Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-κB and STAT-1 in ozone-induced nitric oxide production and toxicity

Molecular and Cellular Biochemistry

Volumn 234-235, Issue , 2002, Pages 91-98

  Laskin, Debra L ^a   Fakhrzadeh, Ladan ^a   Heck, Diane E ^a   Gerecke, Donald ^a   Laskin, Jeffrey D ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

NF B; Ozone; PI 3 K; PKB; STAT 1

Indexed keywords

3 NITROTYROSINE; AUTACOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OZONE; PEROXYNITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P50; STAT1 PROTEIN; SUPEROXIDE DISMUTASE; DNA BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; STAT1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; BIOCHEMISTRY; CELL ACTIVITY; CONTROLLED STUDY; DISEASE MODEL; ENHANCER REGION; ENZYME ACTIVATION; GENE ACTIVATION; GENE ACTIVITY; GENE DISRUPTION; GENE OVEREXPRESSION; GENETIC REGULATION; INHALATION; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; LUNG LAVAGE; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMONIA; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADMINISTRATION, INHALATION; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; DNA-BINDING PROTEINS; ENZYME INDUCTION; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NF-KAPPA B; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; OZONE; PROTO-ONCOGENE PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANS-ACTIVATORS; ANIMALS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; STAT1 TRANSCRIPTION FACTOR;

EID: 4243245597     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015963217045     Document Type: Article

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