HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

Nature Communications

Volumn 7, Issue , 2016, Pages

  Semba, Hiroaki ^a,b   Takeda, Norihiko ^a,c   Isagawa, Takayuki ^a   Sugiura, Yuki ^c,d   Honda, Kurara ^d   Wake, Masaki ^a   Miyazawa, Hidenobu ^e   Yamaguchi, Yoshifumi ^c,e   Miura, Masayuki ^e,f   Jenkins, Dana M R ^g   Choi, Hyunsung ^g   Kim, Jung Whan ^g   Asagiri, Masataka ^h   Cowburn, Andrew S ⁱ   Abe, Hajime ^a   Soma, Katsura ^a   Koyama, Katsuhiro ^a   Katoh, Manami ^a   Sayama, Keimon ^j   Goda, Nobuhito ^j   Johnson, Randall S ⁱ   Manabe, Ichiro ^a   Nagai, Ryozo ^k   Komuro, Issei ^a   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b THE CARDIOVASCULAR INSTITUTE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

^g UNIVERSITY OF TEXAS AT DALLAS   (United States)

^h KYOTO UNIVERSITY   (Japan)

ⁱ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^j WASEDA UNIVERSITY   (Japan)

^k JICHI MEDICAL UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL NUCLEUS DNA; CYTOCHROME C OXIDASE; DICHLOROACETIC ACID; GLUCOSE; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOCHONDRIAL DNA; PHOSPHOGLYCERATE KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 3; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN A; HIF1A PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

ANOXIC CONDITIONS; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE; INHIBITION; METABOLISM; OXIDATION; OXYGEN; PHYSIOLOGY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE METABOLISM; GLYCOLYSIS; HYPOXIA; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; ANIMAL; C57BL MOUSE; CELL MOTION; METABOLISM; PRIMARY CELL CULTURE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; DICHLOROACETIC ACID; ELECTRON TRANSPORT COMPLEX IV; GLUCOSE; GLYCOLYSIS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MACROPHAGES; MICE, INBRED C57BL; PRIMARY CELL CULTURE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84970028181     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11635     Document Type: Article

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