메뉴 건너뛰기




Volumn 3, Issue 1, 2009, Pages 73-80

Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer

Author keywords

Age related diseases; Angiogenesis; Antioxidant; Cancer; Chronic inflammation; DNA damage; Free radicals

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOOXYGENASE 2; CYSTEINE; FREE RADICAL; GAMMA INTERFERON; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; MITOCHONDRIAL DNA; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT;

EID: 61449125226     PISSN: 1872213X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221309787158371     Document Type: Review
Times cited : (730)

References (93)
  • 1
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro environment in tumor progression: The role of tumor-associated macrophages
    • Allavena P, Sica A, Solinas G, Porta C, Mantovanii A. The inflammatory micro environment in tumor progression: The role of tumor-associated macrophages. Crit Rev Oncol Hematol 2008; 66(1): 1-9.
    • (2008) Crit Rev Oncol Hematol , vol.66 , Issue.1 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovanii, A.5
  • 2
    • 40449087027 scopus 로고    scopus 로고
    • Hold GL, El-Omar ME. Genetic aspects of inflammation and cancer. Biochem J 2008 1; 410(2): 225-235.
    • Hold GL, El-Omar ME. Genetic aspects of inflammation and cancer. Biochem J 2008 1; 410(2): 225-235.
  • 3
    • 0027023063 scopus 로고
    • Free radical theory of aging: History
    • Emerita I, Chance B Eds, Birkhauser-Verlag, Basel
    • Harman D. Free radical theory of aging: history. In: Emerita I, Chance B Eds., Free Radicals and Aging, Birkhauser-Verlag, Basel 1992; 1-10.
    • (1992) Free Radicals and Aging , pp. 1-10
    • Harman, D.1
  • 5
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160(1): 1-40.
    • (2006) Chem Biol Interact , vol.160 , Issue.1 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 6
    • 0035162008 scopus 로고    scopus 로고
    • Ageing and the free radical theory
    • Wickens AP. Ageing and the free radical theory. Respir Physiol 2001; 128(3): 379-391.
    • (2001) Respir Physiol , vol.128 , Issue.3 , pp. 379-391
    • Wickens, A.P.1
  • 7
    • 0344513852 scopus 로고    scopus 로고
    • Mitochondrial generation of reactive oxygen species and its role in aerobic life
    • Inoue M, Sato EF, Nishikawa M, et al. Mitochondrial generation of reactive oxygen species and its role in aerobic life. Curr Med Chem 2003; 10(23): 2495-2505.
    • (2003) Curr Med Chem , vol.10 , Issue.23 , pp. 2495-2505
    • Inoue, M.1    Sato, E.F.2    Nishikawa, M.3
  • 8
    • 0030130524 scopus 로고    scopus 로고
    • Inflammation, free radicals, and antioxidants
    • Conner EM, Grisham MB. Inflammation, free radicals, and antioxidants. Nutrition 1996; 12(4): 274-277.
    • (1996) Nutrition , vol.12 , Issue.4 , pp. 274-277
    • Conner, E.M.1    Grisham, M.B.2
  • 10
    • 33847262105 scopus 로고    scopus 로고
    • Role of the Kuppfer cell in mediating hepatic toxicity and arcinogenesis
    • Roberts RA, Gary PE, Ju C, et al. Role of the Kuppfer cell in mediating hepatic toxicity and arcinogenesis. Toxicol Sci 2007; 96: 2-15.
    • (2007) Toxicol Sci , vol.96 , pp. 2-15
    • Roberts, R.A.1    Gary, P.E.2    Ju, C.3
  • 11
    • 33847290839 scopus 로고    scopus 로고
    • Chromatographic and electrophoretic methods for analysis of biomarkers of oxidative damage to macromolecules (DNA, lipids, and proteins)
    • Mateos R, Bravo L. Chromatographic and electrophoretic methods for analysis of biomarkers of oxidative damage to macromolecules (DNA, lipids, and proteins). J Sep Sci 2007; 30: 175-179.
    • (2007) J Sep Sci , vol.30 , pp. 175-179
    • Mateos, R.1    Bravo, L.2
  • 12
    • 0006537416 scopus 로고
    • Lipid peroxidation and metabolism in aging
    • Rothstein, Alan R. Liss, New York
    • Lippman RD. Lipid peroxidation and metabolism in aging. In: Rothstein, M. Ed Review of Biological Research in Aging, Alan R. Liss, New York 1983; 1: 315-342.
    • (1983) M. Ed Review of Biological Research in Aging , vol.1 , pp. 315-342
    • Lippman, R.D.1
  • 13
    • 33745779644 scopus 로고    scopus 로고
    • Glutatione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity
    • Ran O, Gu M, Van Remmen H, et al. Glutatione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J Neurosci Res 2006; 84: 202-208.
    • (2006) J Neurosci Res , vol.84 , pp. 202-208
    • Ran, O.1    Gu, M.2    Van Remmen, H.3
  • 14
    • 0000534774 scopus 로고
    • The status of oxidatively modified proteins as a marker of aging
    • Esser K, Martin GM. Eds, Wiley, Chichester
    • Stadtman ER. The status of oxidatively modified proteins as a marker of aging. In: Esser K, Martin GM. Eds. Molecular Aspects of Aging. Wiley, Chichester 1995; 129-144.
    • (1995) Molecular Aspects of Aging , pp. 129-144
    • Stadtman, E.R.1
  • 15
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90(17): 7915-7922.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.17 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 16
    • 0006614717 scopus 로고
    • DNA repair in mitochondria: How is it limited? What is its function?
    • Esser K, Martin GM. Eds, Wiley, Chichester
    • Linn S. DNA repair in mitochondria: How is it limited? What is its function? In: Esser K, Martin GM. Eds. Molecular Aspects of Aging. Wiley, Chichester 1995; 199-225.
    • (1995) Molecular Aspects of Aging , pp. 199-225
    • Linn, S.1
  • 18
    • 0037505644 scopus 로고    scopus 로고
    • Analysis of glutathione: Implication in redox and detoxification
    • Pastoret A, Federici G, Bertini E, Piemonti F. Analysis of glutathione: Implication in redox and detoxification. Clin Chim Acta 2003; 333: 19-39.
    • (2003) Clin Chim Acta , vol.333 , pp. 19-39
    • Pastoret, A.1    Federici, G.2    Bertini, E.3    Piemonti, F.4
  • 19
    • 1842588614 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF kappaB and interleukin-8 expression
    • Ryan KA, Smith MF Jr, Sanders MK, Ernst PB. Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF kappaB and interleukin-8 expression. Infect Immun 2004; 72: 2123-2130.
    • (2004) Infect Immun , vol.72 , pp. 2123-2130
    • Ryan, K.A.1    Smith Jr, M.F.2    Sanders, M.K.3    Ernst, P.B.4
  • 21
    • 52449115978 scopus 로고    scopus 로고
    • Intramitochondrial signaling: Interactions among mitoKATP, PKC epsilon, ROS and MPT
    • Costa AD, Garlid KD. Intramitochondrial signaling: interactions among mitoKATP, PKC epsilon, ROS and MPT. Am J Physiol Heart Circ Physiol 2007; 294: 874-882.
    • (2007) Am J Physiol Heart Circ Physiol , vol.294 , pp. 874-882
    • Costa, A.D.1    Garlid, K.D.2
  • 22
    • 33845724468 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
    • Flalkow L, Wang Y, Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 2007; 42: 153-164.
    • (2007) Free Radic Biol Med , vol.42 , pp. 153-164
    • Flalkow, L.1    Wang, Y.2    Downey, G.P.3
  • 23
    • 33847740673 scopus 로고    scopus 로고
    • How superoxide production by neutrophil leukocytes kill microbe
    • Segal W. How superoxide production by neutrophil leukocytes kill microbe. Novartis Found Symp 2006; 279: 92-98.
    • (2006) Novartis Found Symp , vol.279 , pp. 92-98
    • Segal, W.1
  • 24
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 25
    • 33748344714 scopus 로고    scopus 로고
    • Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: Role of lipid peroxidation, DNA damage and repair
    • Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: Role of lipid peroxidation, DNA damage and repair. Langenbecks Arch Surg 2006; 391: 499-510.
    • (2006) Langenbecks Arch Surg , vol.391 , pp. 499-510
    • Bartsch, H.1    Nair, J.2
  • 26
  • 28
    • 0036029247 scopus 로고    scopus 로고
    • Cytokines and related receptor-mediated signaling pathways
    • Oct 4;
    • Haddad JJ. Cytokines and related receptor-mediated signaling pathways. Biochem Biophys Res Commun 2002 Oct 4; 297(4): 700-713.
    • (2002) Biochem Biophys Res Commun , vol.297 , Issue.4 , pp. 700-713
    • Haddad, J.J.1
  • 30
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 31
    • 0031134142 scopus 로고    scopus 로고
    • Chapple IL. C Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol 1997; 24: 287-296.
    • Chapple IL. C Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol 1997; 24: 287-296.
  • 33
    • 0030036384 scopus 로고    scopus 로고
    • Interleukin-6 is required for pristaine-induced plasma cell hyperplasia in mice
    • Dedera DA, Urashima M, Chauhan D, et al. Interleukin-6 is required for pristaine-induced plasma cell hyperplasia in mice. Br J Haematol 1996; 94: 53-61.
    • (1996) Br J Haematol , vol.94 , pp. 53-61
    • Dedera, D.A.1    Urashima, M.2    Chauhan, D.3
  • 34
    • 0029956219 scopus 로고    scopus 로고
    • Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: Possible role of cyclooxygenase-2
    • Hinson RM, Williams JA, Shacter E. Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2. Proc Natl Acad Sci USA 1996; 93: 4885-4890.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4885-4890
    • Hinson, R.M.1    Williams, J.A.2    Shacter, E.3
  • 35
    • 0026643286 scopus 로고
    • Elevation of IL-6 in response to a chronic inflammatory stimulus in mice: Inhibition by indomethacin
    • Shacter E, Arzadon GK, Williams J. Elevation of IL-6 in response to a chronic inflammatory stimulus in mice: Inhibition by indomethacin. Blood 1992; 80: 194-202.
    • (1992) Blood , vol.80 , pp. 194-202
    • Shacter, E.1    Arzadon, G.K.2    Williams, J.3
  • 36
    • 0032983865 scopus 로고    scopus 로고
    • Mice deficient in tumor necrosis factor-a are resistant to skin carcinogenesis
    • Moore RJ, Owens DM, Stamp G, et al. Mice deficient in tumor necrosis factor-a are resistant to skin carcinogenesis. Nat Med 1999; 5: 828-831.
    • (1999) Nat Med , vol.5 , pp. 828-831
    • Moore, R.J.1    Owens, D.M.2    Stamp, G.3
  • 37
    • 0343831476 scopus 로고    scopus 로고
    • Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes
    • Zouki C, Jozsef L, Ouellet S, Paquette Y, Filep JG. Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes. J Leukoc Biol 2001; 69: 815-824.
    • (2001) J Leukoc Biol , vol.69 , pp. 815-824
    • Zouki, C.1    Jozsef, L.2    Ouellet, S.3    Paquette, Y.4    Filep, J.G.5
  • 38
    • 47749150261 scopus 로고    scopus 로고
    • Mantovanii A, Pierotti MA. Cancer and inflammation: A complex relationship. Cancer Lett 2008 (article in press).
    • Mantovanii A, Pierotti MA. Cancer and inflammation: A complex relationship. Cancer Lett 2008 (article in press).
  • 39
    • 0037180812 scopus 로고    scopus 로고
    • Points of control in inflammation
    • Nathan C. Points of control in inflammation. Nature 2002; 420: 846-852.
    • (2002) Nature , vol.420 , pp. 846-852
    • Nathan, C.1
  • 41
    • 0018133012 scopus 로고
    • Effects of tumor promoters and steroidal anti-inflammatory agents on skin of newborn mice in vivo and in vitro
    • Slaga TJ, Lichti U, Hennings H, Elgjo K, Yuspa SH. Effects of tumor promoters and steroidal anti-inflammatory agents on skin of newborn mice in vivo and in vitro. J Natl Cancer Inst 1978; 60: 425-431.
    • (1978) J Natl Cancer Inst , vol.60 , pp. 425-431
    • Slaga, T.J.1    Lichti, U.2    Hennings, H.3    Elgjo, K.4    Yuspa, S.H.5
  • 42
    • 0029956219 scopus 로고    scopus 로고
    • Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: Possible role of cyclooxygenase-2
    • Hinson RM, Williams JA, Shacter E. Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: Possible role of cyclooxygenase-2. Proc Natl Acad Sci USA 1996; 93: 4885-4890.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4885-4890
    • Hinson, R.M.1    Williams, J.A.2    Shacter, E.3
  • 43
    • 0030825717 scopus 로고    scopus 로고
    • kappaB in cytokine gene regulation. Adv Immunol1997; 65: 1-46.
    • kappaB in cytokine gene regulation. Adv Immunol1997; 65: 1-46.
  • 45
    • 0026643286 scopus 로고
    • Elevation of IL-6 in response to a chronic inflammatory stimulus in mice: Inhibition by indomethacin
    • Shacter E, Arzadon GK, Williams J. Elevation of IL-6 in response to a chronic inflammatory stimulus in mice: Inhibition by indomethacin. Blood 1992; 80: 194-202.
    • (1992) Blood , vol.80 , pp. 194-202
    • Shacter, E.1    Arzadon, G.K.2    Williams, J.3
  • 46
    • 0034009433 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and cancer prevention
    • Baron JA, Sandler RS. Nonsteroidal anti-inflammatory drugs and cancer prevention. Annu Rev Med 2000; 51: 511-523.
    • (2000) Annu Rev Med , vol.51 , pp. 511-523
    • Baron, J.A.1    Sandler, R.S.2
  • 48
    • 0036312330 scopus 로고    scopus 로고
    • A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer
    • Howe LR, Dannenberg AJ. A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. Semin Oncol 2002; 29: 111-119.
    • (2002) Semin Oncol , vol.29 , pp. 111-119
    • Howe, L.R.1    Dannenberg, A.J.2
  • 49
    • 0035468642 scopus 로고    scopus 로고
    • Cyclooxygenase 2: A pharmacological target for the prevention of cancer
    • Dannenberg AJ, Altorki NK, Boyle JO, et al. Cyclooxygenase 2: A pharmacological target for the prevention of cancer. Lancet Oncol 2001; 2: 544-551.
    • (2001) Lancet Oncol , vol.2 , pp. 544-551
    • Dannenberg, A.J.1    Altorki, N.K.2    Boyle, J.O.3
  • 51
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: A link between cancer genetics and chemotherapy. Cell 2002; 108: 153-164.
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 52
    • 0032959345 scopus 로고    scopus 로고
    • Reactive oxygen intermediates as mediators of programmed cell death in plants and animals
    • Jabs T. Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol 1999; 57: 231-245.
    • (1999) Biochem Pharmacol , vol.57 , pp. 231-245
    • Jabs, T.1
  • 53
    • 18544371009 scopus 로고    scopus 로고
    • Metals, toxicity and oxidative stress
    • Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005; 12: 1161-1208.
    • (2005) Curr Med Chem , vol.12 , pp. 1161-1208
    • Valko, M.1    Morris, H.2    Cronin, M.T.3
  • 55
    • 0031826286 scopus 로고    scopus 로고
    • Peroxynitrite reactions and diffusion in biology
    • Radi R. Peroxynitrite reactions and diffusion in biology. Chem Res Toxicol 1998; 11; 720-721.
    • (1998) Chem Res Toxicol , vol.11 , pp. 720-721
    • Radi, R.1
  • 56
    • 0035793178 scopus 로고    scopus 로고
    • The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2
    • Thomas DD, Liu X, Kantrow SP, Lancaster JR. The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci USA 2001; 98: 355-360.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 355-360
    • Thomas, D.D.1    Liu, X.2    Kantrow, S.P.3    Lancaster, J.R.4
  • 57
    • 0029111530 scopus 로고
    • Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
    • Inoue S, Kawanishi S. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide. FEBS Lett 1995; 371: 86-88.
    • (1995) FEBS Lett , vol.371 , pp. 86-88
    • Inoue, S.1    Kawanishi, S.2
  • 59
    • 0037457876 scopus 로고    scopus 로고
    • 8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis
    • Akaike T, Okamoto S, Sawa T, et al. 8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis. Proc Natl Acad Sci USA 2003; 100: 685-690.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 685-690
    • Akaike, T.1    Okamoto, S.2    Sawa, T.3
  • 60
    • 21744434507 scopus 로고    scopus 로고
    • Nitric oxide-induced nitrative stress involved in microbial pathogenesis
    • Zaki MH, Akuta T, Akaike T. Nitric oxide-induced nitrative stress involved in microbial pathogenesis. J Pharmacol Sci 2005; 98: 117-129.
    • (2005) J Pharmacol Sci , vol.98 , pp. 117-129
    • Zaki, M.H.1    Akuta, T.2    Akaike, T.3
  • 61
    • 21744454850 scopus 로고    scopus 로고
    • Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine
    • Suzuki N, Yasui M, Geacintov NE, Shafirovich V, Shibutani S. Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine. Biochemistry 2005; 44: 9238-9245.
    • (2005) Biochemistry , vol.44 , pp. 9238-9245
    • Suzuki, N.1    Yasui, M.2    Geacintov, N.E.3    Shafirovich, V.4    Shibutani, S.5
  • 62
  • 63
    • 3242866272 scopus 로고
    • Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication
    • Albring M, Griffith J, Attardi G. Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication. Proc Natl Acad Sci USA 1977; 74: 1348-1352.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 1348-1352
    • Albring, M.1    Griffith, J.2    Attardi, G.3
  • 64
    • 0021118509 scopus 로고
    • Transcription of the mammalian mitochondrial genome
    • Clayton DA. Transcription of the mammalian mitochondrial genome. Annu Rev Biochem 1984; 53: 573-594.
    • (1984) Annu Rev Biochem , vol.53 , pp. 573-594
    • Clayton, D.A.1
  • 65
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes FM, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997; 94: 514-519.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 66
    • 0030839865 scopus 로고    scopus 로고
    • Oxidative decay of DNA
    • Beckman KB, Ames BN. Oxidative decay of DNA. J Biol Chem 1997; 272: 19633-19636.
    • (1997) J Biol Chem , vol.272 , pp. 19633-19636
    • Beckman, K.B.1    Ames, B.N.2
  • 67
    • 0030841350 scopus 로고    scopus 로고
    • Protein oxidation in aging, disease, and oxidative stress
    • Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997; 272: 20313-20316.
    • (1997) J Biol Chem , vol.272 , pp. 20313-20316
    • Berlett, B.S.1    Stadtman, E.R.2
  • 68
    • 0039250954 scopus 로고    scopus 로고
    • Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
    • Fliss MS, Usadel H, Caballero OL, et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 2000; 287: 2017-2019.
    • (2000) Science , vol.287 , pp. 2017-2019
    • Fliss, M.S.1    Usadel, H.2    Caballero, O.L.3
  • 70
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • Polyak K, Li Y, Zhu H, et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998; 20: 291-293.
    • (1998) Nat Genet , vol.20 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3
  • 71
    • 30944440458 scopus 로고    scopus 로고
    • Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-Myc
    • Carcamo JM, Golde DW. Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-Myc. Mutat Res 2006; 593: 64-79.
    • (2006) Mutat Res , vol.593 , pp. 64-79
    • Carcamo, J.M.1    Golde, D.W.2
  • 72
    • 0029812283 scopus 로고    scopus 로고
    • A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization
    • Shalon D, Smith SJ, Brown PO. A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Res 1996; 6: 639-645.
    • (1996) Genome Res , vol.6 , pp. 639-645
    • Shalon, D.1    Smith, S.J.2    Brown, P.O.3
  • 73
    • 0021964203 scopus 로고
    • Prooxidant states and tumor promotion
    • Cerutti PA. Prooxidant states and tumor promotion. Science 1985; 227: 375-381.
    • (1985) Science , vol.227 , pp. 375-381
    • Cerutti, P.A.1
  • 75
    • 0033815334 scopus 로고    scopus 로고
    • Nitrosation and oxidation in the regulation of gene expression
    • Marshall HE, Merchant K, Stamler JS. Nitrosation and oxidation in the regulation of gene expression. FASEB J 2000; 14: 1889-1900.
    • (2000) FASEB J , vol.14 , pp. 1889-1900
    • Marshall, H.E.1    Merchant, K.2    Stamler, J.S.3
  • 76
    • 0035853035 scopus 로고    scopus 로고
    • Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line [MDA-MB-231): Potential role of cyclin D1
    • Pervin S, Singh R, Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line [MDA-MB-231): potential role of cyclin D1. Proc Natl Acad Sci USA 2001; 98: 3583-3588.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3583-3588
    • Pervin, S.1    Singh, R.2    Chaudhuri, G.3
  • 77
    • 0030296687 scopus 로고    scopus 로고
    • Rejuvenation of the disposable soma: Repeated injury extends lifespan in asexual annelid
    • Martinez DE. Rejuvenation of the disposable soma: repeated injury extends lifespan in asexual annelid. Exp Gerontol 1996; 31: 699-704.
    • (1996) Exp Gerontol , vol.31 , pp. 699-704
    • Martinez, D.E.1
  • 78
    • 34249729839 scopus 로고    scopus 로고
    • Modalities of gene action predicted by the classical evolutionary biological theory of aging
    • Martin GM. Modalities of gene action predicted by the classical evolutionary biological theory of aging. Ann NY Acad Sci 2007; 1000: 14-20.
    • (2007) Ann NY Acad Sci , vol.1000 , pp. 14-20
    • Martin, G.M.1
  • 79
    • 34548018283 scopus 로고    scopus 로고
    • The oxidative hypothesis of senescence
    • Gilca M, Stoian I, Atarasiu V, et al. The oxidative hypothesis of senescence. J Postgrad Med 2007; 53: 207-213.
    • (2007) J Postgrad Med , vol.53 , pp. 207-213
    • Gilca, M.1    Stoian, I.2    Atarasiu, V.3
  • 81
    • 70350243480 scopus 로고    scopus 로고
    • US20080119440
    • Koya, K.: US20080119440 (2008).
    • (2008)
    • Koya, K.1
  • 84
    • 0029102337 scopus 로고
    • Investigation of antioxidant status. DNArepair capacity and mutation as a function of age in humans
    • Barnett YA, King CM. Investigation of antioxidant status. DNArepair capacity and mutation as a function of age in humans. Mut Res 1995; 338: 115-128.
    • (1995) Mut Res , vol.338 , pp. 115-128
    • Barnett, Y.A.1    King, C.M.2
  • 85
    • 2342518271 scopus 로고    scopus 로고
    • Role of oxidant species in aging
    • Stadtman ER. Role of oxidant species in aging. Curr Med Chem 2004; 11: 1105-1112.
    • (2004) Curr Med Chem , vol.11 , pp. 1105-1112
    • Stadtman, E.R.1
  • 86
    • 0031593219 scopus 로고    scopus 로고
    • Lipid peroxidation, antioxidant protection and aging
    • Rikans LE, Hornbrook KR. Lipid peroxidation, antioxidant protection and aging. Biochim Biophys Acta 1997; 1362: 116-127.
    • (1997) Biochim Biophys Acta , vol.1362 , pp. 116-127
    • Rikans, L.E.1    Hornbrook, K.R.2
  • 87
    • 0025857385 scopus 로고
    • Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver
    • Rikans LE, Moore DR, Snowden CD. Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver. Biochim Biophys Acta 1991; 1074: 195-200.
    • (1991) Biochim Biophys Acta , vol.1074 , pp. 195-200
    • Rikans, L.E.1    Moore, D.R.2    Snowden, C.D.3
  • 88
    • 0026032113 scopus 로고
    • Aging and lung antioxidant enzymes, glutathione, and lipid peroxidation in the rat
    • Perez R, Lopez M, Barja de Quiroga G. Aging and lung antioxidant enzymes, glutathione, and lipid peroxidation in the rat. Free Radic Biol Med 1991; 10: 35-39.
    • (1991) Free Radic Biol Med , vol.10 , pp. 35-39
    • Perez, R.1    Lopez, M.2    Barja de Quiroga, G.3
  • 90
    • 0021049131 scopus 로고
    • Iron accumulation and lipid peroxidation in aging C57BL/6J mice
    • Massie HR, Aiello VR, Banziger V. Iron accumulation and lipid peroxidation in aging C57BL/6J mice. Exp Gerontol 1983; 18: 277-285
    • (1983) Exp Gerontol , vol.18 , pp. 277-285
    • Massie, H.R.1    Aiello, V.R.2    Banziger, V.3
  • 91
    • 0023109386 scopus 로고
    • Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice
    • Koizumi A, Weindruch R, Walford RL. Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr 1987; 117: 361-367.
    • (1987) J Nutr , vol.117 , pp. 361-367
    • Koizumi, A.1    Weindruch, R.2    Walford, R.L.3
  • 92
    • 70350235437 scopus 로고    scopus 로고
    • Heaney, A. P., Hui, H.: WO07025238 (2007).
    • Heaney, A. P., Hui, H.: WO07025238 (2007).
  • 93
    • 0027171266 scopus 로고
    • Oxidants, antioxidants and the generative diseases of aging
    • Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants and the generative diseases of aging. Proc Natl Acad Sci USA 1993; 90: 7915-7922.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.