-
1
-
-
84974560145
-
The 2016 revision to the world health organization who) classification of myeloid neoplasms and acute leukemia
-
Arber, D. A., et al. The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia. Blood 127, 2391-2405 (2016
-
(2016)
Blood
, vol.127
, pp. 2391-2405
-
-
Arber, D.A.1
-
2
-
-
80053646494
-
Familial myelodysplastic syndromes: A review of the literature
-
Liew, E., & Owen, C. Familial myelodysplastic syndromes: a review of the literature. Haematologica 96, 1536-1542 (2011
-
(2011)
Haematologica
, vol.96
, pp. 1536-1542
-
-
Liew, E.1
Owen, C.2
-
3
-
-
84941744568
-
Incidence and burden of the myelodysplastic syndromes
-
Cogle, C. R. Incidence and burden of the myelodysplastic syndromes. Curr. Hematol. Malignancy Rep. 10, 272-281 (2015
-
(2015)
Curr. Hematol. Malignancy Rep
, vol.10
, pp. 272-281
-
-
Cogle, C.R.1
-
4
-
-
34247172535
-
Myelodysplastic syndromes: Incidence and survival in the United States
-
Ma, X., Does, M., Raza, A., & Mayne, S. T. Myelodysplastic syndromes: incidence and survival in the United States. Cancer 109, 1536-1542 (2007
-
(2007)
Cancer
, vol.109
, pp. 1536-1542
-
-
Ma, X.1
Does, M.2
Raza, A.3
Mayne, S.T.4
-
5
-
-
78951473511
-
Epidemiology natural history, and practice patterns of patients with myelodysplastic syndromes in 2010
-
Sekeres, M. A. Epidemiology, natural history, and practice patterns of patients with myelodysplastic syndromes in 2010. J. Natl Compr. Canc. Netw. 9, 57-63 (2011
-
(2011)
J. Natl Compr. Canc. Netw
, vol.9
, pp. 57-63
-
-
Sekeres, M.A.1
-
6
-
-
84866621729
-
Revised international prognostic scoring system for myelodysplastic syndromes
-
Greenberg, P. L., et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood 120, 2454-2465 (2012
-
(2012)
Blood
, vol.120
, pp. 2454-2465
-
-
Greenberg, P.L.1
-
7
-
-
53149113768
-
Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System
-
Kantarjian, H., et al. Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System. Cancer 113, 1351-1361 (2008
-
(2008)
Cancer
, vol.113
, pp. 1351-1361
-
-
Kantarjian, H.1
-
8
-
-
80053186861
-
Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the who classification-based prognostic scoring system (wpss
-
Malcovati, L., et al. Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS). Haematologica 96, 1433-1440 (2011
-
(2011)
Haematologica
, vol.96
, pp. 1433-1440
-
-
Malcovati, L.1
-
9
-
-
79959794787
-
Clinical effect of point mutations in myelodysplastic syndromes
-
Bejar, R., et al. Clinical effect of point mutations in myelodysplastic syndromes. N. Engl. J. Med. 364, 2496-2506 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, pp. 2496-2506
-
-
Bejar, R.1
-
10
-
-
84866749552
-
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
-
Bejar, R., et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J. Clin. Oncol. 30, 3376-3382 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 3376-3382
-
-
Bejar, R.1
-
11
-
-
84902480315
-
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
-
Woll, P. S., et al. Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer Cell 25, 794-808 (2014
-
(2014)
Cancer Cell
, vol.25
, pp. 794-808
-
-
Woll, P.S.1
-
12
-
-
84920053873
-
Age-related clonal hematopoiesis associated with adverse outcomes
-
Jaiswal, S., et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488-2498 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 2488-2498
-
-
Jaiswal, S.1
-
13
-
-
0034691092
-
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
-
Miyamoto, T., Weissman, I. L., & Akashi, K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc. Natl Acad. Sci. USA 97, 7521-7526 (2000
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 7521-7526
-
-
Miyamoto, T.1
Weissman, I.L.2
Akashi, K.3
-
14
-
-
0036659925
-
Involvement and functional impairment of the CD34+CD38-Thy 1+ hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8
-
Nilsson, L., et al. Involvement and functional impairment of the CD34+CD38-Thy 1+ hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. Blood 100, 259-267 (2002
-
(2002)
Blood
, vol.100
, pp. 259-267
-
-
Nilsson, L.1
-
15
-
-
0034665776
-
Isolation and characterization of hematopoietic progenitor/stem cells in 5q deleted myelodysplastic syndromes: Evidence for involvement at the hematopoietic stem cell level
-
Nilsson, L., et al. Isolation and characterization of hematopoietic progenitor/stem cells in 5q deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood 96, 2012-2021 (2000
-
(2000)
Blood
, vol.96
, pp. 2012-2021
-
-
Nilsson, L.1
-
16
-
-
84896617557
-
A targeted mutational landscape of angioimmunoblastic T cell lymphoma
-
Odejide, O., et al. A targeted mutational landscape of angioimmunoblastic T cell lymphoma. Blood 123, 1293-1296 (2014
-
(2014)
Blood
, vol.123
, pp. 1293-1296
-
-
Odejide, O.1
-
17
-
-
80051596015
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
Quivoron, C., et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 20, 25-38 (2011
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
-
18
-
-
84934343560
-
Myelodysplastic syndromes: Diagnosis and treatment
-
Steensma, D. P. Myelodysplastic syndromes: diagnosis and treatment. Mayo Clin. Proc. 90, 969-983 (2015
-
(2015)
Mayo Clin. Proc
, vol.90
, pp. 969-983
-
-
Steensma, D.P.1
-
19
-
-
84868208186
-
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
-
Busque, L., et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat. Genet. 44, 1179-1181 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 1179-1181
-
-
Busque, L.1
-
20
-
-
84930003179
-
Age-related mutations associated with clonal hematopoietic expansion and malignancies
-
Xie, M., et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20, 1472-1478 (2014
-
(2014)
Nat. Med
, vol.20
, pp. 1472-1478
-
-
Xie, M.1
-
21
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
Genovese, G., et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371, 2477-2487 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 2477-2487
-
-
Genovese, G.1
-
22
-
-
84937904208
-
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
-
Steensma, D. P., et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood 126, 9-16 (2015
-
(2015)
Blood
, vol.126
, pp. 9-16
-
-
Steensma, D.P.1
-
23
-
-
84948771021
-
Targeted sequencing identifies patients with preclinical MDS at high risk of disease progression
-
Cargo, C. A., et al. Targeted sequencing identifies patients with preclinical MDS at high risk of disease progression. Blood 126, 2362-2365 (2015
-
(2015)
Blood
, vol.126
, pp. 2362-2365
-
-
Cargo, C.A.1
-
24
-
-
84949035448
-
MDS-Associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance
-
Kwok, B., et al. MDS-Associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance. Blood 126, 2355-2361 (2015
-
(2015)
Blood
, vol.126
, pp. 2355-2361
-
-
Kwok, B.1
-
25
-
-
84893772765
-
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
-
Haferlach, T., et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia 28, 241-247 (2014
-
(2014)
Leukemia
, vol.28
, pp. 241-247
-
-
Haferlach, T.1
-
26
-
-
84888219405
-
Clinical and biological implications of driver mutations in myelodysplastic syndromes
-
Papaemmanuil, E., et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 122, 3616-3627 (2013
-
(2013)
Blood
, vol.122
, pp. 3616-3627
-
-
Papaemmanuil, E.1
-
27
-
-
84905455426
-
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing
-
Hughes, A. E., et al. Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. PLoS Genet. 10, e1004462 (2014
-
(2014)
PLoS Genet
, vol.10
, pp. e1004462
-
-
Hughes, A.E.1
-
28
-
-
84961554506
-
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations
-
Lindsley, R. C., et al. Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Blood 125, 1367-1376 (2015
-
(2015)
Blood
, vol.125
, pp. 1367-1376
-
-
Lindsley, R.C.1
-
29
-
-
84894304555
-
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
-
Corces-Zimmerman, M. R., Hong, W. J., Weissman, I. L., Medeiros, B. C., & Majeti, R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc. Natl Acad. Sci. USA 111, 2548-2553 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 2548-2553
-
-
Corces-Zimmerman, M.R.1
Hong, W.J.2
Weissman, I.L.3
Medeiros, B.C.4
Majeti, R.5
-
30
-
-
84885657625
-
NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes
-
Murphy, D. M., et al. NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes. Leukemia 27, 2077-2081 (2013
-
(2013)
Leukemia
, vol.27
, pp. 2077-2081
-
-
Murphy, D.M.1
-
31
-
-
84885606356
-
Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AML
-
Takahashi, K., et al. Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AML. Leukemia 27, 2081-2083 (2013
-
(2013)
Leukemia
, vol.27
, pp. 2081-2083
-
-
Takahashi, K.1
-
32
-
-
84864255882
-
The origin and evolution of mutations in acute myeloid leukemia
-
Welch, J. S., et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 150, 264-278 (2012
-
(2012)
Cell
, vol.150
, pp. 264-278
-
-
Welch, J.S.1
-
33
-
-
84928348527
-
Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes
-
Gerstung, M., et al. Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes. Nat. Commun. 6, 5901 (2015
-
(2015)
Nat. Commun
, vol.6
, pp. 5901
-
-
Gerstung, M.1
-
34
-
-
84885021313
-
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
-
Kon, A., et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat. Genet. 45, 1232-1237 (2013
-
(2013)
Nat. Genet
, vol.45
, pp. 1232-1237
-
-
Kon, A.1
-
35
-
-
84906809218
-
Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation
-
Bejar, R., et al. Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. J. Clin. Oncol. 32, 2691-2698 (2014
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 2691-2698
-
-
Bejar, R.1
-
36
-
-
84922693801
-
Effect of mutation order on myeloproliferative neoplasms
-
Ortmann, C. A., et al. Effect of mutation order on myeloproliferative neoplasms. N. Engl. J. Med. 372, 601-612 (2015
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 601-612
-
-
Ortmann, C.A.1
-
37
-
-
84926359679
-
Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations
-
Jeromin, S., et al. Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations. Haematologica 100, e125-e127 (2015
-
(2015)
Haematologica
, vol.100
, pp. e125-e127
-
-
Jeromin, S.1
-
38
-
-
84937805127
-
SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
-
Malcovati, L., et al. SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts. Blood 126, 233-241 (2015
-
(2015)
Blood
, vol.126
, pp. 233-241
-
-
Malcovati, L.1
-
39
-
-
84862776906
-
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
-
Ding, L., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 481, 506-510 (2012
-
(2012)
Nature
, vol.481
, pp. 506-510
-
-
Ding, L.1
-
40
-
-
84948953284
-
Profiling of somatic mutations in acute myeloid leukemia with FLT3 ITD at diagnosis and relapse
-
Garg, M., et al. Profiling of somatic mutations in acute myeloid leukemia with FLT3 ITD at diagnosis and relapse. Blood 126, 2491-2501 (2015
-
(2015)
Blood
, vol.126
, pp. 2491-2501
-
-
Garg, M.1
-
41
-
-
84865827060
-
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
-
149ra118
-
Jan, M., et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci. Transl Med. 4, 149ra118 (2012
-
(2012)
Sci. Transl Med
, vol.4
-
-
Jan, M.1
-
42
-
-
84894245627
-
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
-
Shlush, L. I., et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506, 328-333 (2014
-
(2014)
Nature
, vol.506
, pp. 328-333
-
-
Shlush, L.I.1
-
43
-
-
84940545016
-
Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
-
Klco, J. M., et al. Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia. JAMA 314, 811-822 (2015
-
(2015)
JAMA
, vol.314
, pp. 811-822
-
-
Klco, J.M.1
-
44
-
-
84878900540
-
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
-
Walter, M. J., et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia 27, 1275-1282 (2013
-
(2013)
Leukemia
, vol.27
, pp. 1275-1282
-
-
Walter, M.J.1
-
45
-
-
84936160001
-
Somatic mutations and clonal hematopoiesis in aplastic anemia
-
Yoshizato, T., et al. Somatic mutations and clonal hematopoiesis in aplastic anemia. N. Engl. J. Med. 373, 35-47 (2015
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 35-47
-
-
Yoshizato, T.1
-
46
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L. B., et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
47
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman, C., et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
-
48
-
-
84929222950
-
Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome
-
Colla, S., et al. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell 27, 644-657 (2015
-
(2015)
Cancer Cell
, vol.27
, pp. 644-657
-
-
Colla, S.1
-
49
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence, M. S., et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 (2014
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
-
50
-
-
85015586936
-
Spliceosomal gene mutations in myelodysplasia: Molecular links to clonal abnormalities of hematopoiesis
-
Inoue, D., Bradley, R. K., & Abdel-Wahab, O. Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis. Genes Dev. 30, 989-1001 (2016
-
(2016)
Genes Dev
, vol.30
, pp. 989-1001
-
-
Inoue, D.1
Bradley, R.K.2
Abdel-Wahab, O.3
-
51
-
-
84555192302
-
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
-
Graubert, T. A., et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat. Genet. 44, 53-57 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 53-57
-
-
Graubert, T.A.1
-
52
-
-
80054010617
-
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
-
Papaemmanuil, E., et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N. Engl. J. Med. 365, 1384-1395 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 1384-1395
-
-
Papaemmanuil, E.1
-
53
-
-
80053900941
-
Frequent pathway mutations of splicing machinery in myelodysplasia
-
Yoshida, K., et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478, 64-69 (2011
-
(2011)
Nature
, vol.478
, pp. 64-69
-
-
Yoshida, K.1
-
54
-
-
84945480525
-
Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
-
Conte, S., et al. Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts. Br. J. Haematol. 171, 478-490 (2015
-
(2015)
Br. J. Haematol
, vol.171
, pp. 478-490
-
-
Conte, S.1
-
55
-
-
84947417142
-
Cancer-Associated SF3B1 hotspot mutations induce cryptic 3' splice site selection through use of a different branch point
-
Darman, R. B., et al. Cancer-Associated SF3B1 hotspot mutations induce cryptic 3' splice site selection through use of a different branch point. Cell Rep. 13, 1033-1045 (2015
-
(2015)
Cell Rep
, vol.13
, pp. 1033-1045
-
-
Darman, R.B.1
-
56
-
-
84929162813
-
SRSF2 mutations contribute to myelodysplasia by mutant-specific effects on exon recognition
-
Kim, E., et al. SRSF2 mutations contribute to myelodysplasia by mutant-specific effects on exon recognition. Cancer Cell 27, 617-630 (2015
-
(2015)
Cancer Cell
, vol.27
, pp. 617-630
-
-
Kim, E.1
-
57
-
-
84920688391
-
U2AF1 mutations alter splice site recognition in hematological malignancies
-
Ilagan, J. O., et al. U2AF1 mutations alter splice site recognition in hematological malignancies. Genome Res. 25, 14-26 (2015
-
(2015)
Genome Res
, vol.25
, pp. 14-26
-
-
Ilagan, J.O.1
-
58
-
-
84886905271
-
Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
-
Przychodzen, B., et al. Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood 122, 999-1006 (2013
-
(2013)
Blood
, vol.122
, pp. 999-1006
-
-
Przychodzen, B.1
-
59
-
-
84923580247
-
DNMT3A in haematological malignancies
-
Yang, L., Rau, R., & Goodell, M. A. DNMT3A in haematological malignancies. Nat. Rev. Cancer 15, 152-165 (2015
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 152-165
-
-
Yang, L.1
Rau, R.2
Goodell, M.A.3
-
60
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley, T. J., et al. DNMT3A mutations in acute myeloid leukemia. N. Engl. J. Med. 363, 2424-2433 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
-
61
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
Walter, M. J., et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 25, 1153-1158 (2011
-
(2011)
Leukemia
, vol.25
, pp. 1153-1158
-
-
Walter, M.J.1
-
62
-
-
84926450501
-
TET proteins and 5 methylcytosine oxidation in hematological cancers
-
Ko, M., et al. TET proteins and 5 methylcytosine oxidation in hematological cancers. Immunol. Rev. 263, 6-21 (2015
-
(2015)
Immunol. Rev
, vol.263
, pp. 6-21
-
-
Ko, M.1
-
63
-
-
66149146320
-
Conversion of 5 methylcytosine to 5 hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani, M., et al. Conversion of 5 methylcytosine to 5 hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
-
64
-
-
0037350661
-
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11) q22;q23)
-
Lorsbach, R. B., et al. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia 17, 637-641 (2003
-
(2003)
Leukemia
, vol.17
, pp. 637-641
-
-
Lorsbach, R.B.1
-
65
-
-
0037099537
-
LCX, leukemia-Associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11) (q22;q23
-
Ono, R., et al. LCX, leukemia-Associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11) (q22;q23). Cancer Res. 62, 4075-4080 (2002
-
(2002)
Cancer Res
, vol.62
, pp. 4075-4080
-
-
Ono, R.1
-
66
-
-
0031860739
-
Cloning and characterization of a family of novel mammalian DNA (cytosine 5) methyltransferases
-
Okano, M., Xie, S., & Li, E. Cloning and characterization of a family of novel mammalian DNA (cytosine 5) methyltransferases. Nat. Genet. 19, 219-220 (1998
-
(1998)
Nat. Genet
, vol.19
, pp. 219-220
-
-
Okano, M.1
Xie, S.2
Li, E.3
-
67
-
-
84868103289
-
Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre B cells
-
Kallin, E. M., et al. Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre B cells. Mol. Cell 48, 266-276 (2012
-
(2012)
Mol. Cell
, vol.48
, pp. 266-276
-
-
Kallin, E.M.1
-
68
-
-
84929461859
-
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis
-
Rasmussen, K. D., et al. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes Dev. 29, 910-922 (2015
-
(2015)
Genes Dev
, vol.29
, pp. 910-922
-
-
Rasmussen, K.D.1
-
69
-
-
84942881407
-
TET2 mutations affect non-CpG island DNA methylation at enhancers and transcription factor-binding sites in chronic myelomonocytic leukemia
-
CAN 14 0739
-
Yamazaki, J., et al. TET2 mutations affect non-CpG island DNA methylation at enhancers and transcription factor-binding sites in chronic myelomonocytic leukemia. Cancer Res. 75, 2833-2843 CAN 14 0739 (2015
-
(2015)
Cancer Res
, vol.75
, pp. 2833-2843
-
-
Yamazaki, J.1
-
70
-
-
77953702324
-
Cancer-Associated IDH1 mutations produce 2 hydroxyglutarate
-
Dang, L., et al. Cancer-Associated IDH1 mutations produce 2 hydroxyglutarate. Nature 465, 966 (2010
-
(2010)
Nature
, vol.465
, pp. 966
-
-
Dang, L.1
-
71
-
-
77649305610
-
The common feature of leukemia-Associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2 hydroxyglutarate
-
Ward, P. S., et al. The common feature of leukemia-Associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2 hydroxyglutarate. Cancer Cell 17, 225-234 (2010
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
-
72
-
-
78651463452
-
Oncometabolite 2 hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu, W., et al. Oncometabolite 2 hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
-
73
-
-
84875496294
-
R-2 hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
Losman, J. A., et al. (R)-2 hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339, 1621-1625 (2013
-
(2013)
Science
, vol.339
, pp. 1621-1625
-
-
Losman, J.A.1
-
74
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu, C., et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474-478 (2012
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
-
75
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
Challen, G. A., et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat. Genet. 44, 23-31 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
-
76
-
-
84978680214
-
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
-
Zhang, X., et al. DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nat. Genet. 48, 1014-1023 (2016
-
(2016)
Nat. Genet
, vol.48
, pp. 1014-1023
-
-
Zhang, X.1
-
77
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio, K., et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 20, 11-24 (2011
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
-
78
-
-
84891372425
-
Large conserved domains of low DNA methylation maintained by Dnmt3a
-
Jeong, M., et al. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat. Genet. 46, 17-23 (2014
-
(2014)
Nat. Genet
, vol.46
, pp. 17-23
-
-
Jeong, M.1
-
79
-
-
0036830642
-
Role of histone H3 lysine 27 methylation in Polycomb-group silencing
-
Cao, R., et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039-1043 (2002
-
(2002)
Science
, vol.298
, pp. 1039-1043
-
-
Cao, R.1
-
80
-
-
9444244427
-
Chromatin compaction by a polycomb group protein complex
-
Francis, N. J., Kingston, R. E., & Woodcock, C. L. Chromatin compaction by a polycomb group protein complex. Science 306, 1574-1577 (2004
-
(2004)
Science
, vol.306
, pp. 1574-1577
-
-
Francis, N.J.1
Kingston, R.E.2
Woodcock, C.L.3
-
81
-
-
7244234099
-
Role of histone H2A ubiquitination in Polycomb silencing
-
Wang, H., et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature 431, 873-878 (2004
-
(2004)
Nature
, vol.431
, pp. 873-878
-
-
Wang, H.1
-
82
-
-
84903178102
-
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
-
Sashida, G., et al. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat. Commun. 5, 4177 (2014
-
(2014)
Nat. Commun
, vol.5
, pp. 4177
-
-
Sashida, G.1
-
83
-
-
84863011309
-
PCGF homologs CBX proteins and RYBP define functionally distinct PRC1 family complexes
-
Gao, Z., et al. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol. Cell 45, 344-356 (2012
-
(2012)
Mol. Cell
, vol.45
, pp. 344-356
-
-
Gao, Z.1
-
84
-
-
33748641974
-
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets
-
Gearhart, M. D., Corcoran, C. M., Wamstad, J. A., & Bardwell, V. J. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol. Cell. Biol. 26, 6880-6889 (2006
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 6880-6889
-
-
Gearhart, M.D.1
Corcoran, C.M.2
Wamstad, J.A.3
Bardwell, V.J.4
-
85
-
-
0034661112
-
BCoR a novel corepressor involved in BCL 6 repression
-
Huynh, K. D., Fischle, W., Verdin, E., & Bardwell, V. J. BCoR, a novel corepressor involved in BCL 6 repression. Genes Dev. 14, 1810-1823 (2000
-
(2000)
Genes Dev
, vol.14
, pp. 1810-1823
-
-
Huynh, K.D.1
Fischle, W.2
Verdin, E.3
Bardwell, V.J.4
-
86
-
-
84888246901
-
BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders
-
Damm, F., et al. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood 122, 3169-3177 (2013
-
(2013)
Blood
, vol.122
, pp. 3169-3177
-
-
Damm, F.1
-
87
-
-
77952429798
-
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR DUB
-
Scheuermann, J. C., et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR DUB. Nature 465, 243-247 (2010
-
(2010)
Nature
, vol.465
, pp. 243-247
-
-
Scheuermann, J.C.1
-
88
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2 mediated gene repression
-
Abdel-Wahab, O., et al. ASXL1 mutations promote myeloid transformation through loss of PRC2 mediated gene repression. Cancer Cell 22, 180-193 (2012
-
(2012)
Cancer Cell
, vol.22
, pp. 180-193
-
-
Abdel-Wahab, O.1
-
89
-
-
84934945331
-
Cancer-Associated ASXL1 mutations may act as gain of function mutations of the ASXL1-BAP1 complex
-
Balasubramani, A., et al. Cancer-Associated ASXL1 mutations may act as gain of function mutations of the ASXL1-BAP1 complex. Nat. Commun. 6, 7307 (2015
-
(2015)
Nat. Commun
, vol.6
, pp. 7307
-
-
Balasubramani, A.1
-
90
-
-
84959566935
-
BCOR regulates myeloid cell proliferation and differentiation
-
Cao, Q., et al. BCOR regulates myeloid cell proliferation and differentiation. Leukemia 30, 1155-1165 (2016
-
(2016)
Leukemia
, vol.30
, pp. 1155-1165
-
-
Cao, Q.1
-
91
-
-
84908611207
-
Genetic alterations of the cohesin complex genes in myeloid malignancies
-
Thota, S., et al. Genetic alterations of the cohesin complex genes in myeloid malignancies. Blood 124, 1790-1798 (2014
-
(2014)
Blood
, vol.124
, pp. 1790-1798
-
-
Thota, S.1
-
92
-
-
84901419546
-
Cohesin in cancer: Chromosome segregation and beyond
-
Losada, A. Cohesin in cancer: chromosome segregation and beyond. Nat. Rev. Cancer 14, 389-393 (2014
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 389-393
-
-
Losada, A.1
-
93
-
-
34547762839
-
Cohesin-dependent regulation of Runx genes
-
Horsfield, J. A., et al. Cohesin-dependent regulation of Runx genes. Development 134, 2639-2649 (2007
-
(2007)
Development
, vol.134
, pp. 2639-2649
-
-
Horsfield, J.A.1
-
94
-
-
84978025179
-
Cohesin mutations in myeloid malignancies: Underlying mechanisms
-
Leeke, B., Marsman, J., O'Sullivan, J. M., & Horsfield, J. A. Cohesin mutations in myeloid malignancies: underlying mechanisms. Exp. Hematol. Oncol. 3, 13 (2014
-
(2014)
Exp. Hematol. Oncol
, vol.3
, pp. 13
-
-
Leeke, B.1
Marsman, J.2
O'Sullivan, J.M.3
Horsfield, J.A.4
-
95
-
-
84891480203
-
Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development
-
Marsman, J., et al. Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochim. Biophys. Acta 1839, 50-61 (2014
-
(2014)
Biochim. Biophys. Acta
, vol.1839
, pp. 50-61
-
-
Marsman, J.1
-
96
-
-
84951983365
-
Leukemia-Associated cohesin mutants dominantly enforce stem cell programs and impair human hematopoietic progenitor differentiation
-
Mazumdar, C., et al. Leukemia-Associated cohesin mutants dominantly enforce stem cell programs and impair human hematopoietic progenitor differentiation. Cell Stem Cell 17, 675-688 (2015
-
(2015)
Cell Stem Cell
, vol.17
, pp. 675-688
-
-
Mazumdar, C.1
-
97
-
-
80053383273
-
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia
-
Hahn, C. N., et al. Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat. Genet. 43, 1012-1017 (2011
-
(2011)
Nat. Genet
, vol.43
, pp. 1012-1017
-
-
Hahn, C.N.1
-
98
-
-
84923118816
-
The RUNX family: Developmental regulators in cancer
-
Ito, Y., Bae, S. C., & Chuang, L. S. The RUNX family: developmental regulators in cancer. Nat. Rev. Cancer 15, 81-95 (2015
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 81-95
-
-
Ito, Y.1
Bae, S.C.2
Chuang, L.S.3
-
99
-
-
84926216729
-
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
-
Zhang, M. Y., et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat. Genet. 47, 180-185 (2015
-
(2015)
Nat. Genet
, vol.47
, pp. 180-185
-
-
Zhang, M.Y.1
-
100
-
-
22144447520
-
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
-
Growney, J. D., et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 106, 494-504 (2005
-
(2005)
Blood
, vol.106
, pp. 494-504
-
-
Growney, J.D.1
-
101
-
-
58149378467
-
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy
-
Owen, C. J., et al. Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy. Blood 112, 4639-4645 (2008
-
(2008)
Blood
, vol.112
, pp. 4639-4645
-
-
Owen, C.J.1
-
102
-
-
0028022916
-
An early haematopoietic defect in mice lacking the transcription factor GATA 2
-
Tsai, F. Y., et al. An early haematopoietic defect in mice lacking the transcription factor GATA 2. Nature 371, 221-226 (1994
-
(1994)
Nature
, vol.371
, pp. 221-226
-
-
Tsai, F.Y.1
-
103
-
-
84908247072
-
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
-
Bejar, R., et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood 124, 2705-2712 (2014
-
(2014)
Blood
, vol.124
, pp. 2705-2712
-
-
Bejar, R.1
-
104
-
-
84915789576
-
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
-
Rampal, R., et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 9, 1841-1855 (2014
-
(2014)
Cell Rep
, vol.9
, pp. 1841-1855
-
-
Rampal, R.1
-
105
-
-
84923847396
-
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation
-
Wang, Y., et al. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol. Cell 57, 662-673 (2015
-
(2015)
Mol. Cell
, vol.57
, pp. 662-673
-
-
Wang, Y.1
-
106
-
-
0032006824
-
17p Deletion in acute myeloid leukemia and myelodysplastic syndrome Analysis of breakpoints and deleted segments by fluorescence in situ
-
Soenen, V., et al. 17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ. Blood 91, 1008-1015 (1998
-
(1998)
Blood
, vol.91
, pp. 1008-1015
-
-
Soenen, V.1
-
107
-
-
84857734093
-
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
-
Rucker, F. G., et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood 119, 2114-2121 (2012
-
(2012)
Blood
, vol.119
, pp. 2114-2121
-
-
Rucker, F.G.1
-
108
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe, S. W., Cepero, E., & Evan, G. Intrinsic tumour suppression. Nature 432, 307-315 (2004
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
109
-
-
0028955808
-
TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities
-
Kaneko, H., Misawa, S., Horiike, S., Nakai, H., & Kashima, K. TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities. Blood 85, 2189-2193 (1995
-
(1995)
Blood
, vol.85
, pp. 2189-2193
-
-
Kaneko, H.1
Misawa, S.2
Horiike, S.3
Nakai, H.4
Kashima, K.5
-
110
-
-
85010637627
-
Somatic mosaic mutations in PPM1D and TP53 in the blood of women with ovarian carcinoma
-
Swisher, E. M., et al. Somatic mosaic mutations in PPM1D and TP53 in the blood of women with ovarian carcinoma. JAMA Oncol. 2, 370-372 (2016
-
(2016)
JAMA Oncol
, vol.2
, pp. 370-372
-
-
Swisher, E.M.1
-
111
-
-
84925518008
-
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
-
Wong, T. N., et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature 518, 552-555 (2015
-
(2015)
Nature
, vol.518
, pp. 552-555
-
-
Wong, T.N.1
-
112
-
-
77954464666
-
P53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
-
Zhao, Z., et al. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev. 24, 1389-1402 (2010
-
(2010)
Genes Dev
, vol.24
, pp. 1389-1402
-
-
Zhao, Z.1
-
113
-
-
77950563135
-
Irradiation selects for p53 deficient hematopoietic progenitors
-
Marusyk, A., Porter, C. C., Zaberezhnyy, V., & DeGregori, J. Irradiation selects for p53 deficient hematopoietic progenitors. PLoS Biol. 8, e1000324 (2010
-
(2010)
PLoS Biol
, vol.8
, pp. e1000324
-
-
Marusyk, A.1
Porter, C.C.2
Zaberezhnyy, V.3
DeGregori, J.4
-
114
-
-
84863337617
-
Clonal architecture of secondary acute myeloid leukemia
-
Walter, M. J., et al. Clonal architecture of secondary acute myeloid leukemia. N. Engl. J. Med. 366, 1090-1098 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1090-1098
-
-
Walter, M.J.1
-
115
-
-
0027359443
-
Identification of mutations in the coding sequence of the proto-oncogene c kit in a human mast cell leukemia cell line causing ligand-independent activation of c kit product
-
Furitsu, T., et al. Identification of mutations in the coding sequence of the proto-oncogene c kit in a human mast cell leukemia cell line causing ligand-independent activation of c kit product. J. Clin. Invest. 92, 1736-1744 (1993
-
(1993)
J. Clin. Invest
, vol.92
, pp. 1736-1744
-
-
Furitsu, T.1
-
116
-
-
0035885955
-
The presence of a flt3 internal tandem duplication in patients with acute myeloid leukemia (aml) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom medical research council aml 10 and 12 trials
-
Kottaridis, P. D., et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98, 1752-1759 (2001
-
(2001)
Blood
, vol.98
, pp. 1752-1759
-
-
Kottaridis, P.D.1
-
117
-
-
17644424955
-
A gain of function mutation of JAK2 in myeloproliferative disorders
-
Kralovics, R., et al. A gain of function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352, 1779-1790 (2005
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
-
118
-
-
74949108515
-
Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies
-
Makishima, H., et al. Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. J. Clin. Oncol. 27, 6109-6116 (2009
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 6109-6116
-
-
Makishima, H.1
-
119
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
-
Pardanani, A. D., et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 108, 3472-3476 (2006
-
(2006)
Blood
, vol.108
, pp. 3472-3476
-
-
Pardanani, A.D.1
-
120
-
-
68949124841
-
Gain of function of mutated C CBL tumour suppressor in myeloid neoplasms
-
Sanada, M., et al. Gain of function of mutated C CBL tumour suppressor in myeloid neoplasms. Nature 460, 904-908 (2009
-
(2009)
Nature
, vol.460
, pp. 904-908
-
-
Sanada, M.1
-
121
-
-
34547946211
-
Flt3 dependent transformation by inactivating c Cbl mutations in AML
-
Sargin, B., et al. Flt3 dependent transformation by inactivating c Cbl mutations in AML. Blood 110, 1004-1012 (2007
-
(2007)
Blood
, vol.110
, pp. 1004-1012
-
-
Sargin, B.1
-
122
-
-
77949525475
-
Ubiquitination and degradation of the thrombopoietin receptor c Mpl
-
Saur, S. J., Sangkhae, V., Geddis, A. E., Kaushansky, K., & Hitchcock, I. S. Ubiquitination and degradation of the thrombopoietin receptor c Mpl. Blood 115, 1254-1263 (2010
-
(2010)
Blood
, vol.115
, pp. 1254-1263
-
-
Saur, S.J.1
Sangkhae, V.2
Geddis, A.E.3
Kaushansky, K.4
Hitchcock, I.S.5
-
123
-
-
84880062396
-
CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM CSF) signaling via elevated levels of JAK2 and LYN
-
Javadi, M., Richmond, T. D., Huang, K., & Barber, D. L. CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM CSF) signaling via elevated levels of JAK2 and LYN. J. Biol. Chem. 288, 19459-19470 (2013
-
(2013)
J. Biol. Chem
, vol.288
, pp. 19459-19470
-
-
Javadi, M.1
Richmond, T.D.2
Huang, K.3
Barber, D.L.4
-
124
-
-
39649094569
-
New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: Evidence from a core dataset of 2124 patients
-
Haase, D., et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood 110, 4385-4395 (2007
-
(2007)
Blood
, vol.110
, pp. 4385-4395
-
-
Haase, D.1
-
125
-
-
84930574013
-
Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia
-
Bochtler, T., Frohling, S., & Kramer, A. Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia. Leukemia 29, 1243-1252 (2015
-
(2015)
Leukemia
, vol.29
, pp. 1243-1252
-
-
Bochtler, T.1
Frohling, S.2
Kramer, A.3
-
126
-
-
77951644972
-
Does cytogenetic evolution have any prognostic relevance in myelodysplastic syndromes? A study on 153 patients from a single institution
-
Bernasconi, P., et al. Does cytogenetic evolution have any prognostic relevance in myelodysplastic syndromes? A study on 153 patients from a single institution. Ann. Hematol. 89, 545-551 (2010
-
(2010)
Ann. Hematol
, vol.89
, pp. 545-551
-
-
Bernasconi, P.1
-
127
-
-
71649097591
-
Cytogenetic evolution correlates with poor prognosis in myelodysplastic syndrome
-
Wang, H., Wang, X. Q., Xu, X. P., & Lin, G. W. Cytogenetic evolution correlates with poor prognosis in myelodysplastic syndrome. Cancer Genet. Cytogenet. 196, 159-166 (2010
-
(2010)
Cancer Genet. Cytogenet
, vol.196
, pp. 159-166
-
-
Wang, H.1
Wang, X.Q.2
Xu, X.P.3
Lin, G.W.4
-
128
-
-
84893761435
-
Deletion 5q MDS: Molecular and therapeutic implications Best practice and research
-
Komrokji, R. S., Padron, E., Ebert, B. L., & List, A. F. Deletion 5q MDS: molecular and therapeutic implications. Best practice and research. Clin. Haematol. 26, 365-375 (2013
-
(2013)
Clin. Haematol
, vol.26
, pp. 365-375
-
-
Komrokji, R.S.1
Padron, E.2
Ebert, B.L.3
List, A.F.4
-
129
-
-
0016348695
-
Distinct haematological disorder with deletion of long arm of no 5 chromosome
-
Van den Berghe, H., et al. Distinct haematological disorder with deletion of long arm of no. 5 chromosome. Nature 251, 437-438 (1974
-
(1974)
Nature
, vol.251
, pp. 437-438
-
-
Van Den Berghe, H.1
-
130
-
-
79551648987
-
Knockdown of Hspa9 a del(5q31.2) gene results in a decrease in hematopoietic progenitors in mice
-
Chen, T. H., et al. Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice. Blood 117, 1530-1539 (2011
-
(2011)
Blood
, vol.117
, pp. 1530-1539
-
-
Chen, T.H.1
-
131
-
-
80055071687
-
Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q-syndrome
-
Kumar, M. S., et al. Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q-syndrome. Blood 118, 4666-4673 (2011
-
(2011)
Blood
, vol.118
, pp. 4666-4673
-
-
Kumar, M.S.1
-
132
-
-
73849121794
-
Identification of miR 145 and miR 146a as mediators of the 5q-syndrome phenotype
-
Starczynowski, D. T., et al. Identification of miR 145 and miR 146a as mediators of the 5q-syndrome phenotype. Nat. Med. 16, 49-58 (2010
-
(2010)
Nat. Med
, vol.16
, pp. 49-58
-
-
Starczynowski, D.T.1
-
133
-
-
84898779089
-
Haploinsufficiency of del(5q) genes Egr1 and Apc cooperate with Tp53 loss to induce acute myeloid leukemia in mice
-
Stoddart, A., et al. Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. Blood 123, 1069-1078 (2014
-
(2014)
Blood
, vol.123
, pp. 1069-1078
-
-
Stoddart, A.1
-
134
-
-
24344437303
-
Role of nucleophosmin in embryonic development and tumorigenesis
-
Grisendi, S., et al. Role of nucleophosmin in embryonic development and tumorigenesis. Nature 437, 147-153 (2005
-
(2005)
Nature
, vol.437
, pp. 147-153
-
-
Grisendi, S.1
-
135
-
-
84961221099
-
Loss of tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of toll-like receptor traf6 signaling
-
Varney, M. E., et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor TRAF6 signaling. J. Exp. Med. 212, 1967-1985 (2015
-
(2015)
J. Exp. Med
, vol.212
, pp. 1967-1985
-
-
Varney, M.E.1
-
136
-
-
70349512742
-
Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice
-
DeWard, A. D., Leali, K., West, R. A., Prendergast, G. C., & Alberts, A. S. Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice. PLoS ONE 4, e7102 (2009
-
(2009)
PLoS ONE
, vol.4
, pp. e7102
-
-
DeWard, A.D.1
Leali, K.2
West, R.A.3
Prendergast, G.C.4
Alberts, A.S.5
-
137
-
-
84887212500
-
Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis
-
Graubert, T. A., et al. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. PloS ONE 4, e4583 (2009
-
(2009)
PloS ONE
, vol.4
, pp. e4583
-
-
Graubert, T.A.1
-
138
-
-
84929167143
-
Inherited and somatic defects in DDX41 in myeloid neoplasms
-
Polprasert, C., et al. Inherited and somatic defects in DDX41 in myeloid neoplasms. Cancer Cell 27, 658-670 (2015
-
(2015)
Cancer Cell
, vol.27
, pp. 658-670
-
-
Polprasert, C.1
-
139
-
-
84908006668
-
Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS
-
Schneider, R. K., et al. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell 26, 509-520 (2014
-
(2014)
Cancer Cell
, vol.26
, pp. 509-520
-
-
Schneider, R.K.1
-
140
-
-
38349088899
-
Identification of RPS14 as a 5q-syndrome gene by RNA interference screen
-
Ebert, B. L., et al. Identification of RPS14 as a 5q-syndrome gene by RNA interference screen. Nature 451, 335-339 (2008
-
(2008)
Nature
, vol.451
, pp. 335-339
-
-
Ebert, B.L.1
-
141
-
-
73849128091
-
A p53 dependent mechanism underlies macrocytic anemia in a mouse model of human 5q-syndrome
-
Barlow, J. L., et al. A p53 dependent mechanism underlies macrocytic anemia in a mouse model of human 5q-syndrome. Nat. Med. 16, 59-66 (2010
-
(2010)
Nat. Med
, vol.16
, pp. 59-66
-
-
Barlow, J.L.1
-
142
-
-
84958078801
-
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
-
Schneider, R. K., et al. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat. Med. 22, 288-297 (2016
-
(2016)
Nat. Med
, vol.22
, pp. 288-297
-
-
Schneider, R.K.1
-
143
-
-
84904021040
-
Altered translation of GATA1 in Diamond-Blackfan anemia
-
Ludwig, L. S., et al. Altered translation of GATA1 in Diamond-Blackfan anemia. Nat. Med. 20, 748-753 (2014
-
(2014)
Nat. Med
, vol.20
, pp. 748-753
-
-
Ludwig, L.S.1
-
144
-
-
84887767080
-
Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q-syndrome
-
Vlachos, A., et al. Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q-syndrome. Blood 122, 2487-2490 (2013
-
(2013)
Blood
, vol.122
, pp. 2487-2490
-
-
Vlachos, A.1
-
145
-
-
84936930551
-
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
-
Kronke, J., et al. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523, 183-188 (2015
-
(2015)
Nature
, vol.523
, pp. 183-188
-
-
Kronke, J.1
-
146
-
-
33749438404
-
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
-
List, A., et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N. Engl. J. Med. 355, 1456-1465 (2006
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 1456-1465
-
-
List, A.1
-
147
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
Ito, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327, 1345-1350 (2010
-
(2010)
Science
, vol.327
, pp. 1345-1350
-
-
Ito, T.1
-
148
-
-
84900420439
-
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia
-
Chen, C., et al. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell 25, 652-665 (2014
-
(2014)
Cancer Cell
, vol.25
, pp. 652-665
-
-
Chen, C.1
-
149
-
-
84873579853
-
CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
-
McNerney, M. E., et al. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood 121, 975-983 (2013
-
(2013)
Blood
, vol.121
, pp. 975-983
-
-
McNerney, M.E.1
-
150
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
Nikoloski, G., et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat. Genet. 42, 665-667 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
-
151
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
Fenaux, P., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet. Oncol. 10, 223-232 (2009
-
(2009)
Lancet. Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
-
152
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
Kantarjian, H., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106, 1794-1803 (2006
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
-
153
-
-
84891876933
-
Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
-
Traina, F., et al. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Leukemia 28, 78-87 (2014
-
(2014)
Leukemia
, vol.28
, pp. 78-87
-
-
Traina, F.1
-
154
-
-
73149108856
-
Clonal heterogeneity in the 5q-syndrome: 53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression
-
Jadersten, M., et al. Clonal heterogeneity in the 5q-syndrome: 53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression. Haematologica 94, 1762-1766 (2009
-
(2009)
Haematologica
, vol.94
, pp. 1762-1766
-
-
Jadersten, M.1
-
155
-
-
38049113182
-
Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate 1 risk myelodysplastic syndromes with karyotypes other than deletion 5q
-
Raza, A., et al Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate 1 risk myelodysplastic syndromes with karyotypes other than deletion 5q. Blood 111, 86-93 (2008
-
(2008)
Blood
, vol.111
, pp. 86-93
-
-
Raza, A.1
-
156
-
-
84883553488
-
Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: An international collaborative decision analysis
-
Koreth, J., et al. Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis. J. Clin. Oncol. 31, 2662-2670 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 2662-2670
-
-
Koreth, J.1
-
157
-
-
84992425369
-
Clinical effects of driver somatic mutations on the outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem-cell transplantation
-
Della Porta, M. G., et al. Clinical effects of driver somatic mutations on the outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem-cell transplantation. J. Clin. Oncol. 30, 3627-3637 (2016
-
(2016)
J. Clin. Oncol
, vol.30
, pp. 3627-3637
-
-
Della Porta, M.G.1
-
158
-
-
84888265282
-
Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
-
Chaturvedi, A., et al. Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML. Blood 122, 2877-2887 (2013
-
(2013)
Blood
, vol.122
, pp. 2877-2887
-
-
Chaturvedi, A.1
-
159
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang, F., et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 340, 622-626 (2013
-
(2013)
Science
, vol.340
, pp. 622-626
-
-
Wang, F.1
-
160
-
-
84922652321
-
Isocitrate dehydrogenase 1 and 2 mutations induce BCL 2 dependence in acute myeloid leukemia
-
Chan, S. M., et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL 2 dependence in acute myeloid leukemia. Nat. Med. 21, 178-184 (2015
-
(2015)
Nat. Med
, vol.21
, pp. 178-184
-
-
Chan, S.M.1
-
161
-
-
70350506791
-
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5 azacytidine and entinostat in patients with myeloid malignancies
-
Fandy, T. E., et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5 azacytidine and entinostat in patients with myeloid malignancies. Blood 114, 2764-2773 (2009
-
(2009)
Blood
, vol.114
, pp. 2764-2773
-
-
Fandy, T.E.1
-
162
-
-
84965017104
-
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
-
Lee, S. C., et al. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins. Nat. Med. 22, 672-678 (2016
-
(2016)
Nat. Med
, vol.22
, pp. 672-678
-
-
Lee, S.C.1
-
163
-
-
84877608004
-
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML
-
Maxson, J. E., et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N. Engl. J. Med. 368, 1781-1790 (2013
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 1781-1790
-
-
Maxson, J.E.1
-
164
-
-
84883742761
-
SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML monosomy 7 isochromosome i 17)(q10), ASXL1 and CBL mutations
-
Meggendorfer, M., et al. SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations. Leukemia 27, 1852-1860 (2013
-
(2013)
Leukemia
, vol.27
, pp. 1852-1860
-
-
Meggendorfer, M.1
-
165
-
-
84955618325
-
Age-related mutations and chronic myelomonocytic leukemia
-
Mason, C. C., et al. Age-related mutations and chronic myelomonocytic leukemia. Leukemia 30, 906-913 (2016
-
(2016)
Leukemia
, vol.30
, pp. 906-913
-
-
Mason, C.C.1
-
166
-
-
84876157061
-
Low frequency clonal mutations recoverable by deep sequencing in patients with aplastic anemia
-
Lane, A. A., et al. Low frequency clonal mutations recoverable by deep sequencing in patients with aplastic anemia. Leukemia 27, 968-971 (2013
-
(2013)
Leukemia
, vol.27
, pp. 968-971
-
-
Lane, A.A.1
-
167
-
-
84907494617
-
Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria
-
Shen, W., et al. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria. J. Clin. Invest. 124, 4529-4538 (2014
-
(2014)
J. Clin. Invest
, vol.124
, pp. 4529-4538
-
-
Shen, W.1
-
168
-
-
84907061756
-
Inherited bone marrow failure syndromes in adolescents and young adults
-
Wilson, D. B., Link, D. C., Mason, P. J., & Bessler, M. Inherited bone marrow failure syndromes in adolescents and young adults. Ann. Med. 46, 353-363 (2014
-
(2014)
Ann. Med
, vol.46
, pp. 353-363
-
-
Wilson, D.B.1
Link, D.C.2
Mason, P.J.3
Bessler, M.4
-
169
-
-
0041592752
-
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome
-
Yamaguchi, H., et al. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 102, 916-918 (2003
-
(2003)
Blood
, vol.102
, pp. 916-918
-
-
Yamaguchi, H.1
-
170
-
-
15944422499
-
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia
-
Yamaguchi, H., et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N. Engl. J. Med. 352, 1413-1424 (2005
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 1413-1424
-
-
Yamaguchi, H.1
-
171
-
-
0033518188
-
A telomerase component is defective in the human disease dyskeratosis congenita
-
Mitchell, J. R., Wood, E., & Collins, K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402, 551-555 (1999
-
(1999)
Nature
, vol.402
, pp. 551-555
-
-
Mitchell, J.R.1
Wood, E.2
Collins, K.3
-
172
-
-
2442617343
-
Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC
-
Vulliamy, T., et al. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat. Genet. 36, 447-449 (2004
-
(2004)
Nat. Genet
, vol.36
, pp. 447-449
-
-
Vulliamy, T.1
-
173
-
-
84929130522
-
Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia
-
Noetzli, L., et al. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat. Genet. 47, 535-538 (2015
-
(2015)
Nat. Genet
, vol.47
, pp. 535-538
-
-
Noetzli, L.1
-
174
-
-
84899925553
-
Li Fraumeni syndrome: Cancer risk assessment and clinical management
-
McBride, K. A., et al. Li Fraumeni syndrome: cancer risk assessment and clinical management. Nat. Rev. Clin. Oncol. 11, 260-271 (2014
-
(2014)
Nat. Rev. Clin. Oncol
, vol.11
, pp. 260-271
-
-
McBride, K.A.1
-
175
-
-
79961074298
-
Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome
-
Hsu, A. P., et al. Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood 118, 2653-2655 (2011
-
(2011)
Blood
, vol.118
, pp. 2653-2655
-
-
Hsu, A.P.1
-
176
-
-
80053385569
-
Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome
-
Ostergaard, P., et al. Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). Nat. Genet. 43, 929-931 (2011
-
(2011)
Nat. Genet
, vol.43
, pp. 929-931
-
-
Ostergaard, P.1
-
177
-
-
84960389184
-
Novel germ line DDX41 mutations define families with a lower age of MDS/ AML onset and lymphoid malignancies
-
Lewinsohn, M., et al. Novel germ line DDX41 mutations define families with a lower age of MDS/ AML onset and lymphoid malignancies. Blood 127, 1017-1023 (2016
-
(2016)
Blood
, vol.127
, pp. 1017-1023
-
-
Lewinsohn, M.1
-
178
-
-
0037229094
-
Mutations in SBDS are associated with Shwachman-Diamond syndrome
-
Boocock, G. R., et al. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nat. Genet. 33, 97-101 (2003
-
(2003)
Nat. Genet
, vol.33
, pp. 97-101
-
-
Boocock, G.R.1
-
179
-
-
84942523339
-
Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research
-
Zhou, T., Kinney, M. C., Scott, L. M., Zinkel, S. S., & Rebel, V. I. Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research. Blood 126, 1057-1068 (2015
-
(2015)
Blood
, vol.126
, pp. 1057-1068
-
-
Zhou, T.1
Kinney, M.C.2
Scott, L.M.3
Zinkel, S.S.4
Rebel, V.I.5
-
180
-
-
84889598519
-
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
-
Li, Q., et al. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature 504, 143-147 (2013
-
(2013)
Nature
, vol.504
, pp. 143-147
-
-
Li, Q.1
-
181
-
-
84929277822
-
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
-
Dolatshad, H., et al. Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells. Leukemia 29, 1798 (2015
-
(2015)
Leukemia
, vol.29
, pp. 1798
-
-
Dolatshad, H.1
-
182
-
-
58749104518
-
Endochondral ossification is required for haematopoietic stem-cell niche formation
-
Chan, C. K., et al. Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature 457, 490-494 (2009
-
(2009)
Nature
, vol.457
, pp. 490-494
-
-
Chan, C.K.1
-
183
-
-
84856147560
-
Endothelial and perivascular cells maintain haematopoietic stem cells
-
Ding, L., Saunders, T. L., Enikolopov, G., & Morrison, S. J. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481, 457-462 (2012
-
(2012)
Nature
, vol.481
, pp. 457-462
-
-
Ding, L.1
Saunders, T.L.2
Enikolopov, G.3
Morrison, S.J.4
-
184
-
-
84905861462
-
Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow
-
Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154-168 (2014
-
(2014)
Cell Stem Cell
, vol.15
, pp. 154-168
-
-
Zhou, B.O.1
Yue, R.2
Murphy, M.M.3
Peyer, J.G.4
Morrison, S.J.5
-
185
-
-
77950862042
-
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
-
Raaijmakers, M. H., et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464, 852-857 (2010
-
(2010)
Nature
, vol.464
, pp. 852-857
-
-
Raaijmakers, M.H.1
-
186
-
-
84893917461
-
Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts
-
Kode, A., et al. Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts. Nature 506, 240-244 (2014
-
(2014)
Nature
, vol.506
, pp. 240-244
-
-
Kode, A.1
-
187
-
-
84884164883
-
Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche
-
Schepers, K., et al. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell 13, 285-299 (2013
-
(2013)
Cell Stem Cell
, vol.13
, pp. 285-299
-
-
Schepers, K.1
-
188
-
-
0034782479
-
Oligoclonal T cell expansion in myelodysplastic syndrome: Evidence for an autoimmune process
-
Epperson, D. E., Nakamura, R., Saunthararajah, Y., Melenhorst, J., & Barrett, A. J. Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process. Leukemia Res. 25, 1075-1083 (2001
-
(2001)
Leukemia Res
, vol.25
, pp. 1075-1083
-
-
Epperson, D.E.1
Nakamura, R.2
Saunthararajah, Y.3
Melenhorst, J.4
Barrett, A.J.5
-
189
-
-
0037031289
-
Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes
-
Molldrem, J. J., et al. Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Ann. Intern. Med. 137, 156-163 (2002
-
(2002)
Ann. Intern. Med
, vol.137
, pp. 156-163
-
-
Molldrem, J.J.1
-
190
-
-
0141923848
-
A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome
-
Saunthararajah, Y., Nakamura, R., Wesley, R., Wang, Q. J., & Barrett, A. J. A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome. Blood 102, 3025-3027 (2003
-
(2003)
Blood
, vol.102
, pp. 3025-3027
-
-
Saunthararajah, Y.1
Nakamura, R.2
Wesley, R.3
Wang, Q.J.4
Barrett, A.J.5
-
191
-
-
45149093744
-
Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy
-
Sloand, E. M., Wu, C. O., Greenberg, P., Young, N., & Barrett, J. Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy. J. Clin. Oncol. 26, 2505-2511 (2008
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 2505-2511
-
-
Sloand, E.M.1
Wu, C.O.2
Greenberg, P.3
Young, N.4
Barrett, J.5
-
192
-
-
84878372012
-
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N. Engl. J. Med. 368, 2059-2074 (2013
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 2059-2074
-
-
-
193
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel, J. P., et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N. Engl. J. Med. 366, 1079-1089 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
-
194
-
-
84973879698
-
Genomic classification and prognosis in acute myeloid leukemia
-
Papaemmanuil, E., et al. Genomic Classification and Prognosis in Acute Myeloid Leukemia. N. Engl. J. Med. 374, 2209-2221 (2016
-
(2016)
N. Engl. J. Med
, vol.374
, pp. 2209-2221
-
-
Papaemmanuil, E.1
-
195
-
-
84893395823
-
The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes
-
Boultwood, J., Dolatshad, H., Varanasi, S. S., Yip, B. H., & Pellagatti, A. The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes. Adv. Biol. Regul. 54, 153-161 (2014
-
(2014)
Adv. Biol. Regul
, vol.54
, pp. 153-161
-
-
Boultwood, J.1
Dolatshad, H.2
Varanasi, S.S.3
Yip, B.H.4
Pellagatti, A.5
-
196
-
-
80053621748
-
A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate 1 risk myelodysplastic syndromes with del5q
-
Fenaux, P., et al A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate 1 risk myelodysplastic syndromes with del5q. Blood 118, 3765-3776 (2011
-
(2011)
Blood
, vol.118
, pp. 3765-3776
-
-
Fenaux, P.1
-
197
-
-
83855160924
-
Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome
-
Cordoba, I., et al. Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome. Cancer 118, 127-133 (2012
-
(2012)
Cancer
, vol.118
, pp. 127-133
-
-
Cordoba, I.1
-
198
-
-
84896726052
-
Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact
-
Bacher, U., et al. Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact. Br. J. Haematol. 164, 822-833 (2014
-
(2014)
Br. J. Haematol
, vol.164
, pp. 822-833
-
-
Bacher, U.1
-
199
-
-
79952103709
-
Myelodysplastic syndromes with deletions of chromosome 11q lack cryptic MLL rearrangement and exhibit characteristic clinicopathologic features
-
Wang, S. A., et al. Myelodysplastic syndromes with deletions of chromosome 11q lack cryptic MLL rearrangement and exhibit characteristic clinicopathologic features. Leuk. Res. 35, 351-357 (2011
-
(2011)
Leuk. Res
, vol.35
, pp. 351-357
-
-
Wang, S.A.1
-
200
-
-
49449102840
-
Loss of the y chromosome: An age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome?
-
Wong, A. K., et al. Loss of the Y chromosome: an age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome? Arch. Pathol. Lab. Med. 132, 1329-1332 (2008
-
(2008)
Arch. Pathol. Lab. Med
, vol.132
, pp. 1329-1332
-
-
Wong, A.K.1
|