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Volumn 98, Issue 6, 2001, Pages 1752-1759

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; CYCLOSPORIN A; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; FLT3 LIGAND; MITOXANTRONE; RETINOIC ACID;

EID: 0035885955     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.6.1752     Document Type: Article
Times cited : (1327)

References (23)
  • 1
    • 0030895252 scopus 로고    scopus 로고
    • Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML trial (MRC AML10)
    • Adult and Childhood Leukaemia Working Parties of the Medical Research Council
    • Hann IM, Stevens RF, Goldstone AH, et al. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML trial (MRC AML10). Adult and Childhood Leukaemia Working Parties of the Medical Research Council. Blood. 1997;89:2311-2318.
    • (1997) Blood , vol.89 , pp. 2311-2318
    • Hann, I.M.1    Stevens, R.F.2    Goldstone, A.H.3
  • 3
    • 0028152851 scopus 로고
    • Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86
    • Reiter A, Schrappe M, Ludwig WD, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood. 1994;84:3122-3133.
    • (1994) Blood , vol.84 , pp. 3122-3133
    • Reiter, A.1    Schrappe, M.2    Ludwig, W.D.3
  • 4
    • 15644380236 scopus 로고    scopus 로고
    • Long-term survival of patients with acute myeloid leukemia: A third follow-up of the Fourth International Workshop on Chromosomes in Leukemia
    • Bloomfield CD, Shuma C, Regal L, et al. Long-term survival of patients with acute myeloid leukemia: a third follow-up of the Fourth International Workshop on Chromosomes in Leukemia. Cancer. 1997;80:2191-198.
    • (1997) Cancer , vol.80 , pp. 2191-2198
    • Bloomfield, C.D.1    Shuma, C.2    Regal, L.3
  • 5
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
    • The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92:2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 6
    • 0008381951 scopus 로고    scopus 로고
    • A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial
    • United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties
    • Wheatley K, Burnett AK, Goldstone AH, et al. A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties. Br J Haematol. 1999;107:69-79.
    • (1999) Br J Haematol , vol.107 , pp. 69-79
    • Wheatley, K.1    Burnett, A.K.2    Goldstone, A.H.3
  • 7
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 8
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3
  • 9
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 10
    • 0030002950 scopus 로고    scopus 로고
    • Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
    • Drexler HG. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia. 1996;10:588-599.
    • (1996) Leukemia , vol.10 , pp. 588-599
    • Drexler, H.G.1
  • 11
    • 0000796896 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells
    • Fenski R, Flesch K, Serve S, et al. Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells. Br J Haematol. 2000;108:322-330.
    • (2000) Br J Haematol , vol.108 , pp. 322-330
    • Fenski, R.1    Flesch, K.2    Serve, S.3
  • 12
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3
  • 13
    • 0034040255 scopus 로고    scopus 로고
    • Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene
    • Rombouts WJ, Blokland I, Lowenberg B, Ploemacher RE. Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene. Leukemia. 2000;14:675-683.
    • (2000) Leukemia , vol.14 , pp. 675-683
    • Rombouts, W.J.1    Blokland, I.2    Lowenberg, B.3    Ploemacher, R.E.4
  • 14
    • 0000117333 scopus 로고    scopus 로고
    • Flt3 length mutations in AML: Correlation to cytogenetics, FAB-subtype, and prognosis in 652 patients
    • Schnittger S, Schoch C, Kern W, et al. Flt3 length mutations in AML: correlation to cytogenetics, FAB-subtype, and prognosis in 652 patients. Blood. 2000;96:826a.
    • (2000) Blood , vol.96
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 15
    • 0003254672 scopus 로고    scopus 로고
    • Comparison of two chemotherapy regimens, with or without cyclosporin A, in relapsed/refractory acute myeloid leukaemia: Results of the UK Medical Research Council
    • Yin JAL, Wheatley K, Rees J, Burnett A. Comparison of two chemotherapy regimens, with or without cyclosporin A, in relapsed/refractory acute myeloid leukaemia: results of the UK Medical Research Council. Blood. 1998;92:231a.
    • (1998) Blood , vol.92
    • Yin, J.A.L.1    Wheatley, K.2    Rees, J.3    Burnett, A.4
  • 16
    • 0033564337 scopus 로고    scopus 로고
    • Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: Result of the randomized MRC trial
    • Burnett AK, Grimwade D, Solomon E, Wheatley K, Goldstone AH. Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the randomized MRC trial. Blood. 1999;93:4131-4143.
    • (1999) Blood , vol.93 , pp. 4131-4143
    • Burnett, A.K.1    Grimwade, D.2    Solomon, E.3    Wheatley, K.4    Goldstone, A.H.5
  • 17
    • 0025261428 scopus 로고
    • Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia
    • Cheson BD, Cassileth PA, Head DR, et al. Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol. 1990;8:813-819.
    • (1990) J Clin Oncol , vol.8 , pp. 813-819
    • Cheson, B.D.1    Cassileth, P.A.2    Head, D.R.3
  • 18
    • 0017365573 scopus 로고
    • Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples
    • Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977;35:1-39.
    • (1977) Br J Cancer , vol.35 , pp. 1-39
    • Peto, R.1    Pike, M.C.2    Armitage, P.3
  • 19
    • 0023867360 scopus 로고
    • Secondary prevention of vascular disease by prolonged antiplatelet treatment
    • Antiplatelet Trialists' Collaboration. Secondary prevention of vascular disease by prolonged antiplatelet treatment. Br Med J. 1988;296:320-331.
    • (1988) Br Med J , vol.296 , pp. 320-331
  • 20
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 21
    • 0034667690 scopus 로고    scopus 로고
    • High incidence of biallelic point mutations in the runt domain of the AML1/PEBP2alphaB gene in MO acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • Preudhomme C, Warot-Loze D, Roumier C, et al. High incidence of biallelic point mutations in the runt domain of the AML1/PEBP2alphaB gene in MO acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood. 2000;96:2862-2869.
    • (2000) Blood , vol.96 , pp. 2862-2869
    • Preudhomme, C.1    Warot-Loze, D.2    Roumier, C.3
  • 22
    • 4243521490 scopus 로고    scopus 로고
    • Mutations in the AML 1 gene in acute myeloid leukaemia patients with FAB types M0 and M7
    • Langabeer SE, Gale RE, Rollison SJ, Morgan GJ, Linch DC. Mutations in the AML 1 gene in acute myeloid leukaemia patients with FAB types M0 and M7. Blood. 2000;96:698a.
    • (2000) Blood , vol.96
    • Langabeer, S.E.1    Gale, R.E.2    Rollison, S.J.3    Morgan, G.J.4    Linch, D.C.5
  • 23
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker BJ, Lydon NB. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest. 2000;105:3-7.
    • (2000) J Clin Invest , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.