메뉴 건너뛰기




Volumn 1863, Issue 2, 2017, Pages 585-597

Nrf2 signaling pathway: Pivotal roles in inflammation

Author keywords

ARE; Inflammation; Keap1; Nrf2; Oxidative stress; Phytochemical

Indexed keywords

ANTIINFLAMMATORY AGENT; CELL ADHESION MOLECULE; CHEMOKINE; CRYOPYRIN; CYCLOOXYGENASE 2; CYTOKINE; ENZYME; HO 1 ENZYME; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MATRIX METALLOPROTEINASE; PLANT MEDICINAL PRODUCT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 85003904928     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2016.11.005     Document Type: Review
Times cited : (1381)

References (165)
  • 1
    • 33846257261 scopus 로고    scopus 로고
    • Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation
    • [1] Ferrero-Miliani, L., Nielsen, O.H., Andersen, P.S., Girardin, S.E., Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin. Exp. Immunol. 147 (2007), 227–235.
    • (2007) Clin. Exp. Immunol. , vol.147 , pp. 227-235
    • Ferrero-Miliani, L.1    Nielsen, O.H.2    Andersen, P.S.3    Girardin, S.E.4
  • 2
    • 61449125226 scopus 로고    scopus 로고
    • Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer
    • [2] Khansari, N., Shakiba, Y., Mahmoudi, M., Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Patents Inflamm. Allergy Drug Discov. 3 (2009), 73–80.
    • (2009) Recent Patents Inflamm. Allergy Drug Discov. , vol.3 , pp. 73-80
    • Khansari, N.1    Shakiba, Y.2    Mahmoudi, M.3
  • 3
    • 84922400509 scopus 로고    scopus 로고
    • Carotenoids, inflammation, and oxidative stress–implications of cellular signaling pathways and relation to chronic disease prevention
    • [3] Kaulmann, A., Bohn, T., Carotenoids, inflammation, and oxidative stress–implications of cellular signaling pathways and relation to chronic disease prevention. Nutr. Res. 34 (2014), 907–929.
    • (2014) Nutr. Res. , vol.34 , pp. 907-929
    • Kaulmann, A.1    Bohn, T.2
  • 4
    • 78049370987 scopus 로고
    • Oxidative Stress, Inflammation, and Cancer: How are They Linked?, Free Radic. Biol. Med., 49
    • [4] Reuter, S., Gupta, S.C., Chaturvedi, M.M., Aggarwal, B.B., Oxidative Stress, Inflammation, and Cancer: How are They Linked?, Free Radic. Biol. Med., 49. 1603-1616.
    • (1603)
    • Reuter, S.1    Gupta, S.C.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 5
    • 84908529514 scopus 로고    scopus 로고
    • STAT signaling in inflammation
    • e24198
    • [5] Kaplan, M.H., STAT signaling in inflammation. JAKSTAT, 2, 2013, e24198.
    • (2013) JAKSTAT , vol.2
    • Kaplan, M.H.1
  • 6
    • 0036318224 scopus 로고    scopus 로고
    • Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
    • [6] Braun, S., Hanselmann, C., Gassmann, M.G., Keller, U.a.d., Born-Berclaz, C., Chan, K., Kan, Y.W., Werner, S., Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol. Cell. Biol. 22 (2002), 5492–5505.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5492-5505
    • Braun, S.1    Hanselmann, C.2    Gassmann, M.G.3    Keller, U.A.D.4    Born-Berclaz, C.5    Chan, K.6    Kan, Y.W.7    Werner, S.8
  • 8
    • 33646418968 scopus 로고    scopus 로고
    • Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
    • [8] Chen, X.L., Dodd, G., Thomas, S., Zhang, X., Wasserman, M.A., Rovin, B.H., Kunsch, C., Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am. J. Physiol. Heart Circ. Physiol. 290 (2006), H1862–H1870.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290 , pp. H1862-H1870
    • Chen, X.L.1    Dodd, G.2    Thomas, S.3    Zhang, X.4    Wasserman, M.A.5    Rovin, B.H.6    Kunsch, C.7
  • 9
    • 84877846556 scopus 로고    scopus 로고
    • RXRalpha inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2
    • [9] Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Luo, L., Hayes, J.D., Wang, X.J., Tang, X., RXRalpha inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2. Cancer research 73 (2013), 3097–3108.
    • (2013) Cancer research , vol.73 , pp. 3097-3108
    • Wang, H.1    Liu, K.2    Geng, M.3    Gao, P.4    Wu, X.5    Hai, Y.6    Li, Y.7    Luo, L.8    Hayes, J.D.9    Wang, X.J.10    Tang, X.11
  • 10
    • 84902440352 scopus 로고    scopus 로고
    • Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer
    • [10] Namani, A., Li, Y., Wang, X.J., Tang, X., Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer. Biochim. Biophys. Acta 1843 (2014), 1875–1885.
    • (2014) Biochim. Biophys. Acta , vol.1843 , pp. 1875-1885
    • Namani, A.1    Li, Y.2    Wang, X.J.3    Tang, X.4
  • 12
    • 77954937828 scopus 로고    scopus 로고
    • The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2
    • [12] Plafker, K.S., Nguyen, L., Barneche, M., Mirza, S., Crawford, D., Plafker, S.M., The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2. J. Biol. Chem. 285 (2010), 23064–23074.
    • (2010) J. Biol. Chem. , vol.285 , pp. 23064-23074
    • Plafker, K.S.1    Nguyen, L.2    Barneche, M.3    Mirza, S.4    Crawford, D.5    Plafker, S.M.6
  • 13
  • 14
    • 84896123587 scopus 로고    scopus 로고
    • Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs
    • [14] Wang, X.J., Li, Y., Luo, L., Wang, H., Chi, Z., Xin, A., Li, X., Wu, J., Tang, X., Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs. Free Radic. Biol. Med. 70 (2014), 68–77.
    • (2014) Free Radic. Biol. Med. , vol.70 , pp. 68-77
    • Wang, X.J.1    Li, Y.2    Luo, L.3    Wang, H.4    Chi, Z.5    Xin, A.6    Li, X.7    Wu, J.8    Tang, X.9
  • 15
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
    • [15] Cullinan, S.B., Gordan, J.D., Jin, J., Harper, J.W., Diehl, J.A., The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol. Cell. Biol. 24 (2004), 8477–8486.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8477-8486
    • Cullinan, S.B.1    Gordan, J.D.2    Jin, J.3    Harper, J.W.4    Diehl, J.A.5
  • 16
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • [16] Kobayashi, A., Kang, M.I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., Yamamoto, M., Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell. Biol. 24 (2004), 7130–7139.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 17
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • [17] Zhang, D.D., Lo, S.C., Cross, J.V., Templeton, D.J., Hannink, M., Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24 (2004), 10941–10953.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 18
    • 35648970026 scopus 로고    scopus 로고
    • Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
    • [18] Tong, K.I., Padmanabhan, B., Kobayashi, A., Shang, C., Hirotsu, Y., Yokoyama, S., Yamamoto, M., Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol. Cell. Biol. 27 (2007), 7511–7521.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7511-7521
    • Tong, K.I.1    Padmanabhan, B.2    Kobayashi, A.3    Shang, C.4    Hirotsu, Y.5    Yokoyama, S.6    Yamamoto, M.7
  • 19
  • 20
    • 28544450507 scopus 로고    scopus 로고
    • The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
    • [20] Nioi, P., Nguyen, T., Sherratt, P.J., Pickett, C.B., The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol. Cell. Biol. 25 (2005), 10895–10906.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10895-10906
    • Nioi, P.1    Nguyen, T.2    Sherratt, P.J.3    Pickett, C.B.4
  • 21
    • 0034752461 scopus 로고    scopus 로고
    • Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
    • [21] Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., Yamamoto, M., Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6 (2001), 857–868.
    • (2001) Genes Cells , vol.6 , pp. 857-868
    • Katoh, Y.1    Itoh, K.2    Yoshida, E.3    Miyagishi, M.4    Fukamizu, A.5    Yamamoto, M.6
  • 22
    • 84873056802 scopus 로고    scopus 로고
    • The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
    • [22] Kim, J.H., Yu, S., Chen, J.D., Kong, A.N., The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. Oncogene 32 (2013), 514–527.
    • (2013) Oncogene , vol.32 , pp. 514-527
    • Kim, J.H.1    Yu, S.2    Chen, J.D.3    Kong, A.N.4
  • 23
    • 33748752586 scopus 로고    scopus 로고
    • Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain
    • [23] Li, W., Yu, S.W., Kong, A.N., Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain. J. Biol. Chem. 281 (2006), 27251–27263.
    • (2006) J. Biol. Chem. , vol.281 , pp. 27251-27263
    • Li, W.1    Yu, S.W.2    Kong, A.N.3
  • 24
    • 84881476323 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • [24] Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., Hayes, J.D., Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene 32 (2013), 3765–3781.
    • (2013) Oncogene , vol.32 , pp. 3765-3781
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 25
    • 79952256187 scopus 로고    scopus 로고
    • SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    • [25] Rada, P., Rojo, A.I., Chowdhry, S., McMahon, M., Hayes, J.D., Cuadrado, A., SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol. Cell. Biol. 31 (2011), 1121–1133.
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 1121-1133
    • Rada, P.1    Rojo, A.I.2    Chowdhry, S.3    McMahon, M.4    Hayes, J.D.5    Cuadrado, A.6
  • 27
    • 77953366801 scopus 로고    scopus 로고
    • A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
    • [27] Lau, A., Wang, X.J., Zhao, F., Villeneuve, N.F., Wu, T., Jiang, T., Sun, Z., White, E., Zhang, D.D., A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol. Cell. Biol. 30 (2010), 3275–3285.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3275-3285
    • Lau, A.1    Wang, X.J.2    Zhao, F.3    Villeneuve, N.F.4    Wu, T.5    Jiang, T.6    Sun, Z.7    White, E.8    Zhang, D.D.9
  • 28
    • 77954599053 scopus 로고    scopus 로고
    • p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • [28] Jain, A., Lamark, T., Sjottem, E., Larsen, K.B., Awuh, J.A., Overvatn, A., McMahon, M., Hayes, J.D., Johansen, T., p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 285 (2010), 22576–22591.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22576-22591
    • Jain, A.1    Lamark, T.2    Sjottem, E.3    Larsen, K.B.4    Awuh, J.A.5    Overvatn, A.6    McMahon, M.7    Hayes, J.D.8    Johansen, T.9
  • 30
    • 84884334947 scopus 로고    scopus 로고
    • Understanding the role of NRF2-regulated miRNAs in human malignancies
    • [30] Shah, N.M., Rushworth, S.A., Murray, M.Y., Bowles, K.M., MacEwan, D.J., Understanding the role of NRF2-regulated miRNAs in human malignancies. Oncotarget 4 (2013), 1130–1142.
    • (2013) Oncotarget , vol.4 , pp. 1130-1142
    • Shah, N.M.1    Rushworth, S.A.2    Murray, M.Y.3    Bowles, K.M.4    MacEwan, D.J.5
  • 31
    • 78549277802 scopus 로고    scopus 로고
    • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
    • [31] Sangokoya, C., Telen, M.J., Chi, J.T., microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood 116 (2010), 4338–4348.
    • (2010) Blood , vol.116 , pp. 4338-4348
    • Sangokoya, C.1    Telen, M.J.2    Chi, J.T.3
  • 32
    • 80052570740 scopus 로고    scopus 로고
    • MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
    • [32] Yang, M., Yao, Y., Eades, G., Zhang, Y., Zhou, Q., MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. Breast Cancer Res. Treat. 129 (2011), 983–991.
    • (2011) Breast Cancer Res. Treat. , vol.129 , pp. 983-991
    • Yang, M.1    Yao, Y.2    Eades, G.3    Zhang, Y.4    Zhou, Q.5
  • 33
    • 84870859466 scopus 로고    scopus 로고
    • Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells
    • e51111
    • [33] Narasimhan, M., Patel, D., Vedpathak, D., Rathinam, M., Henderson, G., Mahimainathan, L., Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One, 7, 2012, e51111.
    • (2012) PLoS One , vol.7
    • Narasimhan, M.1    Patel, D.2    Vedpathak, D.3    Rathinam, M.4    Henderson, G.5    Mahimainathan, L.6
  • 34
    • 84877113289 scopus 로고    scopus 로고
    • MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
    • [34] Singh, B., Ronghe, A.M., Chatterjee, A., Bhat, N.K., Bhat, H.K., MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis. Carcinogenesis 34 (2013), 1165–1172.
    • (2013) Carcinogenesis , vol.34 , pp. 1165-1172
    • Singh, B.1    Ronghe, A.M.2    Chatterjee, A.3    Bhat, N.K.4    Bhat, H.K.5
  • 35
    • 84930683202 scopus 로고    scopus 로고
    • Elevation of HO-1 expression mitigates intestinal ischemia-reperfusion injury and restores tight junction function in a rat liver transplantation model
    • [35] Chi, X., Yao, W., Xia, H., Jin, Y., Li, X., Cai, J., Hei, Z., Elevation of HO-1 expression mitigates intestinal ischemia-reperfusion injury and restores tight junction function in a rat liver transplantation model. Oxidative Med. Cell. Longev., 986075, 2015.
    • (2015) Oxidative Med. Cell. Longev.
    • Chi, X.1    Yao, W.2    Xia, H.3    Jin, Y.4    Li, X.5    Cai, J.6    Hei, Z.7
  • 36
    • 84974845965 scopus 로고    scopus 로고
    • The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation
    • [36] Choi, Y.H., The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation. Gen. Physiol. Biophys., 2016.
    • (2016) Gen. Physiol. Biophys.
    • Choi, Y.H.1
  • 37
    • 79955467291 scopus 로고    scopus 로고
    • Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages
    • [37] Kuhn, A.M., Tzieply, N., Schmidt, M.V., von Knethen, A., Namgaladze, D., Yamamoto, M., Brune, B., Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages. Free Radic. Biol. Med. 50 (2011), 1382–1391.
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 1382-1391
    • Kuhn, A.M.1    Tzieply, N.2    Schmidt, M.V.3    von Knethen, A.4    Namgaladze, D.5    Yamamoto, M.6    Brune, B.7
  • 38
    • 84893860749 scopus 로고    scopus 로고
    • Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity
    • [38] Lee, D.S., Jeong, G.S., Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity. Eur. J. Pharmacol. 728 (2014), 1–8.
    • (2014) Eur. J. Pharmacol. , vol.728 , pp. 1-8
    • Lee, D.S.1    Jeong, G.S.2
  • 40
    • 84933517472 scopus 로고    scopus 로고
    • Taurine chloramine stimulates efferocytosis through upregulation of Nrf2-mediated heme oxygenase-1 expression in murine macrophages: possible involvement of carbon monoxide, antioxidants & redox signaling
    • [40] Kim, W., Kim, H.U., Lee, H.N., Kim, S.H., Kim, C., Cha, Y.N., Joe, Y., Chung, H.T., Jang, J., Kim, K., Suh, Y.G., Jin, H.O., Lee, J.K., Surh, Y.J., Taurine chloramine stimulates efferocytosis through upregulation of Nrf2-mediated heme oxygenase-1 expression in murine macrophages: possible involvement of carbon monoxide, antioxidants & redox signaling. 23, 2015, 163–177.
    • (2015) , vol.23 , pp. 163-177
    • Kim, W.1    Kim, H.U.2    Lee, H.N.3    Kim, S.H.4    Kim, C.5    Cha, Y.N.6    Joe, Y.7    Chung, H.T.8    Jang, J.9    Kim, K.10    Suh, Y.G.11    Jin, H.O.12    Lee, J.K.13    Surh, Y.J.14
  • 42
    • 0029411321 scopus 로고
    • Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)
    • [42] Prestera, T., Talalay, P., Alam, J., Ahn, Y.I., Lee, P.J., Choi, A.M., Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol. Med. 1 (1995), 827–837.
    • (1995) Mol. Med. , vol.1 , pp. 827-837
    • Prestera, T.1    Talalay, P.2    Alam, J.3    Ahn, Y.I.4    Lee, P.J.5    Choi, A.M.6
  • 43
    • 0037532741 scopus 로고    scopus 로고
    • Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis
    • [43] Liu, Y., Zhu, B., Wang, X., Luo, L., Li, P., Paty, D.W., Cynader, M.S., Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis. J. Neuroimmunol. 139 (2003), 27–35.
    • (2003) J. Neuroimmunol. , vol.139 , pp. 27-35
    • Liu, Y.1    Zhu, B.2    Wang, X.3    Luo, L.4    Li, P.5    Paty, D.W.6    Cynader, M.S.7
  • 45
    • 37349108810 scopus 로고    scopus 로고
    • Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia
    • [45] Kadl, A., Pontiller, J., Exner, M., Leitinger, N., Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock 28 (2007), 582–588.
    • (2007) Shock , vol.28 , pp. 582-588
    • Kadl, A.1    Pontiller, J.2    Exner, M.3    Leitinger, N.4
  • 46
    • 4043058702 scopus 로고    scopus 로고
    • Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats
    • [46] Wang, W.W., Smith, D.L., Zucker, S.D., Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology 40 (2004), 424–433.
    • (2004) Hepatology , vol.40 , pp. 424-433
    • Wang, W.W.1    Smith, D.L.2    Zucker, S.D.3
  • 51
    • 33846264538 scopus 로고    scopus 로고
    • Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis
    • [51] Khor, T.O., Huang, M.T., Kwon, K.H., Chan, J.Y., Reddy, B.S., Kong, A.N., Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res. 66 (2006), 11580–11584.
    • (2006) Cancer Res. , vol.66 , pp. 11580-11584
    • Khor, T.O.1    Huang, M.T.2    Kwon, K.H.3    Chan, J.Y.4    Reddy, B.S.5    Kong, A.N.6
  • 52
    • 34648830424 scopus 로고    scopus 로고
    • Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
    • [52] Osburn, W.O., Karim, B., Dolan, P.M., Liu, G., Yamamoto, M., Huso, D.L., Kensler, T.W., Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int. J. Cancer 121 (2007), 1883–1891.
    • (2007) Int. J. Cancer , vol.121 , pp. 1883-1891
    • Osburn, W.O.1    Karim, B.2    Dolan, P.M.3    Liu, G.4    Yamamoto, M.5    Huso, D.L.6    Kensler, T.W.7
  • 56
    • 33745513491 scopus 로고    scopus 로고
    • 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells
    • [56] Pae, H.O., Oh, G.S., Lee, B.S., Rim, J.S., Kim, Y.M., Chung, H.T., 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Atherosclerosis 187 (2006), 274–284.
    • (2006) Atherosclerosis , vol.187 , pp. 274-284
    • Pae, H.O.1    Oh, G.S.2    Lee, B.S.3    Rim, J.S.4    Kim, Y.M.5    Chung, H.T.6
  • 57
    • 22144446042 scopus 로고    scopus 로고
    • ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow
    • [57] Yang, L., Froio, R.M., Sciuto, T.E., Dvorak, A.M., Alon, R., Luscinskas, F.W., ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood 106 (2005), 584–592.
    • (2005) Blood , vol.106 , pp. 584-592
    • Yang, L.1    Froio, R.M.2    Sciuto, T.E.3    Dvorak, A.M.4    Alon, R.5    Luscinskas, F.W.6
  • 58
    • 22044433408 scopus 로고    scopus 로고
    • NF-kappaB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression
    • [58] Banning, A., Brigelius-Flohe, R., NF-kappaB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression. Antioxid. Redox Signal. 7 (2005), 889–899.
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 889-899
    • Banning, A.1    Brigelius-Flohe, R.2
  • 59
  • 62
    • 34547661858 scopus 로고    scopus 로고
    • 2’,4’,6’-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways
    • [62] Lee, S.H., Sohn, D.H., Jin, X.Y., Kim, S.W., Choi, S.C., Seo, G.S., 2’,4’,6’-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways. Biochem. Pharmacol. 74 (2007), 870–880.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 870-880
    • Lee, S.H.1    Sohn, D.H.2    Jin, X.Y.3    Kim, S.W.4    Choi, S.C.5    Seo, G.S.6
  • 63
    • 84970979632 scopus 로고    scopus 로고
    • Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells
    • [63] Yang, P.M., Wu, Z.Z., Zhang, Y.Q., Wung, B.S., Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells. Life Sci., 2016.
    • (2016) Life Sci.
    • Yang, P.M.1    Wu, Z.Z.2    Zhang, Y.Q.3    Wung, B.S.4
  • 64
    • 34547729625 scopus 로고    scopus 로고
    • The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1
    • [64] Kim, B.C., Jeon, W.K., Hong, H.Y., Jeon, K.B., Hahn, J.H., Kim, Y.M., Numazawa, S., Yosida, T., Park, E.H., Lim, C.J., The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. J. Ethnopharmacol. 113 (2007), 240–247.
    • (2007) J. Ethnopharmacol. , vol.113 , pp. 240-247
    • Kim, B.C.1    Jeon, W.K.2    Hong, H.Y.3    Jeon, K.B.4    Hahn, J.H.5    Kim, Y.M.6    Numazawa, S.7    Yosida, T.8    Park, E.H.9    Lim, C.J.10
  • 66
    • 84884678258 scopus 로고    scopus 로고
    • A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-kappaB and Nrf2-Keap1 signaling pathways
    • [66] Gan, F.F., Ling, H., Ang, X., Reddy, S.A., Lee, S.S., Yang, H., Tan, S.H., Hayes, J.D., Chui, W.K., Chew, E.H., A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-kappaB and Nrf2-Keap1 signaling pathways. Toxicol. Appl. Pharmacol. 272 (2013), 852–862.
    • (2013) Toxicol. Appl. Pharmacol. , vol.272 , pp. 852-862
    • Gan, F.F.1    Ling, H.2    Ang, X.3    Reddy, S.A.4    Lee, S.S.5    Yang, H.6    Tan, S.H.7    Hayes, J.D.8    Chui, W.K.9    Chew, E.H.10
  • 68
    • 52949139019 scopus 로고    scopus 로고
    • Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
    • [68] Lin, W., Wu, R.T., Wu, T., Khor, T.O., Wang, H., Kong, A.N., Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem. Pharmacol. 76 (2008), 967–973.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 967-973
    • Lin, W.1    Wu, R.T.2    Wu, T.3    Khor, T.O.4    Wang, H.5    Kong, A.N.6
  • 70
    • 77749339881 scopus 로고    scopus 로고
    • Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
    • [70] Rojo, A.I., Innamorato, N.G., Martin-Moreno, A.M., De Ceballos, M.L., Yamamoto, M., Cuadrado, A., Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Glia 58 (2010), 588–598.
    • (2010) Glia , vol.58 , pp. 588-598
    • Rojo, A.I.1    Innamorato, N.G.2    Martin-Moreno, A.M.3    De Ceballos, M.L.4    Yamamoto, M.5    Cuadrado, A.6
  • 72
    • 84881526830 scopus 로고    scopus 로고
    • Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving It from p65
    • [72] Kim, S.W., Lee, H.K., Shin, J.H., Lee, J.K., Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving It from p65. Free Radic. Biol. Med. 65 (2013), 468–476.
    • (2013) Free Radic. Biol. Med. , vol.65 , pp. 468-476
    • Kim, S.W.1    Lee, H.K.2    Shin, J.H.3    Lee, J.K.4
  • 73
    • 34249983852 scopus 로고    scopus 로고
    • The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells
    • [73] Ho, F.M., Kang, H.C., Lee, S.T., Chao, Y., Chen, Y.C., Huang, L.J., Lin, W.W., The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells. Biochem. Pharmacol. 74 (2007), 298–308.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 298-308
    • Ho, F.M.1    Kang, H.C.2    Lee, S.T.3    Chao, Y.4    Chen, Y.C.5    Huang, L.J.6    Lin, W.W.7
  • 76
    • 84934917454 scopus 로고    scopus 로고
    • NALP3 inflammasome activation in protein misfolding diseases
    • [76] Shi, F., Kouadir, M., Yang, Y., NALP3 inflammasome activation in protein misfolding diseases. Life Sci. 135 (2015), 9–14.
    • (2015) Life Sci. , vol.135 , pp. 9-14
    • Shi, F.1    Kouadir, M.2    Yang, Y.3
  • 78
    • 84959917649 scopus 로고    scopus 로고
    • Molecular mechanisms regulating NLRP3 inflammasome activation
    • [78] Jo, E.K., Kim, J.K., Shin, D.M., Sasakawa, C., Molecular mechanisms regulating NLRP3 inflammasome activation. Cell. Mol. Immunol. 13 (2016), 148–159.
    • (2016) Cell. Mol. Immunol. , vol.13 , pp. 148-159
    • Jo, E.K.1    Kim, J.K.2    Shin, D.M.3    Sasakawa, C.4
  • 79
    • 84997161890 scopus 로고    scopus 로고
    • Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming
    • [79] Liu, X., Zhang, X., Ding, Y., Zhou, W., Tao, L., Lu, P., Wang, Y., Hu, R., Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming. Antioxid. Redox Signal., 2016.
    • (2016) Antioxid. Redox Signal.
    • Liu, X.1    Zhang, X.2    Ding, Y.3    Zhou, W.4    Tao, L.5    Lu, P.6    Wang, Y.7    Hu, R.8
  • 80
    • 84969540589 scopus 로고    scopus 로고
    • Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation
    • [80] Liu, X., Zhou, W., Zhang, X., Lu, P., Du, Q., Tao, L., Ding, Y., Wang, Y., Hu, R., Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation. Biochem. Pharmacol. 112 (2016), 37–49.
    • (2016) Biochem. Pharmacol. , vol.112 , pp. 37-49
    • Liu, X.1    Zhou, W.2    Zhang, X.3    Lu, P.4    Du, Q.5    Tao, L.6    Ding, Y.7    Wang, Y.8    Hu, R.9
  • 81
    • 79959926939 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
    • [81] Tsai, P.Y., Ka, S.M., Chang, J.M., Chen, H.C., Shui, H.A., Li, C.Y., Hua, K.F., Chang, W.L., Huang, J.J., Yang, S.S., Chen, A., Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic. Biol. Med. 51 (2011), 744–754.
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 744-754
    • Tsai, P.Y.1    Ka, S.M.2    Chang, J.M.3    Chen, H.C.4    Shui, H.A.5    Li, C.Y.6    Hua, K.F.7    Chang, W.L.8    Huang, J.J.9    Yang, S.S.10    Chen, A.11
  • 82
    • 84947912447 scopus 로고    scopus 로고
    • Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
    • [82] Ka, S.M., Lin, J.C., Lin, T.J., Liu, F.C., Chao, L.K., Ho, C.L., Yeh, L.T., Sytwu, H.K., Hua, K.F., Chen, A., Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res. Ther., 17, 2015, 331.
    • (2015) Arthritis Res. Ther. , vol.17 , pp. 331
    • Ka, S.M.1    Lin, J.C.2    Lin, T.J.3    Liu, F.C.4    Chao, L.K.5    Ho, C.L.6    Yeh, L.T.7    Sytwu, H.K.8    Hua, K.F.9    Chen, A.10
  • 83
    • 84975853510 scopus 로고    scopus 로고
    • Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
    • [83] Liu, X., Wang, T., Cai, L., Qi, J., Zhang, P., Li, Y., Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. Int. Immunopharmacol. 38 (2016), 324–331.
    • (2016) Int. Immunopharmacol. , vol.38 , pp. 324-331
    • Liu, X.1    Wang, T.2    Cai, L.3    Qi, J.4    Zhang, P.5    Li, Y.6
  • 84
    • 84912059327 scopus 로고    scopus 로고
    • Mangiferin attenuate sepsis-induced acute kidney injury via antioxidant and anti-inflammatory effects
    • [84] He, L., Peng, X., Zhu, J., Chen, X., Liu, H., Tang, C., Dong, Z., Liu, F., Peng, Y., Mangiferin attenuate sepsis-induced acute kidney injury via antioxidant and anti-inflammatory effects. Am. J. Nephrol. 40 (2014), 441–450.
    • (2014) Am. J. Nephrol. , vol.40 , pp. 441-450
    • He, L.1    Peng, X.2    Zhu, J.3    Chen, X.4    Liu, H.5    Tang, C.6    Dong, Z.7    Liu, F.8    Peng, Y.9
  • 85
    • 84902440210 scopus 로고    scopus 로고
    • Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation
    • [85] Zhao, C., Gillette, D.D., Li, X., Zhang, Z., Wen, H., Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation. J. Biol. Chem. 289 (2014), 17020–17029.
    • (2014) J. Biol. Chem. , vol.289 , pp. 17020-17029
    • Zhao, C.1    Gillette, D.D.2    Li, X.3    Zhang, Z.4    Wen, H.5
  • 86
    • 0034283837 scopus 로고    scopus 로고
    • The Rel/NF-kappa B family: friend and foe
    • [86] Perkins, N.D., The Rel/NF-kappa B family: friend and foe. Trends Biochem. Sci. 25 (2000), 434–440.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 434-440
    • Perkins, N.D.1
  • 88
    • 79954504166 scopus 로고    scopus 로고
    • Basic principles and emerging concepts in the redox control of transcription factors
    • [88] Brigelius-Flohe, R., Flohe, L., Basic principles and emerging concepts in the redox control of transcription factors. Antioxidants & redox signaling 15 (2011), 2335–2381.
    • (2011) Antioxidants & redox signaling , vol.15 , pp. 2335-2381
    • Brigelius-Flohe, R.1    Flohe, L.2
  • 89
    • 41949141296 scopus 로고    scopus 로고
    • NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
    • [89] Liu, G.H., Qu, J., Shen, X., NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim. Biophys. Acta 1783 (2008), 713–727.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 713-727
    • Liu, G.H.1    Qu, J.2    Shen, X.3
  • 90
    • 27444447043 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1
    • [90] Yang, H., Magilnick, N., Ou, X., Lu, S.C., Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Biochem. J. 391 (2005), 399–408.
    • (2005) Biochem. J. , vol.391 , pp. 399-408
    • Yang, H.1    Magilnick, N.2    Ou, X.3    Lu, S.C.4
  • 91
    • 84888162122 scopus 로고    scopus 로고
    • MafK positively regulates NF-kappaB activity by enhancing CBP-mediated p65 acetylation
    • [91] Hwang, Y.J., Lee, E.W., Song, J., Kim, H.R., Jun, Y.C., Hwang, K.A., MafK positively regulates NF-kappaB activity by enhancing CBP-mediated p65 acetylation. Sci. Rep., 3, 2013, 3242.
    • (2013) Sci. Rep. , vol.3 , pp. 3242
    • Hwang, Y.J.1    Lee, E.W.2    Song, J.3    Kim, H.R.4    Jun, Y.C.5    Hwang, K.A.6
  • 92
    • 84869081486 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB nuclear translocation via HO-1 activation underlies alpha-tocopheryl succinate toxicity
    • [92] Bellezza, I., Tucci, A., Galli, F., Grottelli, S., Inhibition of NF-kappaB nuclear translocation via HO-1 activation underlies alpha-tocopheryl succinate toxicity. J. Nutr. Biochem. 23 (2012), 1583–1591.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 1583-1591
    • Bellezza, I.1    Tucci, A.2    Galli, F.3    Grottelli, S.4
  • 94
    • 84895910708 scopus 로고    scopus 로고
    • Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-kappaB-mediated inflammatory response
    • [94] Jiang, T., Tian, F., Zheng, H., Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-kappaB-mediated inflammatory response. Kidney Int. 85 (2014), 333–343.
    • (2014) Kidney Int. , vol.85 , pp. 333-343
    • Jiang, T.1    Tian, F.2    Zheng, H.3
  • 95
    • 33645118005 scopus 로고    scopus 로고
    • 3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats
    • [95] Karuri, A.R., Huang, Y., Bodreddigari, S., Sutter, C.H., Roebuck, B.D., Kensler, T.W., Sutter, T.R., 3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats. J. Pharmacol. Exp. Ther. 317 (2006), 61–67.
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 61-67
    • Karuri, A.R.1    Huang, Y.2    Bodreddigari, S.3    Sutter, C.H.4    Roebuck, B.D.5    Kensler, T.W.6    Sutter, T.R.7
  • 96
    • 0035943597 scopus 로고    scopus 로고
    • Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
    • [96] Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., Gerhauser, C., Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J. Biol. Chem. 276 (2001), 32008–32015.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32008-32015
    • Heiss, E.1    Herhaus, C.2    Klimo, K.3    Bartsch, H.4    Gerhauser, C.5
  • 98
    • 33845976705 scopus 로고    scopus 로고
    • Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179
    • [98] Ahmad, R., Raina, D., Meyer, C., Kharbanda, S., Kufe, D., Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. J. Biol. Chem. 281 (2006), 35764–35769.
    • (2006) J. Biol. Chem. , vol.281 , pp. 35764-35769
    • Ahmad, R.1    Raina, D.2    Meyer, C.3    Kharbanda, S.4    Kufe, D.5
  • 99
    • 67349202556 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling
    • [99] Sriram, N., Kalayarasan, S., Sudhandiran, G., Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm. Pharmacol. Ther. 22 (2009), 221–236.
    • (2009) Pulm. Pharmacol. Ther. , vol.22 , pp. 221-236
    • Sriram, N.1    Kalayarasan, S.2    Sudhandiran, G.3
  • 100
    • 33847633373 scopus 로고    scopus 로고
    • Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile
    • [100] Liu, Y.C., Hsieh, C.W., Wu, C.C., Wung, B.S., Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. Life Sci. 80 (2007), 1420–1430.
    • (2007) Life Sci. , vol.80 , pp. 1420-1430
    • Liu, Y.C.1    Hsieh, C.W.2    Wu, C.C.3    Wung, B.S.4
  • 101
    • 21944452087 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    • [101] Yang, H., Magilnick, N., Lee, C., Kalmaz, D., Ou, X., Chan, J.Y., Lu, S.C., Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol. Cell. Biol. 25 (2005), 5933–5946.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5933-5946
    • Yang, H.1    Magilnick, N.2    Lee, C.3    Kalmaz, D.4    Ou, X.5    Chan, J.Y.6    Lu, S.C.7
  • 106
    • 84913591310 scopus 로고    scopus 로고
    • CD36 upregulation mediated by intranasal LV-NRF2 treatment mitigates hypoxia-induced progression of Alzheimer's-like pathogenesis
    • [106] Wang, C.Y., Wang, Z.Y., Xie, J.W., Cai, J.H., Wang, T., Xu, Y., Wang, X., An, L., CD36 upregulation mediated by intranasal LV-NRF2 treatment mitigates hypoxia-induced progression of Alzheimer's-like pathogenesis. Antioxid. Redox Signal. 21 (2016), 2208–2230.
    • (2016) Antioxid. Redox Signal. , vol.21 , pp. 2208-2230
    • Wang, C.Y.1    Wang, Z.Y.2    Xie, J.W.3    Cai, J.H.4    Wang, T.5    Xu, Y.6    Wang, X.7    An, L.8
  • 107
    • 77953540586 scopus 로고    scopus 로고
    • The Nrf2 pathway as a potential therapeutic target for Huntington disease A commentary on “Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease”
    • [107] Escartin, C., Brouillet, E., The Nrf2 pathway as a potential therapeutic target for Huntington disease A commentary on “Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease”. Free Radic. Biol. Med. 49 (2016), 144–146.
    • (2016) Free Radic. Biol. Med. , vol.49 , pp. 144-146
    • Escartin, C.1    Brouillet, E.2
  • 108
    • 84899749141 scopus 로고    scopus 로고
    • Tert-butylhydroquinone protects the spinal cord against inflammatory response produced by spinal cord injury
    • [108] Jin, W., Ni, H., Hou, X., Ming, X., Wang, J., Yuan, B., Zhu, T., Jiang, J., Wang, H., Liang, W., Tert-butylhydroquinone protects the spinal cord against inflammatory response produced by spinal cord injury. Ann. Clin. Lab. Sci. 44 (2016), 151–157.
    • (2016) Ann. Clin. Lab. Sci. , vol.44 , pp. 151-157
    • Jin, W.1    Ni, H.2    Hou, X.3    Ming, X.4    Wang, J.5    Yuan, B.6    Zhu, T.7    Jiang, J.8    Wang, H.9    Liang, W.10
  • 109
    • 84893067601 scopus 로고    scopus 로고
    • Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress
    • [109] Stachel, I., Geismann, C., Aden, K., Deisinger, F., Rosenstiel, P., Schreiber, S., Sebens, S., Arlt, A., Schafer, H., Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress. J. Biol. Chem. 289 (2016), 1917–1929.
    • (2016) J. Biol. Chem. , vol.289 , pp. 1917-1929
    • Stachel, I.1    Geismann, C.2    Aden, K.3    Deisinger, F.4    Rosenstiel, P.5    Schreiber, S.6    Sebens, S.7    Arlt, A.8    Schafer, H.9
  • 110
    • 84905503739 scopus 로고    scopus 로고
    • Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice
    • [110] Gu, L., Deng, W.S., Liu, Y., Jiang, C.H., Sun, L.C., Sun, X.F., Xu, Q., Zhou, H., Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice. Int. Immunopharmacol. 22 (2016), 341–345.
    • (2016) Int. Immunopharmacol. , vol.22 , pp. 341-345
    • Gu, L.1    Deng, W.S.2    Liu, Y.3    Jiang, C.H.4    Sun, L.C.5    Sun, X.F.6    Xu, Q.7    Zhou, H.8
  • 112
    • 1642540092 scopus 로고    scopus 로고
    • Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
    • [112] Morito, N., Yoh, K., Itoh, K., Hirayama, A., Koyama, A., Yamamoto, M., Takahashi, S., Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels. Oncogene 22 (2003), 9275–9281.
    • (2003) Oncogene , vol.22 , pp. 9275-9281
    • Morito, N.1    Yoh, K.2    Itoh, K.3    Hirayama, A.4    Koyama, A.5    Yamamoto, M.6    Takahashi, S.7
  • 113
    • 67449168081 scopus 로고    scopus 로고
    • Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice
    • [113] Reddy, N.M., Kleeberger, S.R., Kensler, T.W., Yamamoto, M., Hassoun, P.M., Reddy, S.P., Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J. Immunol. 182 (2009), 7264–7271.
    • (2009) J. Immunol. , vol.182 , pp. 7264-7271
    • Reddy, N.M.1    Kleeberger, S.R.2    Kensler, T.W.3    Yamamoto, M.4    Hassoun, P.M.5    Reddy, S.P.6
  • 114
    • 84947931461 scopus 로고    scopus 로고
    • Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2
    • [114] Dong, J., Ma, Q., Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2. Nanotoxicology, 2016, 1–11.
    • (2016) Nanotoxicology , pp. 1-11
    • Dong, J.1    Ma, Q.2
  • 115
    • 9444249870 scopus 로고    scopus 로고
    • The transcription factor NRF2 protects against pulmonary fibrosis
    • [115] Cho, H.Y., Reddy, S.P., Yamamoto, M., Kleeberger, S.R., The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J. 18 (2004), 1258–1260.
    • (2004) FASEB J. , vol.18 , pp. 1258-1260
    • Cho, H.Y.1    Reddy, S.P.2    Yamamoto, M.3    Kleeberger, S.R.4
  • 116
    • 84903148579 scopus 로고    scopus 로고
    • Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-kappaB-mediated COX-2 expression and apoptosis
    • [116] Yang, S.M., Chan, Y.L., Hua, K.F., Chang, J.M., Chen, H.L., Tsai, Y.J., Hsu, Y.J., Chao, L.K., Feng-Ling, Y., Tsai, Y.L., Wu, S.H., Wang, Y.F., Tsai, C.L., Chen, A., Ka, S.M., Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-kappaB-mediated COX-2 expression and apoptosis. Free Radic. Biol. Med. 73 (2016), 260–269.
    • (2016) Free Radic. Biol. Med. , vol.73 , pp. 260-269
    • Yang, S.M.1    Chan, Y.L.2    Hua, K.F.3    Chang, J.M.4    Chen, H.L.5    Tsai, Y.J.6    Hsu, Y.J.7    Chao, L.K.8    Feng-Ling, Y.9    Tsai, Y.L.10    Wu, S.H.11    Wang, Y.F.12    Tsai, C.L.13    Chen, A.14    Ka, S.M.15
  • 118
    • 84938742295 scopus 로고    scopus 로고
    • rhTNFR:Fc increases Nrf2 expression via miR-27a mediation to protect myocardium against sepsis injury
    • [118] Xue, W.L., Bai, X., Zhang, L., rhTNFR:Fc increases Nrf2 expression via miR-27a mediation to protect myocardium against sepsis injury. Biochem. Biophys. Res. Commun. 464 (2016), 855–861.
    • (2016) Biochem. Biophys. Res. Commun. , vol.464 , pp. 855-861
    • Xue, W.L.1    Bai, X.2    Zhang, L.3
  • 123
    • 33846916279 scopus 로고    scopus 로고
    • Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes
    • [123] Zheng, L., Gong, B., Hatala, D.A., Kern, T.S., Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes. Invest. Ophthalmol. Vis. Sci. 48 (2007), 361–367.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 361-367
    • Zheng, L.1    Gong, B.2    Hatala, D.A.3    Kern, T.S.4
  • 124
    • 84930535809 scopus 로고    scopus 로고
    • Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox
    • [124] Aboonabi, A., Singh, I., Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox. Biomed. Pharmacother. 72 (2016), 30–36.
    • (2016) Biomed. Pharmacother. , vol.72 , pp. 30-36
    • Aboonabi, A.1    Singh, I.2
  • 125
    • 19544385612 scopus 로고    scopus 로고
    • Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages
    • [125] Rose, P., Won, Y.K., Ong, C.N., Whiteman, M., Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide 12 (2005), 237–243.
    • (2005) Nitric Oxide , vol.12 , pp. 237-243
    • Rose, P.1    Won, Y.K.2    Ong, C.N.3    Whiteman, M.4
  • 126
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    • [126] Balogun, E., Hoque, M., Gong, P., Killeen, E., Green, C.J., Foresti, R., Alam, J., Motterlini, R., Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371 (2003), 887–895.
    • (2003) Biochem. J. , vol.371 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3    Killeen, E.4    Green, C.J.5    Foresti, R.6    Alam, J.7    Motterlini, R.8
  • 128
    • 84952880588 scopus 로고    scopus 로고
    • Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-kappaB and activating HO-1/Nrf2 pathways
    • [128] Lv, H., Yu, Z., Zheng, Y., Wang, L., Qin, X., Cheng, G., Ci, X., Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-kappaB and activating HO-1/Nrf2 pathways. Int. J. Biol. Sci. 12 (2016), 72–86.
    • (2016) Int. J. Biol. Sci. , vol.12 , pp. 72-86
    • Lv, H.1    Yu, Z.2    Zheng, Y.3    Wang, L.4    Qin, X.5    Cheng, G.6    Ci, X.7
  • 129
    • 85011922034 scopus 로고    scopus 로고
    • Fimasartan, a novel angiotensin-receptor blocker, protects against renal inflammation and fibrosis in mice with unilateral ureteral obstruction: the possible role of Nrf2
    • [129] Kim, S., Kim, S.J., Yoon, H.E., Chung, S., Choi, B.S., Park, C.W., Shin, S.J., Fimasartan, a novel angiotensin-receptor blocker, protects against renal inflammation and fibrosis in mice with unilateral ureteral obstruction: the possible role of Nrf2. Int. J. Med. Sci. 12 (2016), 891–904.
    • (2016) Int. J. Med. Sci. , vol.12 , pp. 891-904
    • Kim, S.1    Kim, S.J.2    Yoon, H.E.3    Chung, S.4    Choi, B.S.5    Park, C.W.6    Shin, S.J.7
  • 133
    • 84855175292 scopus 로고    scopus 로고
    • Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
    • [133] Leonardo, C.C., Dore, S., Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins. Nutr. Neurosci. 14 (2016), 226–236.
    • (2016) Nutr. Neurosci. , vol.14 , pp. 226-236
    • Leonardo, C.C.1    Dore, S.2
  • 135
    • 84953735028 scopus 로고    scopus 로고
    • Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation
    • [135] Li, C.Z., Jin, H.H., Sun, H.X., Zhang, Z.Z., Zheng, J.X., Li, S.H., Han, S.H., Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation. Eur. J. Pharmacol., 2016.
    • (2016) Eur. J. Pharmacol.
    • Li, C.Z.1    Jin, H.H.2    Sun, H.X.3    Zhang, Z.Z.4    Zheng, J.X.5    Li, S.H.6    Han, S.H.7
  • 136
    • 84946556895 scopus 로고    scopus 로고
    • Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity
    • [136] Zhu, G.F., Guo, H.J., Huang, Y., Wu, C.T., Zhang, X.F., Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp. Ther. Med. 10 (2016), 2259–2266.
    • (2016) Exp. Ther. Med. , vol.10 , pp. 2259-2266
    • Zhu, G.F.1    Guo, H.J.2    Huang, Y.3    Wu, C.T.4    Zhang, X.F.5
  • 137
    • 84900495551 scopus 로고    scopus 로고
    • Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial
    • [137] Mielgo-Ayuso, J., Barrenechea, L., Alcorta, P., Larrarte, E., Margareto, J., Labayen, I., Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial. Br. J. Nutr. 111 (2016), 1263–1271.
    • (2016) Br. J. Nutr. , vol.111 , pp. 1263-1271
    • Mielgo-Ayuso, J.1    Barrenechea, L.2    Alcorta, P.3    Larrarte, E.4    Margareto, J.5    Labayen, I.6
  • 138
    • 84949638814 scopus 로고    scopus 로고
    • Epigallocatechin gallate attenuates amyloid beta-induced inflammation and neurotoxicity in EOC 13.31 microglia
    • [138] Cheng-Chung Wei, J., Huang, H.C., Chen, W.J., Huang, C.N., Peng, C.H., Lin, C.L., Epigallocatechin gallate attenuates amyloid beta-induced inflammation and neurotoxicity in EOC 13.31 microglia. Eur. J. Pharmacol. 770 (2016), 16–24.
    • (2016) Eur. J. Pharmacol. , vol.770 , pp. 16-24
    • Cheng-Chung Wei, J.1    Huang, H.C.2    Chen, W.J.3    Huang, C.N.4    Peng, C.H.5    Lin, C.L.6
  • 139
    • 0038288903 scopus 로고    scopus 로고
    • Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial
    • [139] Spiller, G.A., Dewell, A., Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. J. Med. Food 6 (2003), 51–56.
    • (2003) J. Med. Food , vol.6 , pp. 51-56
    • Spiller, G.A.1    Dewell, A.2
  • 141
    • 84908142617 scopus 로고    scopus 로고
    • Effectiveness of topical curcumin for treatment of mastitis in breastfeeding women: a randomized, double-blind, placebo-controlled clinical trial
    • [141] Afshariani, R., Farhadi, P., Ghaffarpasand, F., Roozbeh, J., Effectiveness of topical curcumin for treatment of mastitis in breastfeeding women: a randomized, double-blind, placebo-controlled clinical trial. Oman Med J 29 (2016), 330–334.
    • (2016) Oman Med J , vol.29 , pp. 330-334
    • Afshariani, R.1    Farhadi, P.2    Ghaffarpasand, F.3    Roozbeh, J.4
  • 143
    • 79955710308 scopus 로고    scopus 로고
    • Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
    • [143] Saw, C.L., Huang, M.T., Liu, Y., Khor, T.O., Conney, A.H., Kong, A.N., Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol. Carcinog. 50 (2016), 479–486.
    • (2016) Mol. Carcinog. , vol.50 , pp. 479-486
    • Saw, C.L.1    Huang, M.T.2    Liu, Y.3    Khor, T.O.4    Conney, A.H.5    Kong, A.N.6
  • 145
    • 84910086885 scopus 로고    scopus 로고
    • A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes
    • [145] Mirmiran, P., Bahadoran, Z., Golzarand, M., Zojaji, H., Azizi, F., A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes. J Diabetes Metab Disord, 13, 2016, 64.
    • (2016) J Diabetes Metab Disord , vol.13 , pp. 64
    • Mirmiran, P.1    Bahadoran, Z.2    Golzarand, M.3    Zojaji, H.4    Azizi, F.5
  • 147
    • 84936945451 scopus 로고    scopus 로고
    • Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study
    • [147] Samsami-Kor, M., Daryani, N.E., Asl, P.R., Hekmatdoost, A., Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study. Arch. Med. Res. 46 (2016), 280–285.
    • (2016) Arch. Med. Res. , vol.46 , pp. 280-285
    • Samsami-Kor, M.1    Daryani, N.E.2    Asl, P.R.3    Hekmatdoost, A.4
  • 148
    • 84880970352 scopus 로고    scopus 로고
    • Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy
    • [148] Gill, A.J., Kolson, D.L., Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy. Crit. Rev. Immunol. 33 (2016), 307–359.
    • (2016) Crit. Rev. Immunol. , vol.33 , pp. 307-359
    • Gill, A.J.1    Kolson, D.L.2
  • 149
    • 84908301179 scopus 로고    scopus 로고
    • Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
    • [149] Wang, Y.Y., Yang, Y.X., Zhe, H., He, Z.X., Zhou, S.F., Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties. Drug Des Devel Ther 8 (2016), 2075–2088.
    • (2016) Drug Des Devel Ther , vol.8 , pp. 2075-2088
    • Wang, Y.Y.1    Yang, Y.X.2    Zhe, H.3    He, Z.X.4    Zhou, S.F.5
  • 150
    • 84906690102 scopus 로고    scopus 로고
    • Effect of redox modulating NRF2 activators on chronic kidney disease
    • [150] Choi, B.H., Kang, K.S., Kwak, M.K., Effect of redox modulating NRF2 activators on chronic kidney disease. Molecules 19 (2016), 12727–12759.
    • (2016) Molecules , vol.19 , pp. 12727-12759
    • Choi, B.H.1    Kang, K.S.2    Kwak, M.K.3
  • 152
    • 84893602212 scopus 로고    scopus 로고
    • The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
    • [152] Gao, B., Doan, A., Hybertson, B.M., The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clin. Pharm. 6 (2016), 19–34.
    • (2016) Clin. Pharm. , vol.6 , pp. 19-34
    • Gao, B.1    Doan, A.2    Hybertson, B.M.3
  • 153
    • 84937026323 scopus 로고    scopus 로고
    • Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers
    • [153] Reisman, S.A., Goldsberry, A.R., Lee, C.Y., O'Grady, M.L., Proksch, J.W., Ward, K.W., Meyer, C.J., Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers. BMC Dermatol., 15, 2016, 10.
    • (2016) BMC Dermatol. , vol.15 , pp. 10
    • Reisman, S.A.1    Goldsberry, A.R.2    Lee, C.Y.3    O'Grady, M.L.4    Proksch, J.W.5    Ward, K.W.6    Meyer, C.J.7
  • 154
    • 77954142553 scopus 로고    scopus 로고
    • Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial
    • [154] Heinz, S.A., Henson, D.A., Austin, M.D., Jin, F., Nieman, D.C., Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacol. Res. 62 (2016), 237–242.
    • (2016) Pharmacol. Res. , vol.62 , pp. 237-242
    • Heinz, S.A.1    Henson, D.A.2    Austin, M.D.3    Jin, F.4    Nieman, D.C.5
  • 155
    • 84874850365 scopus 로고    scopus 로고
    • Thermo-reversible green tea catechin gel for local application in chronic periodontitis: a 4-week clinical trial
    • [155] Chava, V.K., Vedula, B.D., Thermo-reversible green tea catechin gel for local application in chronic periodontitis: a 4-week clinical trial. J. Periodontol. 84 (2016), 1290–1296.
    • (2016) J. Periodontol. , vol.84 , pp. 1290-1296
    • Chava, V.K.1    Vedula, B.D.2
  • 156
    • 84885080814 scopus 로고    scopus 로고
    • Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study
    • [156] Sakata, R., Nakamura, T., Torimura, T., Ueno, T., Sata, M., Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study. Int. J. Mol. Med. 32 (2013), 989–994.
    • (2013) Int. J. Mol. Med. , vol.32 , pp. 989-994
    • Sakata, R.1    Nakamura, T.2    Torimura, T.3    Ueno, T.4    Sata, M.5
  • 157
    • 84891703344 scopus 로고    scopus 로고
    • Silymarin in treatment of non-alcoholic steatohepatitis: a randomized clinical trial
    • [157] Solhi, H., Ghahremani, R., Kazemifar, A.M., Hoseini Yazdi, Z., Silymarin in treatment of non-alcoholic steatohepatitis: a randomized clinical trial. Caspian J Intern Med 5 (2016), 9–12.
    • (2016) Caspian J Intern Med , vol.5 , pp. 9-12
    • Solhi, H.1    Ghahremani, R.2    Kazemifar, A.M.3    Hoseini Yazdi, Z.4
  • 159
    • 84859632884 scopus 로고    scopus 로고
    • Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trial
    • [159] Yakoot, M., Salem, A., Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trial. BMC Gastroenterol., 12, 2016, 32.
    • (2016) BMC Gastroenterol. , vol.12 , pp. 32
    • Yakoot, M.1    Salem, A.2
  • 160
    • 84870920381 scopus 로고    scopus 로고
    • Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial
    • [160] Bime, C., Wei, C.Y., Holbrook, J., Smith, L.J., Wise, R.A., Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial. Prim Care Respir J 21 (2016), 398–404.
    • (2016) Prim Care Respir J , vol.21 , pp. 398-404
    • Bime, C.1    Wei, C.Y.2    Holbrook, J.3    Smith, L.J.4    Wise, R.A.5
  • 161
    • 67651054995 scopus 로고    scopus 로고
    • A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
    • [161] Wagenlehner, F.M., Schneider, H., Ludwig, M., Schnitker, J., Brahler, E., Weidner, W., A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study. Eur. Urol. 56 (2009), 544–551.
    • (2009) Eur. Urol. , vol.56 , pp. 544-551
    • Wagenlehner, F.M.1    Schneider, H.2    Ludwig, M.3    Schnitker, J.4    Brahler, E.5    Weidner, W.6
  • 162
    • 84952871133 scopus 로고    scopus 로고
    • Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized, prospective study
    • [162] Iwamura, H., Koie, T., Soma, O., Matsumoto, T., Imai, A., Hatakeyama, S., Yoneyama, T., Hashimoto, Y., Ohyama, C., Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized, prospective study. BMC Urol., 15, 2016, 120.
    • (2016) BMC Urol. , vol.15 , pp. 120
    • Iwamura, H.1    Koie, T.2    Soma, O.3    Matsumoto, T.4    Imai, A.5    Hatakeyama, S.6    Yoneyama, T.7    Hashimoto, Y.8    Ohyama, C.9
  • 164
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • [164] Hayes, J.D., Dinkova-Kostova, A.T., The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem. Sci. 39 (2016), 199–218.
    • (2016) Trends Biochem. Sci. , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.