PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities

Journal of Ethnopharmacology

Volumn 190, Issue , 2016, Pages 251-260

  Hossen, Muhammad Jahangir ^a,b   Cho, Jae Youl ^a   Kim, Daewon ^c  

^a Sungkyunkwan University   (South Korea)

^b PATUAKHALI SCIENCE AND TECHNOLOGY UNIVERSITY   (Bangladesh)

^c Dankook University   (South Korea)

Author keywords

3 phosphoinositide dependent kinase1 (pdk1); Anti inflammatory effect; Asteraceae; Nuclearfactor kappaB; Prostaglandin E2; Resveratrol; Xanthium strumarium

Indexed keywords

ANTIINFLAMMATORY AGENT; CAFFEIC ACID; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; METHANOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLANT EXTRACT; PROSTAGLANDIN E2; PROTEIN KINASE B; RANITIDINE; RESVERATROL; UNCLASSIFIED DRUG; XANTHIUM STRUMARIUM EXTRACT; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; ALCOHOL; AUTACOID; HYDROCHLORIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; PDPK1 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; PTGS2 PROTEIN, MOUSE; SOLVENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GASTRITIS; GENE EXPRESSION; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOPHARMACOLOGY; IMMUNOPRECIPITATION; KINASE ASSAY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION; STOMACH ULCER; TRANSCRIPTION INITIATION; UPREGULATION; XANTHIUM STRUMARIUM; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; MACROPHAGE; MEDICINAL PLANT; METABOLISM; PHOSPHORYLATION; PHYTOTHERAPY; PLANT STRUCTURES; TIME FACTOR; VALIDATION STUDY; XANTHIUM;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 2; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GASTRITIS; HEK293 CELLS; HUMANS; HYDROCHLORIC ACID; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; METHANOL; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RAW 264.7 CELLS; SIGNAL TRANSDUCTION; SOLVENTS; TIME FACTORS; TRANSFECTION; XANTHIUM;

EID: 84974659935     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.06.019     Document Type: Article

References (48)

1. S.S. Back, J. Kim, D. Choi, E.S. Lee, S.Y. Choi, and K. Han Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor BMB Rep. 46 2013 322 327
2. D. Bruch-Gerharz, K. Fehsel, C. Suschek, G. Michel, T. Ruzicka, and V. Kolb-Bachofen A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes J. Exp. Med. 184 1996 2007 2012
3. S.E. Byeon, Y.S. Yi, J. Oh, B.C. Yoo, S. Hong, and J.Y. Cho The role of Src kinase in macrophage-mediated inflammatory responses Mediat. Inflamm. 2012 2012 512926
4. S.E. Byeon, T. Yu, Y. Yang, Y.G. Lee, J.H. Kim, J. Oh, H.Y. Jeong, S. Hong, B.C. Yoo, W.J. Cho, S. Hong, and J.Y. Cho Hydroquinone regulates hemeoxygenase-1 expression via modulation of Src kinase activity through thiolation of cysteine residues Free Radic. Biol. Med. 57 2013 105 118
5. J. Cumanda, G. Marinoni, M. De Bernardi, G. Vidari, and P.V. Finzi New sesquiterpenes from Xanthium catharticum J. Nat. Prod. 54 1991 460 465
6. D. Gerlier, and N. Thomasset Use of MTT colorimetric assay to measure cell activation J. Immunol. Methods 94 1986 57 63
7. M. Ham, and A. Moon Inflammatory and microenvironmental factors involved in breast cancer progression Arch. Pharm. Res. 36 2013 1419 1431
8. T. Han, H.-L. Li, Q.-Y. Zhang, P. Han, H.-C. Zheng, K. Rahman, and L.-P. Qin Bioactivity-guided fractionation for anti-inflammatory and analgesic properties and constituents of Xanthium strumarium L Phytomedicine 14 2007 825 829
9. K. Hiraiwa, and S.F. van Eeden Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants Mediat. Inflamm. 2013 2013 619523
10. M.J. Hossen Alternative Medicine: Health Safety and Therapeutic Potentialities Ec Vet. Sci. 1 2015 28 29
11. M.J. Hossen, M.-Y. Kim, J.-H. Kim, and J.Y. Cho AP-1-Targeted Inhibition of Macrophage Function and Lipopolysaccharide/d-galactosamine-Induced Hepatitis by Phyllanthus acidus Methanolic Extract Am. J. Chin. Med. 2015 1 22
12. M.J. Hossen, S.C. Kim, S. Yang, H.G. Kim, D. Jeong, Y.-S. Yi, N.Y. Sung, J.-O. Lee, J.-H. Kim, and J.Y. Cho PDK1 disruptors and modulators: a patent review Expert. Opin. Ther. Pat. 25 2015 513 537
13. M.J. Hossen, K.S. Baek, E. Kim, W.S. Yang, D. Jeong, J.H. Kim, D.H. Kweon, D.H. Yoon, T.W. Kim, J.H. Kim, and J.Y. Cho In vivo and in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/Syk/NF-kappaB J. Ethnopharmacol. 159 2015 9 16
14. M.J. Hossen, S.C. Kim, Y.J. Son, K.S. Baek, E. Kim, W.S. Yang, D. Jeong, J.G. Park, H.G. Kim, W.J. Chung, K. Yoon, C. Ryou, S.Y. Lee, J.H. Kim, and J.Y. Cho AP-1-targeting anti-inflammatory activity of the methanolic extract of Persicaria chinensis Evid. Based Complement. Altern. Med. 2015 2015 608126
15. M.J. Hossen, S.H. Jeon, S.C. Kim, J.H. Kim, D. Jeong, N.Y. Sung, S. Yang, K.S. Baek, J.H. Kim, D.H. Yoon, W.O. Song, K.D. Yoon, S.H. Cho, S. Lee, J.H. Kim, and J.Y. Cho In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract J. Ethnopharmacol. 168 2015 217 228
16. J.W. Jung, S.J. Kim, E.M. Ahn, S.R. Oh, H.J. Lee, J.A. Jeong, and J.Y. Lee Ribes fasciculatum var. chinense attenuated allergic inflammation in vivo and in vitro Biomol. Ther. (Seoul.) 22 2014 547 552
17. A. Kamboj, and A.K. Saluja Phytopharmacological review of Xanthium strumarium L.(Cocklebur). Int. J Green. Pharm. 4 2010 129
18. C.H. Kim, J. Park, and M. Kim Gut microbiota-derived short-chain fatty acids, T cells, and inflammation Immune Netw. 14 2014 277 288
19. I.-T. Kim, Y.-M. Park, J.-H. Won, H.-J. Jung, H.-J. Park, J.-W. Choi, and K.-T. Lee Methanol extract of Xanthium strumarium L. possesses anti-inflammatory and anti-nociceptive activities Biol. Pharm. Bull. 28 2005 94 100
20. M.H. Kim, D.S. Yoo, S.Y. Lee, S.E. Byeon, Y.G. Lee, T. Min, H.S. Rho, M.H. Rhee, J. Lee, and J.Y. Cho The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects Pharmazie 66 2011 293 300
21. M.J. Kim, T. Kadayat, E. Kim da, E.S. Lee, and P.H. Park TI-I-174, a Synthetic chalcone derivative, suppresses nitric oxide production in murine macrophages via heme oxygenase-1 induction and inhibition of AP-1 Biomol. Ther. (Seoul.) 22 2014 390 399
22. R.S. Labow, E. Meek, and J.P. Santerre Model systems to assess the destructive potential of human neutrophils and monocyte-derived macrophages during the acute and chronic phases of inflammation J. Biomed. Mater. Res. 54 2001 189 197
23. D.H. Lee, H.J. Cho, H.H. Kim, M.H. Rhee, J.H. Ryu, and H.J. Park Inhibitory effects of total saponin from Korean red ginseng via vasodilator-stimulated phosphoprotein-Ser(157) phosphorylation on thrombin-induced platelet aggregation J. Ginseng Res. 37 2013 176 186
24. Y.R. Lee, E.M. Noh, J.H. Han, J.M. Kim, B.M. Hwang, B.S. Kim, S.H. Lee, S.H. Jung, H.J. Youn, E.Y. Chung, and J.S. Kim Sulforaphane controls TPA-induced MMP-9 expression through the NF-kappaB signaling pathway, but not AP-1, in MCF-7, breast cancer cells BMB Rep. 46 2013 201 206
25. J. Leung, and W.K. Suh The CD28-B7 family in anti-tumor immunity: emerging concepts in cancer immunotherapy Immune Netw. 14 2014 265 276
26. B. Lin, Y. Zhao, P. Han, W. Yue, X.-Q. Ma, K. Rahman, C.-J. Zheng, L.-P. Qin, and T. Han Anti-arthritic activity of Xanthium strumarium L. extract on complete Freunds adjuvant induced arthritis in rats J. Ethnopharmacol. 155 2014 248 255
27. M. Lyman, D.G. Lloyd, X. Ji, M.P. Vizcaychipi, and D. Ma Neuroinflammation: the role and consequences Neurosci. Res. 79 2014 1 12
28. A.A. Mahmoud Xanthanolides and xanthane epoxide derivatives from Xanthium strumarium Planta Med. 64 1998 724 727
29. N. Momi, S. Kaur, S.R. Krishn, and S.K. Batra Discovering the route from inflammation to pancreatic cancer Minerva Gastroenterol. Dietol. 58 2012 283 297
30. E. Nibret, M. Youns, R.L. Krauth-Siegel, and M. Wink Biological activities of xanthatin from Xanthium strumarium leaves Phytother. Res. 25 2011 1883 1890
31. L. Qin, T. Han, H. Li, Q. Zhang, and H. Zheng A new thiazinedione from Xanthium strumarium Fitoterapia 77 2006 245 246
32. T. Ruzicka, and J. Ring Enhanced releasability of prostaglandin E2 and leukotrienes B4 and C4 from leukocytes of patients with atopic eczema Acta Derm.-Venereol. 67 1987 469 475
33. S. Ryoo, J. Choi, J. Kim, S. Bae, J. Hong, S. Jo, S. Kim, and Y. Lee BIRB 796 has distinctive anti-inflammatory effects on different cell types Immune Netw. 13 2013 283 288
34. T. Shen, J. Lee, M.H. Park, Y.G. Lee, H.S. Rho, Y.S. Kwak, M.H. Rhee, Y.C. Park, and J.Y. Cho Ginsenoside Rp1, a ginsenoside derivative, blocks promoter activation of iNOS and COX-2 genes by suppression of an IKKbeta-mediated NF-kappaB Pathway in HEK293 Cells J. Ginseng Res. 35 2011 200 208
35. S.H. Sohn, S.K. Kim, Y.O. Kim, H.D. Kim, Y.S. Shin, S.O. Yang, S.Y. Kim, and S.W. Lee A comparison of antioxidant activity of Korean White and Red Ginsengs on H2O2-induced oxidative stress in HepG2 hepatoma cells J. Ginseng Res. 37 2013 442 450
36. H.C. Steel, R. Cockeran, R. Anderson, and C. Feldman Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease Mediat. Inflamm. 2013 2013 490346
37. C.-K. Tseng, C.-K. Lin, H.-W. Chang, Y.-H. Wu, F.-L. Yen, F.-R. Chang, W.-C. Chen, C.-C. Yeh, and J.-C. Lee Aqueous extract of Gracilaria tenuistipitata suppresses LPS-induced NF-κB and MAPK activation in RAW 264.7 and rat peritoneal macrophages and exerts hepatoprotective effects on carbon tetrachloride-treated rat PLoS One 9 2014 e86557
38. T. Winters, T.A. Geissman, and D. Safir Sesquiterpene lactones of Xanthium species. Xanthanol and isoxanthanol, and correlation of xanthinin with ivalbin J. Org. Chem. 34 1969 153 155
39. R.-C. Yang, C.-C. Chang, J.-M. Sheen, H.-T. Wu, J.-H.S. Pang, and S.-T. Huang Davallia bilabiata inhibits TNF-α-induced adhesion molecules and chemokines by suppressing IKK/NF-kappa B pathway in vascular endothelial cells Am. J. Chin. Med. 42 2014 1411 1429
40. W.S. Yang, D. Jeong, Y.S. Yi, B.H. Lee, T.W. Kim, K.M. Htwe, Y.D. Kim, K.D. Yoon, S. Hong, W.S. Lee, and J.Y. Cho Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1 J. Ethnopharmacol. 151 2014 1165 1174
41. Y. Yang, S.C. Kim, T. Yu, Y.S. Yi, M.H. Rhee, G.H. Sung, B.C. Yoo, and J.Y. Cho Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses Mediat. Inflamm. 2014 2014 352371
42. Y. Yang, T. Yu, Y.G. Lee, W.S. Yang, J. Oh, D. Jeong, S. Lee, T.W. Kim, Y.C. Park, G.H. Sung, and J.Y. Cho Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases J. Ethnopharmacol. 145 2013 598 607
43. M. Yeom, J.H. Kim, J.H. Min, M.K. Hwang, H.S. Jung, and Y. Sohn Xanthii fructus inhibits inflammatory responses in LPS-stimulated RAW 264.7 macrophages through suppressing NF-kappaB and JNK/p38 MAPK J. Ethnopharmacol. 176 2015 394 401
44. Y.-S. Yi, Y.-J. Son, C. Ryou, G.-H. Sung, J.-H. Kim, and J.Y. Cho Functional roles of Syk in macrophage-mediated inflammatory responses Mediat. Inflamm. 2014 2014 950472
45. D.S. Yoe, H.S. Rho, Y.G. Lee, M.H. Yeom, D.H. Kim, S.J. Lee, S. Hong, J. Lee, and J.Y. Cho Ginsenoside F1 modulates cellular responses of skin melanoma cells J. Ginseng Res. 35 2011 86 91
46. T. Yu, J. Shim, Y. Yang, S.E. Byeon, J.H. Kim, H.S. Rho, H. Park, G.H. Sung, T.W. Kim, M.H. Rhee, and J.Y. Cho 3-(4-(tert-Octy)l)(phenox)y)(propane-1),2-diol suppresses inflammatory responses via inhibition of multiple kinases Biochem. Pharmacol. 83 2012 1540 1551
47. T. Yu, H.M. Ahn, T. Shen, K. Yoon, H.J. Jang, Y.J. Lee, H.M. Yang, J.H. Kim, C. Kim, M.H. Han, S.H. Cha, T.W. Kim, S.Y. Kim, J. Lee, and J.Y. Cho Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans J. Ethnopharmacol. 137 2011 1197 1206
48. Y.-P. Zhu, 1998. Chinese materia medica: Chemistry, (pharmacology and applications: CRC Press).