Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice

Journal of Immunology

Volumn 182, Issue 11, 2009, Pages 7264-7271

  Reddy, Narsa M ^a   Kleeberger, Steven R ^c   Kensler, Thomas W ^a   Yamamoto, Masayuki ^d   Hassoun, Paul M ^b   Reddy, Sekhar P ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL REGENERATION; CONTROLLED STUDY; FEMALE; GENOTYPE; HYPEROXIA; INFLAMMATION; KNOCKOUT MOUSE; LUNG ALVEOLUS CELL; LUNG ENDOTHELIUM; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TISSUE REPAIR; TRANSCRIPTION REGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; GENETIC TRANSCRIPTION; LUNG; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION;

ACUTE LUNG INJURY; ANIMALS; GLUTATHIONE; HYPEROXIA; INFLAMMATION; LUNG; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REGENERATION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 67449168081     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804248     Document Type: Article

References (35)

1. Crapo, J. D. 1986. Morphologic changes in pulmonary oxygen toxicity. Annu. Rev. Physiol. 48: 721-731.
2. Cho, H. Y., A. E. Jedlicka, S. P. Reddy, L. Y. Zhang, T. W. Kensler, and S. R. Kleeberger. 2002. Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. Am. J. Respir. Cell Mol. Biol. 26: 42-51.
3. Cho, H.-Y., A. E. Jedlicka, S. P. M. Reddy, T. W. Kensler, M. Yamamoto, L.-Y. Zhang, and S. R. Kleeberger. 2002. Role of NRF2 in protection against hyperoxic lung injury in mice. Am. J. Respir. Cell Mol. Biol. 26: 175-182.
4. Cho, H. Y., S. P. Reddy, M. Yamamoto, and S. R. Kleeberger. 2004. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J. 18: 1258-1260.
5. Cho, H. Y., S. P. Reddy, and S. R. Kleeberger. 2006. Nrf2 defends the lung from oxidative stress. Antioxid. Redox Signal. 8: 76-87.
6. Kensler, T. W., N. Wakabayashi, and S. Biswal. 2006. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47: 89-116.
7. Nguyen, T., P. J. Sherratt, and C. B. Pickett. 2003. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43: 233-260.
8. Marzec, J. M., J. D. Christie, S. P. Reddy, A. E. Jedlicka, H. Vuong, P. N. Lanken, R. Aplenc, T. Yamamoto, M. Yamamoto, H. Y. Cho, and S. R. Kleeberger. 2007. Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J. 21: 2237-2246.
9. Arisawa, T., T. Tahara, T. Shibata, M. Nagasaka, M. Nakamura, Y. Kamiya, H. Fujita, S. Hasegawa, T. Takagi, F. Y. Wang, et al. 2007. The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis. Int. J. Mol. Med. 19: 143-148.
10. Yamada, T., Y. Iwasaki, K. Nagata, S. Fushiki, H. Nakamura, Y. Marunaka, and J. Yodoi. 2007. Thioredoxin-1 protects against hyperoxia-induced apoptosis in cells of the alveolar walls. Pulm. Pharmacol. Ther. 20: 650-659.
11. Wang, Y., S. I. Feinstein, Y. Manevich, Y. S. Ho, and A. B. Fisher. 2006. Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress. Antioxid. Redox Signal. 8: 229-237.
12. Das, A., L. Kole, L. Wang, R. Barrios, B. Moorthy, and A. K. Jaiswal. 2006. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Free Radical Biol. Med. 40: 1843-1856.
13. MacNee, W. 2001. Oxidants/antioxidants and chronic obstructive pulmonary disease: pathogenesis to therapy. Novartis Found. Symp. 234: 169-185.
14. O'Reilly, M. A. 2001. DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking to facilitate repair. Am. J. Physiol. 281: L291-L305.
15. Comhair, S. A., and S. C. Erzurum. 2002. Antioxidant responses to oxidant-mediated lung diseases. Am. J. Physiol. 283: L246-L255.
16. Reddy, N. M., S. R. Kleeberger, H. Y. Cho, M. Yamamoto, T. W. Kensler, S. Biswal, and S. P. Reddy. 2007. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am. J. Respir. Cell Mol. Biol. 37: 3-8.
17. Reddy, N. M., S. R. Kleeberger, J. H. Bream, P. G. Fallon, T. W. Kensler, M. Yamamoto, and S. P. Reddy. 2008. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene 27: 5821-5832.
18. Noble, P. W., and D. Jiang. 2006. Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity. Proc. Am. Thorac. Soc. 3: 401-404.
19. Puchelle, E., J. M. Zahm, J. M. Tournier, and C. Coraux. 2006. Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 3: 726-733.
20. Staversky, R. J., R. H. Watkins, T. W. Wright, E. Hernady, M. B. LoMonaco, C. T. D'Angio, J. P. Williams, W. M. Maniscalco, and M. A. O'Reilly. 2002. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21Cip1/WAF1/Sdi1. Am. J. Pathol. 161: 1383-1393.
21. Baleeiro, C. E., S. E. Wilcoxen, S. B. Morris, T. J. Standiford, and R. Paine III. 2003. Sublethal hyperoxia impairs pulmonary innate immunity. J. Immunol. 171: 955-963.
22. Lee, J., R. Reddy, L. Barsky, K. Weinberg, and B. Driscoll. 2006. Contribution of proliferation and DNA damage repair to alveolar epithelial type 2 cell recovery from hyperoxia. Am. J. Physiol. 290: L685-L694.
23. Bhandari, V. 2008. Molecular mechanisms of hyperoxia-induced acute lung injury. Front. Biosci. 13: 6653-6661.
24. Tang, P. S., M. Mura, R. Seth, and M. Liu. 2008. Acute lung injury and cell death: how many ways can cells die? Am. J. Physiol. 294: L632-L641.
25. Minamino, T., and I. Komuro. 2006. Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. J. Clin. Invest. 116: 2316-2319.
26. Ware, L. B. 2006. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin. Respir. Crit. Care Med. 27: 337-349.
27. Roper, J. M., D. J. Mazzatti, R. H. Watkins, W. M. Maniscalco, P. C. Keng, and M. A. O'Reilly. 2004. In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells. Am. J. Physiol. 286: L1045-L1054.
28. 2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia. Am. J. Physiol. 284: L368-L375.
29. Cip1 and activation of the retinoblastoma protein. J. Biol. Chem. 278: 36099-36106.
30. Reddy, N. M., S. R. Kleeberger, M. Yamamoto, T. W. Kensler, C. Scollick, S. Biswal, and S. P. Reddy. 2007. Genetic dissection of the Nrf2-dependent redox signaling regulated transcriptional programs of cell proliferation and cytoprotection. Physiol. Genomics 32: 74-81.
31. Goodman, R. B., J. Pugin, J. S. Lee, and M. A. Matthay. 2003. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 14: 523-535.
32. Serhan, C. N., and J. Savill. 2005. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6: 1191-1197.
33. Zhang, X., and D. M. Mosser. 2008. Macrophage activation by endogenous danger signals. J. Pathol. 214: 161-178.
34. Nathan, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79: 319-326.
35. Takemura, R., and Z. Werb. 1984. Secretory products of macrophages and their physiological functions. Am. J. Physiol. 246: C1-C9.