Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression

Journal of Biological Chemistry

Volumn 291, Issue 8, 2016, Pages 3932-3946

  Meiser, Johannes ^a   Krämer, Lisa ^a   Sapcariu, Sean C ^a   Battello, Nadia ^a   Ghelfi, Jenny ^a   D'Herouel, Aymeric Fouquier ^a   Skupin, Alexander ^a   Hiller, Karsten ^a  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME ACTIVITY; GENE ENCODING; METABOLISM; METABOLITES; OXIDATION;

ACTIVATED MACROPHAGES; ANTIMICROBIAL METABOLITES; CHRONIC INFLAMMATORY DISEASE; INNATE IMMUNE RESPONSE; MACROPHAGE ACTIVATION; PYRUVATE DEHYDROGENASE KINASE; TRANSLATIONAL MEDICINE; TRICARBOXYLIC ACID CYCLE;

MACROPHAGES;

CYTOKINE; ITACONIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; PYRUVIC ACID; UNCLASSIFIED DRUG; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPOPOLYSACCHARIDE; MONOKINE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE COMPLEX; SUCCINIC ACID DERIVATIVE;

ARTICLE; CARBOXYLATION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME METABOLISM; INTRACELLULAR SIGNALING; LIPOGENESIS; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLOMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SYNTHESIS; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MONOKINES; OXIDATION-REDUCTION; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; SUCCINATES;

EID: 84964495165     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.676817     Document Type: Article

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