-
1
-
-
0035502498
-
A new molecular target of insulin action: regulating the pivotal PDK1
-
Wick KL, Liu F. A new molecular target of insulin action: regulating the pivotal PDK1. Curr Drug Targets Immune, Endocr Metabol Disord. 2001;1:209–221.
-
(2001)
Curr Drug Targets Immune, Endocr Metabol Disord
, vol.1
, pp. 209-221
-
-
Wick, K.L.1
Liu, F.2
-
2
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Current biology : CB. 1997;7:261–269.
-
(1997)
Current biology : CB
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
-
3
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
Stokoe D, Stephens LR, Copeland T, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 1997;277:567–570.
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
-
4
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol. 2004;15:161–170.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
van Aalten, D.M.3
Alessi, D.R.4
-
5
-
-
79952110243
-
PDK1: the major transducer of PI 3-kinase actions
-
Bayascas JR. PDK1: the major transducer of PI 3-kinase actions. Curr Top Microbiol Immunol. 2010;346:9–29.
-
(2010)
Curr Top Microbiol Immunol
, vol.346
, pp. 9-29
-
-
Bayascas, J.R.1
-
6
-
-
84907195505
-
Acute regulation of PDK1 by a complex interplay of molecular switches
-
Calleja V, Laguerre M, de Las H-MG, Parker PJ, Requejo-Isidro J, Larijani B. Acute regulation of PDK1 by a complex interplay of molecular switches. Biochem Soc Trans. 2014;42:1435–1440.
-
(2014)
Biochem Soc Trans
, vol.42
, pp. 1435-1440
-
-
Calleja, V.1
Laguerre, M.2
de Las, H.-M.G.3
Parker, P.J.4
Requejo-Isidro, J.5
Larijani, B.6
-
7
-
-
84875960670
-
PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development
-
Venigalla RK, McGuire VA, Clarke R, et al. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. EMBO J. 2013;32:1008–1022.
-
(2013)
EMBO J
, vol.32
, pp. 1008-1022
-
-
Venigalla, R.K.1
McGuire, V.A.2
Clarke, R.3
-
8
-
-
0344270855
-
Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function
-
Lim MA, Kikani CK, Wick MJ, Dong LQ. Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. Proc Natl Acad Sci U S A. 2003;100:14006–14011.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14006-14011
-
-
Lim, M.A.1
Kikani, C.K.2
Wick, M.J.3
Dong, L.Q.4
-
9
-
-
27944467785
-
New”-clear functions of PDK1: beyond a master kinase in the cytosol?
-
Kikani CK, Dong LQ, Liu F. “New”-clear functions of PDK1: beyond a master kinase in the cytosol? J Cell Biochem. 2005;96:1157–1162.
-
(2005)
J Cell Biochem
, vol.96
, pp. 1157-1162
-
-
Kikani, C.K.1
Dong, L.Q.2
Liu, F.3
-
10
-
-
0035499454
-
Ten years of protein kinase B signalling: a hard Akt to follow
-
Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci. 2001;26:657–664.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
11
-
-
0035225023
-
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity
-
Avruch J, Belham C, Weng Q, Hara K, Yonezawa K. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog Mol Subcell Biol. 2001;26:115–154.
-
(2001)
Prog Mol Subcell Biol
, vol.26
, pp. 115-154
-
-
Avruch, J.1
Belham, C.2
Weng, Q.3
Hara, K.4
Yonezawa, K.5
-
12
-
-
0035856598
-
Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms
-
Lang F, Cohen P. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE. 2001;108:1–12.
-
(2001)
Sci STKE
, vol.108
, pp. 1-12
-
-
Lang, F.1
Cohen, P.2
-
13
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams MR, Arthur JS, Balendran A, et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol. 2000;10:439–448.
-
(2000)
Curr Biol
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.2
Balendran, A.3
-
14
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
-
Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J. 2003;370:361–371.
-
(2003)
Biochem J
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
15
-
-
84863877938
-
Perspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organisms
-
Dittrich AC, Devarenne TP. Perspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organisms. Plant Signal Behav. 2012;7:642–649.
-
(2012)
Plant Signal Behav
, vol.7
, pp. 642-649
-
-
Dittrich, A.C.1
Devarenne, T.P.2
-
16
-
-
38149076512
-
3-Phosphoinositide-dependent kinase 1 deficiency perturbs toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells
-
Zaru R, Mollahan P, Watts C. 3-Phosphoinositide-dependent kinase 1 deficiency perturbs toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells. J Biol Chem. 2008;283:929–939.
-
(2008)
J Biol Chem
, vol.283
, pp. 929-939
-
-
Zaru, R.1
Mollahan, P.2
Watts, C.3
-
17
-
-
84880436146
-
Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1
-
Jeong JJ, Kim B, Kim DH. Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1. Biol Pharm Bull. 2013;36:1088–1094.
-
(2013)
Biol Pharm Bull
, vol.36
, pp. 1088-1094
-
-
Jeong, J.J.1
Kim, B.2
Kim, D.H.3
-
18
-
-
84864384870
-
Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance
-
Kawano Y, Nakae J, Watanabe N, et al. Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes. 2012;61:1935–1948.
-
(2012)
Diabetes
, vol.61
, pp. 1935-1948
-
-
Kawano, Y.1
Nakae, J.2
Watanabe, N.3
-
19
-
-
77950629143
-
IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling
-
Furundzija V, Fritzsche J, Kaufmann J, et al. IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling. Biochem Biophys Res Commun. 2010;394:786–791.
-
(2010)
Biochem Biophys Res Commun
, vol.394
, pp. 786-791
-
-
Furundzija, V.1
Fritzsche, J.2
Kaufmann, J.3
-
20
-
-
84876775203
-
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
-
Hashimoto D, Chow A, Noizat C, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013;38:792–804.
-
(2013)
Immunity
, vol.38
, pp. 792-804
-
-
Hashimoto, D.1
Chow, A.2
Noizat, C.3
-
21
-
-
79955001101
-
Functional role of Akt in macrophage-mediated innate immunity
-
Lee YG, Lee J, Byeon SE, et al. Functional role of Akt in macrophage-mediated innate immunity. Front Biosci. 2011;16:517–530.
-
(2011)
Front Biosci
, vol.16
, pp. 517-530
-
-
Lee, Y.G.1
Lee, J.2
Byeon, S.E.3
-
22
-
-
84900014717
-
Macrophage plasticity in skeletal muscle repair
-
Rigamonti E, Zordan P, Sciorati C, Rovere-Querini P, Brunelli S. Macrophage plasticity in skeletal muscle repair. Biomed Res Int. 2014;2014:1–9
-
(2014)
Biomed Res Int
, vol.2014
, pp. 1-9
-
-
Rigamonti, E.1
Zordan, P.2
Sciorati, C.3
Rovere-Querini, P.4
Brunelli, S.5
-
23
-
-
84944734865
-
Dimethyl cardamonin exhibits anti-inflammatory effects via interfering with the PI3K-PDK1-PKCalpha signaling pathway
-
Yu WG, He H, Yao JY, Zhu YX, Lu YH. Dimethyl cardamonin exhibits anti-inflammatory effects via interfering with the PI3K-PDK1-PKCalpha signaling pathway. Biomol Ther (Seoul). 2015;23:549–556.
-
(2015)
Biomol Ther (Seoul)
, vol.23
, pp. 549-556
-
-
Yu, W.G.1
He, H.2
Yao, J.Y.3
Zhu, Y.X.4
Lu, Y.H.5
-
24
-
-
18844440663
-
Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes
-
Mosheimer BA, Kaneider NC, Feistritzer C, et al. Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes. J Clin Endocrinol Metab. 2005;90:2964–2971.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 2964-2971
-
-
Mosheimer, B.A.1
Kaneider, N.C.2
Feistritzer, C.3
-
25
-
-
84873390649
-
Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds
-
Chanput W, Mes JJ, Savelkoul HF, Wichers HJ. Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds. Food Funct. 2013;4:266–276.
-
(2013)
Food Funct
, vol.4
, pp. 266-276
-
-
Chanput, W.1
Mes, J.J.2
Savelkoul, H.F.3
Wichers, H.J.4
-
26
-
-
76149096253
-
Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens
-
Jin JH, Kim JS, Kang SS, Son KH, Chang HW, Kim HP. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. J Ethnopharmacol. 2010;127:589–595.
-
(2010)
J Ethnopharmacol
, vol.127
, pp. 589-595
-
-
Jin, J.H.1
Kim, J.S.2
Kang, S.S.3
Son, K.H.4
Chang, H.W.5
Kim, H.P.6
-
27
-
-
44949214708
-
Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells
-
Lee YG, Lee WM, Kim JY, et al. Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells. Br J Pharmacol. 2008;154:852–863.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 852-863
-
-
Lee, Y.G.1
Lee, W.M.2
Kim, J.Y.3
-
28
-
-
62149131518
-
Dual and beneficial roles of macrophages during skeletal muscle regeneration
-
Chazaud B, Brigitte M, Yacoub-Youssef H, et al. Dual and beneficial roles of macrophages during skeletal muscle regeneration. Exerc Sport Sci Rev. 2009;37:18–22.
-
(2009)
Exerc Sport Sci Rev
, vol.37
, pp. 18-22
-
-
Chazaud, B.1
Brigitte, M.2
Yacoub-Youssef, H.3
-
29
-
-
84893487976
-
Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9
-
Zajac E, Schweighofer B, Kupriyanova TA, et al. Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9. Blood. 2013;122:4054–4067.
-
(2013)
Blood
, vol.122
, pp. 4054-4067
-
-
Zajac, E.1
Schweighofer, B.2
Kupriyanova, T.A.3
-
30
-
-
84961325725
-
Brazilian red propolis attenuates inflammatory signaling cascade in LPS-activated macrophages
-
Bueno-Silva B, Kawamoto D, Ando-Suguimoto ES, Alencar SM, Rosalen PL, Mayer MP. Brazilian red propolis attenuates inflammatory signaling cascade in LPS-activated macrophages. PLoS One. 2015;10:1–14.
-
(2015)
PLoS One
, vol.10
, pp. 1-14
-
-
Bueno-Silva, B.1
Kawamoto, D.2
Ando-Suguimoto, E.S.3
Alencar, S.M.4
Rosalen, P.L.5
Mayer, M.P.6
-
31
-
-
84905987779
-
Response gene to complement 32 protein promotes macrophage phagocytosis via activation of protein kinase C pathway
-
Tang R, Zhang G, Chen SY. Response gene to complement 32 protein promotes macrophage phagocytosis via activation of protein kinase C pathway. J Biol Chem. 2014;289:22715–22722.
-
(2014)
J Biol Chem
, vol.289
, pp. 22715-22722
-
-
Tang, R.1
Zhang, G.2
Chen, S.Y.3
-
33
-
-
4243245597
-
Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity
-
Laskin DL, Fakhrzadeh L, Heck DE, Gerecke D, Laskin JD. Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity. Mol Cell Biochem. 2002;234-235:91–98.
-
(2002)
Mol Cell Biochem
, vol.234-235
, pp. 91-98
-
-
Laskin, D.L.1
Fakhrzadeh, L.2
Heck, D.E.3
Gerecke, D.4
Laskin, J.D.5
-
34
-
-
84939178397
-
Macrophage differentiation from monocytes is influenced by the lipid oxidation degree of low density lipoprotein
-
Seo JW, Yang EJ, Yoo KH, Choi IH. Macrophage differentiation from monocytes is influenced by the lipid oxidation degree of low density lipoprotein. Mediators Inflamm. 2015;2015:1–10.
-
(2015)
Mediators Inflamm
, vol.2015
, pp. 1-10
-
-
Seo, J.W.1
Yang, E.J.2
Yoo, K.H.3
Choi, I.H.4
-
35
-
-
66949179759
-
PI3K p110beta positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role
-
Utsugi M, Dobashi K, Ono A, et al. PI3K p110beta positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role. J Immunol. 2009;182:5225–5231.
-
(2009)
J Immunol
, vol.182
, pp. 5225-5231
-
-
Utsugi, M.1
Dobashi, K.2
Ono, A.3
-
36
-
-
77953509671
-
Regulatory effect of cinnamaldehyde on monocyte/macrophage-mediated inflammatory responses
-
Kim BH, Lee YG, Lee J, Lee JY, Cho JY. Regulatory effect of cinnamaldehyde on monocyte/macrophage-mediated inflammatory responses. Mediators Inflamm. 2010;2010:1–9.
-
(2010)
Mediators Inflamm
, vol.2010
, pp. 1-9
-
-
Kim, B.H.1
Lee, Y.G.2
Lee, J.3
Lee, J.Y.4
Cho, J.Y.5
-
37
-
-
84899546121
-
Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells
-
Xie S, Chen M, Yan B, He X, Chen X, Li D. Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. PLoS One. 2014;9:1–10.
-
(2014)
PLoS One
, vol.9
, pp. 1-10
-
-
Xie, S.1
Chen, M.2
Yan, B.3
He, X.4
Chen, X.5
Li, D.6
-
38
-
-
78650266432
-
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
-
Fan W, Morinaga H, Kim JJ, et al. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010;29:4223–4236.
-
(2010)
EMBO J
, vol.29
, pp. 4223-4236
-
-
Fan, W.1
Morinaga, H.2
Kim, J.J.3
-
39
-
-
70350539525
-
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages
-
Su D, Coudriet GM, Hyun Kim D, et al. FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes. 2009;58:2624–2633.
-
(2009)
Diabetes
, vol.58
, pp. 2624-2633
-
-
Su, D.1
Coudriet, G.M.2
Hyun Kim, D.3
-
40
-
-
23944486750
-
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
-
Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol. 2005;6:777–784.
-
(2005)
Nat Immunol
, vol.6
, pp. 777-784
-
-
Martin, M.1
Rehani, K.2
Jope, R.S.3
Michalek, S.M.4
-
41
-
-
23944499155
-
GSK3: an in-toll-erant protein kinase?
-
Woodgett JR, Ohashi PS. GSK3: an in-toll-erant protein kinase? Nat Immunol. 2005;6:751–752.
-
(2005)
Nat Immunol
, vol.6
, pp. 751-752
-
-
Woodgett, J.R.1
Ohashi, P.S.2
-
42
-
-
34548649547
-
Role of phosphoinositide 3-kinase in innate immunity
-
Hazeki K, Nigorikawa K, Hazeki O. Role of phosphoinositide 3-kinase in innate immunity. Biol Pharm Bull. 2007;30:1617–1623.
-
(2007)
Biol Pharm Bull
, vol.30
, pp. 1617-1623
-
-
Hazeki, K.1
Nigorikawa, K.2
Hazeki, O.3
-
43
-
-
57749101270
-
Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro
-
Tachado SD, Li X, Swan K, Patel N, Koziel H. Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro. J Biol Chem. 2008;283:33191–33198.
-
(2008)
J Biol Chem
, vol.283
, pp. 33191-33198
-
-
Tachado, S.D.1
Li, X.2
Swan, K.3
Patel, N.4
Koziel, H.5
-
44
-
-
0344950490
-
IL-10 synergistically enhances GM-CSF-induced CCR1 expression in myelomonocytic cells
-
Li H, Cheung W, Choo HH, Chan JH, Lai PS, Fred Wong WS. IL-10 synergistically enhances GM-CSF-induced CCR1 expression in myelomonocytic cells. Biochem Biophys Res Commun. 2003;304:417–424.
-
(2003)
Biochem Biophys Res Commun
, vol.304
, pp. 417-424
-
-
Li, H.1
Cheung, W.2
Choo, H.H.3
Chan, J.H.4
Lai, P.S.5
Fred Wong, W.S.6
-
45
-
-
84974659935
-
PDK1 in NF-kappaB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities
-
Hossen MJ, Cho JY, Kim D. PDK1 in NF-kappaB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities. J Ethnopharmacol. 2016;190:251–260.
-
(2016)
J Ethnopharmacol
, vol.190
, pp. 251-260
-
-
Hossen, M.J.1
Cho, J.Y.2
Kim, D.3
-
46
-
-
80051892393
-
CKD712, (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C
-
Oh YJ, Youn JH, Min HJ, et al. CKD712, (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C. Int Immunopharmacol. 2011;11:1160–1165.
-
(2011)
Int Immunopharmacol
, vol.11
, pp. 1160-1165
-
-
Oh, Y.J.1
Youn, J.H.2
Min, H.J.3
-
47
-
-
84940383819
-
The anti-inflammatory effect of algae-derived lipid extracts on lipopolysaccharide (LPS)-stimulated human THP-1 macrophages
-
Robertson RC, Guiheneuf F, Bahar B, et al. The anti-inflammatory effect of algae-derived lipid extracts on lipopolysaccharide (LPS)-stimulated human THP-1 macrophages. Mar Drugs. 2015;13:5402–5424.
-
(2015)
Mar Drugs
, vol.13
, pp. 5402-5424
-
-
Robertson, R.C.1
Guiheneuf, F.2
Bahar, B.3
-
48
-
-
84875511431
-
Dipterocarpus tuberculatus ethanol extract strongly suppresses in vitro macrophage-mediated inflammatory responses and in vivo acute gastritis
-
Yang WS, Lee BH, Kim SH, Kim HG, Yi YS, et al. Dipterocarpus tuberculatus ethanol extract strongly suppresses in vitro macrophage-mediated inflammatory responses and in vivo acute gastritis. J Ethnopharmacol. 2013;146:873–880.
-
(2013)
J Ethnopharmacol
, vol.146
, pp. 873-880
-
-
Yang, W.S.1
Lee, B.H.2
Kim, S.H.3
Kim, H.G.4
Yi, Y.S.5
-
49
-
-
84931386872
-
Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism
-
Tan Z, Xie N, Cui H, et al. Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol. 2015;194:6082–6089.
-
(2015)
J Immunol
, vol.194
, pp. 6082-6089
-
-
Tan, Z.1
Xie, N.2
Cui, H.3
-
50
-
-
84906997281
-
High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists
-
Al-Jarallah A, Chen X, Gonzalez L, Trigatti BL. High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. PLoS One. 2014;9:1–14.
-
(2014)
PLoS One
, vol.9
, pp. 1-14
-
-
Al-Jarallah, A.1
Chen, X.2
Gonzalez, L.3
Trigatti, B.L.4
-
51
-
-
70350560546
-
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
-
Fujisaka S, Usui I, Bukhari A, et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes. 2009;58:2574–2582.
-
(2009)
Diabetes
, vol.58
, pp. 2574-2582
-
-
Fujisaka, S.1
Usui, I.2
Bukhari, A.3
-
52
-
-
84970028181
-
HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
-
Semba H, Takeda N, Isagawa T, et al. HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:1–10.
-
(2016)
Nat Commun
, vol.7
, pp. 1-10
-
-
Semba, H.1
Takeda, N.2
Isagawa, T.3
-
53
-
-
84964495165
-
Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression
-
Meiser J, Kramer L, Sapcariu SC, et al. Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression. J Biol Chem. 2016;291:3932–3946.
-
(2016)
J Biol Chem
, vol.291
, pp. 3932-3946
-
-
Meiser, J.1
Kramer, L.2
Sapcariu, S.C.3
-
54
-
-
84900524942
-
Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment
-
Lovewell RR, Hayes SM, O'Toole GA, Berwin B. Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment. Am J Physiol Lung Cell Mol Physiol. 2014;306:L698–L707.
-
(2014)
Am J Physiol Lung Cell Mol Physiol
, vol.306
, pp. L698-L707
-
-
Lovewell, R.R.1
Hayes, S.M.2
O'Toole, G.A.3
Berwin, B.4
-
55
-
-
84886876102
-
Cross talk between the Akt and p38alpha pathways in macrophages downstream of toll-like receptor signaling
-
McGuire VA, Gray A, Monk CE, et al. Cross talk between the Akt and p38alpha pathways in macrophages downstream of toll-like receptor signaling. Mol Cell Biol. 2013;33:4152–4165.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4152-4165
-
-
McGuire, V.A.1
Gray, A.2
Monk, C.E.3
-
56
-
-
84926454260
-
Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages
-
Yoshida S, Gaeta I, Pacitto R, et al. Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages. Frontiers in physiology. 2015;6:1–9.
-
(2015)
Frontiers in physiology
, vol.6
, pp. 1-9
-
-
Yoshida, S.1
Gaeta, I.2
Pacitto, R.3
-
57
-
-
84865214853
-
A novel regulatory mechanism links PLCgamma1 to PDK1
-
Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M. A novel regulatory mechanism links PLCgamma1 to PDK1. J Cell Sci. 2012;125:3153–3163.
-
(2012)
J Cell Sci
, vol.125
, pp. 3153-3163
-
-
Raimondi, C.1
Chikh, A.2
Wheeler, A.P.3
Maffucci, T.4
Falasca, M.5
-
58
-
-
11144228631
-
The serine/threonine kinase Akt promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase
-
Ganesan LP, Wei G, Pengal RA, et al. The serine/threonine kinase Akt promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. J Biol Chem. 2004;279:54416–54425.
-
(2004)
J Biol Chem
, vol.279
, pp. 54416-54425
-
-
Ganesan, L.P.1
Wei, G.2
Pengal, R.A.3
-
59
-
-
84914670355
-
C5a stimulates the proliferation of breast cancer cells via Akt-dependent RGC-32 gene activation
-
Lu Y, Hu XB. C5a stimulates the proliferation of breast cancer cells via Akt-dependent RGC-32 gene activation. Oncol Rep. 2014;32:2817–2823.
-
(2014)
Oncol Rep
, vol.32
, pp. 2817-2823
-
-
Lu, Y.1
Hu, X.B.2
-
60
-
-
84906319549
-
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
-
Huang SC, Everts B, Ivanova Y, et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol. 2014;15:846–855.
-
(2014)
Nat Immunol
, vol.15
, pp. 846-855
-
-
Huang, S.C.1
Everts, B.2
Ivanova, Y.3
-
61
-
-
51349156218
-
Insulin sensitivity: modulation by nutrients and inflammation
-
Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008;118:2992–3002.
-
(2008)
J Clin Invest
, vol.118
, pp. 2992-3002
-
-
Schenk, S.1
Saberi, M.2
Olefsky, J.M.3
-
62
-
-
41649093318
-
Inflammatory mechanisms in the regulation of insulin resistance
-
Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med. 2008;14:222–231.
-
(2008)
Mol Med
, vol.14
, pp. 222-231
-
-
Tilg, H.1
Moschen, A.R.2
-
63
-
-
84886400216
-
Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance
-
Aroor AR, McKarns S, Demarco VG, Jia G, Sowers JR. Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance. Metabolism: Clinical and Experimental. 2013;62:1543–1552.
-
(2013)
Metabolism: Clinical and Experimental
, vol.62
, pp. 1543-1552
-
-
Aroor, A.R.1
McKarns, S.2
Demarco, V.G.3
Jia, G.4
Sowers, J.R.5
-
64
-
-
84864244872
-
Metabolic syndrome, insulin resistance, and roles of inflammation—mechanisms and therapeutic targets
-
Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation—mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol. 2012;32:1771–1776.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 1771-1776
-
-
Romeo, G.R.1
Lee, J.2
Shoelson, S.E.3
-
65
-
-
0034646633
-
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes
-
Zhao AZ, Shinohara MM, Huang D, et al. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem. 2000;275:11348–11354.
-
(2000)
J Biol Chem
, vol.275
, pp. 11348-11354
-
-
Zhao, A.Z.1
Shinohara, M.M.2
Huang, D.3
-
66
-
-
38349174747
-
Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism
-
Maya-Monteiro CM, Almeida PE, D'Avila H, et al. Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. J Biol Chem. 2008;283:2203–2210.
-
(2008)
J Biol Chem
, vol.283
, pp. 2203-2210
-
-
Maya-Monteiro, C.M.1
Almeida, P.E.2
D'Avila, H.3
-
67
-
-
47249142005
-
Leptin and mTOR: partners in metabolism and inflammation
-
Maya-Monteiro CM, Bozza PT. Leptin and mTOR: partners in metabolism and inflammation. Cell Cycle. 2008;7:1713–1717.
-
(2008)
Cell Cycle
, vol.7
, pp. 1713-1717
-
-
Maya-Monteiro, C.M.1
Bozza, P.T.2
-
68
-
-
84957812411
-
Saikosaponin-a attenuates oxidized LDL uptake and prompts cholesterol efflux in THP-1 cells
-
He D, Wang H, Xu L, et al. Saikosaponin-a attenuates oxidized LDL uptake and prompts cholesterol efflux in THP-1 cells. J Cardiovasc Pharmacol. 2016;67:510–518.
-
(2016)
J Cardiovasc Pharmacol
, vol.67
, pp. 510-518
-
-
He, D.1
Wang, H.2
Xu, L.3
-
69
-
-
84922689808
-
Nifedipine inhibits ox-LDL–induced lipid accumulation in human blood-derived macrophages
-
Zhang Q, Sha Ma AZ, Wang C, Tang WQ, Song ZY. Nifedipine inhibits ox-LDL–induced lipid accumulation in human blood-derived macrophages. Biochem Biophys Res Commun. 2015;457:440–444.
-
(2015)
Biochem Biophys Res Commun
, vol.457
, pp. 440-444
-
-
Zhang, Q.1
Sha Ma, A.Z.2
Wang, C.3
Tang, W.Q.4
Song, Z.Y.5
-
70
-
-
0037092038
-
Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
-
Villalba M, Bi K, Hu J, et al. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 2002;157:253–263.
-
(2002)
J Cell Biol
, vol.157
, pp. 253-263
-
-
Villalba, M.1
Bi, K.2
Hu, J.3
-
71
-
-
84979703587
-
Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages
-
Zheng H, Cui D, Quan X, et al. Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages. Biochem Biophys Res Commun. 2016;477:1017–1023.
-
(2016)
Biochem Biophys Res Commun
, vol.477
, pp. 1017-1023
-
-
Zheng, H.1
Cui, D.2
Quan, X.3
-
72
-
-
84855614902
-
Macrophages, meta-inflammation, and immuno-metabolism
-
Shapiro H, Lutaty A, Ariel A. Macrophages, meta-inflammation, and immuno-metabolism. ScientificWorldJournal. 2011;11:2509–2529.
-
(2011)
ScientificWorldJournal
, vol.11
, pp. 2509-2529
-
-
Shapiro, H.1
Lutaty, A.2
Ariel, A.3
|