PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

EMBO Journal

Volumn 32, Issue 7, 2013, Pages 1008-1022

  Venigalla, Ram K C ^a,c   McGuire, Victoria A ^a   Clarke, Rosemary ^a   Patterson Kane, Janet C ^b   Najafov, Ayaz ^a   Toth, Rachel ^a   McCarthy, Pierre C ^a   Simeons, Frederick ^a   Stojanovski, Laste ^a   Arthur, J Simon C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

B cell; Pax5; PDK1; preB; VDJ recombination

Indexed keywords

BCL2 RELATED PROTEIN A1; IMMUNOGLOBULIN HEAVY CHAIN; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; TRANSCRIPTION FACTOR PAX5;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL SURVIVAL; CONTROLLED STUDY; GENE INACTIVATION; HEMATOPOIETIC CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; VDJ RECOMBINATION;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; B-LYMPHOCYTES; CELL CYCLE CHECKPOINTS; CYCLIN D3; GENE KNOCKDOWN TECHNIQUES; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; INTERFERON REGULATORY FACTORS; MICE; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANS-ACTIVATORS; UP-REGULATION; V(D)J RECOMBINATION;

EID: 84875960670     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.40     Document Type: Article

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