-
1
-
-
4544243747
-
At the crossroads of inflammation and cancer
-
Clevers, H. (2004) At the crossroads of inflammation and cancer. Cell 118, 671-674
-
(2004)
Cell
, vol.118
, pp. 671-674
-
-
Clevers, H.1
-
2
-
-
77955279767
-
Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
-
O'Connor, P. M., Lapointe, T. K., Beck, P. L., and Buret, A. G. (2010) Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm. Bowel Dis. 16, 1411-1420
-
(2010)
Inflamm. Bowel Dis.
, vol.16
, pp. 1411-1420
-
-
O'Connor, P.M.1
Lapointe, T.K.2
Beck, P.L.3
Buret, A.G.4
-
3
-
-
0037357426
-
Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models
-
Seril, D. N., Liao, J., Yang, G. Y., and Yang, C. S. (2003) Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 24, 353-362
-
(2003)
Carcinogenesis
, vol.24
, pp. 353-362
-
-
Seril, D.N.1
Liao, J.2
Yang, G.Y.3
Yang, C.S.4
-
4
-
-
36148934915
-
Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
-
Chang, W. C., Coudry, R. A., Clapper, M. L., Zhang, X., Williams, K. L., Spittle, C. S., Li, T., and Cooper, H. S. (2007) Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis 28, 2375-2381
-
(2007)
Carcinogenesis
, vol.28
, pp. 2375-2381
-
-
Chang, W.C.1
Coudry, R.A.2
Clapper, M.L.3
Zhang, X.4
Williams, K.L.5
Spittle, C.S.6
Li, T.7
Cooper, H.S.8
-
5
-
-
47849083585
-
Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
-
Osburn, W. O., and Kensler, T. W. (2008) Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat. Res. 659, 31-39
-
(2008)
Mutat. Res.
, vol.659
, pp. 31-39
-
-
Osburn, W.O.1
Kensler, T.W.2
-
6
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler, T. W., Wakabayashi, N., and Biswal, S. (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47, 89-116
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
7
-
-
56249086316
-
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
-
Khor, T. O., Huang, M. T., Prawan, A., Liu, Y., Hao, X., Yu, S., Cheung, W. K., Chan, J. Y., Reddy, B. S., Yang, C. S., and Kong, A. N. (2008) Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev. Res. 1, 187-191
-
(2008)
Cancer Prev. Res.
, vol.1
, pp. 187-191
-
-
Khor, T.O.1
Huang, M.T.2
Prawan, A.3
Liu, Y.4
Hao, X.5
Yu, S.6
Cheung, W.K.7
Chan, J.Y.8
Reddy, B.S.9
Yang, C.S.10
Kong, A.N.11
-
8
-
-
74049120454
-
Nrf2: Friend or foe for chemoprevention?
-
Kensler, T. W., and Wakabayashi, N. (2010) Nrf2: friend or foe for chemoprevention? Carcinogenesis 31, 90-99
-
(2010)
Carcinogenesis
, vol.31
, pp. 90-99
-
-
Kensler, T.W.1
Wakabayashi, N.2
-
9
-
-
77958130983
-
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
-
Hayes, J. D., McMahon, M., Chowdhry, S., and Dinkova-Kostova, A. T. (2010). Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid. Redox Signal. 13, 1713-1748
-
(2010)
Antioxid. Redox Signal.
, vol.13
, pp. 1713-1748
-
-
Hayes, J.D.1
McMahon, M.2
Chowdhry, S.3
Dinkova-Kostova, A.T.4
-
10
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
Lau, A., Villeneuve, N. F., Sun, Z., Wong, P. K., and Zhang, D. D. (2008) Dual roles of Nrf2 in cancer. Pharmacol. Res. 58, 262-270
-
(2008)
Pharmacol. Res.
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
-
11
-
-
78049370987
-
Oxidative stress, inflammation, and cancer: How are they linked? Free Rad
-
Reuter, S., Gupta, S. C., Chaturvedi, M. M., and Aggarwal, B. B. (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Rad. Biol. Med. 49, 1603-1616
-
(2010)
Biol. Med.
, vol.49
, pp. 1603-1616
-
-
Reuter, S.1
Gupta, S.C.2
Chaturvedi, M.M.3
Aggarwal, B.B.4
-
12
-
-
70449674487
-
Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
-
Arlt, A., Bauer, I., Schafmayer, C., Tepel, J., Müerköster, S. S., Brosch, M., Röder, C., Kalthoff, H., Hampe, J., Moyer, M. P., Fölsch, U. R., and Schäfer, H. (2009) Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). Oncogene 28, 3983-3996
-
(2009)
Oncogene
, vol.28
, pp. 3983-3996
-
-
Arlt, A.1
Bauer, I.2
Schafmayer, C.3
Tepel, J.4
Müerköster, S.S.5
Brosch, M.6
Röder, C.7
Kalthoff, H.8
Hampe, J.9
Moyer, M.P.10
Fölsch, U.R.11
Schäfer, H.12
-
13
-
-
79952749190
-
NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
-
Kim, T. H., Hur, E. G., Kang, S. J., Kim, J. A., Thapa, D., Lee, Y. M., Ku, S. K., Jung, Y., and Kwak, M. K. (2011) NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res. 71, 2260-2275
-
(2011)
Cancer Res.
, vol.71
, pp. 2260-2275
-
-
Kim, T.H.1
Hur, E.G.2
Kang, S.J.3
Kim, J.A.4
Thapa, D.5
Lee, Y.M.6
Ku, S.K.7
Jung, Y.8
Kwak, M.K.9
-
14
-
-
84892434876
-
Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue
-
Chang, L. C., Fan, C. W., Tseng, W. K., Chen, J. R., Chein, H. P., Hwang, C. C., and Hua, C. C. (2013) Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue. Appl. Immunohistochem. Mol. Morphol. 21, 511-517
-
(2013)
Appl. Immunohistochem. Mol. Morphol.
, vol.21
, pp. 511-517
-
-
Chang, L.C.1
Fan, C.W.2
Tseng, W.K.3
Chen, J.R.4
Chein, H.P.5
Hwang, C.C.6
Hua, C.C.7
-
15
-
-
77951710223
-
Nuclear factor (erythroidderived 2)-like 2 regulates drug resistance in pancreatic cancer cells
-
Hong, Y. B., Kang, H. J., Kwon, S. Y., Kim, H. J., Kwon, K. Y., Cho, C. H., Lee, J. M., Kallakury, B. V., and Bae, I. (2010) Nuclear factor (erythroidderived 2)-like 2 regulates drug resistance in pancreatic cancer cells. Pancreas 39, 463-472
-
(2010)
Pancreas
, vol.39
, pp. 463-472
-
-
Hong, Y.B.1
Kang, H.J.2
Kwon, S.Y.3
Kim, H.J.4
Kwon, K.Y.5
Cho, C.H.6
Lee, J.M.7
Kallakury, B.V.8
Bae, I.9
-
16
-
-
79960060305
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., Scrimieri, F., Winter, J. M., Hruban, R. H., Iacobuzio-Donahue, C., Kern, S. E., Blair, I. A., and Tuveson, D. A. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475, 106-109
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
Denicola, G.M.1
Karreth, F.A.2
Humpton, T.J.3
Gopinathan, A.4
Wei, C.5
Frese, K.6
Mangal, D.7
Yu, K.H.8
Yeo, C.J.9
Calhoun, E.S.10
Scrimieri, F.11
Winter, J.M.12
Hruban, R.H.13
Iacobuzio-Donahue, C.14
Kern, S.E.15
Blair, I.A.16
Tuveson, D.A.17
-
17
-
-
63549121490
-
NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
-
Hayes, J. D., and McMahon, M. (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem. Sci. 34, 176-188
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
18
-
-
84862786878
-
Somatic mutations of the KEAP1 gene in common solid cancers
-
Yoo, N. J., Kim, H. R., Kim, Y. R., An, C. H., and Lee, S. H. (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60, 943-952
-
(2012)
Histopathology
, vol.60
, pp. 943-952
-
-
Yoo, N.J.1
Kim, H.R.2
Kim, Y.R.3
An, C.H.4
Lee, S.H.5
-
19
-
-
45849133744
-
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
-
Wang, R., An, J., Ji, F., Jiao, H., Sun, H., and Zhou, D. (2008) Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem. Biophys. Res. Commun. 373, 151-154
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.373
, pp. 151-154
-
-
Wang, R.1
An, J.2
Ji, F.3
Jiao, H.4
Sun, H.5
Zhou, D.6
-
20
-
-
81755171451
-
MiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
-
Eades, G., Yang, M., Ya, Y., Zhang, Y., and Zhou, Q. (2011) miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J. Biol. Chem. 286, 40725-40733
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 40725-40733
-
-
Eades, G.1
Yang, M.2
Ya, Y.3
Zhang, Y.4
Zhou, Q.5
-
21
-
-
80054767730
-
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: Roles for fumarate in KEAP1 succination and Nrf2 signaling
-
Adam, J., Hatipoglu, E., O'Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G. W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P. H., Pugh, C. W., Frizzell, N., Soga, T., Kessler, B. M., El-Bahrawy, M., Ratcliffe, P. J., and Pollard, P. J. (2011) Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 20, 524-537
-
(2011)
Cancer Cell
, vol.20
, pp. 524-537
-
-
Adam, J.1
Hatipoglu, E.2
O'Flaherty, L.3
Ternette, N.4
Sahgal, N.5
Lockstone, H.6
Baban, D.7
Nye, E.8
Stamp, G.W.9
Wolhuter, K.10
Stevens, M.11
Fischer, R.12
Carmeliet, P.13
Maxwell, P.H.14
Pugh, C.W.15
Frizzell, N.16
Soga, T.17
Kessler, B.M.18
El-Bahrawy, M.19
Ratcliffe, P.J.20
Pollard, P.J.21
more..
-
22
-
-
80054724249
-
Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2
-
Kinch, L., Grishin, N. V., and Brugarolas, J. (2011) Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2. Cancer Cell 20, 418-420
-
(2011)
Cancer Cell
, vol.20
, pp. 418-420
-
-
Kinch, L.1
Grishin, N.V.2
Brugarolas, J.3
-
23
-
-
79954617446
-
Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression
-
Kaspar, J. W., and Jaiswal, A. K. (2011) Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression. FASEB J. 25, 1076-1087
-
(2011)
FASEB J.
, vol.25
, pp. 1076-1087
-
-
Kaspar, J.W.1
Jaiswal, A.K.2
-
25
-
-
77958004285
-
Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
-
Singh, S., Vrishni, S., Singh, B.K., Rahman, I., and Kakkar, P. (2010) Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radic. Res. 44, 1267-1288
-
(2010)
Free Radic. Res.
, vol.44
, pp. 1267-1288
-
-
Singh, S.1
Vrishni, S.2
Singh, B.K.3
Rahman, I.4
Kakkar, P.5
-
26
-
-
81755181689
-
Inflammatory macrophages induce NRF2-dependent proteasome activity in colonic NCM460 cells and thereby confer antiapoptotic protection
-
Sebens, S., Bauer, I., Geismann, C., Grage-Griebenow, E., Ehlers, S., and Kruse, M. L. (2011) Inflammatory macrophages induce NRF2-dependent proteasome activity in colonic NCM460 cells and thereby confer antiapoptotic protection. J. Biol. Chem. 286, 40911-40921
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 40911-40921
-
-
Sebens, S.1
Bauer, I.2
Geismann, C.3
Grage-Griebenow, E.4
Ehlers, S.5
Kruse, M.L.6
-
27
-
-
73949136139
-
Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB
-
Sina, C., Arlt, A., Gavrilova, O., Midtling, E., Kruse, M. L., Muerkoster, S. S., Kumar, R., Fölsch, U. R., Schreiber, S., Rosenstiel, P., and Schäfer, H. (2010) Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-κB. Inflamm. Bowel Dis. 16, 320-331
-
(2010)
Inflamm. Bowel Dis.
, vol.16
, pp. 320-331
-
-
Sina, C.1
Arlt, A.2
Gavrilova, O.3
Midtling, E.4
Kruse, M.L.5
Muerkoster, S.S.6
Kumar, R.7
Fölsch, U.R.8
Schreiber, S.9
Rosenstiel, P.10
Schäfer, H.11
-
28
-
-
79955485454
-
Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis
-
Arlt, A., and Schäfer, H. (2011) Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis. Eur. J. Cell Biol. 90, 545-552
-
(2011)
Eur. J. Cell Biol.
, vol.90
, pp. 545-552
-
-
Arlt, A.1
Schäfer, H.2
-
29
-
-
0037246194
-
Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis
-
Wu, M. X. (2003) Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. Apoptosis 8, 11-18
-
(2003)
Apoptosis
, vol.8
, pp. 11-18
-
-
Wu, M.X.1
-
30
-
-
0029965054
-
Identification and characterization of a radiation-inducible glycosylated human early response gene
-
Kondratyev, A. D., Chung, K. N., and Jung, M. O. (1996) Identification and characterization of a radiation-inducible glycosylated human early response gene. Cancer Res. 56, 1498-1502
-
(1996)
Cancer Res.
, vol.56
, pp. 1498-1502
-
-
Kondratyev, A.D.1
Chung, K.N.2
Jung, M.O.3
-
31
-
-
0035804222
-
Expression of the NF-κB target gene IEX-1 (p22/ PRG1) does not prevent cell death but instead triggers apoptosis in HeLa cells
-
Arlt, A., Grobe, O., Sieke, A., Kruse, M. L., Fölsch, U. R., Schmidt, W. E., and Schäfer, H. (2001) Expression of the NF-κB target gene IEX-1 (p22/ PRG1) does not prevent cell death but instead triggers apoptosis in HeLa cells. Oncogene 20, 69-76
-
(2001)
Oncogene
, vol.20
, pp. 69-76
-
-
Arlt, A.1
Grobe, O.2
Sieke, A.3
Kruse, M.L.4
Fölsch, U.R.5
Schmidt, W.E.6
Schäfer, H.7
-
32
-
-
0038282473
-
The early response gene IEX-1 attenuates NF-κB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death
-
Arlt, A., Kruse, M. L., Breitenbroich, M., Gehrz, A., Koc, B., Minkenberg, J., Fölsch, U. R., and Schäfer, H. (2003) The early response gene IEX-1 attenuates NF-κB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death. Oncogene 22, 3343-3351
-
(2003)
Oncogene
, vol.22
, pp. 3343-3351
-
-
Arlt, A.1
Kruse, M.L.2
Breitenbroich, M.3
Gehrz, A.4
Koc, B.5
Minkenberg, J.6
Fölsch, U.R.7
Schäfer, H.8
-
33
-
-
0037446526
-
Expression of the NF-κB target gene x-rayinducible immediate early response factor-1 short enhances TNF-α-induced hepatocyte apoptosis by inhibiting Akt activation
-
Osawa, Y., Nagaki, M., Banno, Y., Brenner, D. A., Nozawa, Y., Moriwaki, H., and Nakashima S. (2003) Expression of the NF-κB target gene x-rayinducible immediate early response factor-1 short enhances TNF-α-induced hepatocyte apoptosis by inhibiting Akt activation. J. Immunol. 170, 4053-4060
-
(2003)
J. Immunol.
, vol.170
, pp. 4053-4060
-
-
Osawa, Y.1
Nagaki, M.2
Banno, Y.3
Brenner, D.A.4
Nozawa, Y.5
Moriwaki, H.6
Nakashima, S.7
-
34
-
-
81255203856
-
Clinical significance of IEX-1 expression in ovarian carcinoma
-
Han, L., Geng, L., Liu, X., Shi, H., He, W., and Wu, M. X. (2011) Clinical significance of IEX-1 expression in ovarian carcinoma. Ultrastruct. Pathol. 35, 260-266
-
(2011)
Ultrastruct. Pathol.
, vol.35
, pp. 260-266
-
-
Han, L.1
Geng, L.2
Liu, X.3
Shi, H.4
He, W.5
Wu, M.X.6
-
35
-
-
40649087407
-
Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer
-
Sasada, T., Azuma, K., Hirai, T., Hashida, H., Kanai, M., Yanagawa, T., and Takabayashi A. (2008) Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer. Ann. Surg. Oncol. 15, 609-617
-
(2008)
Ann. Surg. Oncol.
, vol.15
, pp. 609-617
-
-
Sasada, T.1
Azuma, K.2
Hirai, T.3
Hashida, H.4
Kanai, M.5
Yanagawa, T.6
Takabayashi, A.7
-
36
-
-
4644286712
-
Genetic signatures of high-and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer
-
Nambiar, P. R., Nakanishi, M., Gupta, R., Cheung, E., Firouzi, A., Ma, X. J., Flynn, C., Dong, M., Guda, K., Levine, J., Raja, R., Achenie, L., and Rosenberg, D. W. (2004) Genetic signatures of high-and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer. Cancer Res. 64, 6394-6401
-
(2004)
Cancer Res.
, vol.64
, pp. 6394-6401
-
-
Nambiar, P.R.1
Nakanishi, M.2
Gupta, R.3
Cheung, E.4
Firouzi, A.5
Ma, X.J.6
Flynn, C.7
Dong, M.8
Guda, K.9
Levine, J.10
Raja, R.11
Achenie, L.12
Rosenberg, D.W.13
-
37
-
-
84864568868
-
Emerging role of IEX-1 in tumor pathogenesis and prognosis
-
Kapoor, S. (2012) Emerging role of IEX-1 in tumor pathogenesis and prognosis. Ultrastruct. Pathol. 36, 285
-
(2012)
Ultrastruct. Pathol.
, vol.36
, pp. 285
-
-
Kapoor, S.1
-
38
-
-
84876245655
-
Immediate early response gene X-1, a potential prognostic biomarker in cancers
-
Wu, M. X., Ustyugova, I. V., Han, L., and Akilov, O. E. (2013) Immediate early response gene X-1, a potential prognostic biomarker in cancers. Expert Opin. Ther. Targets 17, 593-606
-
(2013)
Expert Opin. Ther. Targets
, vol.17
, pp. 593-606
-
-
Wu, M.X.1
Ustyugova, I.V.2
Han, L.3
Akilov, O.E.4
-
39
-
-
84855705638
-
Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon
-
Ustyugova, I. V., Zhi, L., and Wu, M. X. (2012) Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon. Inflamm. Bowel Dis. 18, 333-343
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 333-343
-
-
Ustyugova, I.V.1
Zhi, L.2
Wu, M.X.3
-
40
-
-
84864800622
-
Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
-
Zhi, L., Ustyugova, I. V., Chen, X., Zhang, Q., and Wu, M. X. (2012) Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling. J. Immunol. 189, 1639-1647
-
(2012)
J. Immunol.
, vol.189
, pp. 1639-1647
-
-
Zhi, L.1
Ustyugova, I.V.2
Chen, X.3
Zhang, Q.4
Wu, M.X.5
-
41
-
-
0030158341
-
NCM460, a normal human colon mucosal epithelial cell line
-
Moyer, M. P., Manzano, L. A., Merriman, R. L., Stauffer, J. S., and Tanzer, L. R. (1996) NCM460, a normal human colon mucosal epithelial cell line. In Vitro Cell Dev. Biol. Anim. 32, 315-317
-
(1996)
Vitro Cell Dev. Biol. Anim.
, vol.32
, pp. 315-317
-
-
Moyer, M.P.1
Manzano, L.A.2
Merriman, R.L.3
Stauffer, J.S.4
Tanzer, L.R.5
-
42
-
-
33646366708
-
Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene
-
Sommer, S. L., Berndt, T. J., Frank, E., Patel, J. B., Redfield, M. M., Dong, X., Griffin, M. D., Grande, J. P., van Deursen, J. M., Sieck, G. C., Romero, J. C., and Kumar, R. (2006) Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J. Appl. Physiol. 100, 707-716
-
(2006)
J. Appl. Physiol.
, vol.100
, pp. 707-716
-
-
Sommer, S.L.1
Berndt, T.J.2
Frank, E.3
Patel, J.B.4
Redfield, M.M.5
Dong, X.6
Griffin, M.D.7
Grande, J.P.8
Van Deursen, J.M.9
Sieck, G.C.10
Romero, J.C.11
Kumar, R.12
-
43
-
-
13944252061
-
Increased expression of the E3-ubiquitin ligase receptor subunit βtRCP1 relates to constitutive NF-κB activation and chemoresistance in pancreatic carcinoma cells
-
Müerköster, S., Arlt, A., Sipos, B., Witt, M., Grossmann, M., Klöppel, G., Kalthoff, H., Fölsch, U. R., and Schäfer, H. (2005) Increased expression of the E3-ubiquitin ligase receptor subunit βTRCP1 relates to constitutive NF-κB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res. 65, 1316-1324
-
(2005)
Cancer Res.
, vol.65
, pp. 1316-1324
-
-
Müerköster, S.1
Arlt, A.2
Sipos, B.3
Witt, M.4
Grossmann, M.5
Klöppel, G.6
Kalthoff, H.7
Fölsch, U.R.8
Schäfer, H.9
-
44
-
-
62849106939
-
IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
-
Shen, L., Zhi, L., Hu, W., and Wu, M. X. (2009) IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ. 16, 603-612
-
(2009)
Cell Death Differ.
, vol.16
, pp. 603-612
-
-
Shen, L.1
Zhi, L.2
Hu, W.3
Wu, M.X.4
-
45
-
-
34447526197
-
GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor
-
Jain, A. K., and Jaiswal, A. K. (2007) GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor. J. Biol. Chem. 282, 16502-16510
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16502-16510
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
46
-
-
77958140054
-
The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer
-
Zhang, D. D. (2010) The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer. Antioxid. Redox Signal. 13, 1623-1626
-
(2010)
Antioxid. Redox Signal.
, vol.13
, pp. 1623-1626
-
-
Zhang, D.D.1
-
47
-
-
0242721624
-
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway
-
Kwak, M. K., Wakabayashi, N., Greenlaw, J. L., Yamamoto, M., and Kensler, T. W. (2003) Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol. Cell. Biol. 23, 8786-8794
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8786-8794
-
-
Kwak, M.K.1
Wakabayashi, N.2
Greenlaw, J.L.3
Yamamoto, M.4
Kensler, T.W.5
-
48
-
-
84885177241
-
Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
-
Arlt, A., Sebens, S., Krebs, S., Geismann, C., Grossmann, M., Kruse, M. L., Schreiber, S., and Schäfer, H. (2013) Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene 32, 4825-4835
-
(2013)
Oncogene
, vol.32
, pp. 4825-4835
-
-
Arlt, A.1
Sebens, S.2
Krebs, S.3
Geismann, C.4
Grossmann, M.5
Kruse, M.L.6
Schreiber, S.7
Schäfer, H.8
-
49
-
-
67650922529
-
Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
-
Akhdar, H., Loyer, P., Rauch, C., Corlu, A., Guillouzo, A., and Morel, F. (2009) Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. Eur. J. Cancer 45, 2219-2227
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 2219-2227
-
-
Akhdar, H.1
Loyer, P.2
Rauch, C.3
Corlu, A.4
Guillouzo, A.5
Morel, F.6
-
50
-
-
80054772589
-
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
-
Ooi, A., Wong, J. C., Petillo, D., Roossien, D., Perrier-Trudova, V., Whitten, D., Min, B. W., Tan, M. H., Zhang, Z., Yang, X. J., Zhou, M., Gardie, B., Molinié, V., Richard, S., Tan, P. H., Teh, B. T., and Furge, K. A. (2011) An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 20, 511-523
-
(2011)
Cancer Cell
, vol.20
, pp. 511-523
-
-
Ooi, A.1
Wong, J.C.2
Petillo, D.3
Roossien, D.4
Perrier-Trudova, V.5
Whitten, D.6
Min, B.W.7
Tan, M.H.8
Zhang, Z.9
Yang, X.J.10
Zhou, M.11
Gardie, B.12
Molinié, V.13
Richard, S.14
Tan, P.H.15
Teh, B.T.16
Furge, K.A.17
-
51
-
-
84856257180
-
Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner
-
Deng, C., Tao, R., Yu, S. Z., and Jin, H. (2012) Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner. Mol. Med. Rep. 5, 847-851
-
(2012)
Mol. Med. Rep.
, vol.5
, pp. 847-851
-
-
Deng, C.1
Tao, R.2
Yu, S.Z.3
Jin, H.4
-
52
-
-
84860393361
-
Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway
-
Leoncini, E., Malaguti, M., Angeloni, C., Motori, E., Fabbri, D., and Hrelia, S. (2011) Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway. J. Food Sci. 76, H175-H181
-
(2011)
J. Food Sci.
, vol.76
-
-
Leoncini, E.1
Malaguti, M.2
Angeloni, C.3
Motori, E.4
Fabbri, D.5
Hrelia, S.6
-
53
-
-
41949114612
-
IEX-1 directly interferes with RelA/p65-dependent transactivation and regulation of apoptosis
-
Arlt, A., Rosenstiel, P., Kruse, M. L., Grohmann, F., Minkenberg, J., Perkins, N. D., Fölsch, U. R., Schreiber, S., and Schäfer, H. (2008) IEX-1 directly interferes with RelA/p65-dependent transactivation and regulation of apoptosis. Biochim. Biophys. Acta 1783, 941-952
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 941-952
-
-
Arlt, A.1
Rosenstiel, P.2
Kruse, M.L.3
Grohmann, F.4
Minkenberg, J.5
Perkins, N.D.6
Fölsch, U.R.7
Schreiber, S.8
Schäfer, H.9
-
54
-
-
79955018886
-
Genome-wide expression profiling identifies an impairment of negative feed-back signals in the Crohn disease-associated NOD2 variant L1007fsinsC1
-
Billmann-Born, S., Till, A., Arlt, A., Lipinski, S., Sina, C., Latiano, A., Annese, V., Häsler, R., Kerick, M., Manke, T., Seegert, D., Hanidu, A., Schäfer, H., van Heel, D., Li, J., Schreiber, S., and Rosenstiel P. (2011) Genome-wide expression profiling identifies an impairment of negative feed-back signals in the Crohn disease-associated NOD2 variant L1007fsinsC1. J. Immunol. 186, 4027-4038
-
(2011)
J. Immunol.
, vol.186
, pp. 4027-4038
-
-
Billmann-Born, S.1
Till, A.2
Arlt, A.3
Lipinski, S.4
Sina, C.5
Latiano, A.6
Annese, V.7
Häsler, R.8
Kerick, M.9
Manke, T.10
Seegert, D.11
Hanidu, A.12
Schäfer, H.13
Van Heel, D.14
Li, J.15
Schreiber, S.16
Rosenstiel, P.17
-
55
-
-
33644847555
-
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays
-
Costello, C. M., Mah, N., Häsler, R., Rosenstiel, P., Waetzig, G. H., Hahn, A., Lu, T., Gurbuz, Y., Nikolaus, S., Albrecht, M., Hampe, J., Lucius, R., Klöppel, G., Eickhoff, H., Lehrach, H., Lengauer, T., and Schreiber, S. (2005) Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med. 2, e199
-
(2005)
PLoS Med.
, vol.2
-
-
Costello, C.M.1
Mah, N.2
Häsler, R.3
Rosenstiel, P.4
Waetzig, G.H.5
Hahn, A.6
Lu, T.7
Gurbuz, Y.8
Nikolaus, S.9
Albrecht, M.10
Hampe, J.11
Lucius, R.12
Klöppel, G.13
Eickhoff, H.14
Lehrach, H.15
Lengauer, T.16
Schreiber, S.17
-
56
-
-
84893155306
-
The "n-factors" in pancreatic cancer: Functional relevance of NF-κB, NFAT, and Nrf2 in pancreatic cancer
-
Arlt, A., Schäfer, H., and Kalthoff, H. (2012) The "N-factors" in pancreatic cancer: functional relevance of NF-κB, NFAT, and Nrf2 in pancreatic cancer. Oncogenesis 1, e35
-
(2012)
Oncogenesis
, vol.1
-
-
Arlt, A.1
Schäfer, H.2
Kalthoff, H.3
-
57
-
-
84871519753
-
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemoresistance
-
Rushworth, S. A., Zaitseva, L., Murray, M. Y., Shah, N. M., Bowles, K. M., and MacEwan, D. J. (2012) The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemoresistance. Blood 120, 5188-5198
-
(2012)
Blood
, vol.120
, pp. 5188-5198
-
-
Rushworth, S.A.1
Zaitseva, L.2
Murray, M.Y.3
Shah, N.M.4
Bowles, K.M.5
Macewan, D.J.6
-
58
-
-
79951853800
-
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
-
Yu, M., Li, H., Liu, Q., Liu, F., Tang, L., Li, C., Yuan, Y., Zhan, Y., Xu, W., Li, W., Chen, H., Ge, C., Wang, J., and Yang, X. (2011) Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell. Signal. 23, 883-892
-
(2011)
Cell. Signal.
, vol.23
, pp. 883-892
-
-
Yu, M.1
Li, H.2
Liu, Q.3
Liu, F.4
Tang, L.5
Li, C.6
Yuan, Y.7
Zhan, Y.8
Xu, W.9
Li, W.10
Chen, H.11
Ge, C.12
Wang, J.13
Yang, X.14
-
59
-
-
77955279350
-
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
-
Kim, J., Cha, Y. N., and Surh, Y. J. (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 690, 12-23
-
(2010)
Mutat. Res.
, vol.690
, pp. 12-23
-
-
Kim, J.1
Cha, Y.N.2
Surh, Y.J.3
|