CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C

International Immunopharmacology

Volumn 11, Issue 9, 2011, Pages 1160-1165

  Oh, Young Joo ^a   Youn, Ju Ho ^a   Min, Hyun Jin ^a   Kim, Dal Hyun ^b   Lee, Sung Sook ^b   Choi, In Hong ^a   Shin, Jeon Soo ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Chong Kun Dang Research Institute   (South Korea)

Author keywords

High mobility group box 1 (HMGB1); Inflammation; Lipopolysaccharide; Monocytes; Protein kinase C; Sepsis

Indexed keywords

1 (ALPHA NAPHTHYLMETHYL) 6,7 DIHYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CKD 712; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE ACETYLTRANSFERASE; LIPOTEICHOIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DEPENDENT KINASE 1; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; HISTONE ACETYLTRANSFERASES; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TEICHOIC ACIDS; TETRAHYDROISOQUINOLINES;

EID: 80051892393     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.03.013     Document Type: Article

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