메뉴 건너뛰기




Volumn 27, Issue 12, 2014, Pages 2036-2043

Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHENETHYL ISOTHIOCYANATE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, MOUSE; NITRITE; PRIMER DNA;

EID: 84918590311     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx500234h     Document Type: Article
Times cited : (101)

References (61)
  • 2
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis, J., and Pollard, J. W. (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 3
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • Colotta, F., Allavena, P., Sica, A., Garlanda, C., and Mantovani, A. (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30, 1073-1081.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 4
    • 0026989386 scopus 로고
    • Bacterial endotoxins
    • Rietschel, E. T., and Brade, H. (1992) Bacterial endotoxins. Sci. Am. 267, 54-61.
    • (1992) Sci. Am. , vol.267 , pp. 54-61
    • Rietschel, E.T.1    Brade, H.2
  • 5
    • 0242552753 scopus 로고    scopus 로고
    • Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex
    • Fujihara, M., Muroi, M., Tanamoto, K., Suzuki, T., Azuma, H., and Ikeda, H. (2003) Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol. Ther. 100, 171-194.
    • (2003) Pharmacol. Ther. , vol.100 , pp. 171-194
    • Fujihara, M.1    Muroi, M.2    Tanamoto, K.3    Suzuki, T.4    Azuma, H.5    Ikeda, H.6
  • 6
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., and Edwards, J. P. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 7
    • 2342514015 scopus 로고    scopus 로고
    • An important role of Nrf2-ARE pathway in the cellular defense mechanism
    • Lee, J. M., and Johnson, J. A. (2004) An important role of Nrf2-ARE pathway in the cellular defense mechanism. J. Biochem. Mol. Biol. 37, 139-143.
    • (2004) J. Biochem. Mol. Biol. , vol.37 , pp. 139-143
    • Lee, J.M.1    Johnson, J.A.2
  • 8
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen, T., Nioi, P., and Pickett, C. B. (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 284, 13291-13295.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 9
    • 38949193198 scopus 로고    scopus 로고
    • The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis
    • Horvath, K., Varga, C., Berko, A., Posa, A., Laszlo, F., and Whittle, B. J. (2008) The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis. Eur. J. Pharmacol. 581, 315-323.
    • (2008) Eur. J. Pharmacol. , vol.581 , pp. 315-323
    • Horvath, K.1    Varga, C.2    Berko, A.3    Posa, A.4    Laszlo, F.5    Whittle, B.J.6
  • 10
    • 45849142596 scopus 로고    scopus 로고
    • Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice
    • Pae, H. O., Ae Ha, Y., Chai, K. Y., and Chung, H. T. (2008) Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice. Immunopharmacol. Immunotoxicol. 30, 207-216.
    • (2008) Immunopharmacol. Immunotoxicol. , vol.30 , pp. 207-216
    • Pae, H.O.1    Ae Ha, Y.2    Chai, K.Y.3    Chung, H.T.4
  • 11
    • 54949143147 scopus 로고    scopus 로고
    • Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders
    • Syapin, P. J. (2008) Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br. J. Pharmacol. 155, 623-640.
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 623-640
    • Syapin, P.J.1
  • 14
    • 34648830424 scopus 로고    scopus 로고
    • Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
    • Osburn, W. O., Karim, B., Dolan, P. M., Liu, G., Yamamoto, M., Huso, D. L., and Kensler, T. W. (2007) Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int. J. Cancer 121, 1883-1891.
    • (2007) Int. J. Cancer , vol.121 , pp. 1883-1891
    • Osburn, W.O.1    Karim, B.2    Dolan, P.M.3    Liu, G.4    Yamamoto, M.5    Huso, D.L.6    Kensler, T.W.7
  • 17
    • 77955279350 scopus 로고    scopus 로고
    • A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
    • Kim, J., Cha, Y. N., and Surh, Y. J. (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 690, 12-23.
    • (2010) Mutat. Res. , vol.690 , pp. 12-23
    • Kim, J.1    Cha, Y.N.2    Surh, Y.J.3
  • 18
    • 84875202416 scopus 로고    scopus 로고
    • Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and radix Angelica sinensis via promoter CpG demethylation
    • Su, Z. Y., Khor, T. O., Shu, L., Lee, J. H., Saw, C. L., Wu, T. Y., Huang, Y., Suh, N., Yang, C. S., Conney, A. H., Wu, Q., and Kong, A. N. (2013) Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and radix Angelica sinensis via promoter CpG demethylation. Chem. Res. Toxicol. 26, 477-485.
    • (2013) Chem. Res. Toxicol. , vol.26 , pp. 477-485
    • Su, Z.Y.1    Khor, T.O.2    Shu, L.3    Lee, J.H.4    Saw, C.L.5    Wu, T.Y.6    Huang, Y.7    Suh, N.8    Yang, C.S.9    Conney, A.H.10    Wu, Q.11    Kong, A.N.12
  • 19
    • 84883882350 scopus 로고    scopus 로고
    • Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and antiinflammation
    • Saw, C. L., Wu, Q., Su, Z. Y., Wang, H., Yang, Y., Xu, X., Huang, Y., Khor, T. O., and Kong, A. N. (2013) Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and antiinflammation. Biopharm. Drug. Dispos. 34, 303-311.
    • (2013) Biopharm. Drug. Dispos. , vol.34 , pp. 303-311
    • Saw, C.L.1    Wu, Q.2    Su, Z.Y.3    Wang, H.4    Yang, Y.5    Xu, X.6    Huang, Y.7    Khor, T.O.8    Kong, A.N.9
  • 20
    • 19544385612 scopus 로고    scopus 로고
    • Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages
    • Rose, P., Won, Y. K., Ong, C. N., and Whiteman, M. (2005) Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide 12, 237-243.
    • (2005) Nitric Oxide , vol.12 , pp. 237-243
    • Rose, P.1    Won, Y.K.2    Ong, C.N.3    Whiteman, M.4
  • 21
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidantresponsive element
    • Balogun, E., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J., and Motterlini, R. (2003) Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidantresponsive element. Biochem. J. 371, 887-895.
    • (2003) Biochem. J. , vol.371 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3    Killeen, E.4    Green, C.J.5    Foresti, R.6    Alam, J.7    Motterlini, R.8
  • 22
    • 84934436223 scopus 로고    scopus 로고
    • Regulation of COX and LOX by curcumin
    • Rao, C. V. (2007) Regulation of COX and LOX by curcumin. Adv. Exp. Med. Biol. 595, 213-226.
    • (2007) Adv. Exp. Med. Biol. , vol.595 , pp. 213-226
    • Rao, C.V.1
  • 23
    • 79955710308 scopus 로고    scopus 로고
    • Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
    • Saw, C. L., Huang, M. T., Liu, Y., Khor, T. O., Conney, A. H., and Kong, A. N. (2011) Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol. Carcinog. 50, 479-486.
    • (2011) Mol. Carcinog. , vol.50 , pp. 479-486
    • Saw, C.L.1    Huang, M.T.2    Liu, Y.3    Khor, T.O.4    Conney, A.H.5    Kong, A.N.6
  • 24
    • 84886792157 scopus 로고    scopus 로고
    • Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFkappaB activation
    • Huang, C. S., Lin, A. H., Liu, C. T., Tsai, C. W., Chang, I. S., Chen, H. W., and Lii, C. K. (2013) Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFkappaB activation. Mol. Nutr. Food Res. 57, 1918-1930.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 1918-1930
    • Huang, C.S.1    Lin, A.H.2    Liu, C.T.3    Tsai, C.W.4    Chang, I.S.5    Chen, H.W.6    Lii, C.K.7
  • 25
    • 0028107128 scopus 로고
    • Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes
    • Hempel, S. L., Monick, M. M., and Hunninghake, G. W. (1994) Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J. Clin. Invest. 93, 391-396.
    • (1994) J. Clin. Invest. , vol.93 , pp. 391-396
    • Hempel, S.L.1    Monick, M.M.2    Hunninghake, G.W.3
  • 26
    • 52949139019 scopus 로고    scopus 로고
    • Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
    • Lin, W., Wu, R. T., Wu, T., Khor, T. O., Wang, H., and Kong, A. N. (2008) Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem. Pharmacol. 76, 967-973.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 967-973
    • Lin, W.1    Wu, R.T.2    Wu, T.3    Khor, T.O.4    Wang, H.5    Kong, A.N.6
  • 27
    • 78649449021 scopus 로고    scopus 로고
    • Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid
    • Wang, H., Khor, T. O., Saw, C. L., Lin, W., Wu, T., Huang, Y., and Kong, A. N. (2010) Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid. Mol. Pharmaceutics 7, 2185-2193.
    • (2010) Mol. Pharmaceutics , vol.7 , pp. 2185-2193
    • Wang, H.1    Khor, T.O.2    Saw, C.L.3    Lin, W.4    Wu, T.5    Huang, Y.6    Kong, A.N.7
  • 29
    • 0027527363 scopus 로고
    • A fluorometric assay for the measurement of nitrite in biological samples
    • Misko, T. P., Schilling, R. J., Salvemini, D., Moore, W. M., and Currie, M. G. (1993) A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem. 214, 11-16.
    • (1993) Anal. Biochem. , vol.214 , pp. 11-16
    • Misko, T.P.1    Schilling, R.J.2    Salvemini, D.3    Moore, W.M.4    Currie, M.G.5
  • 30
    • 46149101224 scopus 로고    scopus 로고
    • Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes
    • Gonzales, A. M., and Orlando, R. A. (2008) Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr. Metab. 5, 17.
    • (2008) Nutr. Metab. , vol.5 , pp. 17
    • Gonzales, A.M.1    Orlando, R.A.2
  • 31
    • 79951975847 scopus 로고    scopus 로고
    • Anti-inflammatory/ anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis
    • Wu, T. Y., Khor, T. O., Saw, C. L., Loh, S. C., Chen, A. I., Lim, S. S., Park, J. H., Cai, L., and Kong, A. N. (2011) Anti-inflammatory/ anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. AAPS J. 13, 1-13.
    • (2011) AAPS J. , vol.13 , pp. 1-13
    • Wu, T.Y.1    Khor, T.O.2    Saw, C.L.3    Loh, S.C.4    Chen, A.I.5    Lim, S.S.6    Park, J.H.7    Cai, L.8    Kong, A.N.9
  • 36
    • 77955771915 scopus 로고    scopus 로고
    • Effects of sappanchalcone on the cytoprotection and antiinflammation via heme oxygenase-1 in human pulp and periodontal ligament cells
    • Jeong, G. S., Lee, D. S., Li, B., Lee, H. J., Kim, E. C., and Kim, Y. C. (2010) Effects of sappanchalcone on the cytoprotection and antiinflammation via heme oxygenase-1 in human pulp and periodontal ligament cells. Eur. J. Pharmacol. 644, 230-237.
    • (2010) Eur. J. Pharmacol. , vol.644 , pp. 230-237
    • Jeong, G.S.1    Lee, D.S.2    Li, B.3    Lee, H.J.4    Kim, E.C.5    Kim, Y.C.6
  • 37
    • 84877066676 scopus 로고    scopus 로고
    • 4,2′,5′-Trihydroxy-4′-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages
    • Lee, D. S., Li, B., Im, N. K., Kim, Y. C., and Jeong, G. S. (2013) 4,2′,5′-Trihydroxy-4′-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages. Int. Immunopharmacol. 16, 114-121.
    • (2013) Int. Immunopharmacol. , vol.16 , pp. 114-121
    • Lee, D.S.1    Li, B.2    Im, N.K.3    Kim, Y.C.4    Jeong, G.S.5
  • 40
    • 38349165342 scopus 로고    scopus 로고
    • Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
    • Pae, H. O., Jeong, G. S., Kim, H. S., Woo, W. H., Rhew, H. Y., Kim, H. S., Sohn, D. H., Kim, Y. C., and Chung, H. T. (2007) Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages. Inflammation Res. 56 , 520-526.
    • (2007) Inflammation Res. , vol.56 , pp. 520-526
    • Pae, H.O.1    Jeong, G.S.2    Kim, H.S.3    Woo, W.H.4    Rhew, H.Y.5    Kim, H.S.6    Sohn, D.H.7    Kim, Y.C.8    Chung, H.T.9
  • 41
    • 84890109914 scopus 로고    scopus 로고
    • Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
    • Kumar, H., Kim, I. S., More, S. V., Kim, B. W., and Choi, D. K. (2013) Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Nat. Prod. Rep. 31, 109-139.
    • (2013) Nat. Prod. Rep. , vol.31 , pp. 109-139
    • Kumar, H.1    Kim, I.S.2    More, S.V.3    Kim, B.W.4    Choi, D.K.5
  • 43
    • 33744729373 scopus 로고    scopus 로고
    • Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2
    • Ma, Q., Battelli, L., and Hubbs, A. F. (2006) Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. Am. J. Pathol. 168, 1960-1974.
    • (2006) Am. J. Pathol. , vol.168 , pp. 1960-1974
    • Ma, Q.1    Battelli, L.2    Hubbs, A.F.3
  • 44
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan, K., Lu, R., Chang, J. C., and Kan, Y. W. (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl. Acad. Sci. U.S.A. 93, 13943-13948.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 46
    • 57749182206 scopus 로고    scopus 로고
    • Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation
    • Cheung, K. L., Khor, T. O., and Kong, A. N. (2009) Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. Pharm. Res. 26 , 224-231.
    • (2009) Pharm. Res. , vol.26 , pp. 224-231
    • Cheung, K.L.1    Khor, T.O.2    Kong, A.N.3
  • 47
    • 77449106593 scopus 로고    scopus 로고
    • Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    • Cheung, K. L., and Kong, A. N. (2010) Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 12, 87-97.
    • (2010) AAPS J. , vol.12 , pp. 87-97
    • Cheung, K.L.1    Kong, A.N.2
  • 48
    • 31544454684 scopus 로고    scopus 로고
    • Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice
    • Khor, T. O., Keum, Y. S., Lin, W., Kim, J. H., Hu, R., Shen, G., Xu, C., Gopalakrishnan, A., Reddy, B., Zheng, X., Conney, A. H., and Kong, A. N. (2006) Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res. 66, 613-621.
    • (2006) Cancer Res. , vol.66 , pp. 613-621
    • Khor, T.O.1    Keum, Y.S.2    Lin, W.3    Kim, J.H.4    Hu, R.5    Shen, G.6    Xu, C.7    Gopalakrishnan, A.8    Reddy, B.9    Zheng, X.10    Conney, A.H.11    Kong, A.N.12
  • 49
    • 84896779620 scopus 로고    scopus 로고
    • Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-kappaB signaling pathway in lipopolysaccharide-induced mastitis in mice
    • Fu, Y., Gao, R., Cao, Y., Guo, M., Wei, Z., Zhou, E., Li, Y., Yao, M., Yang, Z., and Zhang, N. (2014) Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-kappaB signaling pathway in lipopolysaccharide-induced mastitis in mice. Int. Immunopharmacol. 20, 54-58.
    • (2014) Int. Immunopharmacol. , vol.20 , pp. 54-58
    • Fu, Y.1    Gao, R.2    Cao, Y.3    Guo, M.4    Wei, Z.5    Zhou, E.6    Li, Y.7    Yao, M.8    Yang, Z.9    Zhang, N.10
  • 50
    • 84863172398 scopus 로고    scopus 로고
    • Th2 skewing by activation of Nrf2 in CD4+ T cells
    • Rockwell, C. E., Zhang, M., Fields, P. E., and Klaassen, C. D. (2012) Th2 skewing by activation of Nrf2 in CD4+ T cells. J. Immunol. 188, 1630-1637.
    • (2012) J. Immunol. , vol.188 , pp. 1630-1637
    • Rockwell, C.E.1    Zhang, M.2    Fields, P.E.3    Klaassen, C.D.4
  • 51
    • 5644250880 scopus 로고    scopus 로고
    • The role of iNOS in chronic inflammatory processes in vivo: Is it damagepromoting, protective, or active at all?
    • Suschek, C. V., Schnorr, O., and Kolb-Bachofen, V. (2004) The role of iNOS in chronic inflammatory processes in vivo: is it damagepromoting, protective, or active at all? Curr. Mol. Med. 4, 763-775.
    • (2004) Curr. Mol. Med. , vol.4 , pp. 763-775
    • Suschek, C.V.1    Schnorr, O.2    Kolb-Bachofen, V.3
  • 52
    • 84934436057 scopus 로고    scopus 로고
    • Antioxidant and antiinflammatory properties of curcumin
    • Menon, V. P., and Sudheer, A. R. (2007) Antioxidant and antiinflammatory properties of curcumin. Adv. Exp. Med. Biol. 595, 105-125.
    • (2007) Adv. Exp. Med. Biol. , vol.595 , pp. 105-125
    • Menon, V.P.1    Sudheer, A.R.2
  • 53
    • 0141816815 scopus 로고    scopus 로고
    • Suppression of inducible nitric oxide production by indole and isothiocyanate derivatives from Brassica plants in stimulated macrophages
    • Chen, Y. H., Dai, H. J., and Chang, H. P. (2003) Suppression of inducible nitric oxide production by indole and isothiocyanate derivatives from Brassica plants in stimulated macrophages. Planta Med. 69, 696-700.
    • (2003) Planta Med. , vol.69 , pp. 696-700
    • Chen, Y.H.1    Dai, H.J.2    Chang, H.P.3
  • 54
    • 67650252237 scopus 로고    scopus 로고
    • Chemoprevention with phytochemicals targeting inducible nitric oxide synthase
    • Murakami, A. (2009) Chemoprevention with phytochemicals targeting inducible nitric oxide synthase. Forum Nutr. 61, 193-203.
    • (2009) Forum Nutr. , vol.61 , pp. 193-203
    • Murakami, A.1
  • 55
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
    • Ryter, S. W., Alam, J., and Choi, A. M. (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86, 583-650.
    • (2006) Physiol. Rev. , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 56
    • 69949086594 scopus 로고    scopus 로고
    • Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress
    • Surh, Y. J., Kundu, J. K., Li, M. H., Na, H. K., and Cha, Y. N. (2009) Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Arch. Pharm. Res. 32, 1163-1176.
    • (2009) Arch. Pharm. Res. , vol.32 , pp. 1163-1176
    • Surh, Y.J.1    Kundu, J.K.2    Li, M.H.3    Na, H.K.4    Cha, Y.N.5
  • 57
    • 38949110010 scopus 로고    scopus 로고
    • Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
    • Ashino, T., Yamanaka, R., Yamamoto, M., Shimokawa, H., Sekikawa, K., Iwakura, Y., Shioda, S., Numazawa, S., and Yoshida, T. (2008) Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. Mol. Immunol. 45, 2106-2115.
    • (2008) Mol. Immunol. , vol.45 , pp. 2106-2115
    • Ashino, T.1    Yamanaka, R.2    Yamamoto, M.3    Shimokawa, H.4    Sekikawa, K.5    Iwakura, Y.6    Shioda, S.7    Numazawa, S.8    Yoshida, T.9
  • 58
    • 0043268709 scopus 로고    scopus 로고
    • Heme oxygenase-1: Unleashing the protective properties of heme
    • Otterbein, L. E., Soares, M. P., Yamashita, K., and Bach, F. H. (2003) Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 24, 449-455.
    • (2003) Trends Immunol. , vol.24 , pp. 449-455
    • Otterbein, L.E.1    Soares, M.P.2    Yamashita, K.3    Bach, F.H.4
  • 59
    • 13244289773 scopus 로고    scopus 로고
    • Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity
    • Biswas, S. K., McClure, D., Jimenez, L. A., Megson, I. L., and Rahman, I. (2005) Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid. Redox Signaling 7, 32-41.
    • (2005) Antioxid. Redox Signaling , vol.7 , pp. 32-41
    • Biswas, S.K.1    McClure, D.2    Jimenez, L.A.3    Megson, I.L.4    Rahman, I.5
  • 60
    • 38049067227 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages
    • Murakami, A., Song, M., and Ohigashi, H. (2007) Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages. Biofactors 30, 1-11.
    • (2007) Biofactors , vol.30 , pp. 1-11
    • Murakami, A.1    Song, M.2    Ohigashi, H.3
  • 61
    • 22744440329 scopus 로고    scopus 로고
    • Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
    • Xu, C., Shen, G., Chen, C., Gelinas, C., and Kong, A. N. (2005) Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene 24, 4486-4495.
    • (2005) Oncogene , vol.24 , pp. 4486-4495
    • Xu, C.1    Shen, G.2    Chen, C.3    Gelinas, C.4    Kong, A.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.