메뉴 건너뛰기




Volumn 23, Issue 12, 2012, Pages 1583-1591

Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity

Author keywords

Cystine glutamic acid exchange transporter; Glutathione; Heme oxygenase 1; NF B; Nrf2; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; ELECTROPHILE; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

EID: 84869081486     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.10.012     Document Type: Article
Times cited : (183)

References (48)
  • 1
    • 17744376942 scopus 로고    scopus 로고
    • Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements
    • Neuzil J., Weber T., Schröder A., Lu M., Ostermann G., Gellert N., et al. Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements. FASEB J 2001, 15:403-415.
    • (2001) FASEB J , vol.15 , pp. 403-415
    • Neuzil, J.1    Weber, T.2    Schröder, A.3    Lu, M.4    Ostermann, G.5    Gellert, N.6
  • 2
    • 0037387334 scopus 로고    scopus 로고
    • Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review
    • Prasad K.N., Kumar B., Yan X.D., Hanson A.J., Cole W.C. Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. J Am Coll Nutr 2003, 22:108-117.
    • (2003) J Am Coll Nutr , vol.22 , pp. 108-117
    • Prasad, K.N.1    Kumar, B.2    Yan, X.D.3    Hanson, A.J.4    Cole, W.C.5
  • 3
    • 0036301439 scopus 로고    scopus 로고
    • Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo
    • Weber T., Lu M., Andera L., Lahm H., Gellert N., Fariss M.W., et al. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res. 2002, 8:863-869.
    • (2002) Clin Cancer Res. , vol.8 , pp. 863-869
    • Weber, T.1    Lu, M.2    Andera, L.3    Lahm, H.4    Gellert, N.5    Fariss, M.W.6
  • 4
    • 1042267393 scopus 로고    scopus 로고
    • The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation
    • Galli F., Stabile A.M., Betti M., Conte C., Pistilli A., Rende M., et al. The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. Arch Biochem Biophys 2004, 423:97-102.
    • (2004) Arch Biochem Biophys , vol.423 , pp. 97-102
    • Galli, F.1    Stabile, A.M.2    Betti, M.3    Conte, C.4    Pistilli, A.5    Rende, M.6
  • 5
    • 34249934598 scopus 로고    scopus 로고
    • Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
    • Neuzil J., Dyason J.C., Freeman R., Dong L.F., Prochazka L., Wang X.F., et al. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr 2007, 39:65-72.
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 65-72
    • Neuzil, J.1    Dyason, J.C.2    Freeman, R.3    Dong, L.F.4    Prochazka, L.5    Wang, X.F.6
  • 6
    • 47549092354 scopus 로고    scopus 로고
    • Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
    • Dong L.F., Low P., Dyason J.C., Wang X.F., Prochazka L., Witting P.K., et al. Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene 2008, 27:4324-4335.
    • (2008) Oncogene , vol.27 , pp. 4324-4335
    • Dong, L.F.1    Low, P.2    Dyason, J.C.3    Wang, X.F.4    Prochazka, L.5    Witting, P.K.6
  • 7
    • 63549096948 scopus 로고    scopus 로고
    • Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II
    • Dong L.F., Freeman R., Liu J., Zobalova R., Marin-Hernandez A., Stantic M., et al. Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res 2009, 15:1593-1600.
    • (2009) Clin Cancer Res , vol.15 , pp. 1593-1600
    • Dong, L.F.1    Freeman, R.2    Liu, J.3    Zobalova, R.4    Marin-Hernandez, A.5    Stantic, M.6
  • 8
    • 84858001991 scopus 로고    scopus 로고
    • (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo
    • Dos Santos G.A., Abreu E., Lima R.S., Pestana C.R., Lima A.S., Scheucher P.S., et al. (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. Leukemia 2011, 10.1038/leu.2011.216.
    • (2011) Leukemia
    • Dos Santos, G.A.1    Abreu, E.2    Lima, R.S.3    Pestana, C.R.4    Lima, A.S.5    Scheucher, P.S.6
  • 9
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999, 13:76-86.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6
  • 11
    • 67649868135 scopus 로고    scopus 로고
    • Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence
    • Minelli A., Conte C., Grottelli S., Bellezza M., Cacciatore I., Bolaños J.P. Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence. J Cell Mol Med 2009, 13:1149-1161.
    • (2009) J Cell Mol Med , vol.13 , pp. 1149-1161
    • Minelli, A.1    Conte, C.2    Grottelli, S.3    Bellezza, M.4    Cacciatore, I.5    Bolaños, J.P.6
  • 12
    • 35848942608 scopus 로고    scopus 로고
    • Heme oxygenase-1 in tumors: is it a false friend?
    • Jozkowicz A., Was H., Dulak J. Heme oxygenase-1 in tumors: is it a false friend?. Antioxid Redox Signal 2007, 9:2099-2117.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 2099-2117
    • Jozkowicz, A.1    Was, H.2    Dulak, J.3
  • 13
    • 28844446987 scopus 로고    scopus 로고
    • Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection
    • Prawan A., Kundu J.K., Surh Y.J. Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection. Antioxid Redox Signal 2005, 7:1688-16703.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1688-16703
    • Prawan, A.1    Kundu, J.K.2    Surh, Y.J.3
  • 14
    • 37049008246 scopus 로고    scopus 로고
    • Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer
    • Sacca P., Meiss R., Casas G., Mazza O., Calvo J.C., Navone N., et al. Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer. Br J Cancer 2007, 97:1683-1689.
    • (2007) Br J Cancer , vol.97 , pp. 1683-1689
    • Sacca, P.1    Meiss, R.2    Casas, G.3    Mazza, O.4    Calvo, J.C.5    Navone, N.6
  • 15
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005, 5:749-759.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 16
    • 33749265867 scopus 로고    scopus 로고
    • The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development
    • Dejardin E. The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development. Biochem Pharmacol 2006, 72:1161-1179.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1161-1179
    • Dejardin, E.1
  • 17
    • 79952271561 scopus 로고    scopus 로고
    • Nrf2 and NF-κB and their concerted modulation in cancer pathogenesis and progression
    • Bellezza I., Mierla A.L., Minelli A. Nrf2 and NF-κB and their concerted modulation in cancer pathogenesis and progression. Cancers 2010, 2:483-497.
    • (2010) Cancers , vol.2 , pp. 483-497
    • Bellezza, I.1    Mierla, A.L.2    Minelli, A.3
  • 18
    • 59549099432 scopus 로고    scopus 로고
    • Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury
    • Jin W., Wang H., Yan W., Xu L., Wang X., Zhao X., et al. Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm 2008, 2008:725174.
    • (2008) Mediators Inflamm , vol.2008 , pp. 725174
    • Jin, W.1    Wang, H.2    Yan, W.3    Xu, L.4    Wang, X.5    Zhao, X.6
  • 19
    • 79954504166 scopus 로고    scopus 로고
    • Basic principles and emerging concepts in the redox control of transcription factors
    • [Epub ahead of print]
    • Brigelius-Flohé R., Flohé L. Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 2011, [Epub ahead of print].
    • (2011) Antioxid Redox Signal
    • Brigelius-Flohé, R.1    Flohé, L.2
  • 22
    • 77950366686 scopus 로고    scopus 로고
    • Identification of ROS using oxidized DCFDA and flow-cytometry
    • Eruslanov E., Kusmartsev S. Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol 2010, 594:57-72.
    • (2010) Methods Mol Biol , vol.594 , pp. 57-72
    • Eruslanov, E.1    Kusmartsev, S.2
  • 23
    • 62749138413 scopus 로고    scopus 로고
    • Oxidative stress-related aging: a role for prostate cancer?
    • Minelli A., Bellezza I., Conte C., Culig Z. Oxidative stress-related aging: a role for prostate cancer?. Biochim Biophys Acta 2009, 1795:83-91.
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 83-91
    • Minelli, A.1    Bellezza, I.2    Conte, C.3    Culig, Z.4
  • 24
    • 41649096518 scopus 로고    scopus 로고
    • Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer
    • Rigas B., Sun Y. Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer. Br J Cancer 2008, 98:1157-1160.
    • (2008) Br J Cancer , vol.98 , pp. 1157-1160
    • Rigas, B.1    Sun, Y.2
  • 25
    • 33750523632 scopus 로고    scopus 로고
    • NF-kappaB activation by reactive oxygen species: fifteen years later
    • Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006, 72:1493-1505.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 26
    • 34247571820 scopus 로고    scopus 로고
    • Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention
    • Crispen P.L., Uzzo R.G., Golovine K., Makhov P., Pollack A., Horwitz E.M., et al. Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. Prostate 2007, 67:582-590.
    • (2007) Prostate , vol.67 , pp. 582-590
    • Crispen, P.L.1    Uzzo, R.G.2    Golovine, K.3    Makhov, P.4    Pollack, A.5    Horwitz, E.M.6
  • 27
    • 0033517999 scopus 로고    scopus 로고
    • Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
    • Palayoor S.T., Youmell M.Y., Calderwood S.K., Coleman C.N., Price B.D. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene 1999, 18:7389-7394.
    • (1999) Oncogene , vol.18 , pp. 7389-7394
    • Palayoor, S.T.1    Youmell, M.Y.2    Calderwood, S.K.3    Coleman, C.N.4    Price, B.D.5
  • 28
    • 0043157958 scopus 로고    scopus 로고
    • Selenium compounds inhibit I kappa B kinase (IKK) and nuclear factor-kappa B (NF-kappa B) in prostate cancer cells
    • Gasparian A.V., Yao Y.J., Lü J., Yemelyanov A.Y., Lyakh L.A., Slaga T.J., et al. Selenium compounds inhibit I kappa B kinase (IKK) and nuclear factor-kappa B (NF-kappa B) in prostate cancer cells. Mol Cancer Ther 2002, 1:1079-1087.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1079-1087
    • Gasparian, A.V.1    Yao, Y.J.2    Lü, J.3    Yemelyanov, A.Y.4    Lyakh, L.A.5    Slaga, T.J.6
  • 29
    • 0028229468 scopus 로고
    • The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds
    • Fariss M.W., Fortuna M.B., Everett C.K., Smith J.D., Trent D.F., Djuric Z. The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. Cancer Res 1994, 4:3346-3351.
    • (1994) Cancer Res , vol.4 , pp. 3346-3351
    • Fariss, M.W.1    Fortuna, M.B.2    Everett, C.K.3    Smith, J.D.4    Trent, D.F.5    Djuric, Z.6
  • 30
    • 0034074981 scopus 로고    scopus 로고
    • Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis
    • Israel K., Yu W., Sanders B.G., Kline K. Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis. Nutr Cancer. 2000, 36:90-100.
    • (2000) Nutr Cancer. , vol.36 , pp. 90-100
    • Israel, K.1    Yu, W.2    Sanders, B.G.3    Kline, K.4
  • 31
    • 0035882482 scopus 로고    scopus 로고
    • Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria
    • Fariss M.W., Nicholls-Grzemski F.A., Tirmenstein M.A., Zhang J.G. Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria. Free Radic Biol Med 2001, 31:530-541.
    • (2001) Free Radic Biol Med , vol.31 , pp. 530-541
    • Fariss, M.W.1    Nicholls-Grzemski, F.A.2    Tirmenstein, M.A.3    Zhang, J.G.4
  • 32
    • 77954570017 scopus 로고    scopus 로고
    • Alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels
    • Prochazka L., Dong L.F., Valis K., Freeman R., Ralph S.J., Turanek J., et al. alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels. Apoptosis 2010, 15:782-794.
    • (2010) Apoptosis , vol.15 , pp. 782-794
    • Prochazka, L.1    Dong, L.F.2    Valis, K.3    Freeman, R.4    Ralph, S.J.5    Turanek, J.6
  • 33
    • 0345103741 scopus 로고    scopus 로고
    • Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling
    • Weber T., Dalen H., Andera L., Nègre-Salvayre A., Augé N., Sticha M., et al. Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry 2003, 42:4277-4291.
    • (2003) Biochemistry , vol.42 , pp. 4277-4291
    • Weber, T.1    Dalen, H.2    Andera, L.3    Nègre-Salvayre, A.4    Augé, N.5    Sticha, M.6
  • 34
    • 33744959427 scopus 로고    scopus 로고
    • Alpha-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function
    • Shiau C.W., Huang J.W., Wang D.S., Weng J.R., Yang C.C., Lin C.H., et al. alpha-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. J Biol Chem 2006, 281:11819-11825.
    • (2006) J Biol Chem , vol.281 , pp. 11819-11825
    • Shiau, C.W.1    Huang, J.W.2    Wang, D.S.3    Weng, J.R.4    Yang, C.C.5    Lin, C.H.6
  • 35
    • 0038520017 scopus 로고    scopus 로고
    • RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria
    • Yu W., Sanders B.G., Kline K. RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Res 2003, 63:2483-2491.
    • (2003) Cancer Res , vol.63 , pp. 2483-2491
    • Yu, W.1    Sanders, B.G.2    Kline, K.3
  • 36
    • 24644490717 scopus 로고    scopus 로고
    • Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis
    • D'Alessio M., De Nicola M., Coppola S., Gualandi G., Pugliese L., Cerella C., et al. Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis. FASEB J 2005, 19:1504-1506.
    • (2005) FASEB J , vol.19 , pp. 1504-1506
    • D'Alessio, M.1    De Nicola, M.2    Coppola, S.3    Gualandi, G.4    Pugliese, L.5    Cerella, C.6
  • 37
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
    • Hayes J.D., McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 2009, 34:176-188.
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 38
    • 36949011602 scopus 로고    scopus 로고
    • Interactions of polyphenolic compounds with drug disposition and metabolism
    • Galli F. Interactions of polyphenolic compounds with drug disposition and metabolism. Curr Drug Metab 2007, 8:830-838.
    • (2007) Curr Drug Metab , vol.8 , pp. 830-838
    • Galli, F.1
  • 39
    • 11144264060 scopus 로고    scopus 로고
    • Potentiation by alpha-tocopheryl succinate of the etoposide response in multidrug resistance protein 1-expressing glioblastoma cells
    • Kang Y.H., Lee E., Youk H.J., Kim S.H., Lee H.J., Park Y.G., et al. Potentiation by alpha-tocopheryl succinate of the etoposide response in multidrug resistance protein 1-expressing glioblastoma cells. Cancer Lett 2005, 217:181-190.
    • (2005) Cancer Lett , vol.217 , pp. 181-190
    • Kang, Y.H.1    Lee, E.2    Youk, H.J.3    Kim, S.H.4    Lee, H.J.5    Park, Y.G.6
  • 40
    • 55649086173 scopus 로고    scopus 로고
    • Enhancement in alpha-tocopherol succinate-induced apoptosis by all-trans-retinoic acid in primary leukemic cells: role of antioxidant defense, Bax and c-myc
    • Khanduja K.L., Kumar S., Varma N., Varma S.C., Avti P.K., Pathak C.M. Enhancement in alpha-tocopherol succinate-induced apoptosis by all-trans-retinoic acid in primary leukemic cells: role of antioxidant defense, Bax and c-myc. Mol Cell Biochem 2008, 319:133-139.
    • (2008) Mol Cell Biochem , vol.319 , pp. 133-139
    • Khanduja, K.L.1    Kumar, S.2    Varma, N.3    Varma, S.C.4    Avti, P.K.5    Pathak, C.M.6
  • 41
    • 0038146898 scopus 로고    scopus 로고
    • Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    • Lee J.M., Calkins M.J., Chan K., Kan Y.W., Johnson J.A. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 2003, 278:12029-12038.
    • (2003) J Biol Chem , vol.278 , pp. 12029-12038
    • Lee, J.M.1    Calkins, M.J.2    Chan, K.3    Kan, Y.W.4    Johnson, J.A.5
  • 42
    • 33645235475 scopus 로고    scopus 로고
    • Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses
    • Qiang W., Kuang X., Liu J., Liu N., Scofield V.L., Reid A.J., et al. Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses. J Virol 2006, 80:3273-3284.
    • (2006) J Virol , vol.80 , pp. 3273-3284
    • Qiang, W.1    Kuang, X.2    Liu, J.3    Liu, N.4    Scofield, V.L.5    Reid, A.J.6
  • 43
    • 0037434422 scopus 로고    scopus 로고
    • Alpha-tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kappaB activation
    • Dalen H., Neuzil J. Alpha-tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kappaB activation. Br J Cancer 2003, 88:153-158.
    • (2003) Br J Cancer , vol.88 , pp. 153-158
    • Dalen, H.1    Neuzil, J.2
  • 44
    • 0030770774 scopus 로고    scopus 로고
    • Alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization
    • Erl W., Weber C., Wardemann C., Weber P.C. alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization. Am J Physiol 1997, 273:H634-H640.
    • (1997) Am J Physiol , vol.273
    • Erl, W.1    Weber, C.2    Wardemann, C.3    Weber, P.C.4
  • 45
    • 34547128886 scopus 로고    scopus 로고
    • Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB
    • Qanungo S., Starke D.W., Pai H.V., Mieyal J.J., Nieminen A.L. Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB. J Biol Chem 2007, 282:18427-18436.
    • (2007) J Biol Chem , vol.282 , pp. 18427-18436
    • Qanungo, S.1    Starke, D.W.2    Pai, H.V.3    Mieyal, J.J.4    Nieminen, A.L.5
  • 46
    • 22044433408 scopus 로고    scopus 로고
    • NF-kappaB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression
    • Banning A., Brigelius-Flohé R. NF-kappaB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression. Antioxid Redox Signal 2005, 7:889-899.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 889-899
    • Banning, A.1    Brigelius-Flohé, R.2
  • 47
    • 43649105393 scopus 로고    scopus 로고
    • Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2
    • Liao B.C., Hsieh C.W., Liu Y.C., Tzeng T.T., Sun Y.W., Wung B.S. Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol 2008, 229:161-171.
    • (2008) Toxicol Appl Pharmacol , vol.229 , pp. 161-171
    • Liao, B.C.1    Hsieh, C.W.2    Liu, Y.C.3    Tzeng, T.T.4    Sun, Y.W.5    Wung, B.S.6
  • 48
    • 35648987863 scopus 로고    scopus 로고
    • Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase
    • Gibbs P.E., Maines M.D. Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase. Int J Cancer 2007, 121:2567-2574.
    • (2007) Int J Cancer , vol.121 , pp. 2567-2574
    • Gibbs, P.E.1    Maines, M.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.