Bardoxolone methyl (CDDO-Me) as a therapeutic agent: An update on its pharmacokinetic and pharmacodynamic properties

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 2075-2088

  Wang, Yan Yang ^a,b   Yang, Yin Xue ^a   Zhe, Hong ^a   He, Zhi Xu ^c   Zhou, Shu Feng ^b,c  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c GUIZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cancer; CDDO Me; Chronic kidney disease; Keap1; NF B; Nrf2; Pulmonary arterial hypertension

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; BARDOXOLONE METHYL; GEMCITABINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PLACEBO; TRANSCRIPTION FACTOR NRF2; METHYL 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OATE; OLEANOLIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ANTICOAGULATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL LEVEL; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL (TOPIC); CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG RESPONSE; DRUG SAFETY; DRUG TARGETING; DRUG TOLERANCE; FATIGUE; GASTROINTESTINAL DISEASE; HEART FAILURE; HUMAN; HYPOMAGNESEMIA; INFLAMMATION; KIDNEY FUNCTION; METABOLIC DISORDER; MULTIPLE CYCLE TREATMENT; MUSCLE SPASM; NAUSEA; NEOPLASM; NEUROPROTECTION; NONHUMAN; OPTIMAL DRUG DOSE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PULMONARY HYPERTENSION; RADIATION PROTECTION; SIDE EFFECT; TOXICITY TESTING; ANALOGS AND DERIVATIVES; ANIMAL; HYPERTENSION, PULMONARY; METABOLISM; NEOPLASMS; RENAL INSUFFICIENCY, CHRONIC;

ANIMALS; HUMANS; HYPERTENSION, PULMONARY; INFLAMMATION; NEOPLASMS; OLEANOLIC ACID; RENAL INSUFFICIENCY, CHRONIC;

EID: 84908301179     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S68872     Document Type: Article

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