Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

Journal of Cell Biology

Volumn 157, Issue 2, 2002, Pages 253-263

  Villalba, Martin ^a,b   Bi, Kun ^a   Hu, Junru ^a   Altman, Yoav ^a   Bushway, Paul ^a   Reits, Eric ^c   Neefjes, Jacques ^c   Baier, Gottfried ^d   Abraham, Robert T ^e   Altman, Amnon ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b CNRS   (France)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d UNIVERSITY OF INNSBRUCK   (Austria)

^e BURNHAM INSTITUTE   (United States)

Author keywords

Phosphatidylinositol 3 kinase; Phospholipase C; Protein kinase C ; T cell; Vav

Indexed keywords

ACTIN; ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C THETA; RAC PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; VAV PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IMMUNOFLUORESCENCE; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL MEMBRANE; ENZYME INHIBITORS; GENE DELETION; HUMANS; ISOENZYMES; JURKAT CELLS; MICE; MICROSCOPY, CONFOCAL; ONCOGENE PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-VAV; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

ANIMALIA;

EID: 0037092038     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201097     Document Type: Article

References (62)

1. Structural basis for the relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
2. T lymphocyte activation: A biological model of signal transduction
3. PKCθ: A new essential superstar on the T cell stage
4. Molecular cloning and characterization of PKCθ, a human novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
5. PKCθ isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
6. Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms
7. Complex formation and cooperation of PKCθ and Akt1/PKBα in the transactivation of the IKKβ/1-κBα-/NF-κB signaling cascade in T cells
8. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
9. Regulatory and signaling properties of the Vav family
10. Mitogenic signaling from the EGF receptor is attenuated by a phospholipase C-γ/protein kinase C feedback mechanism
11. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
12. Views on Vav
13. The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways
14. NF-κB activation induced by CD28 costimulation is mediated by PKCθ
15. Synergistic activation of NF-κB by functional cooperation between vav and PKCθ in T lymphocytes
16. Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol
17. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
18. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
19. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinosi-tide-dependent kinase, PDK-1
20. The immunological synapse: A molecular machine controlling T cell activation
21. PLCγ1, a possible mediator of T cell receptor function
22. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
23. Vav synergizes with protein kinase Cq to mediate IL-4 gene expression in response to CD28 costimulation in T cells
24. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
25. Pleiotropic contributions of phospholipase C-γ1 to T-cell antigen receptor-mediated signaling: Reconstitution studies of a PLC-γ1-deficient Jurkat T-cell line
26. PKCθ in T cell activation
27. Signal transduction by the TCR for antigen
28. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
29. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells
30. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
31. Protein kinase C θ participates in NF-κB/Rel activation induced by CD3/CD28 costimulation through selective activation of Iκ β (IKKβ)
32. Phosphorylation of the protein kinase C-θ activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-κB induction
33. Interplay of C1 and C2 domains of protein kinase C-α in its membrane binding and activation
34. PKC-θ cooperates with Vav1 to induce JNK activity in T-cells
35. Selective modulation of protein kinase C-θ during T-cell activation
36. Three-dimensional segregation of supramolecular clusters in T cells
37. Regulation of protein kinase C
38. Protein kinase C and lipid signaling for sustained cellular responses
39. Mammalian TOR controls one of two kinase pathways acting upon nPKCδ and nPKCε
40. Multiple pathways control protein kinase C phosphorylation
41. CD3 stimulation causes phosphorylation of phospholipase Cγ1 on serine and tyrosine residues in a T cell line
42. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
43. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
44. Upstream-downstream: CD28 cosignaling pathways and T cell function
45. T cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase Cγ1
46. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase
47. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
48. Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells
49. Cellular signaling: Pivoting around PDK-1
50. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes
51. T cell antigen-receptor signal transduction
52. Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells
53. PKCθ is a necessary component, and cooperates with calcineurin, to induce FasL expression during activation-induced T cell death
54. Functional interactions between Vav and PKCθ are required for TCR-induced T cell activation
55. Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 upregulation
56. Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
57. 2+-increase and arachidonic acid release in FRTL-5 thyroid cells
58. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ 1
59. The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
60. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
61. Association of Grb2, Gads, and phospholipase C-γ 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
62. Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex