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Volumn 70, Issue 4, 2011, Pages 264-280

Localization of MAP1-LC3 in vulnerable neurons and lewy bodies in brains of patients with dementia with lewy bodies

Author keywords

Synuclein; Autophagy; Dementia with Lewy bodies; Endosome; LC3; Lysosome

Indexed keywords

BRAIN PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 1A 1B LIGHT CHAIN 3; RAS RELATED PROTEIN RAB 7B; UNCLASSIFIED DRUG;

EID: 79953167820     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e318211c86a     Document Type: Article
Times cited : (54)

References (69)
  • 2
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger R, Kuhn W, Muller T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 1998;18:106-8
    • (1998) Nat Genet , vol.18 , pp. 106-8
    • Kruger, R.1    Kuhn, W.2    Muller, T.3
  • 5
    • 0035097503 scopus 로고    scopus 로고
    • Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr α-synuclein mutation
    • DOI 10.1002/ana.67
    • Spira PJ, Sharpe DM, Halliday G, et al. Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation. Ann Neurol 2001;49:313-19 (Pubitemid 32202784)
    • (2001) Annals of Neurology , vol.49 , Issue.3 , pp. 313-319
    • Spira, P.J.1    Sharpe, D.M.2    Halliday, G.3    Cavanagh, J.4    Nicholson, G.A.5
  • 8
    • 38149131788 scopus 로고    scopus 로고
    • Clinicopathologic study of an SNCA gene duplication patient with Parkinson disease and dementia
    • Obi T, Nishioka K, Ross OA, et al. Clinicopathologic study of an SNCA gene duplication patient with Parkinson disease and dementia. Neurology 2008;70:238-41
    • (2008) Neurology , vol.70 , pp. 238-41
    • Obi, T.1    Nishioka, K.2    Ross, O.A.3
  • 10
    • 38949139507 scopus 로고    scopus 로고
    • Conformational equilibria in mono-meric alpha-synuclein at the single-molecule level
    • Sandal M, Valle F, Tessari I, et al. Conformational equilibria in mono-meric alpha-synuclein at the single-molecule level. PLoS Biol 2008;6:e6
    • (2008) PLoS Biol , vol.6
    • Sandal, M.1    Valle, F.2    Tessari, I.3
  • 11
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
    • DOI 10.1038/3311
    • Conway KA, Harper JD, Lansbury PT. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 1998;4:1318-20 (Pubitemid 28512115)
    • (1998) Nature Medicine , vol.4 , Issue.11 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 13
    • 0033515471 scopus 로고    scopus 로고
    • Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation
    • Narhi L, Wood SJ, Steavenson S, et al. Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. J Biol Chem 1999;274: 9843-46
    • (1999) J Biol Chem , vol.274 , pp. 9843-46
    • Narhi, L.1    Wood, S.J.2    Steavenson, S.3
  • 14
    • 33748345432 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system and Parkinson's disease
    • DOI 10.1002/mds.21013
    • Olanow CW, McNaught KS. Ubiquitin-proteasome system and Parkinson's disease. Mov Disord 2006;21:1806-23 (Pubitemid 44856478)
    • (2006) Movement Disorders , vol.21 , Issue.11 , pp. 1806-1823
    • Olanow, C.W.1    McNaught, K.St.P.2
  • 16
    • 0032190090 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson's disease
    • Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson's disease. Nature 1998;395:451-52
    • (1998) Nature , vol.395 , pp. 451-52
    • Leroy, E.1    Boyer, R.2    Auburger, G.3
  • 17
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • Kirkin V, McEwan DG, Novak I, et al. A role for ubiquitin in selective autophagy. Mol Cell 2009;34:259-69
    • (2009) Mol Cell , vol.34 , pp. 259-69
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3
  • 20
    • 0035919837 scopus 로고    scopus 로고
    • Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
    • Kuusisto E, Salminen A, Alafuzoff I. Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synu-cleinopathies. Neuroreport 2001;12:2085-90 (Pubitemid 32646250)
    • (2001) NeuroReport , vol.12 , Issue.10 , pp. 2085-2090
    • Kuusisto, E.1    Salminen, A.2    Alafuzoff, I.3
  • 21
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-89
    • (2006) Nature , vol.441 , pp. 885-89
    • Hara, T.1    Nakamura, K.2    Matsui, M.3
  • 22
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006;441: 880-84
    • (2006) Nature , vol.441 , pp. 880-84
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3
  • 23
    • 0031036896 scopus 로고    scopus 로고
    • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
    • Anglade P, Vyas S, Javoy-Agid F, et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 1997;12:25-31 (Pubitemid 27106916)
    • (1997) Histology and Histopathology , vol.12 , Issue.1 , pp. 25-31
    • Anglade, P.1
  • 24
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
    • DOI 10.1126/science.1101738
    • Cuervo AM, Stefanis L, Fredenburg R, et al. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004; 305:1292-95 (Pubitemid 39129234)
    • (2004) Science , vol.305 , Issue.5688 , pp. 1292-1295
    • Cuervo, A.M.1    Stafanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 25
    • 1442275729 scopus 로고    scopus 로고
    • Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
    • DOI 10.1523/JNEUROSCI.3809-03.2004
    • Lee HJ, Khoshaghideh F, Patel S, et al. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci 2004;24:1888-96 (Pubitemid 38292800)
    • (2004) Journal of Neuroscience , vol.24 , Issue.8 , pp. 1888-1896
    • Lee, H.-J.1    Khoshaghideh, F.2    Patel, S.3    Lee, S.-J.4
  • 27
    • 39549117093 scopus 로고    scopus 로고
    • Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
    • DOI 10.1111/j.1471-4159.2008.05217.x
    • Plowey ED, Cherra SJ 3rd, Liu YJ, et al. Role of autophagy in G2019S-LRRK2Yassociated neurite shortening in differentiated SH-SY5Y cells. J Neurochem 2008;105:1048-56 (Pubitemid 351565713)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.3 , pp. 1048-1056
    • Plowey, E.D.1    Cherra III, S.J.2    Liu, Y.-J.3    Chu, C.T.4
  • 28
    • 33751256567 scopus 로고    scopus 로고
    • The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology
    • DOI 10.1016/j.neuron.2006.10.008, PII S0896627306008075
    • MacLeod D, Dowman J, Hammond R, et al. The familial parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 2006;52:587-93 (Pubitemid 44781171)
    • (2006) Neuron , vol.52 , Issue.4 , pp. 587-593
    • MacLeod, D.1    Dowman, J.2    Hammond, R.3    Leete, T.4    Inoue, K.5    Abeliovich, A.6
  • 30
    • 3242877218 scopus 로고    scopus 로고
    • Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
    • DOI 10.1242/jcs.01114
    • Gutierrez MG, Munafo DB, Beron W, et al. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004;117:2687-97 (Pubitemid 38997252)
    • (2004) Journal of Cell Science , vol.117 , Issue.13 , pp. 2687-2697
    • Gutierrez, M.G.1    Munafo, D.B.2    Beron, W.3    Colombo, M.I.4
  • 33
    • 33749150163 scopus 로고    scopus 로고
    • Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
    • DOI 10.1007/s00401-006-0127-z
    • Braak H, Alafuzoff I, Arzberger T, et al. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immuno-cytochemistry. Acta Neuropathol 2006;112:389-404 (Pubitemid 44469160)
    • (2006) Acta Neuropathologica , vol.112 , Issue.4 , pp. 389-404
    • Braak, H.1    Alafuzoff, I.2    Arzberger, T.3    Kretzschmar, H.4    Tredici, K.5
  • 35
    • 4344676234 scopus 로고    scopus 로고
    • Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease
    • Marui W, Iseki E, Kato M, et al. Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease. Acta Neuropathol 2004;108:121-28 (Pubitemid 39136297)
    • (2004) Acta Neuropathologica , vol.108 , Issue.2 , pp. 121-128
    • Marui, W.1    Iseki, E.2    Kato, M.3    Akatsu, H.4    Kosaka, K.5
  • 36
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997;18:S1-2
    • (1997) Neurobiol Aging , vol.18
  • 38
    • 53049101345 scopus 로고    scopus 로고
    • Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy
    • Kabuta T, Furuta A, Aoki S, et al. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem 2008;283:23731-38
    • (2008) J Biol Chem , vol.283 , pp. 23731-38
    • Kabuta, T.1    Furuta, A.2    Aoki, S.3
  • 39
    • 78651325259 scopus 로고    scopus 로고
    • GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation
    • Higashi S, Iseki E, Minegishi M, et al. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. J Neurochem 2010;115:423-37
    • (2010) J Neurochem , vol.115 , pp. 423-37
    • Higashi, S.1    Iseki, E.2    Minegishi, M.3
  • 41
    • 0001889963 scopus 로고
    • Some k-sample rank-order tests
    • Olkin I, Ghurye SG, Hoeffding H, Madow WG, Mann HB, eds Palo Alto, CA: Stanford University Press
    • Dwass M. Some k-sample rank-order tests. In: Olkin I, Ghurye SG, Hoeffding H, Madow WG, Mann HB, eds. Contributions to Probability and Statistics. Palo Alto, CA: Stanford University Press, 1960
    • (1960) Contributions to Probability and Statistics
    • Dwass, M.1
  • 42
    • 84946643368 scopus 로고
    • A rank sum test for comparing all pairs of treatments
    • Steel RGD. A rank sum test for comparing all pairs of treatments. Technometrics 1960;2:197-207
    • (1960) Technometrics , vol.2 , pp. 197-207
    • Rgd, S.1
  • 44
    • 33748754701 scopus 로고    scopus 로고
    • Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease
    • DOI 10.1111/j.1365-2990.2006.00756.x
    • Barrachina M, Maes T, Buesa C, et al. Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol 2006;32:505-16 (Pubitemid 44401512)
    • (2006) Neuropathology and Applied Neurobiology , vol.32 , Issue.5 , pp. 505-516
    • Barrachina, M.1    Maes, T.2    Buesa, C.3    Ferrer, I.4
  • 45
    • 0036174010 scopus 로고    scopus 로고
    • Alpha-synuclein is phos-phorylated in synucleinopathy lesions
    • Fujiwara H, Hasegawa M, Dohmae N, et al. Alpha-synuclein is phos-phorylated in synucleinopathy lesions. Nat Cell Biol 2002;4:160-64
    • (2002) Nat Cell Biol , vol.4 , pp. 160-64
    • Fujiwara, H.1    Hasegawa, M.2    Dohmae, N.3
  • 46
    • 1542283812 scopus 로고    scopus 로고
    • In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker
    • DOI 10.1091/mbc.E03-09-0704
    • Mizushima N, Yamamoto A, Matsui M, et al. In vivo analysis of au-tophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004;15: 1101-11 (Pubitemid 38316219)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.3 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 47
    • 0035706436 scopus 로고    scopus 로고
    • The cellular pathology of Parkinson's disease
    • DOI 10.1046/j.1440-1789.2001.00403.x
    • Takahashi H, Wakabayashi K. The cellular pathology of Parkinson's disease. Neuropathology 2001;21:315-22 (Pubitemid 34130639)
    • (2001) Neuropathology , vol.21 , Issue.4 , pp. 315-322
    • Takahashi, H.1    Wakabayashi, K.2
  • 48
    • 0017288256 scopus 로고
    • Ultrastructure of Lewy bodies in the stellate ganglion
    • Forno LS, Norville RL. Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol 1976;34:183-97
    • (1976) Acta Neuropathol , vol.34 , pp. 183-97
    • Forno, L.S.1    Norville, R.L.2
  • 49
    • 0017641210 scopus 로고
    • Dense core vesicles around the lewy body in incidental Parkinson's disease: an electron microscopic study
    • DOI 10.1007/BF00703325
    • Watanabe I, Vachal E, Tomita T. Dense core vesicles around the Lewy body in incidental Parkinson's disease: An electron microscopic study. Acta Neuropathol 1977;39:173-75 (Pubitemid 8153210)
    • (1977) Acta Neuropathologica , vol.39 , Issue.2 , pp. 173-175
    • Watanabe, I.1    Vachal, E.2    Tomita, T.3
  • 50
    • 38349160161 scopus 로고    scopus 로고
    • The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
    • Gitler AD, Bevis BJ, Shorter J, et al. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci USA 2008;105:145-50
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 145-50
    • Gitler, A.D.1    Bevis, B.J.2    Shorter, J.3
  • 51
    • 70349574622 scopus 로고    scopus 로고
    • Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in Lewy body disease
    • Higashi S, Moore DJ, Yamamoto R, et al. Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in Lewy body disease. J Neuropathol Exp Neurol 2009;68:994-1005
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 994-1005
    • Higashi, S.1    Moore, D.J.2    Yamamoto, R.3
  • 54
    • 46549089664 scopus 로고    scopus 로고
    • LRRK2 regulates synaptic vesicle endocytosis
    • Shin N, Jeong H, Kwon J, et al. LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res 2008;314:2055-65
    • (2008) Exp Cell Res , vol.314 , pp. 2055-65
    • Shin, N.1    Jeong, H.2    Kwon, J.3
  • 56
    • 70349991886 scopus 로고    scopus 로고
    • LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    • Alegre-Abarrategui J, Christian H, Lufino MM, et al. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 2009;18: 4022-34
    • (2009) Hum Mol Genet , vol.18 , pp. 4022-34
    • Alegre-Abarrategui, J.1    Christian, H.2    Lufino, M.M.3
  • 57
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF, et al. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183:795-803
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3
  • 58
    • 77952391573 scopus 로고    scopus 로고
    • GTPase activity plays a key role in the pathobiology of LRRK2
    • Xiong Y, Coombes CE, Kilaru A, et al. GTPase activity plays a key role in the pathobiology of LRRK2. PLoS Genet 2010;6:e1000902
    • (2010) PLoS Genet , vol.6
    • Xiong, Y.1    Coombes, C.E.2    Kilaru, A.3
  • 59
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T, Xilouri M, Vekrellis K, et al. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008;283:23542-56
    • (2008) J Biol Chem , vol.283 , pp. 23542-56
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3
  • 60
    • 77949504405 scopus 로고    scopus 로고
    • Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
    • Crews L, Spencer B, Desplats P, et al. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 2010;5:9313
    • (2010) PLoS One , vol.5 , pp. 9313
    • Crews, L.1    Spencer, B.2    Desplats, P.3
  • 61
    • 77956855813 scopus 로고    scopus 로고
    • Pathogenic lysosomal depletion in Parkinson's disease
    • Dehay B, Bove J, Rodriguez-Muela N, et al. Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci 2010;30:12535-44
    • (2010) J Neurosci , vol.30 , pp. 12535-44
    • Dehay, B.1    Bove, J.2    Rodriguez-Muela, N.3
  • 62
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • DOI 10.1038/nrm1666
    • Baehrecke EH. Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 2005;6:505-10 (Pubitemid 40780562)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 63
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • DOI 10.1038/nature05293, PII NATURE05293
    • Bredesen DE, Rao RV, Mehlen P. Cell death in the nervous system. Nature 2006;443:796-802 (Pubitemid 44622684)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 65
    • 41549114279 scopus 로고    scopus 로고
    • The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
    • Pan T, Kondo S, Le W, et al. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 2008;131: 1969-78
    • (2008) Brain , vol.131 , pp. 1969-78
    • Pan, T.1    Kondo, S.2    Le, W.3
  • 67
    • 38349046973 scopus 로고    scopus 로고
    • Autophagy, amyloidogenesis and Alzheimer disease
    • Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 2007;120:4081-91
    • (2007) J Cell Sci , vol.120 , pp. 4081-91
    • Nixon, R.A.1
  • 68
    • 77952362726 scopus 로고    scopus 로고
    • Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease
    • Ma JF, Huang Y, Chen SD, et al. Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease. Neuropathol Appl Neurobiol 2010;36:312-19
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 312-19
    • Ma, J.F.1    Huang, Y.2    Chen, S.D.3
  • 69
    • 70350759686 scopus 로고    scopus 로고
    • Pathogenesis of familial Parkinson's disease: New insights based on monogenic forms of Parkinson's disease
    • Hatano T, Kubo SI, Sato S, et al. Pathogenesis of familial Parkinson's disease: New insights based on monogenic forms of Parkinson's disease. J Neurochem 2009;111:1075-93
    • (2009) J Neurochem , vol.111 , pp. 1075-93
    • Hatano, T.1    Kubo, S.I.2    Sato, S.3


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