3H-1,2-dithiole-3-thione targets nuclear factor κB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 1, 2006, Pages 61-67

  Karuri, Asok R ^a   Huang, Yong ^a   Bodreddigari, Sridevi ^a   Sutter, Carrie Hayes ^a   Roebuck, Bill D ^b   Kensler, Thomas W ^c   Sutter, Thomas R ^a  

^a UNIVERSITY OF MEMPHIS   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3H 1,2 DITHIOLE 3 THIONE; ANTINEOPLASTIC AGENT; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG INHIBITION; ENDOTOXEMIA; ENZYME BLOOD LEVEL; ENZYME REGULATION; ENZYME REPRESSION; HISTOPATHOLOGY; HYPOTENSION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SURVIVAL;

ANIMALS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTOXEMIA; GLUTATHIONE; HYPOTENSION; LIPOPOLYSACCHARIDES; LIVER; MALE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, INBRED F344; THIONES; THIOPHENES;

EID: 33645118005     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.096396     Document Type: Article

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