Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

Nature Genetics

Volumn 44, Issue 11, 2012, Pages 1179-1181

  Busque, Lambert ^a,b   Patel, Jay P ^c   Figueroa, Maria E ^d   Vasanthakumar, Aparna ^e   Provost, Sylvie ^f   Hamilou, Zineb ^a,b   Mollica, Luigina ^a,b   Li, Juan ^c   Viale, Agnes ^c   Heguy, Adriana ^c   Hassimi, Maryam ^c   Socci, Nicholas ^c   Bhatt, Parva K ^c   Gonen, Mithat ^c   Mason, Christopher E ^g,h   Melnick, Ari ^g,h   Godley, Lucy A ^e   Brennan, Cameron W ^c   Abdel Wahab, Omar ^c   Levine, Ross L ^c,h  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f MONTREAL HEART INSTITUTE   (Canada)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ARTICLE; CATALYSIS; CELL EXPANSION; CELL RENEWAL; CHROMOSOME ANALYSIS; DNA METHYLATION; EPITHELIUM CELL; EXOME; FEMALE; GENE; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HYDROXYLATION; MAJOR CLINICAL STUDY; PHENOTYPE; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; SOMATIC MUTATION; TET2 MUTATION; X CHROMOSOME INACTIVATION;

5-METHYLCYTOSINE; AGING; DNA METHYLATION; DNA-BINDING PROTEINS; EXOME; FEMALE; HEMATOPOIESIS; HUMANS; PROTO-ONCOGENE PROTEINS; X CHROMOSOME INACTIVATION;

EID: 84868208186     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2413     Document Type: Article

References (13)

1. Beerman, I., Maloney, W.J., Weissmann, I.L. & Rossi, D.J. Curr. Opin. Immunol. 22, 500-506 (2010).
2. Beerman, I. et al. Proc. Natl. Acad. Sci. USA 107, 5465-5470 (2010).
3. Busque, L. et al. Blood 88, 59 (1996).
4. Gale, R.E., Fielding, A.K., Harrison, C.N. & Linch, D.C. Br. J. Haematol. 98, 512-519 (1997).
5. Busque, L. & Gilliland, D.G. Leukemia 12, 128-135 (1998).
6. Delhommeau, F. et al. N. Engl. J. Med. 360, 2289-2301 (2009).
7. Moran-Crusio, K. et al. Cancer Cell 20, 11-24 (2011).
8. Quivoron, C. et al. Cancer Cell 20, 25-38 (2011).
9. Li, Z. et al. Blood 118, 4509-4518 (2011).
10. Ko, M. et al. Proc. Natl. Acad. Sci. USA 108, 14566-14571 (2011).
11. Tefferi, A. et al. Leukemia 23, 905-911 (2009).
12. Ko, M. et al. Nature 468, 839-843 (2010).
13. Figueroa, M.E. et al. Cancer Cell 18, 553-567 (2010).