-
1
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning BD, Cantley LC. 2007. AKT/PKB signaling: navigating downstream. Cell 129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
3
-
-
54949109808
-
PI3K/Akt: getting it right matters
-
Franke TF. 2008. PI3K/Akt: getting it right matters. Oncogene 27:6473-6488.
-
(2008)
Oncogene
, vol.27
, pp. 6473-6488
-
-
Franke, T.F.1
-
4
-
-
84857875585
-
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
-
So L, Fruman DA. 2012. PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem. J. 442:465-481.
-
(2012)
Biochem. J.
, vol.442
, pp. 465-481
-
-
So, L.1
Fruman, D.A.2
-
5
-
-
34548649547
-
Role of phosphoinositide 3-kinase in innate immunity
-
Hazeki K, Nigorikawa K, Hazeki O. 2007. Role of phosphoinositide 3-kinase in innate immunity. Biol. Pharm. Bull. 30:1617-1623.
-
(2007)
Biol. Pharm. Bull.
, vol.30
, pp. 1617-1623
-
-
Hazeki, K.1
Nigorikawa, K.2
Hazeki, O.3
-
6
-
-
79955001101
-
Functional role of Akt in macrophage-mediated innate immunity
-
Lee YG, Lee J, Byeon SE, Yoo DS, Kim MH, Lee SY, Cho JY. 2011. Functional role of Akt in macrophage-mediated innate immunity. Front. Biosci. 16:517-530.
-
(2011)
Front. Biosci.
, vol.16
, pp. 517-530
-
-
Lee, Y.G.1
Lee, J.2
Byeon, S.E.3
Yoo, D.S.4
Kim, M.H.5
Lee, S.Y.6
Cho, J.Y.7
-
7
-
-
0037629646
-
PI3K and negative regulation of TLR signaling
-
Fukao T, Koyasu S. 2003. PI3K and negative regulation of TLR signaling. Trends Immunol. 24:358-363.
-
(2003)
Trends Immunol
, vol.24
, pp. 358-363
-
-
Fukao, T.1
Koyasu, S.2
-
8
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, Kadowaki T, Takeuchi T, Koyasu S. 2002. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3:875-881.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 875-881
-
-
Fukao, T.1
Tanabe, M.2
Terauchi, Y.3
Ota, T.4
Matsuda, S.5
Asano, T.6
Kadowaki, T.7
Takeuchi, T.8
Koyasu, S.9
-
9
-
-
33644506745
-
Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt
-
Pengal RA, Ganesan LP, Wei G, Fang H, Ostrowski MC, Tridandapani S. 2006. Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt. Mol. Immunol. 43:1557-1564.
-
(2006)
Mol. Immunol.
, vol.43
, pp. 1557-1564
-
-
Pengal, R.A.1
Ganesan, L.P.2
Wei, G.3
Fang, H.4
Ostrowski, M.C.5
Tridandapani, S.6
-
10
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu S. 2003. The role of PI3K in immune cells. Nat. Immunol. 4:313-319.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
11
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. 2001. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 17:615-675.
-
(2001)
Annu. Rev. Cell Dev. Biol.
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
White, S.4
Timms, J.5
Waterfield, M.D.6
-
12
-
-
0035494493
-
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
-
Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. 2001. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J. Cell Biol. 155:19-25.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 19-25
-
-
Vieira, O.V.1
Botelho, R.J.2
Rameh, L.3
Brachmann, S.M.4
Matsuo, T.5
Davidson, H.W.6
Schreiber, A.7
Backer, J.M.8
Cantley, L.C.9
Grinstein, S.10
-
13
-
-
0032053709
-
Mechanisms and consequences of activation of protein kinase B/Akt
-
Downward J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10:262-267.
-
(1998)
Curr. Opin. Cell Biol.
, vol.10
, pp. 262-267
-
-
Downward, J.1
-
14
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
-
Chan TO, Rittenhouse SE, Tsichlis PN. 1999. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu. Rev. Biochem. 68:965-1014.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
15
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR. 2000. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10:439-448.
-
(2000)
Curr. Biol.
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.2
Balendran, A.3
van der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
-
16
-
-
2942563750
-
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
-
McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR. 2004. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J. 23:2071-2082.
-
(2004)
EMBO J.
, vol.23
, pp. 2071-2082
-
-
McManus, E.J.1
Collins, B.J.2
Ashby, P.R.3
Prescott, A.R.4
Murray-Tait, V.5
Armit, L.J.6
Arthur, J.S.7
Alessi, D.R.8
-
17
-
-
43249093752
-
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
-
Bayascas JR, Wullschleger S, Sakamoto K, Garcia-Martinez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR. 2008. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol. Cell. Biol. 28: 3258-3272.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3258-3272
-
-
Bayascas, J.R.1
Wullschleger, S.2
Sakamoto, K.3
Garcia-Martinez, J.M.4
Clacher, C.5
Komander, D.6
van Aalten, D.M.7
Boini, K.M.8
Lang, F.9
Lipina, C.10
Logie, L.11
Sutherland, C.12
Chudek, J.A.13
van Diepen, J.A.14
Voshol, P.J.15
Lucocq, J.M.16
Alessi, D.R.17
-
18
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:6541-6551.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
19
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343
-
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. 2001. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276:27462-27469.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Mawji, N.4
Deng, J.T.5
Leung, D.6
Yan, J.7
Sanghera, J.8
Walsh, M.P.9
Dedhar, S.10
-
20
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
Feng J, Park J, Cron P, Hess D, Hemmings BA. 2004. Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J. Biol. Chem. 279:41189-41196.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
21
-
-
2442562698
-
Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells
-
Partovian C, Simons M. 2004. Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells. Cell. Signal. 16:951-957.
-
(2004)
Cell. Signal.
, vol.16
, pp. 951-957
-
-
Partovian, C.1
Simons, M.2
-
22
-
-
20044390541
-
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
-
Viniegra JG, Martinez N, Modirassari P, Hernandez Losa J, Parada Cobo C, Sanchez-Arevalo Lobo VJ, Aceves Luquero CI, Alvarez-Vallina L, Ramon y Cajal S, Rojas JM, Sanchez-Prieto R. 2005. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J. Biol. Chem. 280:4029-4036.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4029-4036
-
-
Viniegra, J.G.1
Martinez, N.2
Modirassari, P.3
Hernandez Losa, J.4
Parada Cobo, C.5
Sanchez-Arevalo Lobo, V.J.6
Aceves Luquero, C.I.7
Alvarez-Vallina, L.8
Ramon y Cajal, S.9
Rojas, J.M.10
Sanchez-Prieto, R.11
-
23
-
-
23044467856
-
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle
-
doi:10.1152/ajpendo.00011.2005
-
Dong LQ, Liu F. 2005. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. Am. J. Physiol. Endocrinol. Metab. 289: E187-E196. doi:10.1152/ajpendo.00011.2005.
-
(2005)
Am. J. Physiol. Endocrinol. Metab
, vol.289
-
-
Dong, L.Q.1
Liu, F.2
-
24
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
25
-
-
28844434558
-
mTOR. RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko RC, Mueckler M. 2005. mTOR. RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280:40406-40416.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
26
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22:159-168.
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
27
-
-
33748950810
-
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
-
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11:583-589.
-
(2006)
Dev. Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
28
-
-
37549000623
-
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
-
Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC, Jr. 2008. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity. Mol. Cell. Biol. 28:61-70.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 61-70
-
-
Kumar, A.1
Harris, T.E.2
Keller, S.R.3
Choi, K.M.4
Magnuson, M.A.5
Lawrence Jr., J.C.6
-
29
-
-
33244471768
-
MAPKAP kinases-MKs-two's company, three's a crowd
-
Gaestel M. 2006. MAPKAP kinases-MKs-two's company, three's a crowd. Nat. Rev. Mol. Cell Biol. 7:120-130.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 120-130
-
-
Gaestel, M.1
-
30
-
-
0032533546
-
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
-
Shaw M, Cohen P, Alessi DR. 1998. The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J. 336(Part 1):241-246.
-
(1998)
Biochem. J.
, vol.336
, Issue.PART 1
, pp. 241-246
-
-
Shaw, M.1
Cohen, P.2
Alessi, D.R.3
-
31
-
-
0035793574
-
p38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
-
Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR. 2001. p38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J. Biol. Chem. 276:3517-3523.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3517-3523
-
-
Rane, M.J.1
Coxon, P.Y.2
Powell, D.W.3
Webster, R.4
Klein, J.B.5
Pierce, W.6
Ping, P.7
McLeish, K.R.8
-
32
-
-
3242677091
-
Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells
-
doi:10.1152/ajpcell.00439.2003
-
Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, Weber DS, Alexander RW, Griendling KK. 2004. Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 287:C494-C499. doi:10.1152/ajpcell.00439.2003.
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.287
-
-
Taniyama, Y.1
Ushio-Fukai, M.2
Hitomi, H.3
Rocic, P.4
Kingsley, M.J.5
Pfahnl, C.6
Weber, D.S.7
Alexander, R.W.8
Griendling, K.K.9
-
33
-
-
34547588567
-
-
Wu R, Kausar H, Johnson P, Montoya-Durango DE, Merchant M, Rane MJ. 2007. Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. J. Biol. Chem. 282:21598-21608.
-
(2007)
, vol.282
, pp. 21598-21608
-
-
Wu, R.1
Kausar, H.2
Johnson, P.3
Montoya-Durango, D.E.4
Merchant, M.5
Rane, M.J.6
-
34
-
-
35548930283
-
The MAPKactivated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
-
Zaru R, Ronkina N, Gaestel M, Arthur JS, Watts C. 2007. The MAPKactivated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat. Immunol. 8:1227-1235.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1227-1235
-
-
Zaru, R.1
Ronkina, N.2
Gaestel, M.3
Arthur, J.S.4
Watts, C.5
-
35
-
-
36849034334
-
Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation
-
O'Keefe SJ, Mudgett JS, Cupo S, Parsons JN, Chartrain NA, Fitzgerald C, Chen SL, Lowitz K, Rasa C, Visco D, Luell S, Carballo-Jane E, Owens K, Zaller DM. 2007. Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation. J. Biol. Chem. 282:34663-34671.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34663-34671
-
-
O'Keefe, S.J.1
Mudgett, J.S.2
Cupo, S.3
Parsons, J.N.4
Chartrain, N.A.5
Fitzgerald, C.6
Chen, S.L.7
Lowitz, K.8
Rasa, C.9
Visco, D.10
Luell, S.11
Carballo-Jane, E.12
Owens, K.13
Zaller, D.M.14
-
36
-
-
0037099658
-
Essential role of PDK1 in regulating cell size and development in mice
-
Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR. 2002. Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 21:3728-3738.
-
(2002)
EMBO J
, vol.21
, pp. 3728-3738
-
-
Lawlor, M.A.1
Mora, A.2
Ashby, P.R.3
Williams, M.R.4
Murray-Tait, V.5
Malone, L.6
Prescott, A.R.7
Lucocq, J.M.8
Alessi, D.R.9
-
37
-
-
84861719535
-
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
-
Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M. 2012. Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J. Exp. Med. 209:713-728.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 713-728
-
-
Lee, K.1
Nam, K.T.2
Cho, S.H.3
Gudapati, P.4
Hwang, Y.5
Park, D.S.6
Potter, R.7
Chen, J.8
Volanakis, E.9
Boothby, M.10
-
38
-
-
0037332003
-
Transgenic mice with hematopoietic and lymphoid specific expression of Cre
-
de Boer J, Williams A, Skavdis G, Harker N, Coles M, Tolaini M, Norton T, Williams K, Roderick K, Potocnik AJ, Kioussis D. 2003. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur. J. Immunol. 33:314-325.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 314-325
-
-
de Boer, J.1
Williams, A.2
Skavdis, G.3
Harker, N.4
Coles, M.5
Tolaini, M.6
Norton, T.7
Williams, K.8
Roderick, K.9
Potocnik, A.J.10
Kioussis, D.11
-
39
-
-
27944461325
-
Generation and characterization of p38beta (MAPK11) gene-targeted mice
-
Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Armaka M, Darragh J, McIlrath J, Carr JM, Armit LJ, Clacher C, Malone L, Kollias G, Arthur JS. 2005. Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol. Cell. Biol. 25:10454-10464.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10454-10464
-
-
Beardmore, V.A.1
Hinton, H.J.2
Eftychi, C.3
Apostolaki, M.4
Armaka, M.5
Darragh, J.6
McIlrath, J.7
Carr, J.M.8
Armit, L.J.9
Clacher, C.10
Malone, L.11
Kollias, G.12
Arthur, J.S.13
-
40
-
-
77953262646
-
The phosphoproteome of toll-like receptor-activated macrophages
-
doi:10.1038/msb.2010.29
-
Weintz G, Olsen JV, Fruhauf K, Niedzielska M, Amit I, Jantsch J, Mages J, Frech C, Dolken L, Mann M, Lang R. 2010. The phosphoproteome of toll-like receptor-activated macrophages. Mol. Syst. Biol. 6:371. doi:10.1038/msb.2010.29.
-
(2010)
Mol. Syst. Biol.
, vol.6
-
-
Weintz, G.1
Olsen, J.V.2
Fruhauf, K.3
Niedzielska, M.4
Amit, I.5
Jantsch, J.6
Mages, J.7
Frech, C.8
Dolken, L.9
Mann, M.10
Lang, R.11
-
41
-
-
0032055131
-
-
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR. 1998. Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem. J. 331(Part 1):299-308.
-
(1998)
, vol.331
, Issue.PART 1
, pp. 299-308
-
-
Walker, K.S.1
Deak, M.2
Paterson, A.3
Hudson, K.4
Cohen, P.5
Alessi, D.R.6
-
42
-
-
35048897386
-
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2
-
Batty IH, van der Kaay J, Gray A, Telfer JF, Dixon MJ, Downes CP. 2007. The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. Biochem. J. 407:255-266.
-
(2007)
SHIP2. Biochem. J.
, vol.407
, pp. 255-266
-
-
Batty, I.H.1
van der Kaay, J.2
Gray, A.3
Telfer, J.F.4
Dixon, M.J.5
Downes, C.P.6
-
43
-
-
1542314814
-
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
-
Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR. 2004. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem. J. 378:257-268.
-
(2004)
Biochem. J.
, vol.378
, pp. 257-268
-
-
Vitari, A.C.1
Deak, M.2
Collins, B.J.3
Morrice, N.4
Prescott, A.R.5
Phelan, A.6
Humphreys, S.7
Alessi, D.R.8
-
44
-
-
0037442448
-
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
-
Gray A, Olsson H, Batty IH, Priganica L, Downes CP. 2003. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts. Anal. Biochem. 313:234-245.
-
(2003)
Anal. Biochem.
, vol.313
, pp. 234-245
-
-
Gray, A.1
Olsson, H.2
Batty, I.H.3
Priganica, L.4
Downes, C.P.5
-
45
-
-
0031053360
-
Akt signaling: linking membrane events to life and death decisions
-
Hemmings BA. 1997. Akt signaling: linking membrane events to life and death decisions. Science 275:628-630.
-
(1997)
Science
, vol.275
, pp. 628-630
-
-
Hemmings, B.A.1
-
46
-
-
36549040859
-
The selectivity of protein kinase inhibitors: a further update
-
Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. 2007. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 408:297-315.
-
(2007)
Biochem. J.
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
Shpiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
-
47
-
-
52449106253
-
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-t hieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
-
Folkes AJ, Ahmadi K, Alderton WK, Alix S, Baker SJ, Box G, Chuckowree IS, Clarke PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendradas A, Lensun L, Moore P, Olivero AG, Pang J, Patel S, Pergl-Wilson GH, Raynaud FI, Robson A, Saghir N, Salphati L, Sohal S, Ultsch MH, Valenti M, Wallweber HJ, Wan NC, Wiesmann C, Workman P, Zhyvoloup A, Zvelebil MJ, Shuttleworth SJ. 2008. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-t hieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J. Med. Chem. 51:5522-5532.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5522-5532
-
-
Folkes, A.J.1
Ahmadi, K.2
Alderton, W.K.3
Alix, S.4
Baker, S.J.5
Box, G.6
Chuckowree, I.S.7
Clarke, P.A.8
Depledge, P.9
Eccles, S.A.10
Friedman, L.S.11
Hayes, A.12
Hancox, T.C.13
Kugendradas, A.14
Lensun, L.15
Moore, P.16
Olivero, A.G.17
Pang, J.18
Patel, S.19
Pergl-Wilson, G.H.20
Raynaud, F.I.21
Robson, A.22
Saghir, N.23
Salphati, L.24
Sohal, S.25
Ultsch, M.H.26
Valenti, M.27
Wallweber, H.J.28
Wan, N.C.29
Wiesmann, C.30
Workman, P.31
Zhyvoloup, A.32
Zvelebil, M.J.33
Shuttleworth, S.J.34
more..
-
48
-
-
83255162603
-
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors
-
Yap TA, Yan L, Patnaik A, Fearen I, Olmos D, Papadopoulos K, Baird RD, Delgado L, Taylor A, Lupinacci L, Riisnaes R, Pope LL, Heaton SP, Thomas G, Garrett MD, Sullivan DM, de Bono JS, Tolcher AW. 2011. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J. Clin. Oncol. 29:4688-4695.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 4688-4695
-
-
Yap, T.A.1
Yan, L.2
Patnaik, A.3
Fearen, I.4
Olmos, D.5
Papadopoulos, K.6
Baird, R.D.7
Delgado, L.8
Taylor, A.9
Lupinacci, L.10
Riisnaes, R.11
Pope, L.L.12
Heaton, S.P.13
Thomas, G.14
Garrett, M.D.15
Sullivan, D.M.16
de Bono, J.S.17
Tolcher, A.W.18
-
49
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
-
Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. 2006. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125:733-747.
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
Zunder, E.R.4
Goldenberg, D.D.5
Williams, O.6
Loewith, R.7
Stokoe, D.8
Balla, A.9
Toth, B.10
Balla, T.11
Weiss, W.A.12
Williams, R.L.13
Shokat, K.M.14
-
50
-
-
33845807361
-
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
-
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB. 2007. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol. Cell. Biol. 27:170-181.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 170-181
-
-
Ronkina, N.1
Kotlyarov, A.2
Dittrich-Breiholz, O.3
Kracht, M.4
Hitti, E.5
Milarski, K.6
Askew, R.7
Marusic, S.8
Lin, L.L.9
Gaestel, M.10
Telliez, J.B.11
-
51
-
-
77952334511
-
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation
-
Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ, Schindler JF, South SA, Webb EG, Zhang J, Anderson DR. 2010. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J. Pharmacol. Exp. Ther. 333:797-807.
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.333
, pp. 797-807
-
-
Mourey, R.J.1
Burnette, B.L.2
Brustkern, S.J.3
Daniels, J.S.4
Hirsch, J.L.5
Hood, W.F.6
Meyers, M.J.7
Mnich, S.J.8
Pierce, B.S.9
Saabye, M.J.10
Schindler, J.F.11
South, S.A.12
Webb, E.G.13
Zhang, J.14
Anderson, D.R.15
-
52
-
-
34250318956
-
Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling
-
Alford KA, Glennie S, Turrell BR, Rawlinson L, Saklatvala J, Dean JL. 2007. Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. J. Biol. Chem. 282:6232-6241.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6232-6241
-
-
Alford, K.A.1
Glennie, S.2
Turrell, B.R.3
Rawlinson, L.4
Saklatvala, J.5
Dean, J.L.6
-
53
-
-
33846312875
-
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
-
Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M, Cohen P, Alessi DR. 2007. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem. J. 401:29-38.
-
(2007)
Biochem. J.
, vol.401
, pp. 29-38
-
-
Sapkota, G.P.1
Cummings, L.2
Newell, F.S.3
Armstrong, C.4
Bain, J.5
Frodin, M.6
Grauert, M.7
Hoffmann, M.8
Schnapp, G.9
Steegmaier, M.10
Cohen, P.11
Alessi, D.R.12
-
54
-
-
0038558249
-
Collaborative induction of inflammatory responses by dectin-1 and Tolllike receptor 2
-
Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. 2003. Collaborative induction of inflammatory responses by dectin-1 and Tolllike receptor 2. J. Exp. Med. 197:1107-1117.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1107-1117
-
-
Gantner, B.N.1
Simmons, R.M.2
Canavera, S.J.3
Akira, S.4
Underhill, D.M.5
-
55
-
-
84875323963
-
Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers
-
doi:10.1371/journal.pone.0060086 e60086
-
Elcombe SE, Naqvi S, Van Den Bosch MW, MacKenzie KF, Cianfanelli F, Brown GD, Arthur JS. 2013. Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS One 8:e60086. doi:10.1371/journal.pone.0060086.
-
(2013)
PLoS One
, vol.8
-
-
Elcombe, S.E.1
Naqvi, S.2
Van Den Bosch, M.W.3
MacKenzie, K.F.4
Cianfanelli, F.5
Brown, G.D.6
Arthur, J.S.7
-
56
-
-
42149110310
-
Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264. 7 cells
-
Tsukamoto K, Hazeki K, Hoshi M, Nigorikawa K, Inoue N, Sasaki T, Hazeki O. 2008. Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J. Immunol. 180: 2054-2061.
-
(2008)
J. Immunol.
, vol.180
, pp. 2054-2061
-
-
Tsukamoto, K.1
Hazeki, K.2
Hoshi, M.3
Nigorikawa, K.4
Inoue, N.5
Sasaki, T.6
Hazeki, O.7
-
57
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP. 2000. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
58
-
-
33846000629
-
MAPKactivated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27
-
Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H, Shen X. 2006. MAPKactivated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27. J. Biol. Chem. 281:37215-37226.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 37215-37226
-
-
Zheng, C.1
Lin, Z.2
Zhao, Z.J.3
Yang, Y.4
Niu, H.5
Shen, X.6
-
59
-
-
84875960670
-
PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development
-
Venigalla RK, McGuire VA, Clarke R, Patterson-Kane JC, Najafov A, Toth R, McCarthy PC, Simeons F, Stojanovski L, Arthur JS. 2013. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. EMBO J. 32:1008-1022.
-
(2013)
EMBO J
, vol.32
, pp. 1008-1022
-
-
Venigalla, R.K.1
McGuire, V.A.2
Clarke, R.3
Patterson-Kane, J.C.4
Najafov, A.5
Toth, R.6
McCarthy, P.C.7
Simeons, F.8
Stojanovski, L.9
Arthur, J.S.10
-
60
-
-
67650312583
-
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
-
García-Martínez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM, Alessi DR. 2009. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem. J. 421:29-42.
-
(2009)
Biochem. J.
, vol.421
, pp. 29-42
-
-
García-Martínez, J.M.1
Moran, J.2
Clarke, R.G.3
Gray, A.4
Cosulich, S.C.5
Chresta, C.M.6
Alessi, D.R.7
-
61
-
-
84866887471
-
P38alpha negatively regulates T helper type 2 responses by orchestrating multiple TCR-associated signals
-
doi:10.1074/jbc. M112.355594
-
Hu P, Nebreda AR, Liu Y, Carlesso N, Kaplan M, Kapur R. 2012. P38alpha negatively regulates T helper type 2 responses by orchestrating multiple TCR-associated signals. J. Biol. Chem. doi:10.1074/jbc. M112.355594.
-
(2012)
J. Biol. Chem
-
-
Hu, P.1
Nebreda, A.R.2
Liu, Y.3
Carlesso, N.4
Kaplan, M.5
Kapur, R.6
-
62
-
-
0037352702
-
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
-
Ojaniemi M, GlumoffV, Harju K, Liljeroos M, Vuori K, Hallman M. 2003. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 33:597-605.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 597-605
-
-
Ojaniemi, M.1
Glumoff, V.2
Harju, K.3
Liljeroos, M.4
Vuori, K.5
Hallman, M.6
-
63
-
-
67149121074
-
TLR4/MyD88/PI3K interactions regulate TLR4 signaling
-
Laird MH, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, Vogel SN. 2009. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J. Leukoc. Biol. 85:966-977.
-
(2009)
J. Leukoc. Biol.
, vol.85
, pp. 966-977
-
-
Laird, M.H.1
Rhee, S.H.2
Perkins, D.J.3
Medvedev, A.E.4
Piao, W.5
Fenton, M.J.6
Vogel, S.N.7
-
64
-
-
0034577944
-
Toll-like receptor 2-mediated NFkappa B activation requires a Rac1-dependent pathway
-
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG. 2000. Toll-like receptor 2-mediated NFkappa B activation requires a Rac1-dependent pathway. Nat. Immunol. 1:533-540.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 533-540
-
-
Arbibe, L.1
Mira, J.P.2
Teusch, N.3
Kline, L.4
Guha, M.5
Mackman, N.6
Godowski, P.J.7
Ulevitch, R.J.8
Knaus, U.G.9
-
65
-
-
7544225495
-
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
-
Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. 2004. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat. Struct. Mol. Biol. 11:1060-1067.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 1060-1067
-
-
Sarkar, S.N.1
Peters, K.L.2
Elco, C.P.3
Sakamoto, S.4
Pal, S.5
Sen, G.C.6
-
66
-
-
33846122035
-
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4_T cells and enables CpG oligodeoxynucleotide-mediated costimulation
-
Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA. 2006. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4_T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 25:783-793.
-
(2006)
Immunity
, vol.25
, pp. 783-793
-
-
Gelman, A.E.1
LaRosa, D.F.2
Zhang, J.3
Walsh, P.T.4
Choi, Y.5
Sunyer, J.O.6
Turka, L.A.7
-
67
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
-
Kagan JC, Medzhitov R. 2006. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125:943-955.
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
68
-
-
70349763941
-
Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages
-
Tamura N, Hazeki K, Okazaki N, Kametani Y, Murakami H, Takaba Y, Ishikawa Y, Nigorikawa K, Hazeki O. 2009. Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages. Biochem. J. 423:99-108.
-
(2009)
Biochem. J.
, vol.423
, pp. 99-108
-
-
Tamura, N.1
Hazeki, K.2
Okazaki, N.3
Kametani, Y.4
Murakami, H.5
Takaba, Y.6
Ishikawa, Y.7
Nigorikawa, K.8
Hazeki, O.9
-
69
-
-
84867713025
-
The p110delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
-
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V, Vanhaesebroeck B. 2012. The p110delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat. Immunol. 13:1045-1054.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 1045-1054
-
-
Aksoy, E.1
Taboubi, S.2
Torres, D.3
Delbauve, S.4
Hachani, A.5
Whitehead, M.A.6
Pearce, W.P.7
Berenjeno-Martin, I.8
Nock, G.9
Filloux, A.10
Beyaert, R.11
Flamand, V.12
Vanhaesebroeck, B.13
-
70
-
-
2942700196
-
Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP
-
Fang H, Pengal RA, Cao X, Ganesan LP, Wewers MD, Marsh CB, Tridandapani S. 2004. Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. J. Immunol. 173:360-366.
-
(2004)
J. Immunol.
, vol.173
, pp. 360-366
-
-
Fang, H.1
Pengal, R.A.2
Cao, X.3
Ganesan, L.P.4
Wewers, M.D.5
Marsh, C.B.6
Tridandapani, S.7
-
71
-
-
1842424697
-
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages
-
Cao X, Wei G, Fang H, Guo J, Weinstein M, Marsh CB, Ostrowski MC, Tridandapani S. 2004. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J. Immunol. 172:4851-4857.
-
(2004)
J. Immunol.
, vol.172
, pp. 4851-4857
-
-
Cao, X.1
Wei, G.2
Fang, H.3
Guo, J.4
Weinstein, M.5
Marsh, C.B.6
Ostrowski, M.C.7
Tridandapani, S.8
-
72
-
-
0345097326
-
SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide
-
Sly LM, Rauh MJ, KalesnikoffJ, Buchse T, Krystal G. 2003. SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp. Hematol. 31:1170-1181.
-
(2003)
Exp. Hematol.
, vol.31
, pp. 1170-1181
-
-
Sly, L.M.1
Rauh, M.J.2
Kalesnikoff, J.3
Buchse, T.4
Krystal, G.5
-
73
-
-
0142137134
-
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
-
Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP. 2003. Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J. 22:5501-5510.
-
(2003)
EMBO J
, vol.22
, pp. 5501-5510
-
-
Leslie, N.R.1
Bennett, D.2
Lindsay, Y.E.3
Stewart, H.4
Gray, A.5
Downes, C.P.6
-
74
-
-
84875498622
-
MK2 regulates Ras oncogenesis through stimulating ROS production
-
Kobayashi Y, Qi X, Chen G. 2012. MK2 regulates Ras oncogenesis through stimulating ROS production. Genes Cancer 3:521-530.
-
(2012)
Genes Cancer
, vol.3
, pp. 521-530
-
-
Kobayashi, Y.1
Qi, X.2
Chen, G.3
-
75
-
-
79957553362
-
Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: implications for NO synthase 2 expression
-
López-Pelaez M, Soria-Castro I, Bosca L, Fernandez M, Alemany S. 2011. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: implications for NO synthase 2 expression. Eur. J. Immunol. 41:1733-1741.
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 1733-1741
-
-
López-Pelaez, M.1
Soria-Castro, I.2
Bosca, L.3
Fernandez, M.4
Alemany, S.5
-
76
-
-
84864767892
-
Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages
-
López-Pelaez M, Fumagalli S, Sanz C, Herrero C, Guerra S, Fernandez M, Alemany S. 2012. Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages. Mol. Biol. Cell 23:2982-2992.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2982-2992
-
-
López-Pelaez, M.1
Fumagalli, S.2
Sanz, C.3
Herrero, C.4
Guerra, S.5
Fernandez, M.6
Alemany, S.7
|