Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance

Diabetes

Volumn 61, Issue 8, 2012, Pages 1935-1948

  Kawano, Yoshinaga ^a   Nakae, Jun ^a   Watanabe, Nobuyuki ^b   Fujisaka, Shiho ^c   Iskandar, Kristy ^d   Sekioka, Risa ^a   Hayashi, Yoshitake ^e   Tobe, Kazuyuki ^c   Kasuga, Masato ^f   Noda, Tetsuo ^g   Yoshimura, Akihiko ^a   Onodera, Masafumi ^b   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

^d GADJAH MADA UNIVERSITY   (Indonesia)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^g CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; INSULIN RECEPTOR; INTERLEUKIN 4; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; TRANSCRIPTION FACTOR FKHR;

ADIPOSE TISSUE; ADIPOSE TISSUE MACROPHAGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE MIGRATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ADIPOSE TISSUE; ANIMALS; DIET, HIGH-FAT; FORKHEAD TRANSCRIPTION FACTORS; INSULIN RESISTANCE; INTERLEUKIN-4; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PANNICULITIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, CCR2;

EID: 84864384870     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0770     Document Type: Article

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