2′,4′,6′-Tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-α-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways

Biochemical Pharmacology

Volumn 74, Issue 6, 2007, Pages 870-880

  Lee, Sung Hee ^a   Sohn, Dong Hwan ^a   Jin, Xing Yu ^a   Kim, Sang Wook ^b   Choi, Suck Chei ^c   Seo, Geom Seog ^c  

^a Wonkwang University   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

^c Wonkwang University School of Medicine   (South Korea)

Author keywords

2 ,4 ,6 Tris(methoxymethoxy) chalcone; Heme oxygenase 1; Nuclear factor B; Trinitrobenzene sulfonic acid; Tumor necrosis factor

Indexed keywords

2',4',6' TRIS(METHOXYMETHOXY)CHALCONE; BILIRUBIN; CARBON MONOXIDE; CHALCONE DERIVATIVE; HEME OXYGENASE 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 8; MATRILYSIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEAR FACTOR KAPPA B P65; TRANSCRIPTION FACTOR NRF2; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CHALCONE; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELL STRAIN HT29; COLITIS; COLON INJURY; CONTROLLED STUDY; DISEASE MODEL; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; INTESTINE ULCER; INTRACOLONIC DRUG ADMINISTRATION; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; WEIGHT REDUCTION; ANIMAL; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; EPITHELIUM; INFLAMMATION; INTESTINE; METABOLISM; MUCOSA; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CHALCONE; COLITIS; EPITHELIUM; HEME OXYGENASE-1; INFLAMMATION; INTESTINES; MICE; MUCOUS MEMBRANE; PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34547661858     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.06.034     Document Type: Article

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