Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

Free Radical Biology and Medicine

Volumn 51, Issue 3, 2011, Pages 744-754

  Tsai, Pei Yi ^a   Ka, Shuk Man ^b   Chang, Jia Ming ^c   Chen, Hsiang Cheng ^b   Shui, Hao Ai ^a   Li, Chen Yun ^b   Hua, Kuo Feng ^d   Chang, Wen Liang ^a   Huang, Jiann Jyh ^c   Yang, Sung Sen ^b   Chen, Ann ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^d NATIONAL ILAN UNIVERSITY   (Taiwan)

Author keywords

Epigallocatechin 3 gallate (EGCG); IL 1 ; IL 18; Inflammation; Lupus nephritis; NLRP3 inflammasome; Nuclear factor E2 related factor 2 (Nrf2); Oxidative stress; Regulatory T cell (Treg cell)

Indexed keywords

CASPASE; CRYOPYRIN; EPIGALLOCATECHIN GALLATE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 18; INTERLEUKIN 1BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY DYSFUNCTION; KIDNEY INJURY; LUPUS ERYTHEMATOSUS NEPHRITIS; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CARRIER PROTEINS; CATECHIN; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; KIDNEY; LUPUS NEPHRITIS; MICE; MICE, INBRED NZB; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS;

MUS;

EID: 79959926939     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.05.016     Document Type: Article

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