruption of the Chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival. Mol Cell Proteomics 10: M110 000570.
-
(2010)
Mol Cell Proteomics
, vol.10
-
-
Posokhova, E.1
Song, H.2
Belcastro, M.3
Higgins, L.4
Bigley, L.R.5
Michaud, N.A.6
Martemyanov, K.A.7
Sokolov, M.8
-
103
-
-
67650410543
-
Biological and chemical approaches to diseases of proteostasis deficiency
-
Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. 2009. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 78: 959-991.
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 959-991
-
-
Powers, E.T.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
Balch, W.E.5
-
104
-
-
44049095652
-
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
-
Prahlad V, Cornelius T, Morimoto RI. 2008. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 320: 811-814.
-
(2008)
Science
, vol.320
, pp. 811-814
-
-
Prahlad, V.1
Cornelius, T.2
Morimoto, R.I.3
-
105
-
-
59249106080
-
Integrating the stress response: Lessons for neurodegenerative diseases from C. elegans
-
Prahlad V, Morimoto RI. 2009. Integrating the stress response: Lessons for neurodegenerative diseases from C. elegans. Trends Cell Biol 19: 52-61.
-
(2009)
Trends Cell Biol
, vol.19
, pp. 52-61
-
-
Prahlad, V.1
Morimoto, R.I.2
-
106
-
-
0030925683
-
Steroid receptor interactions with heat shock protein and immunophilin chaperones
-
Pratt WB, Toft DO. 1997. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 18: 306-360.
-
(1997)
Endocr Rev
, vol.18
, pp. 306-360
-
-
Pratt, W.B.1
Toft, D.O.2
-
107
-
-
0037315208
-
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery
-
Pratt WB, Toft DO. 2003. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) 228: 111-133.
-
(2003)
Exp Biol Med (Maywood)
, vol.228
, pp. 111-133
-
-
Pratt, W.B.1
Toft, D.O.2
-
108
-
-
53149118242
-
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts
-
Pratt WB, Morishima Y, Osawa Y. 2008. The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem 283: 22885-22889.
-
(2008)
J Biol Chem
, vol.283
, pp. 22885-22889
-
-
Pratt, W.B.1
Morishima, Y.2
Osawa, Y.3
-
110
-
-
0037342270
-
Quantitating protein synthesis, degradation, and endogenous antigen processing
-
Princiotta MF, Finzi D, Qian SB, Gibbs J, Schuchmann S, Buttgereit F, Bennink JR, Yewdell JW. 2003. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity 18: 343-354.
-
(2003)
Immunity
, vol.18
, pp. 343-354
-
-
Princiotta, M.F.1
Finzi, D.2
Qian, S.B.3
Gibbs, J.4
Schuchmann, S.5
Buttgereit, F.6
Bennink, J.R.7
Yewdell, J.W.8
-
111
-
-
77956260496
-
mTORC1 links protein quality and quantity control by sensing chaperone availability
-
Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C. 2010. mTORC1 links protein quality and quantity control by sensing chaperone availability. J Biol Chem 285: 27385-27395.
-
(2010)
J Biol Chem
, vol.285
, pp. 27385-27395
-
-
Qian, S.B.1
Zhang, X.2
Sun, J.3
Bennink, J.R.4
Yewdell, J.W.5
Patterson, C.6
-
112
-
-
0037030713
-
Hsp90 as a capacitor of phenotypic variation
-
Queitsch C, Sangster TA, Lindquist S. 2002. Hsp90 as a capacitor of phenotypic variation. Nature 417: 618-624.
-
(2002)
Nature
, vol.417
, pp. 618-624
-
-
Queitsch, C.1
Sangster, T.A.2
Lindquist, S.3
-
113
-
-
23044445756
-
A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans
-
Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE. 2005. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet 37: 894-898.
-
(2005)
Nat Genet
, vol.37
, pp. 894-898
-
-
Rea, S.L.1
Wu, D.2
Cypser, J.R.3
Vaupel, J.W.4
Johnson, T.E.5
-
114
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
RonD, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
115
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford SL, Lindquist S. 1998. Hsp90 as a capacitor for morphological evolution. Nature 396: 336-342.
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
116
-
-
0035865322
-
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
-
Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, et al. 2001. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409: 928-933.
-
(2001)
Nature
, vol.409
, pp. 928-933
-
-
Sachidanandam, R.1
Weissman, D.2
Schmidt, S.C.3
Kakol, J.M.4
Stein, L.D.5
Marth, G.6
Sherry, S.7
Mullikin, J.C.8
Mortimore, B.J.9
Willey, D.L.10
-
117
-
-
34249853249
-
Network of general and specialty J protein chaperones of the yeast cytosol
-
Sahi C, Craig EA. 2007. Network of general and specialty J protein chaperones of the yeast cytosol. Proc Natl Acad Sci 104: 7163-7168.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 7163-7168
-
-
Sahi, C.1
Craig, E.A.2
-
118
-
-
78650479464
-
Mutational analysis of kinetic partitioning in protein folding and protein-DNA binding
-
Sanchez IE, Ferreiro DU, Gay Gde P. 2010. Mutational analysis of kinetic partitioning in protein folding and protein-DNA binding. Protein Eng Des Sel 24: 179-184.
-
(2010)
Protein Eng Des Sel
, vol.24
, pp. 179-184
-
-
Sanchez, I.E.1
Ferreiro, D.U.2
de Gay, G.P.3
-
119
-
-
0032911874
-
Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp
-
Santos MA, Cheesman C, Costa V, Moradas-Ferreira P, Tuite MF. 1999. Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp. Mol Microbiol 31: 937-947.
-
(1999)
Mol Microbiol
, vol.31
, pp. 937-947
-
-
Santos, M.A.1
Cheesman, C.2
Costa, V.3
Moradas-Ferreira, P.4
Tuite, M.F.5
-
120
-
-
0032031725
-
Molecular chaperones as HSF1-specific transcriptional repressors
-
Shi Y, Mosser DD, Morimoto RI. 1998. Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev 12: 654-666.
-
(1998)
Genes Dev
, vol.12
, pp. 654-666
-
-
Shi, Y.1
Mosser, D.D.2
Morimoto, R.I.3
-
121
-
-
0028426938
-
Kinetic partitioning during protein folding yields multiple native states
-
Sinclair JF, Ziegler MM, Baldwin TO. 1994. Kinetic partitioning during protein folding yields multiple native states. Nat Struct Biol 1: 320-326.
-
(1994)
Nat Struct Biol
, vol.1
, pp. 320-326
-
-
Sinclair, J.F.1
Ziegler, M.M.2
Baldwin, T.O.3
-
122
-
-
0032539619
-
The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP
-
Skowronek MH, Hendershot LM, Haas IG. 1998. The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP. Proc Natl Acad Sci 95: 1574-1578.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 1574-1578
-
-
Skowronek, M.H.1
Hendershot, L.M.2
Haas, I.G.3
-
123
-
-
0027447541
-
Steroid receptors and their associated proteins
-
Smith DF, Toft DO. 1993. Steroid receptors and their associated proteins. Mol Endocrinol 7: 4-11.
-
(1993)
Mol Endocrinol
, vol.7
, pp. 4-11
-
-
Smith, D.F.1
Toft, D.O.2
-
124
-
-
0028949615
-
Proteins and temperature
-
Somero GN. 1995. Proteins and temperature. Annu Rev Physiol 57: 43-68.
-
(1995)
Annu Rev Physiol
, vol.57
, pp. 43-68
-
-
Somero, G.N.1
-
125
-
-
0034745354
-
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth
-
Song J, Takeda M, Morimoto RI. 2001. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol 3: 276-282.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 276-282
-
-
Song, J.1
Takeda, M.2
Morimoto, R.I.3
-
126
-
-
0024282785
-
Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation
-
Sorger PK, Pelham HR. 1988. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54: 855-864.
-
(1988)
Cell
, vol.54
, pp. 855-864
-
-
Sorger, P.K.1
Pelham, H.R.2
-
127
-
-
0033215279
-
Pathogenic light chains and the B-cell repertoire
-
Stevens FJ, Argon Y. 1999a. Pathogenic light chains and the B-cell repertoire. Immunol Today 20: 451-457.
-
(1999)
Immunol Today
, vol.20
, pp. 451-457
-
-
Stevens, F.J.1
Argon, Y.2
-
129
-
-
2342519701
-
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure
-
Suckow J, Markiewicz P, Kleina LG, Miller J, Kisters-Woike B, Muller-Hill B. 1996. Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol 261: 509-523.
-
(1996)
J Mol Biol
, vol.261
, pp. 509-523
-
-
Suckow, J.1
Markiewicz, P.2
Kleina, L.G.3
Miller, J.4
Kisters-Woike, B.5
Muller-Hill, B.6
-
130
-
-
0023511826
-
Posttranscriptional regulation of hsp70 expression in human cells: Effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability
-
Theodorakis NG, Morimoto RI. 1987. Posttranscriptional regulation of hsp70 expression in human cells: Effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Mol Cell Biol 7: 4357-4368.
-
(1987)
Mol Cell Biol
, vol.7
, pp. 4357-4368
-
-
Theodorakis, N.G.1
Morimoto, R.I.2
-
131
-
-
0033521588
-
In vivo newly translated polypeptides are sequestered in a protected folding environment
-
Thulasiraman V, Yang CF, Frydman J. 1999. In vivo newly translated polypeptides are sequestered in a protected folding environment. EMBO J 18: 85-95.
-
(1999)
EMBO J
, vol.18
, pp. 85-95
-
-
Thulasiraman, V.1
Yang, C.F.2
Frydman, J.3
-
132
-
-
0037332128
-
Sequentialwaves of functionally related proteins are expressed when B cells prepare for antibody secretion
-
van Anken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R, Braakman I, Heck AJ. 2003. Sequentialwaves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 18: 243-253.
-
(2003)
Immunity
, vol.18
, pp. 243-253
-
-
van Anken, E.1
Romijn, E.P.2
Maggioni, C.3
Mezghrani, A.4
Sitia, R.5
Braakman, I.6
Heck, A.J.7
-
133
-
-
0033572725
-
Effects of macromolecular crowding on protein folding and aggregation
-
van den Berg B, Ellis RJ, Dobson CM. 1999. Effects of macromolecular crowding on protein folding and aggregation. EMBO J 18: 6927-6933.
-
(1999)
EMBO J
, vol.18
, pp. 6927-6933
-
-
van den Berg, B.1
Ellis, R.J.2
Dobson, C.M.3
-
134
-
-
0034254189
-
Macromolecular crowding perturbs protein refolding kinetics: Implications for folding inside the cell
-
van den Berg B, Wain R, Dobson CM, Ellis RJ. 2000. Macromolecular crowding perturbs protein refolding kinetics: Implications for folding inside the cell. EMBO J 19: 3870-3875.
-
(2000)
EMBO J
, vol.19
, pp. 3870-3875
-
-
van den Berg, B.1
Wain, R.2
Dobson, C.M.3
Ellis, R.J.4
-
135
-
-
0024439338
-
Demonstration by genetic suppression of interaction of GroE products with many proteins
-
Van Dyk TK, Gatenby AA, LaRossa RA. 1989. Demonstration by genetic suppression of interaction of GroE products with many proteins. Nature 342: 451-453.
-
(1989)
Nature
, vol.342
, pp. 451-453
-
-
van Dyk, T.K.1
Gatenby, A.A.2
LaRossa, R.A.3
-
136
-
-
84934440933
-
Chaperone regulation of the heat shock protein response
-
Voellmy R, Boellmann F. 2007. Chaperone regulation of the heat shock protein response. Adv Exp Med Biol 594: 89-99.
-
(2007)
Adv Exp Med Biol
, vol.594
, pp. 89-99
-
-
Voellmy, R.1
Boellmann, F.2
-
137
-
-
77955844171
-
Chaperone networks: Tipping the balance in protein folding diseases
-
Voisine C, Pedersen JS, Morimoto RI. 2010. Chaperone networks: Tipping the balance in protein folding diseases. Neurobiol Dis 40: 12-20.
-
(2010)
Neurobiol Dis
, vol.40
, pp. 12-20
-
-
Voisine, C.1
Pedersen, J.S.2
Morimoto, R.I.3
-
138
-
-
0033621681
-
Mice lacking HSP90β fail to develop a placental labyrinth
-
Voss AK, Thomas T, Gruss P. 2000. Mice lacking HSP90β fail to develop a placental labyrinth. Development 127: 1-11.
-
(2000)
Development
, vol.127
, pp. 1-11
-
-
Voss, A.K.1
Thomas, T.2
Gruss, P.3
-
139
-
-
34948853214
-
GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion
-
Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y. 2007. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell 18: 3764-3775.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 3764-3775
-
-
Wanderling, S.1
Simen, B.B.2
Ostrovsky, O.3
Ahmed, N.T.4
Vogen, S.M.5
Gidalevitz, T.6
Argon, Y.7
-
140
-
-
0026460892
-
Mammalian stress response: Cell physiology, structure/function of stress proteins, and implications for medicine and disease
-
Welch WJ. 1992. Mammalian stress response: Cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev 72: 1063-1081.
-
(1992)
Physiol Rev
, vol.72
, pp. 1063-1081
-
-
Welch, W.J.1
-
141
-
-
0022976650
-
Cellular and biochemical events in mammalian cells during and after recovery from physiological stress
-
Welch WJ, Suhan JP. 1986. Cellular and biochemical events in mammalian cells during and after recovery from physiological stress. J Cell Biol 103: 2035-2052.
-
(1986)
J Cell Biol
, vol.103
, pp. 2035-2052
-
-
Welch, W.J.1
Suhan, J.P.2
-
142
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI. 2009. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323: 1063-1066.
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens Jr., S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
143
-
-
0033520987
-
Posttranslational quality control: Folding, refolding, and degrading proteins
-
Wickner S, Maurizi MR, Gottesman S. 1999. Posttranslational quality control: Folding, refolding, and degrading proteins. Science 286: 1888-1893.
-
(1999)
Science
, vol.286
, pp. 1888-1893
-
-
Wickner, S.1
Maurizi, M.R.2
Gottesman, S.3
-
145
-
-
0029564954
-
Heat shock transcription factors: Structure and regulation
-
Wu C. 1995. Heat shock transcription factors: Structure and regulation. Annu Rev Cell Dev Biol 11: 441-469.
-
(1995)
Annu Rev Cell Dev Biol
, vol.11
, pp. 441-469
-
-
Wu, C.1
-
146
-
-
33644958967
-
Visualizing hidden heterogeneity in isogenic populations of C. elegans
-
WuD, Rea SL, Yashin AI, Johnson TE. 2006. Visualizing hidden heterogeneity in isogenic populations of C. elegans. Exp Gerontol 41: 261-270.
-
(2006)
Exp Gerontol
, vol.41
, pp. 261-270
-
-
Wu, D.1
Rea, S.L.2
Yashin, A.I.3
Johnson, T.E.4
-
147
-
-
0023666534
-
Purification and properties of Drosophila heat shock activator protein
-
Wu C, Wilson S, Walker B, Dawid I, Paisley T, Zimarino V, Ueda H. 1987. Purification and properties of Drosophila heat shock activator protein. Science 238: 1247-1253.
-
(1987)
Science
, vol.238
, pp. 1247-1253
-
-
Wu, C.1
Wilson, S.2
Walker, B.3
Dawid, I.4
Paisley, T.5
Zimarino, V.6
Ueda, H.7
-
148
-
-
33748304273
-
Dynamics of heat shock factor association with native gene loci in living cells
-
Yao J, Munson KM, Webb WW, Lis JT. 2006. Dynamics of heat shock factor association with native gene loci in living cells. Nature 442: 1050-1053.
-
(2006)
Nature
, vol.442
, pp. 1050-1053
-
-
Yao, J.1
Munson, K.M.2
Webb, W.W.3
Lis, J.T.4
-
149
-
-
0036196356
-
Heat shock changes the heterogeneity distribution in populations of Caenorhabditis elegans: Does it tell us anything about the biological mechanism of stress response?
-
Yashin AI, Cypser JW, Johnson TE, Michalski AI, Boyko SI, Novoseltsev VN. 2002. Heat shock changes the heterogeneity distribution in populations of Caenorhabditis elegans: Does it tell us anything about the biological mechanism of stress response? J Gerontol A Biol Sci Med Sci 57: B83-92.
-
(2002)
J Gerontol A Biol Sci Med Sci
, vol.57
, pp. 83-92
-
-
Yashin, A.I.1
Cypser, J.W.2
Johnson, T.E.3
Michalski, A.I.4
Boyko, S.I.5
Novoseltsev, V.N.6
-
151
-
-
0032560505
-
Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins
-
Zavodszky P, Kardos J, Svingor, Petsko GA. 1998. Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins. Proc Natl Acad Sci 95: 7406-7411.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 7406-7411
-
-
Zavodszky, P.1
Kardos, J.2
Svingor, P.G.A.3
-
152
-
-
20044382800
-
Navigating the chaperone network: An integrative map of physical and genetic interactions mediated by the hsp90 chaperone
-
Zhao R, Davey M, Hsu YC, Kaplanek P, Tong A, Parsons AB, Krogan N, Cagney G, Mai D, Greenblatt J, et al. 2005. Navigating the chaperone network: An integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 120: 715-727.
-
(2005)
Cell
, vol.120
, pp. 715-727
-
-
Zhao, R.1
Davey, M.2
Hsu, Y.C.3
Kaplanek, P.4
Tong, A.5
Parsons, A.B.6
Krogan, N.7
Cagney, G.8
Mai, D.9
Greenblatt, J.10
-
153
-
-
0032112367
-
Direct sensing of heat and oxidation by Drosophila heat shock transcription factor
-
Zhong M, Orosz A, Wu C. 1998. Direct sensing of heat and oxidation by Drosophila heat shock transcription factor. Mol Cell 2: 101-108.
-
(1998)
Mol Cell
, vol.2
, pp. 101-108
-
-
Zhong, M.1
Orosz, A.2
Wu, C.3
-
154
-
-
0023193610
-
Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis
-
Zimarino V, Wu C. 1987. Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis. Nature 327: 727-730.
-
(1987)
Nature
, vol.327
, pp. 727-730
-
-
Zimarino, V.1
Wu, C.2
-
155
-
-
0025014982
-
Complex modes of heat shock factor activation
-
Zimarino V, Tsai C, Wu C. 1990. Complex modes of heat shock factor activation. Mol Cell Biol 10: 752-759.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 752-759
-
-
Zimarino, V.1
Tsai, C.2
Wu, C.3
-
156
-
-
0032555685
-
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1
-
Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R. 1998. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 94: 471-480.
-
(1998)
Cell
, vol.94
, pp. 471-480
-
-
Zou, J.1
Guo, Y.2
Guettouche, T.3
Smith, D.F.4
Voellmy, R.5
|