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Volumn 289, Issue 4, 2014, Pages 1917-1929

Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: A novel mechanism of cellular adaption to inflammatory stress

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPROTECTION; DUAL ROLE; EPITHELIAL CELLS; LOSS OF CONTROL; NUCLEAR FACTORS; STRESS RESPONSE GENES; TUMORIGENESIS;

EID: 84893067601     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.490920     Document Type: Article
Times cited : (46)

References (59)
  • 1
    • 4544243747 scopus 로고    scopus 로고
    • At the crossroads of inflammation and cancer
    • Clevers, H. (2004) At the crossroads of inflammation and cancer. Cell 118, 671-674
    • (2004) Cell , vol.118 , pp. 671-674
    • Clevers, H.1
  • 2
    • 77955279767 scopus 로고    scopus 로고
    • Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
    • O'Connor, P. M., Lapointe, T. K., Beck, P. L., and Buret, A. G. (2010) Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm. Bowel Dis. 16, 1411-1420
    • (2010) Inflamm. Bowel Dis. , vol.16 , pp. 1411-1420
    • O'Connor, P.M.1    Lapointe, T.K.2    Beck, P.L.3    Buret, A.G.4
  • 3
    • 0037357426 scopus 로고    scopus 로고
    • Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models
    • Seril, D. N., Liao, J., Yang, G. Y., and Yang, C. S. (2003) Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 24, 353-362
    • (2003) Carcinogenesis , vol.24 , pp. 353-362
    • Seril, D.N.1    Liao, J.2    Yang, G.Y.3    Yang, C.S.4
  • 5
    • 47849083585 scopus 로고    scopus 로고
    • Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
    • Osburn, W. O., and Kensler, T. W. (2008) Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat. Res. 659, 31-39
    • (2008) Mutat. Res. , vol.659 , pp. 31-39
    • Osburn, W.O.1    Kensler, T.W.2
  • 6
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler, T. W., Wakabayashi, N., and Biswal, S. (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47, 89-116
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 8
    • 74049120454 scopus 로고    scopus 로고
    • Nrf2: Friend or foe for chemoprevention?
    • Kensler, T. W., and Wakabayashi, N. (2010) Nrf2: friend or foe for chemoprevention? Carcinogenesis 31, 90-99
    • (2010) Carcinogenesis , vol.31 , pp. 90-99
    • Kensler, T.W.1    Wakabayashi, N.2
  • 11
    • 78049370987 scopus 로고    scopus 로고
    • Oxidative stress, inflammation, and cancer: How are they linked? Free Rad
    • Reuter, S., Gupta, S. C., Chaturvedi, M. M., and Aggarwal, B. B. (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Rad. Biol. Med. 49, 1603-1616
    • (2010) Biol. Med. , vol.49 , pp. 1603-1616
    • Reuter, S.1    Gupta, S.C.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 12
    • 70449674487 scopus 로고    scopus 로고
    • Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
    • Arlt, A., Bauer, I., Schafmayer, C., Tepel, J., Müerköster, S. S., Brosch, M., Röder, C., Kalthoff, H., Hampe, J., Moyer, M. P., Fölsch, U. R., and Schäfer, H. (2009) Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). Oncogene 28, 3983-3996
    • (2009) Oncogene , vol.28 , pp. 3983-3996
    • Arlt, A.1    Bauer, I.2    Schafmayer, C.3    Tepel, J.4    Müerköster, S.S.5    Brosch, M.6    Röder, C.7    Kalthoff, H.8    Hampe, J.9    Moyer, M.P.10    Fölsch, U.R.11    Schäfer, H.12
  • 13
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
    • Kim, T. H., Hur, E. G., Kang, S. J., Kim, J. A., Thapa, D., Lee, Y. M., Ku, S. K., Jung, Y., and Kwak, M. K. (2011) NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res. 71, 2260-2275
    • (2011) Cancer Res. , vol.71 , pp. 2260-2275
    • Kim, T.H.1    Hur, E.G.2    Kang, S.J.3    Kim, J.A.4    Thapa, D.5    Lee, Y.M.6    Ku, S.K.7    Jung, Y.8    Kwak, M.K.9
  • 14
    • 84892434876 scopus 로고    scopus 로고
    • Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue
    • Chang, L. C., Fan, C. W., Tseng, W. K., Chen, J. R., Chein, H. P., Hwang, C. C., and Hua, C. C. (2013) Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue. Appl. Immunohistochem. Mol. Morphol. 21, 511-517
    • (2013) Appl. Immunohistochem. Mol. Morphol. , vol.21 , pp. 511-517
    • Chang, L.C.1    Fan, C.W.2    Tseng, W.K.3    Chen, J.R.4    Chein, H.P.5    Hwang, C.C.6    Hua, C.C.7
  • 15
    • 77951710223 scopus 로고    scopus 로고
    • Nuclear factor (erythroidderived 2)-like 2 regulates drug resistance in pancreatic cancer cells
    • Hong, Y. B., Kang, H. J., Kwon, S. Y., Kim, H. J., Kwon, K. Y., Cho, C. H., Lee, J. M., Kallakury, B. V., and Bae, I. (2010) Nuclear factor (erythroidderived 2)-like 2 regulates drug resistance in pancreatic cancer cells. Pancreas 39, 463-472
    • (2010) Pancreas , vol.39 , pp. 463-472
    • Hong, Y.B.1    Kang, H.J.2    Kwon, S.Y.3    Kim, H.J.4    Kwon, K.Y.5    Cho, C.H.6    Lee, J.M.7    Kallakury, B.V.8    Bae, I.9
  • 17
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes, J. D., and McMahon, M. (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem. Sci. 34, 176-188
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 18
    • 84862786878 scopus 로고    scopus 로고
    • Somatic mutations of the KEAP1 gene in common solid cancers
    • Yoo, N. J., Kim, H. R., Kim, Y. R., An, C. H., and Lee, S. H. (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60, 943-952
    • (2012) Histopathology , vol.60 , pp. 943-952
    • Yoo, N.J.1    Kim, H.R.2    Kim, Y.R.3    An, C.H.4    Lee, S.H.5
  • 19
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • Wang, R., An, J., Ji, F., Jiao, H., Sun, H., and Zhou, D. (2008) Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem. Biophys. Res. Commun. 373, 151-154
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3    Jiao, H.4    Sun, H.5    Zhou, D.6
  • 20
    • 81755171451 scopus 로고    scopus 로고
    • MiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
    • Eades, G., Yang, M., Ya, Y., Zhang, Y., and Zhou, Q. (2011) miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J. Biol. Chem. 286, 40725-40733
    • (2011) J. Biol. Chem. , vol.286 , pp. 40725-40733
    • Eades, G.1    Yang, M.2    Ya, Y.3    Zhang, Y.4    Zhou, Q.5
  • 22
    • 80054724249 scopus 로고    scopus 로고
    • Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2
    • Kinch, L., Grishin, N. V., and Brugarolas, J. (2011) Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2. Cancer Cell 20, 418-420
    • (2011) Cancer Cell , vol.20 , pp. 418-420
    • Kinch, L.1    Grishin, N.V.2    Brugarolas, J.3
  • 23
    • 79954617446 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression
    • Kaspar, J. W., and Jaiswal, A. K. (2011) Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression. FASEB J. 25, 1076-1087
    • (2011) FASEB J. , vol.25 , pp. 1076-1087
    • Kaspar, J.W.1    Jaiswal, A.K.2
  • 25
    • 77958004285 scopus 로고    scopus 로고
    • Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
    • Singh, S., Vrishni, S., Singh, B.K., Rahman, I., and Kakkar, P. (2010) Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radic. Res. 44, 1267-1288
    • (2010) Free Radic. Res. , vol.44 , pp. 1267-1288
    • Singh, S.1    Vrishni, S.2    Singh, B.K.3    Rahman, I.4    Kakkar, P.5
  • 26
    • 81755181689 scopus 로고    scopus 로고
    • Inflammatory macrophages induce NRF2-dependent proteasome activity in colonic NCM460 cells and thereby confer antiapoptotic protection
    • Sebens, S., Bauer, I., Geismann, C., Grage-Griebenow, E., Ehlers, S., and Kruse, M. L. (2011) Inflammatory macrophages induce NRF2-dependent proteasome activity in colonic NCM460 cells and thereby confer antiapoptotic protection. J. Biol. Chem. 286, 40911-40921
    • (2011) J. Biol. Chem. , vol.286 , pp. 40911-40921
    • Sebens, S.1    Bauer, I.2    Geismann, C.3    Grage-Griebenow, E.4    Ehlers, S.5    Kruse, M.L.6
  • 28
    • 79955485454 scopus 로고    scopus 로고
    • Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis
    • Arlt, A., and Schäfer, H. (2011) Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis. Eur. J. Cell Biol. 90, 545-552
    • (2011) Eur. J. Cell Biol. , vol.90 , pp. 545-552
    • Arlt, A.1    Schäfer, H.2
  • 29
    • 0037246194 scopus 로고    scopus 로고
    • Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis
    • Wu, M. X. (2003) Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. Apoptosis 8, 11-18
    • (2003) Apoptosis , vol.8 , pp. 11-18
    • Wu, M.X.1
  • 30
    • 0029965054 scopus 로고    scopus 로고
    • Identification and characterization of a radiation-inducible glycosylated human early response gene
    • Kondratyev, A. D., Chung, K. N., and Jung, M. O. (1996) Identification and characterization of a radiation-inducible glycosylated human early response gene. Cancer Res. 56, 1498-1502
    • (1996) Cancer Res. , vol.56 , pp. 1498-1502
    • Kondratyev, A.D.1    Chung, K.N.2    Jung, M.O.3
  • 31
    • 0035804222 scopus 로고    scopus 로고
    • Expression of the NF-κB target gene IEX-1 (p22/ PRG1) does not prevent cell death but instead triggers apoptosis in HeLa cells
    • Arlt, A., Grobe, O., Sieke, A., Kruse, M. L., Fölsch, U. R., Schmidt, W. E., and Schäfer, H. (2001) Expression of the NF-κB target gene IEX-1 (p22/ PRG1) does not prevent cell death but instead triggers apoptosis in HeLa cells. Oncogene 20, 69-76
    • (2001) Oncogene , vol.20 , pp. 69-76
    • Arlt, A.1    Grobe, O.2    Sieke, A.3    Kruse, M.L.4    Fölsch, U.R.5    Schmidt, W.E.6    Schäfer, H.7
  • 32
    • 0038282473 scopus 로고    scopus 로고
    • The early response gene IEX-1 attenuates NF-κB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death
    • Arlt, A., Kruse, M. L., Breitenbroich, M., Gehrz, A., Koc, B., Minkenberg, J., Fölsch, U. R., and Schäfer, H. (2003) The early response gene IEX-1 attenuates NF-κB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death. Oncogene 22, 3343-3351
    • (2003) Oncogene , vol.22 , pp. 3343-3351
    • Arlt, A.1    Kruse, M.L.2    Breitenbroich, M.3    Gehrz, A.4    Koc, B.5    Minkenberg, J.6    Fölsch, U.R.7    Schäfer, H.8
  • 33
    • 0037446526 scopus 로고    scopus 로고
    • Expression of the NF-κB target gene x-rayinducible immediate early response factor-1 short enhances TNF-α-induced hepatocyte apoptosis by inhibiting Akt activation
    • Osawa, Y., Nagaki, M., Banno, Y., Brenner, D. A., Nozawa, Y., Moriwaki, H., and Nakashima S. (2003) Expression of the NF-κB target gene x-rayinducible immediate early response factor-1 short enhances TNF-α-induced hepatocyte apoptosis by inhibiting Akt activation. J. Immunol. 170, 4053-4060
    • (2003) J. Immunol. , vol.170 , pp. 4053-4060
    • Osawa, Y.1    Nagaki, M.2    Banno, Y.3    Brenner, D.A.4    Nozawa, Y.5    Moriwaki, H.6    Nakashima, S.7
  • 34
    • 81255203856 scopus 로고    scopus 로고
    • Clinical significance of IEX-1 expression in ovarian carcinoma
    • Han, L., Geng, L., Liu, X., Shi, H., He, W., and Wu, M. X. (2011) Clinical significance of IEX-1 expression in ovarian carcinoma. Ultrastruct. Pathol. 35, 260-266
    • (2011) Ultrastruct. Pathol. , vol.35 , pp. 260-266
    • Han, L.1    Geng, L.2    Liu, X.3    Shi, H.4    He, W.5    Wu, M.X.6
  • 35
    • 40649087407 scopus 로고    scopus 로고
    • Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer
    • Sasada, T., Azuma, K., Hirai, T., Hashida, H., Kanai, M., Yanagawa, T., and Takabayashi A. (2008) Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer. Ann. Surg. Oncol. 15, 609-617
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 609-617
    • Sasada, T.1    Azuma, K.2    Hirai, T.3    Hashida, H.4    Kanai, M.5    Yanagawa, T.6    Takabayashi, A.7
  • 37
    • 84864568868 scopus 로고    scopus 로고
    • Emerging role of IEX-1 in tumor pathogenesis and prognosis
    • Kapoor, S. (2012) Emerging role of IEX-1 in tumor pathogenesis and prognosis. Ultrastruct. Pathol. 36, 285
    • (2012) Ultrastruct. Pathol. , vol.36 , pp. 285
    • Kapoor, S.1
  • 38
    • 84876245655 scopus 로고    scopus 로고
    • Immediate early response gene X-1, a potential prognostic biomarker in cancers
    • Wu, M. X., Ustyugova, I. V., Han, L., and Akilov, O. E. (2013) Immediate early response gene X-1, a potential prognostic biomarker in cancers. Expert Opin. Ther. Targets 17, 593-606
    • (2013) Expert Opin. Ther. Targets , vol.17 , pp. 593-606
    • Wu, M.X.1    Ustyugova, I.V.2    Han, L.3    Akilov, O.E.4
  • 39
    • 84855705638 scopus 로고    scopus 로고
    • Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon
    • Ustyugova, I. V., Zhi, L., and Wu, M. X. (2012) Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon. Inflamm. Bowel Dis. 18, 333-343
    • (2012) Inflamm. Bowel Dis. , vol.18 , pp. 333-343
    • Ustyugova, I.V.1    Zhi, L.2    Wu, M.X.3
  • 40
    • 84864800622 scopus 로고    scopus 로고
    • Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
    • Zhi, L., Ustyugova, I. V., Chen, X., Zhang, Q., and Wu, M. X. (2012) Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling. J. Immunol. 189, 1639-1647
    • (2012) J. Immunol. , vol.189 , pp. 1639-1647
    • Zhi, L.1    Ustyugova, I.V.2    Chen, X.3    Zhang, Q.4    Wu, M.X.5
  • 43
    • 13944252061 scopus 로고    scopus 로고
    • Increased expression of the E3-ubiquitin ligase receptor subunit βtRCP1 relates to constitutive NF-κB activation and chemoresistance in pancreatic carcinoma cells
    • Müerköster, S., Arlt, A., Sipos, B., Witt, M., Grossmann, M., Klöppel, G., Kalthoff, H., Fölsch, U. R., and Schäfer, H. (2005) Increased expression of the E3-ubiquitin ligase receptor subunit βTRCP1 relates to constitutive NF-κB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res. 65, 1316-1324
    • (2005) Cancer Res. , vol.65 , pp. 1316-1324
    • Müerköster, S.1    Arlt, A.2    Sipos, B.3    Witt, M.4    Grossmann, M.5    Klöppel, G.6    Kalthoff, H.7    Fölsch, U.R.8    Schäfer, H.9
  • 44
    • 62849106939 scopus 로고    scopus 로고
    • IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
    • Shen, L., Zhi, L., Hu, W., and Wu, M. X. (2009) IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ. 16, 603-612
    • (2009) Cell Death Differ. , vol.16 , pp. 603-612
    • Shen, L.1    Zhi, L.2    Hu, W.3    Wu, M.X.4
  • 45
    • 34447526197 scopus 로고    scopus 로고
    • GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor
    • Jain, A. K., and Jaiswal, A. K. (2007) GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor. J. Biol. Chem. 282, 16502-16510
    • (2007) J. Biol. Chem. , vol.282 , pp. 16502-16510
    • Jain, A.K.1    Jaiswal, A.K.2
  • 46
    • 77958140054 scopus 로고    scopus 로고
    • The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer
    • Zhang, D. D. (2010) The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer. Antioxid. Redox Signal. 13, 1623-1626
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 1623-1626
    • Zhang, D.D.1
  • 47
    • 0242721624 scopus 로고    scopus 로고
    • Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway
    • Kwak, M. K., Wakabayashi, N., Greenlaw, J. L., Yamamoto, M., and Kensler, T. W. (2003) Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol. Cell. Biol. 23, 8786-8794
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8786-8794
    • Kwak, M.K.1    Wakabayashi, N.2    Greenlaw, J.L.3    Yamamoto, M.4    Kensler, T.W.5
  • 48
    • 84885177241 scopus 로고    scopus 로고
    • Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
    • Arlt, A., Sebens, S., Krebs, S., Geismann, C., Grossmann, M., Kruse, M. L., Schreiber, S., and Schäfer, H. (2013) Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene 32, 4825-4835
    • (2013) Oncogene , vol.32 , pp. 4825-4835
    • Arlt, A.1    Sebens, S.2    Krebs, S.3    Geismann, C.4    Grossmann, M.5    Kruse, M.L.6    Schreiber, S.7    Schäfer, H.8
  • 49
    • 67650922529 scopus 로고    scopus 로고
    • Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
    • Akhdar, H., Loyer, P., Rauch, C., Corlu, A., Guillouzo, A., and Morel, F. (2009) Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. Eur. J. Cancer 45, 2219-2227
    • (2009) Eur. J. Cancer , vol.45 , pp. 2219-2227
    • Akhdar, H.1    Loyer, P.2    Rauch, C.3    Corlu, A.4    Guillouzo, A.5    Morel, F.6
  • 51
    • 84856257180 scopus 로고    scopus 로고
    • Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner
    • Deng, C., Tao, R., Yu, S. Z., and Jin, H. (2012) Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner. Mol. Med. Rep. 5, 847-851
    • (2012) Mol. Med. Rep. , vol.5 , pp. 847-851
    • Deng, C.1    Tao, R.2    Yu, S.Z.3    Jin, H.4
  • 52
    • 84860393361 scopus 로고    scopus 로고
    • Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway
    • Leoncini, E., Malaguti, M., Angeloni, C., Motori, E., Fabbri, D., and Hrelia, S. (2011) Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway. J. Food Sci. 76, H175-H181
    • (2011) J. Food Sci. , vol.76
    • Leoncini, E.1    Malaguti, M.2    Angeloni, C.3    Motori, E.4    Fabbri, D.5    Hrelia, S.6
  • 56
    • 84893155306 scopus 로고    scopus 로고
    • The "n-factors" in pancreatic cancer: Functional relevance of NF-κB, NFAT, and Nrf2 in pancreatic cancer
    • Arlt, A., Schäfer, H., and Kalthoff, H. (2012) The "N-factors" in pancreatic cancer: functional relevance of NF-κB, NFAT, and Nrf2 in pancreatic cancer. Oncogenesis 1, e35
    • (2012) Oncogenesis , vol.1
    • Arlt, A.1    Schäfer, H.2    Kalthoff, H.3
  • 57
    • 84871519753 scopus 로고    scopus 로고
    • The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemoresistance
    • Rushworth, S. A., Zaitseva, L., Murray, M. Y., Shah, N. M., Bowles, K. M., and MacEwan, D. J. (2012) The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemoresistance. Blood 120, 5188-5198
    • (2012) Blood , vol.120 , pp. 5188-5198
    • Rushworth, S.A.1    Zaitseva, L.2    Murray, M.Y.3    Shah, N.M.4    Bowles, K.M.5    Macewan, D.J.6
  • 59
    • 77955279350 scopus 로고    scopus 로고
    • A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
    • Kim, J., Cha, Y. N., and Surh, Y. J. (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 690, 12-23
    • (2010) Mutat. Res. , vol.690 , pp. 12-23
    • Kim, J.1    Cha, Y.N.2    Surh, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.