-
1
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
-
Abdel-Wahab O., Adli M., LaFave L.M., Gao J., Hricik T., Shih A.H., et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 2012, 22:180-193.
-
(2012)
Cancer Cell
, vol.22
, pp. 180-193
-
-
Abdel-Wahab, O.1
Adli, M.2
LaFave, L.M.3
Gao, J.4
Hricik, T.5
Shih, A.H.6
-
2
-
-
80054747873
-
The spliceosome as an indicted conspirator in myeloid malignancies
-
Abdel-Wahab O., Levine R. The spliceosome as an indicted conspirator in myeloid malignancies. Cancer Cell 2011, 20:420-423.
-
(2011)
Cancer Cell
, vol.20
, pp. 420-423
-
-
Abdel-Wahab, O.1
Levine, R.2
-
3
-
-
79952164235
-
Unraveling the molecular pathophysiology of myelodysplastic syndromes
-
Bejar R., Levine R., Ebert B.L. Unraveling the molecular pathophysiology of myelodysplastic syndromes. JClin Oncol 2011, 29:504-515.
-
(2011)
JClin Oncol
, vol.29
, pp. 504-515
-
-
Bejar, R.1
Levine, R.2
Ebert, B.L.3
-
4
-
-
84866749552
-
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
-
Bejar R., Stevenson K.E., Caughey B.A., Abdel-Wahab O., Steensma D.P., Galili N., et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. JClin Oncol 2012, 30:3376-3382.
-
(2012)
JClin Oncol
, vol.30
, pp. 3376-3382
-
-
Bejar, R.1
Stevenson, K.E.2
Caughey, B.A.3
Abdel-Wahab, O.4
Steensma, D.P.5
Galili, N.6
-
5
-
-
78650668810
-
Advances in the 5q- syndrome
-
Boultwood J., Pellagatti A., McKenzie A.N., Wainscoat J.S. Advances in the 5q- syndrome. Blood 2010, 116:5803-5811.
-
(2010)
Blood
, vol.116
, pp. 5803-5811
-
-
Boultwood, J.1
Pellagatti, A.2
McKenzie, A.N.3
Wainscoat, J.S.4
-
6
-
-
84874010025
-
Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies
-
Boultwood J., Yip B.H., Vuppusetty C., Pellagatti A., Wainscoat J.S. Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies. Adv Biol Regul 2013, 53:8-17.
-
(2013)
Adv Biol Regul
, vol.53
, pp. 8-17
-
-
Boultwood, J.1
Yip, B.H.2
Vuppusetty, C.3
Pellagatti, A.4
Wainscoat, J.S.5
-
7
-
-
33846515640
-
Myelodysplastic syndromes: the complexity of stem-cell diseases
-
Corey S.J., Minden M.D., Barber D.L., Kantarjian H., Wang J.C., Schimmer A.D. Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Cancer 2007, 7:118-129.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 118-129
-
-
Corey, S.J.1
Minden, M.D.2
Barber, D.L.3
Kantarjian, H.4
Wang, J.C.5
Schimmer, A.D.6
-
8
-
-
79952220808
-
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
-
Corrionero A., Minana B., Valcarcel J. Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes Dev 2011, 25:445-459.
-
(2011)
Genes Dev
, vol.25
, pp. 445-459
-
-
Corrionero, A.1
Minana, B.2
Valcarcel, J.3
-
9
-
-
84859595800
-
Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
-
Damm F., Kosmider O., Gelsi-Boyer V., Renneville A., Carbuccia N., Hidalgo-Curtis C., et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood 2012, 119:3211-3218.
-
(2012)
Blood
, vol.119
, pp. 3211-3218
-
-
Damm, F.1
Kosmider, O.2
Gelsi-Boyer, V.3
Renneville, A.4
Carbuccia, N.5
Hidalgo-Curtis, C.6
-
10
-
-
38349088899
-
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
-
Ebert B.L., Pretz J., Bosco J., Chang C.Y., Tamayo P., Galili N., et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 2008, 451:335-339.
-
(2008)
Nature
, vol.451
, pp. 335-339
-
-
Ebert, B.L.1
Pretz, J.2
Bosco, J.3
Chang, C.Y.4
Tamayo, P.5
Galili, N.6
-
11
-
-
79551602983
-
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin
-
Edmond V., Moysan E., Khochbin S., Matthias P., Brambilla C., Brambilla E., et al. Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J 2011, 30:510-523.
-
(2011)
EMBO J
, vol.30
, pp. 510-523
-
-
Edmond, V.1
Moysan, E.2
Khochbin, S.3
Matthias, P.4
Brambilla, C.5
Brambilla, E.6
-
13
-
-
84555192302
-
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
-
Graubert T.A., Shen D., Ding L., Okeyo-Owuor T., Lunn C.L., Shao J., et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet 2012, 44:53-57.
-
(2012)
Nat Genet
, vol.44
, pp. 53-57
-
-
Graubert, T.A.1
Shen, D.2
Ding, L.3
Okeyo-Owuor, T.4
Lunn, C.L.5
Shao, J.6
-
14
-
-
84882953089
-
The multifaceted nature of myelodysplastic syndromes: clinical, molecular, and biological prognostic features
-
Greenberg P.L. The multifaceted nature of myelodysplastic syndromes: clinical, molecular, and biological prognostic features. JNatl Compr Canc Netw 2013, 11:877-885.
-
(2013)
JNatl Compr Canc Netw
, vol.11
, pp. 877-885
-
-
Greenberg, P.L.1
-
15
-
-
84860513145
-
The spliceosome: a flexible, reversible macromolecular machine
-
Hoskins A.A., Moore M.J. The spliceosome: a flexible, reversible macromolecular machine. Trends Biochem Sci 2012, 37:179-188.
-
(2012)
Trends Biochem Sci
, vol.37
, pp. 179-188
-
-
Hoskins, A.A.1
Moore, M.J.2
-
16
-
-
84881665644
-
Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes
-
Kulasekararaj A.G., Mohamedali A.M., Mufti G.J. Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes. Br J Haematol 2013, 162:587-605.
-
(2013)
Br J Haematol
, vol.162
, pp. 587-605
-
-
Kulasekararaj, A.G.1
Mohamedali, A.M.2
Mufti, G.J.3
-
17
-
-
77149180424
-
Release of SF3 from the intron branch point activates the first step of pre-mRNA splicing
-
Lardelli R.M., Thompson J.X., Yates J.R., Stevens S.W. Release of SF3 from the intron branch point activates the first step of pre-mRNA splicing. RNA 2010, 16:516-528.
-
(2010)
RNA
, vol.16
, pp. 516-528
-
-
Lardelli, R.M.1
Thompson, J.X.2
Yates, J.R.3
Stevens, S.W.4
-
18
-
-
84875910316
-
Molecular pathophysiology of myelodysplastic syndromes
-
Lindsley R.C., Ebert B.L. Molecular pathophysiology of myelodysplastic syndromes. Annu Rev Pathol 2013, 8:21-47.
-
(2013)
Annu Rev Pathol
, vol.8
, pp. 21-47
-
-
Lindsley, R.C.1
Ebert, B.L.2
-
19
-
-
33749438404
-
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
-
List A., Dewald G., Bennett J., Giagounidis A., Raza A., Feldman E., et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. NEngl J Med 2006, 355:1456-1465.
-
(2006)
NEngl J Med
, vol.355
, pp. 1456-1465
-
-
List, A.1
Dewald, G.2
Bennett, J.3
Giagounidis, A.4
Raza, A.5
Feldman, E.6
-
20
-
-
84859597590
-
Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
-
Makishima H., Visconte V., Sakaguchi H., Jankowska A.M., Abu Kar S., Jerez A., et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood 2012, 119:3203-3210.
-
(2012)
Blood
, vol.119
, pp. 3203-3210
-
-
Makishima, H.1
Visconte, V.2
Sakaguchi, H.3
Jankowska, A.M.4
Abu Kar, S.5
Jerez, A.6
-
21
-
-
83455234787
-
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
-
Malcovati L., Papaemmanuil E., Bowen D.T., Boultwood J., Della Porta M.G., Pascutto C., et al. Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. Blood 2011, 118:6239-6246.
-
(2011)
Blood
, vol.118
, pp. 6239-6246
-
-
Malcovati, L.1
Papaemmanuil, E.2
Bowen, D.T.3
Boultwood, J.4
Della Porta, M.G.5
Pascutto, C.6
-
22
-
-
0742323558
-
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
-
Maquat L.E. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol 2004, 5:89-99.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 89-99
-
-
Maquat, L.E.1
-
23
-
-
84879565619
-
Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
-
Mian S.A., Smith A.E., Kulasekararaj A.G., Kizilors A., Mohamedali A.M., Lea N.C., et al. Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome. Haematologica 2013, 98:1058-1066.
-
(2013)
Haematologica
, vol.98
, pp. 1058-1066
-
-
Mian, S.A.1
Smith, A.E.2
Kulasekararaj, A.G.3
Kizilors, A.4
Mohamedali, A.M.5
Lea, N.C.6
-
24
-
-
84868148842
-
Splicing factor mutations in myelodysplasia
-
Ogawa S. Splicing factor mutations in myelodysplasia. Int J Hematol 2012, 96:438-442.
-
(2012)
Int J Hematol
, vol.96
, pp. 438-442
-
-
Ogawa, S.1
-
25
-
-
78651417715
-
Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464
-
Osman S., Albert B.J., Wang Y., Li M., Czaicki N.L., Koide K. Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464. Chemistry 2011, 17:895-904.
-
(2011)
Chemistry
, vol.17
, pp. 895-904
-
-
Osman, S.1
Albert, B.J.2
Wang, Y.3
Li, M.4
Czaicki, N.L.5
Koide, K.6
-
26
-
-
56749098074
-
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
-
Pan Q., Shai O., Lee L.J., Frey B.J., Blencowe B.J. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008, 40:1413-1415.
-
(2008)
Nat Genet
, vol.40
, pp. 1413-1415
-
-
Pan, Q.1
Shai, O.2
Lee, L.J.3
Frey, B.J.4
Blencowe, B.J.5
-
27
-
-
80054010617
-
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
-
Papaemmanuil E., Cazzola M., Boultwood J., Malcovati L., Vyas P., Bowen D., et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. NEngl J Med 2011, 365:1384-1395.
-
(2011)
NEngl J Med
, vol.365
, pp. 1384-1395
-
-
Papaemmanuil, E.1
Cazzola, M.2
Boultwood, J.3
Malcovati, L.4
Vyas, P.5
Bowen, D.6
-
28
-
-
84888219405
-
Clinical and biological implications of driver mutations in myelodysplastic syndromes
-
Papaemmanuil E., Gerstung M., Malcovati L., Tauro S., Gundem G., Van Loo P., et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 2013, 10.1182/blood-2013-08-518886.
-
(2013)
Blood
-
-
Papaemmanuil, E.1
Gerstung, M.2
Malcovati, L.3
Tauro, S.4
Gundem, G.5
Van Loo, P.6
-
29
-
-
84855841586
-
SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value
-
Patnaik M.M., Lasho T.L., Hodnefield J.M., Knudson R.A., Ketterling R.P., Garcia-Manero G., et al. SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value. Blood 2012, 119:569-572.
-
(2012)
Blood
, vol.119
, pp. 569-572
-
-
Patnaik, M.M.1
Lasho, T.L.2
Hodnefield, J.M.3
Knudson, R.A.4
Ketterling, R.P.5
Garcia-Manero, G.6
-
30
-
-
34547474047
-
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients
-
Pellagatti A., Jadersten M., Forsblom A.M., Cattan H., Christensson B., Emanuelsson E.K., et al. Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients. Proc Natl Acad Sci U S A 2007, 104:11406-11411.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11406-11411
-
-
Pellagatti, A.1
Jadersten, M.2
Forsblom, A.M.3
Cattan, H.4
Christensson, B.5
Emanuelsson, E.K.6
-
31
-
-
84886905271
-
Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
-
Przychodzen B., Jerez A., Guinta K., Sekeres M.A., Padgett R., Maciejewski J.P., et al. Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood 2013, 122:999-1006.
-
(2013)
Blood
, vol.122
, pp. 999-1006
-
-
Przychodzen, B.1
Jerez, A.2
Guinta, K.3
Sekeres, M.A.4
Padgett, R.5
Maciejewski, J.P.6
-
32
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
-
Quesada V., Conde L., Villamor N., Ordonez G.R., Jares P., Bassaganyas L., et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2012, 44:47-52.
-
(2012)
Nat Genet
, vol.44
, pp. 47-52
-
-
Quesada, V.1
Conde, L.2
Villamor, N.3
Ordonez, G.R.4
Jares, P.5
Bassaganyas, L.6
-
33
-
-
84870221419
-
The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes
-
Raza A., Galili N. The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes. Nat Rev Cancer 2012, 12:849-859.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 849-859
-
-
Raza, A.1
Galili, N.2
-
34
-
-
78650428748
-
Structural model of the p14/SF3b155. branch duplex complex
-
Schellenberg M.J., Dul E.L., MacMillan A.M. Structural model of the p14/SF3b155. branch duplex complex. RNA 2011, 17:155-165.
-
(2011)
RNA
, vol.17
, pp. 155-165
-
-
Schellenberg, M.J.1
Dul, E.L.2
MacMillan, A.M.3
-
35
-
-
80053185907
-
Molecular biology of myelodysplastic syndromes
-
Shih A.H., Levine R.L. Molecular biology of myelodysplastic syndromes. Semin Oncol 2011, 38:613-620.
-
(2011)
Semin Oncol
, vol.38
, pp. 613-620
-
-
Shih, A.H.1
Levine, R.L.2
-
36
-
-
84859856420
-
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
-
Thol F., Kade S., Schlarmann C., Loffeld P., Morgan M., Krauter J., et al. Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood 2012, 119:3578-3584.
-
(2012)
Blood
, vol.119
, pp. 3578-3584
-
-
Thol, F.1
Kade, S.2
Schlarmann, C.3
Loffeld, P.4
Morgan, M.5
Krauter, J.6
-
37
-
-
84871236747
-
Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders
-
Visconte V., Makishima H., Maciejewski J.P., Tiu R.V. Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders. Leukemia 2012, 26:2447-2454.
-
(2012)
Leukemia
, vol.26
, pp. 2447-2454
-
-
Visconte, V.1
Makishima, H.2
Maciejewski, J.P.3
Tiu, R.V.4
-
38
-
-
84868091622
-
SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
-
Visconte V., Rogers H.J., Singh J., Barnard J., Bupathi M., Traina F., et al. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood 2012, 120:3173-3186.
-
(2012)
Blood
, vol.120
, pp. 3173-3186
-
-
Visconte, V.1
Rogers, H.J.2
Singh, J.3
Barnard, J.4
Bupathi, M.5
Traina, F.6
-
39
-
-
84871924824
-
The development and application of small molecule modulators of SF3b as therapeutic agents for cancer
-
Webb T.R., Joyner A.S., Potter P.M. The development and application of small molecule modulators of SF3b as therapeutic agents for cancer. Drug Discov Today 2013, 18:43-49.
-
(2013)
Drug Discov Today
, vol.18
, pp. 43-49
-
-
Webb, T.R.1
Joyner, A.S.2
Potter, P.M.3
-
40
-
-
34547190674
-
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis
-
Xiao R., Sun Y., Ding J.H., Lin S., Rose D.W., Rosenfeld M.G., et al. Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol 2007, 27:5393-5402.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 5393-5402
-
-
Xiao, R.1
Sun, Y.2
Ding, J.H.3
Lin, S.4
Rose, D.W.5
Rosenfeld, M.G.6
-
41
-
-
80053900941
-
Frequent pathway mutations of splicing machinery in myelodysplasia
-
Yoshida K., Sanada M., Shiraishi Y., Nowak D., Nagata Y., Yamamoto R., et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011, 478:64-69.
-
(2011)
Nature
, vol.478
, pp. 64-69
-
-
Yoshida, K.1
Sanada, M.2
Shiraishi, Y.3
Nowak, D.4
Nagata, Y.5
Yamamoto, R.6
-
42
-
-
84861082246
-
Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome
-
Zhang S.J., Rampal R., Manshouri T., Patel J., Mensah N., Kayserian A., et al. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Blood 2012, 119:4480-4485.
-
(2012)
Blood
, vol.119
, pp. 4480-4485
-
-
Zhang, S.J.1
Rampal, R.2
Manshouri, T.3
Patel, J.4
Mensah, N.5
Kayserian, A.6
|