A single amino acid substitution differentiates Hsp70-dependent effects on α-synuclein degradation and toxicity

Biochemical and Biophysical Research Communications

Volumn 325, Issue 1, 2004, Pages 367-373

  Klucken, Jochen ^a   Shin, Youngah ^a   Hyman, Bradley T ^a   McLean, Pamela J ^a  

^a Massachusetts Gen H   (United States)

Author keywords

Chaperone; Dementia with Lewy bodies; Neurodegeneration; Parkinson's disease; Protein aggregation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALPHA SYNUCLEIN; HEAT SHOCK PROTEIN 70; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; TOXICITY; WILD TYPE;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; DROSOPHILA MELANOGASTER; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LEWY BODY DISEASE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SYNUCLEINS;

EID: 7444256611     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.10.037     Document Type: Article

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