Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179

Journal of Biological Chemistry

Volumn 281, Issue 47, 2006, Pages 35764-35769

  Ahmad, Rehan ^a   Raina, Deepak ^a   Meyer, Colin ^b   Kharbanda, Surender ^a   Kufe, Donald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Reata Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; HUMAN TUMOR CELLS; PHOSPHORYLATION;

CELL CULTURE; ENZYME INHIBITION; ENZYMES; MUTAGENESIS; OXIDATION;

CARBOXYLIC ACIDS;

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID METHYL ESTER; BIOTIN; CYSTEINE; ESTER DERIVATIVE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; SYNAPTOTAGMIN I; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME RELEASE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; UBIQUITINATION;

CELL LINE; CYSTEINE; ENZYME INHIBITORS; HUMANS; I-KAPPA B KINASE; MUTATION; NF-KAPPA B; OLEANOLIC ACID; OXIDATION-REDUCTION; OXYGEN; PHOSPHORYLATION; RECOMBINANT PROTEINS; SUBCELLULAR FRACTIONS; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 33845976705     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607160200     Document Type: Article

References (30)

1. Suh, N., Wang, Y., Honda, T., Gribble, G. W., Dmitrovsky, E., Hickey, W. F., Maue, R. A., Place, A. E., Porter, D. M., Spinella, M. J., Williams, C. R., Wu, G., Dannenberg, A. J., Flanders, K. C., Letterio, J. J., Mangelsdorf, D. J., Nathan, C. F., Nguyen, L., Porter, W. W., Ren, R. F., Roche, N. S., Subbaramaiah, K., and Sporn, M. B. (1999) Cancer Res. 59, 336-341
2. Wang, Y., Porter, W. W., Suh, N., Honda, T., Gribble, G. W., Leesnitzer, L. M., Plunket, K. D., Mangelsdorf, D. J., Blanchard, S. G., Willson, T. M., and Sporn, M. B. (2000) Mol. Endocrinol. 14, 1550-1556
3. Ito, Y., Pandey, P., Place, A., Sporn, M., Gribble, G., Honda, T., Kharbanda, S., and Kufe, D. (2000) Cell Growth Differ. 11, 261-267
4. Konopleva, M., Tsao, T., Ruvolo, P., Stiouf, I., Estrov, Z., Leysath, C. E., Zhao, S., Harris, D., Chang, S., Jackson, C. E., Munsell, M., Suh, N., Gribble, G., Honda, T., May, W. S., Sporn, M. B., and Andreeff, M. (2002) Blood 99, 326-335
5. Stadheim, T. A., Suh, N., Ganju, N., Sporn, M. B., and Eastman, A. (2002) J. Biol. Chem. 277, 16448-16455
6. Ikeda, T., Kimura, F., Nakata, Y., Sato, K., Ogura, K., Motoyoshi, K., Sporn, M., and Kufe, D. (2005) Cell Death Differ. 12, 523-531
7. Konopleva, M., Tsao, T., Estrov, Z., Lee, R. M., Wang, R. Y., Jackson, C. E., McQueen, T., Monaco, G., Munsell, M., Belmont, J., Kantarjian, H., Sporn, M. B., and Andreeff, M. (2004) Cancer Res. 64, 7927-7935
8. Ito, Y., Pandey, P., Sporn, M., Datta, R., Kharbanda, S., and Kufe, D. (2001) Mol. Pharmacol. 59, 1094-1099
9. Ikeda, T., Nakata, Y., Kimura, F., Sato, K., Anderson, K., Motoyoshi, K., Sporn, M., and Kufe, D. (2004) Mol. Cancer Ther. 3, 39-45
10. Kim, K., Lotan, R., Yue, P., Sporn, M., Suh, N., Gribble, G., Honda, T., Wu, G., Hong, W., and Sun, S. (2002) Mol. Cancer Ther. 1, 177-184
11. Zou, W., Liu, X., Yue, P., Zhou, Z., Sporn, M. B., Lotan, R., Khuri, F. R., and Sun, S. Y. (2004) Cancer Res. 64, 7570-7578
12. Lapillonne, H., Konopleva, M., Tsao, T., Gold, D., McQueen, T., Sutherland, R. L., Madden, T., and Andreeff, M. (2003) Cancer Res. 63, 5926-5939
13. Hyer, M. L., Croxton, R., Krajewska, M., Krajewski, S., Kress, C. L., Lu, M., Suh, N., Sporn, M. B., Cryns, V. L., Zapata, J. M., and Reed, J. C. (2005) Cancer Res. 65, 4799-4808
14. Samudio, I., Konopleva, M., Hail, N., Jr., Shi, Y. X., McQueen, T., Hsu, T., Evans, R., Honda, T., Gribble, G. W., Sporn, M., Gilbert, H. F., Safe, S., and Andreeff, M. (2005) J. Biol. Chem. 280, 36273-36282
15. Ikeda, T., Sporn, M., Honda, T., Gribble, G., and Kufe, D. (2003) Cancer Res. 63, 5551-5558
16. Couch, R. D., Browning, R. G., Honda, T., Gribble, G. W., Wright, D. L., Sporn, M. B., and Anderson, A. C. (2005) Bioorg. Med. Chem. Lett. 15, 2215-2219
17. Dinkova-Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G. W., Sporn, M. B., and Talalay, P. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 4584-4589
18. Karin, M., Cao, Y., Greten, F. R., and Li, Z. W. (2002) Nat. Rev. Cancer 2, 301-310
19. Hayden, M. S., and Ghosh, S. (2004) Genes Dev. 18, 2195-2224
20. Yamamoto, Y., and Gaynor, R. (2003) Trends Biochem. Sci. 29, 72-79
21. Kharbanda, S., Saleem, A., Yuan, Z.-M., Kraeft, S., Weichselbaum, R., Chen, L. B., and Kufe, D. (1996) Cancer Res. 56, 3617-3621
22. Ren, J., Agata, N., Chen, D., Li, Y., Yu, W.-H., Huang, L., Raina, D., Chen, W., Kharbanda, S., and Kufe, D. (2004) Cancer Cell 5, 163-175
23. Honda, T., Janosik, T., Honda, Y., Han, J., Liby, K. T., Williams, C. R., Couch, R. D., Anderson, A. C., Sporn, M. B., and Gribble, G. W. (2004) J. Med. Chem. 47, 4923-4932
24. Chen, Z. J. (2005) Nat. Cell Biol. 7, 758-765
25. Karin, M., and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. 18, 621-663
26. Liang, M. C., Bardhan, S., Pace, E. A., Rosman, D., Beutler, J. A., Porco, J. A., Jr., and Gilmore, T. D. (2006) Biochem. Pharmacol. 71, 634-645
27. Bernier, M., Kwon, Y. K., Pandey, S. K., Zhu, T. N., Zhao, R. J., Maciuk, A., He, H. J., Decabo, R., and Kole, S. (2006) J. Biol. Chem. 281, 2551-2561
28. Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M., and Santoro, M. G. (2000) Nature 403, 103-108
29. Shishodia, S., Sethi, G., Konopleva, M., Andreeff, M., and Aggarwal, B. B. (2006) Clin. Cancer Res. 12, 1828-1838
30. Zhang, Y., and Chen, F. (2004) Cancer Res. 64, 1902-1905