Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-α release in alveolar macrophages from asymptomatic HIV-positive persons in vitro

Journal of Biological Chemistry

Volumn 283, Issue 48, 2008, Pages 33191-33198

  Tachado, Souvenir D ^a,b   Li, Xin ^a   Swan, Katharine ^a   Patel, Naimish ^a   Koziel, Henry ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL SIGNALING; CHEMICAL ACTIVATION; ENZYMES; MACROPHAGES; PATTERN RECOGNITION; PHOSPHORYLATION; SIGNALING;

ALVEOLAR MACROPHAGES; GLYCOGEN SYNTHASE KINASE-3; MITOGEN ACTIVATED PROTEIN KINASE; PATTERN RECOGNITION RECEPTORS; PHARMACOLOGICAL INHIBITION; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; TUMOR NECROSIS FACTOR ALPHA;

DISEASES;

2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 10; LIPID A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEF PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE SILENCING; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LUNG ALVEOLUS MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS);

EID: 57749101270     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805067200     Document Type: Article

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