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Volumn 25, Issue 9, 2000, Pages 434-440

The Rel/NF-κB family: Friend and foe

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DORSAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; ONCOPROTEIN; ONCOPROTEIN C REL; ONCOPROTEIN V REL; PROTEIN P100; PROTEIN P50; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 0034283837     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01617-0     Document Type: Review
Times cited : (341)

References (50)
  • 1
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen R.et al. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell. 46:1986;705-716.
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1
  • 2
    • 0029874138 scopus 로고    scopus 로고
    • THE NF-κB and IκB proteins: New discoveries and insights
    • Baldwin A.S. THE NF-κB and IκB proteins. new discoveries and insights Annu. Rev. Immunol. 14:1996;649-681.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-681
    • Baldwin, A.S.1
  • 3
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene. 18:1999;6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 4
    • 0033595893 scopus 로고    scopus 로고
    • How NF-κB is activated: The role of the IκB kinase (IKK) complex
    • Karin M. How NF-κB is activated. the role of the IκB kinase (IKK) complex Oncogene. 18:1999;6867-6874.
    • (1999) Oncogene , vol.18 , pp. 6867-6874
    • Karin, M.1
  • 5
    • 0033596123 scopus 로고    scopus 로고
    • Genetic approaches in mice to understand Rel/NF-κB and IκB function: Transgenics and knockouts
    • Gerondakis S.et al. Genetic approaches in mice to understand Rel/NF-κB and IκB function. transgenics and knockouts Oncogene. 18:1999;6888-6895.
    • (1999) Oncogene , vol.18 , pp. 6888-6895
    • Gerondakis, S.1
  • 6
    • 0034175632 scopus 로고    scopus 로고
    • Severe liver degeneration and lack of NF-κB activation in NEMO/IKK gamma-deficient mice
    • Rudolph D.et al. Severe liver degeneration and lack of NF-κB activation in NEMO/IKK gamma-deficient mice. Genes Dev. 14:2000;854-862.
    • (2000) Genes Dev. , vol.14 , pp. 854-862
    • Rudolph, D.1
  • 7
    • 0032498962 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis
    • Bushdid P.B.et al. Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature. 392:1998;615-618.
    • (1998) Nature , vol.392 , pp. 615-618
    • Bushdid, P.B.1
  • 8
    • 0032499286 scopus 로고    scopus 로고
    • Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb
    • Kanegae Y.et al. Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb. Nature. 392:1998;611-614.
    • (1998) Nature , vol.392 , pp. 611-614
    • Kanegae, Y.1
  • 9
    • 0033623848 scopus 로고    scopus 로고
    • IKKε is part of a novel PMA-inducible IκB kinase complex
    • Peters R.T.et al. IKKε is part of a novel PMA-inducible IκB kinase complex. Mol. Cell. 5:2000;513-522.
    • (2000) Mol. Cell , vol.5 , pp. 513-522
    • Peters, R.T.1
  • 10
    • 0033153320 scopus 로고    scopus 로고
    • The interaction of p62 with RIP links the atypical PKCs to NF-κB activation
    • Sanz L.et al. The interaction of p62 with RIP links the atypical PKCs to NF-κB activation. EMBO J. 18:1999;3044-3053.
    • (1999) EMBO J. , vol.18 , pp. 3044-3053
    • Sanz, L.1
  • 11
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova J.A.et al. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature. 401:1999;86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1
  • 12
    • 0033517189 scopus 로고    scopus 로고
    • NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes O.N.et al. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 401:1999;82-85.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1
  • 13
    • 0034643170 scopus 로고    scopus 로고
    • NAK is an IκB kinase-activating kinase
    • Tojima Y.et al. NAK is an IκB kinase-activating kinase. Nature. 404:2000;778-782.
    • (2000) Nature , vol.404 , pp. 778-782
    • Tojima, Y.1
  • 14
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NF-κB by the Akt PKB kinase
    • Kane L.P.et al. Induction of NF-κB by the Akt PKB kinase. Curr. Biol. 9:1999;601-604.
    • (1999) Curr. Biol. , vol.9 , pp. 601-604
    • Kane, L.P.1
  • 15
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
    • Sizemore N.et al. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19:1999;4798-4805.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4798-4805
    • Sizemore, N.1
  • 16
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB
    • Madrid L.V.et al. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB. Mol. Cell. Biol. 20:2000;1626-1638.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1626-1638
    • Madrid, L.V.1
  • 17
    • 0031461976 scopus 로고    scopus 로고
    • Achieving transcriptional specificity with NF-κB
    • Perkins N.D. Achieving transcriptional specificity with NF-κB. Int. J. Biochem. Cell Biol. 29:1997;1433-1448.
    • (1997) Int. J. Biochem. Cell Biol. , vol.29 , pp. 1433-1448
    • Perkins, N.D.1
  • 18
    • 0032039076 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
    • Zhong H.H.et al. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell. 1:1998;661-671.
    • (1998) Mol. Cell , vol.1 , pp. 661-671
    • Zhong, H.H.1
  • 19
    • 0343417089 scopus 로고    scopus 로고
    • The p300/CBP family: Integrating signals with transcription factors and chromatin
    • Shikama N.et al. The p300/CBP family. integrating signals with transcription factors and chromatin Trends Cell Biol. 7:1997;230-236.
    • (1997) Trends Cell Biol. , vol.7 , pp. 230-236
    • Shikama, N.1
  • 20
    • 0032100763 scopus 로고    scopus 로고
    • Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300
    • Hottiger M.O.et al. Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300. EMBO J. 17:1998;3124-3134.
    • (1998) EMBO J. , vol.17 , pp. 3124-3134
    • Hottiger, M.O.1
  • 21
    • 0030983079 scopus 로고    scopus 로고
    • Transcription factor NF-κB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease
    • Kaltschmidt B.et al. Transcription factor NF-κB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 94:1997;2642-2647.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 2642-2647
    • Kaltschmidt, B.1
  • 22
    • 0030615201 scopus 로고    scopus 로고
    • Mechanisms of disease- nuclear factor-κB- a pivotal transcription factor in chronic inflammatory diseases
    • Barnes P.J.et al. Mechanisms of disease- nuclear factor-κB- a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336:1997;1066-1071.
    • (1997) New Engl. J. Med. , vol.336 , pp. 1066-1071
    • Barnes, P.J.1
  • 23
    • 0033486033 scopus 로고    scopus 로고
    • An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκB alpha
    • Johnson C.et al. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκB alpha. EMBO J. 18:1999;6682-6693.
    • (1999) EMBO J. , vol.18 , pp. 6682-6693
    • Johnson, C.1
  • 24
    • 0000564581 scopus 로고    scopus 로고
    • The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation
    • Song H.Y.et al. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation. Proc. Natl. Acad. Sci. U. S. A. 93:1996;6721-6725.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 6721-6725
    • Song, H.Y.1
  • 25
    • 0033527549 scopus 로고    scopus 로고
    • Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding
    • Schottelius A.J.G.et al. Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding. J. Biol. Chem. 274:1999;31868-31874.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31868-31874
    • Schottelius, A.J.G.1
  • 26
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
    • Rossi A.et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 403:2000;103-108.
    • (2000) Nature , vol.403 , pp. 103-108
    • Rossi, A.1
  • 27
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-κB transcription factors
    • Barkett M.et al. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene. 18:1999;6910-6924.
    • (1999) Oncogene , vol.18 , pp. 6910-6924
    • Barkett, M.1
  • 28
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • Rayet B.et al. Aberrant rel/nfkb genes and activity in human cancer. Oncogene. 18:1999;6938-6947.
    • (1999) Oncogene , vol.18 , pp. 6938-6947
    • Rayet, B.1
  • 29
    • 0033141406 scopus 로고    scopus 로고
    • NF-κB to the rescue - RELs, apoptosis and cellular transformation
    • Foo S.Y.et al. NF-κB to the rescue - RELs, apoptosis and cellular transformation. Trends Genet. 15:1999;229-235.
    • (1999) Trends Genet. , vol.15 , pp. 229-235
    • Foo, S.Y.1
  • 30
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D.et al. The hallmarks of cancer. Cell. 100:2000;57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1
  • 31
    • 0032014073 scopus 로고    scopus 로고
    • DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1
    • Kasibhatla S.et al. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell. 1:1998;543-551.
    • (1998) Mol. Cell , vol.1 , pp. 543-551
    • Kasibhatla, S.1
  • 32
    • 0033174072 scopus 로고    scopus 로고
    • Apoptosis overrides survival signals through a caspase-mediated dominant negative NF-κB loop
    • Levkau B.et al. Apoptosis overrides survival signals through a caspase-mediated dominant negative NF-κB loop. Nat. Cell Biol. 1:1999;227-233.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 227-233
    • Levkau, B.1
  • 33
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-κB in p53-mediated programmed cell death
    • Ryan K.M.et al. Role of NF-κB in p53-mediated programmed cell death. Nature. 404:2000;892-897.
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1
  • 34
    • 0033572270 scopus 로고    scopus 로고
    • Down-regulation of nuclear factor κB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes
    • Kawai H.et al. Down-regulation of nuclear factor κB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes. Cancer Res. 59:1999;6038-6041.
    • (1999) Cancer Res. , vol.59 , pp. 6038-6041
    • Kawai, H.1
  • 35
    • 0034053965 scopus 로고    scopus 로고
    • Inactivation of p53 by human T-cell lymphotropic virus type 1 tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation
    • Pise-Masison C.A.et al. Inactivation of p53 by human T-cell lymphotropic virus type 1 tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation. Mol. Cell. Biol. 20:2000;3377-3386.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3377-3386
    • Pise-Masison, C.A.1
  • 36
    • 0032485072 scopus 로고    scopus 로고
    • Nuclear factor-κB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug
    • Hellin A.C.et al. Nuclear factor-κB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug. Oncogene. 16:1998;1187-1195.
    • (1998) Oncogene , vol.16 , pp. 1187-1195
    • Hellin, A.C.1
  • 37
    • 0032954928 scopus 로고    scopus 로고
    • Transcriptional cross talk between NF-κB and p53
    • Webster G.A.et al. Transcriptional cross talk between NF-κB and p53. Mol. Cell. Biol. 19:1999;3485-3495.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3485-3495
    • Webster, G.A.1
  • 38
    • 0032588186 scopus 로고    scopus 로고
    • NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge D.C.et al. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19:1999;5785-5799.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1
  • 39
    • 0033587084 scopus 로고    scopus 로고
    • Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα
    • Cabannes E.et al. Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα Oncogene. 18:1999;3063-3070.
    • (1999) Oncogene , vol.18 , pp. 3063-3070
    • Cabannes, E.1
  • 40
    • 0033611588 scopus 로고    scopus 로고
    • Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells
    • Krappmann D.et al. Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene. 18:1999;943-953.
    • (1999) Oncogene , vol.18 , pp. 943-953
    • Krappmann, D.1
  • 41
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
    • Nakshatri H.et al. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 17:1997;3629-3639.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3629-3639
    • Nakshatri, H.1
  • 42
    • 0032034216 scopus 로고    scopus 로고
    • A requirement for NF-κB activation in Bcr-Abl-mediated transformation
    • Reuther J.Y.et al. A requirement for NF-κB activation in Bcr-Abl-mediated transformation. Genes Dev. 12:1998;968-981.
    • (1998) Genes Dev. , vol.12 , pp. 968-981
    • Reuther, J.Y.1
  • 43
    • 0034677549 scopus 로고    scopus 로고
    • NF-κB is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis
    • Jo H.et al. NF-κB is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis. Oncogene. 19:2000;841-849.
    • (2000) Oncogene , vol.19 , pp. 841-849
    • Jo, H.1
  • 44
    • 0033519690 scopus 로고    scopus 로고
    • The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators
    • Dechend R.et al. The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators. Oncogene. 18:1999;3316-3323.
    • (1999) Oncogene , vol.18 , pp. 3316-3323
    • Dechend, R.1
  • 45
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
    • Wang C.Y.et al. Control of inducible chemoresistance. enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB Nat. Med. 5:1999;412-417.
    • (1999) Nat. Med. , vol.5 , pp. 412-417
    • Wang, C.Y.1
  • 46
    • 0033596126 scopus 로고    scopus 로고
    • Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway
    • Epinat J.C.et al. Diverse agents act at multiple levels to inhibit the Rel/NF-κB signal transduction pathway. Oncogene. 18:1999;6896-6909.
    • (1999) Oncogene , vol.18 , pp. 6896-6909
    • Epinat, J.C.1
  • 47
    • 0033545863 scopus 로고    scopus 로고
    • Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
    • Bondeson J.et al. Defining therapeutic targets by using adenovirus. blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators Proc. Natl. Acad. Sci. U. S. A. 96:1999;5668-5673.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 5668-5673
    • Bondeson, J.1
  • 48
    • 0030700305 scopus 로고    scopus 로고
    • Novel approaches for the treatment of inflammatory diseases: Inhibitors of NF-κB and AP-1
    • Suto M.J.et al. Novel approaches for the treatment of inflammatory diseases. inhibitors of NF-κB and AP-1 Curr. Pharm. Design. 3:1997;515-528.
    • (1997) Curr. Pharm. Design , vol.3 , pp. 515-528
    • Suto, M.J.1
  • 49
    • 0033179001 scopus 로고    scopus 로고
    • Abnormal NF-κB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression
    • Wong H.K.et al. Abnormal NF-κB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J. Immunol. 163:1999;1682-1689.
    • (1999) J. Immunol. , vol.163 , pp. 1682-1689
    • Wong, H.K.1
  • 50
    • 0032497587 scopus 로고    scopus 로고
    • A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κB
    • Lee S.J.et al. A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κB. Oncogene. 17:1998;1821-1826.
    • (1998) Oncogene , vol.17 , pp. 1821-1826
    • Lee, S.J.1


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