Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 39, 2015, Pages 12169-12174

  Keleku Lukwete, Nadine ^a,b   Suzuki, Mikiko ^a   Otsuki, Akihito ^a   Tsuchida, Kouhei ^a   Katayama, Saori ^a   Hayashi, Makiko ^a   Naganuma, Eriko ^a   Moriguchi, Takashi ^a   Tanabe, Osamu ^c   Engel, James Douglas ^d   Imaizumi, Masue ^b   Yamamoto, Masayuki ^a,c   Groudine, Mark ^e  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MIYAGI CHILDREN S HOSPITAL   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Keap1; Nrf2; Sickle cell disease

Indexed keywords

2 CYANO 3,12 DIOOLEANA 1,9 DIENE 28 IMIDAZOLIDE; HEME; IMIDAZOLE DERIVATIVE; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PADGEM PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; CYTOSKELETON PROTEIN; KEAP1 PROTEIN, MOUSE; LUCIFERASE; NFE2L2 PROTEIN, MOUSE; PRIMER DNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ERYTHROBLAST; ERYTHROCYTE LIFESPAN; ERYTHROPOIESIS; GENE SILENCING; HEMOLYSIS; LIVER INJURY; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; RETICULOCYTE COUNT; SICKLE CELL ANEMIA; STRESS; ANEMIA, SICKLE CELL; ANIMAL; COMPLICATION; FLOW CYTOMETRY; GENE INACTIVATION; GENETICS; IMMUNOBLOTTING; INFLAMMATION; LIVER; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANEMIA, SICKLE CELL; ANIMALS; CYTOSKELETAL PROTEINS; DNA PRIMERS; FLOW CYTOMETRY; GENE KNOCKOUT TECHNIQUES; IMMUNOBLOTTING; INFLAMMATION; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LIVER; LUCIFERASES; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84942856730     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1509158112     Document Type: Article

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