메뉴 건너뛰기




Volumn 5, Issue 1, 2014, Pages 12-20

Inflammasomes in cancer: A double-edged sword

Author keywords

cancer; inflammasome; inflammation

Indexed keywords

CASPASE 8; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR SUPPRESSOR PROTEIN;

EID: 84895168155     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-013-0001-4     Document Type: Review
Times cited : (232)

References (89)
  • 3
    • 0030481288 scopus 로고    scopus 로고
    • Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2
    • Basso D, Scrigner M, Toma A, Navaglia F, Di Mario F, Rugge M, Plebani M (1996) Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. Int J Clin Lab Res 26: 207-210.
    • (1996) Int J Clin Lab Res , vol.26 , pp. 207-210
    • Basso, D.1    Scrigner, M.2    Toma, A.3    Navaglia, F.4    Di Mario, F.5    Rugge, M.6    Plebani, M.7
  • 5
    • 84878740998 scopus 로고    scopus 로고
    • Of inflammasomes and pathogens-sensing of microbes by the inflammasome
    • Bauernfeind F, Hornung V (2013) Of inflammasomes and pathogens-sensing of microbes by the inflammasome. EMBO Mol Med 5: 814-826.
    • (2013) EMBO Mol Med , vol.5 , pp. 814-826
    • Bauernfeind, F.1    Hornung, V.2
  • 8
    • 67149115417 scopus 로고    scopus 로고
    • Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4
    • Bunt SK, Clements VK, Hanson EM, Sinha P, Ostrand-Rosenberg S (2009) Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85: 996-1004.
    • (2009) J Leukoc Biol , vol.85 , pp. 996-1004
    • Bunt, S.K.1    Clements, V.K.2    Hanson, E.M.3    Sinha, P.4    Ostrand-Rosenberg, S.5
  • 9
    • 84855919439 scopus 로고    scopus 로고
    • Hepatitis C virus activates interleukin-1beta via caspase-1-inflammasome complex
    • Burdette D, Haskett A, Presser L, McRae S, Iqbal J, Waris G (2012) Hepatitis C virus activates interleukin-1beta via caspase-1-inflammasome complex. J Gen Virol 93: 235-246.
    • (2012) J Gen Virol , vol.93 , pp. 235-246
    • Burdette, D.1    Haskett, A.2    Presser, L.3    McRae, S.4    Iqbal, J.5    Waris, G.6
  • 11
    • 81855228056 scopus 로고    scopus 로고
    • Inflammasomes in intestinal inflammation and cancer
    • Chen GY, Nunez G (2011) Inflammasomes in intestinal inflammation and cancer. Gastroenterology 141: 1986-1999.
    • (2011) Gastroenterology , vol.141 , pp. 1986-1999
    • Chen, G.Y.1    Nunez, G.2
  • 12
    • 79959540809 scopus 로고    scopus 로고
    • A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
    • Chen GY, Liu M, Wang F, Bertin J, Nunez G (2011) A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol 186: 7187-7194.
    • (2011) J Immunol , vol.186 , pp. 7187-7194
    • Chen, G.Y.1    Liu, M.2    Wang, F.3    Bertin, J.4    Nunez, G.5
  • 14
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: a magic bullet?
    • Coussens LM, Zitvogel L, Palucka AK (2013) Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science 339: 286-291.
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 15
    • 84876350807 scopus 로고    scopus 로고
    • The therapeutic potential of modifying inflammasomes and NOD-Like receptors
    • Di Virgilio F (2013) The therapeutic potential of modifying inflammasomes and NOD-Like receptors. Pharmacol Rev 65: 872-905.
    • (2013) Pharmacol Rev , vol.65 , pp. 872-905
    • Di Virgilio, F.1
  • 16
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27: 519-550.
    • (2009) Annu Rev Immunol , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 17
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117: 3720-3732.
    • (2011) Blood , vol.117 , pp. 3720-3732
    • Dinarello, C.A.1
  • 18
  • 20
    • 82355175161 scopus 로고    scopus 로고
    • Inflammasomes as molecular mediators of inflammation and cancer: potential role in melanoma
    • Dunn JH, Ellis LZ, Fujita M (2012) Inflammasomes as molecular mediators of inflammation and cancer: potential role in melanoma. Cancer Lett 314: 24-33.
    • (2012) Cancer Lett , vol.314 , pp. 24-33
    • Dunn, J.H.1    Ellis, L.Z.2    Fujita, M.3
  • 22
    • 77953566560 scopus 로고    scopus 로고
    • Innate instruction of adaptive immunity revisited: the inflammasome
    • Eisenbarth SC, Flavell RA (2009) Innate instruction of adaptive immunity revisited: the inflammasome. EMBO Mol Med 1: 92-98.
    • (2009) EMBO Mol Med , vol.1 , pp. 92-98
    • Eisenbarth, S.C.1    Flavell, R.A.2
  • 27
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458: 509-513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 29
    • 77956905415 scopus 로고    scopus 로고
    • Dual roles for immunity in gastrointestinal cancers
    • Ferrone C, Dranoff G (2010) Dual roles for immunity in gastrointestinal cancers. J Clin Oncol 28: 4045-4051.
    • (2010) J Clin Oncol , vol.28 , pp. 4045-4051
    • Ferrone, C.1    Dranoff, G.2
  • 30
    • 84866108688 scopus 로고    scopus 로고
    • Immunology. Orchestrating inflammasomes
    • Franchi L, Nunez G (2012) Immunology. Orchestrating inflammasomes. Science 337: 1299-1300.
    • (2012) Science , vol.337 , pp. 1299-1300
    • Franchi, L.1    Nunez, G.2
  • 33
    • 26444434342 scopus 로고    scopus 로고
    • Pharmacological manipulation of cell death: clinical applications in sight?
    • Green DR, Kroemer G (2005) Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest 115: 2610-2617.
    • (2005) J Clin Invest , vol.115 , pp. 2610-2617
    • Green, D.R.1    Kroemer, G.2
  • 34
    • 84857175933 scopus 로고    scopus 로고
    • Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome
    • Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TB (2012) Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome. Nat Immunol 13: 246-254.
    • (2012) Nat Immunol , vol.13 , pp. 246-254
    • Gringhuis, S.I.1    Kaptein, T.M.2    Wevers, B.A.3    Theelen, B.4    van der Vlist, M.5    Boekhout, T.6    Geijtenbeek, T.B.7
  • 35
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140: 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 38
    • 79959221313 scopus 로고    scopus 로고
    • Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation
    • Hu B, Elinav E, Flavell RA (2011) Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation. Cell Cycle 10: 1936-1939.
    • (2011) Cell Cycle , vol.10 , pp. 1936-1939
    • Hu, B.1    Elinav, E.2    Flavell, R.A.3
  • 39
    • 0036682506 scopus 로고    scopus 로고
    • Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors
    • Idzko M, Dichmann S, Ferrari D, Di Virgilio F, la Sala A, Girolomoni G, Panther E, Norgauer J (2002) Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood 100: 925-932.
    • (2002) Blood , vol.100 , pp. 925-932
    • Idzko, M.1    Dichmann, S.2    Ferrari, D.3    Di Virgilio, F.4    la Sala, A.5    Girolomoni, G.6    Panther, E.7    Norgauer, J.8
  • 43
    • 84867770402 scopus 로고    scopus 로고
    • Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
    • Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287: 36617-36622.
    • (2012) J Biol Chem , vol.287 , pp. 36617-36622
    • Juliana, C.1    Fernandes-Alnemri, T.2    Kang, S.3    Farias, A.4    Qin, F.5    Alnemri, E.S.6
  • 48
    • 84869875206 scopus 로고    scopus 로고
    • IL-1beta promotes stemness and invasiveness of colon cancer cells through Zeb1 activation
    • Li Y, Wang L, Pappan L, Galliher-Beckley A, Shi J (2012) IL-1beta promotes stemness and invasiveness of colon cancer cells through Zeb1 activation. Mol Cancer 11: 87.
    • (2012) Mol Cancer , vol.11 , pp. 87
    • Li, Y.1    Wang, L.2    Pappan, L.3    Galliher-Beckley, A.4    Shi, J.5
  • 49
    • 78649288528 scopus 로고    scopus 로고
    • Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis
    • Liu X, Wang Z, Yu J, Lei G, Wang S (2010) Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis. Breast Cancer Res Treat 124: 821-825.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 821-825
    • Liu, X.1    Wang, Z.2    Yu, J.3    Lei, G.4    Wang, S.5
  • 50
    • 84872607356 scopus 로고    scopus 로고
    • Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma
    • Liu W, Luo Y, Dunn JH, Norris DA, Dinarello CA, Fujita M (2013) Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma. J Invest Dermatol 133: 518-527.
    • (2013) J Invest Dermatol , vol.133 , pp. 518-527
    • Liu, W.1    Luo, Y.2    Dunn, J.H.3    Norris, D.A.4    Dinarello, C.A.5    Fujita, M.6
  • 55
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 57
    • 79960426821 scopus 로고    scopus 로고
    • Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors
    • Mattarollo SR, Loi S, Duret H, Ma Y, Zitvogel L, Smyth MJ (2011) Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors. Cancer Res 71: 4809-4820.
    • (2011) Cancer Res , vol.71 , pp. 4809-4820
    • Mattarollo, S.R.1    Loi, S.2    Duret, H.3    Ma, Y.4    Zitvogel, L.5    Smyth, M.J.6
  • 58
    • 44949137137 scopus 로고    scopus 로고
    • Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions
    • McNamara D, El-Omar E (2008) Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions. Dig Liver Dis 40: 504-509.
    • (2008) Dig Liver Dis , vol.40 , pp. 504-509
    • McNamara, D.1    El-Omar, E.2
  • 61
    • 80052179138 scopus 로고    scopus 로고
    • Caspase-1-induced pyroptotic cell death
    • Miao EA, Rajan JV, Aderem A (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev 243: 206-214.
    • (2011) Immunol Rev , vol.243 , pp. 206-214
    • Miao, E.A.1    Rajan, J.V.2    Aderem, A.3
  • 64
    • 77949889567 scopus 로고    scopus 로고
    • Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    • Okamoto M, Liu W, Luo Y, Tanaka A, Cai X, Norris DA, Dinarello CA, Fujita M (2010) Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J Biol Chem 285: 6477-6488.
    • (2010) J Biol Chem , vol.285 , pp. 6477-6488
    • Okamoto, M.1    Liu, W.2    Luo, Y.3    Tanaka, A.4    Cai, X.5    Norris, D.A.6    Dinarello, C.A.7    Fujita, M.8
  • 68
    • 68349102201 scopus 로고    scopus 로고
    • Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis
    • Reed JR, Leon RP, Hall MK, Schwertfeger KL (2009) Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis. Breast Cancer Res 11: R21.
    • (2009) Breast Cancer Res , vol.11
    • Reed, J.R.1    Leon, R.P.2    Hall, M.K.3    Schwertfeger, K.L.4
  • 70
    • 48649109203 scopus 로고    scopus 로고
    • Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    • Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M (2008) Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14: 156-165.
    • (2008) Cancer Cell , vol.14 , pp. 156-165
    • Sakurai, T.1    He, G.2    Matsuzawa, A.3    Yu, G.Y.4    Maeda, S.5    Hardiman, G.6    Karin, M.7
  • 72
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tschopp J (2010) The inflammasomes. Cell 140: 821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 74
    • 84879159574 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves
    • Sevko A, Umansky V (2013) Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves. J Cancer 4: 3-11.
    • (2013) J Cancer , vol.4 , pp. 3-11
    • Sevko, A.1    Umansky, V.2
  • 76
    • 35748938246 scopus 로고    scopus 로고
    • Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma
    • Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Chouchane L (2005) Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma. Eur Cytokine Netw 16: 253-260.
    • (2005) Eur Cytokine Netw , vol.16 , pp. 253-260
    • Snoussi, K.1    Strosberg, A.D.2    Bouaouina, N.3    Ben Ahmed, S.4    Chouchane, L.5
  • 77
    • 77957945366 scopus 로고    scopus 로고
    • Interleukin-18: biology and role in the immunotherapy of cancer
    • Srivastava S, Salim N, Robertson MJ (2010) Interleukin-18: biology and role in the immunotherapy of cancer. Curr Med Chem 17: 3353-3357.
    • (2010) Curr Med Chem , vol.17 , pp. 3353-3357
    • Srivastava, S.1    Salim, N.2    Robertson, M.J.3
  • 78
    • 0037121940 scopus 로고    scopus 로고
    • The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
    • Stehlik C, Fiorentino L, Dorfleutner A, Bruey JM, Ariza EM, Sagara J, Reed JC (2002) The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med 196: 1605-1615.
    • (2002) J Exp Med , vol.196 , pp. 1605-1615
    • Stehlik, C.1    Fiorentino, L.2    Dorfleutner, A.3    Bruey, J.M.4    Ariza, E.M.5    Sagara, J.6    Reed, J.C.7
  • 83
    • 33845706436 scopus 로고    scopus 로고
    • Association of interleukin-1 gene polymorphisms with gastric cancer: a meta-analysis
    • Wang P, Xia HH, Zhang JY, Dai LP, Xu XQ, Wang KJ (2007) Association of interleukin-1 gene polymorphisms with gastric cancer: a meta-analysis. Int J Cancer 120: 552-562.
    • (2007) Int J Cancer , vol.120 , pp. 552-562
    • Wang, P.1    Xia, H.H.2    Zhang, J.Y.3    Dai, L.P.4    Xu, X.Q.5    Wang, K.J.6
  • 84
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD (2010a) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32: 379-391.
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1    Boyd, K.L.2    Vogel, P.3    Kastan, M.B.4    Lamkanfi, M.5    Kanneganti, T.D.6
  • 85
    • 78049488908 scopus 로고    scopus 로고
    • IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
    • Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD (2010b) IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol 185: 4912-4920.
    • (2010) J Immunol , vol.185 , pp. 4912-4920
    • Zaki, M.H.1    Vogel, P.2    Body-Malapel, M.3    Lamkanfi, M.4    Kanneganti, T.D.5
  • 88
    • 84866338314 scopus 로고    scopus 로고
    • IL1beta-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells
    • Zhu Y, Zhu M, Lance P (2012) IL1beta-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells. Exp Cell Res 318: 2520-2530.
    • (2012) Exp Cell Res , vol.318 , pp. 2520-2530
    • Zhu, Y.1    Zhu, M.2    Lance, P.3
  • 89
    • 84858643750 scopus 로고    scopus 로고
    • Inflammasomes in carcinogenesis and anticancer immune responses
    • Zitvogel L, Kepp O, Galluzzi L, Kroemer G (2012) Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol 13: 343-351.
    • (2012) Nat Immunol , vol.13 , pp. 343-351
    • Zitvogel, L.1    Kepp, O.2    Galluzzi, L.3    Kroemer, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.